| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.239775 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.19072 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.16801 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.152115 |
| CD44 | CD44 molecule (Indian blood group) | 0.0978296 |
| MT2A | metallothionein 2A | 0.0940379 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0823249 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0739258 |
| MKI67 | marker of proliferation Ki-67 | 0.0736424 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0725974 |
| RUNX1 | runt-related transcription factor 1 | 0.0668555 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0648886 |
| CENPF | centromere protein F, 350/400kDa | 0.0593119 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.059245 |
| TPM3 | tropomyosin 3 | 0.0572806 |
| STC1 | stanniocalcin 1 | 0.0508128 |
| DST | dystonin | 0.0486308 |
| EFNA5 | ephrin-A5 | 0.0466295 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0441211 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0426328 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0418917 |
| HLA-B | major histocompatibility complex, class I, B | 0.0405122 |
| B2M | beta-2-microglobulin | 0.0402618 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0389925 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0377807 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.037273 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.035682 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0355223 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0352797 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0350444 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0349906 |
| LDHA | lactate dehydrogenase A | 0.0347324 |
| SVIL | supervillin | 0.0324713 |
| SEPTIN9 | septin 9 | 0.0323268 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0320654 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0320411 |
| PODXL | podocalyxin-like | 0.0316123 |
| FAT1 | FAT atypical cadherin 1 | 0.0312884 |
| KIF5B | kinesin family member 5B | 0.030637 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0300728 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0300491 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0297897 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0296558 |
| EZR | ezrin | 0.029393 |
| MYADM | myeloid-associated differentiation marker | 0.0293915 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0293613 |
| EGR1 | early growth response 1 | 0.0288871 |
| ENO1 | enolase 1, (alpha) | 0.0283259 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0282936 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.028147 |
| RAI14 | retinoic acid induced 14 | 0.0280176 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0274871 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0273559 |
| KATNAL1 | katanin p60 subunit A-like 1 | 0.0270316 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0270229 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0269462 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0269322 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0267638 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0263191 |
| MX2 | MX dynamin-like GTPase 2 | 0.026178 |
| GLIS3 | GLIS family zinc finger 3 | 0.0261392 |
| RPS6 | ribosomal protein S6 | 0.0258002 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0257443 |
| SMAD3 | SMAD family member 3 | 0.0251391 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0251328 |
| MB21D2 | Mab-21 domain containing 2 | 0.024996 |
| SET | SET nuclear proto-oncogene | 0.024923 |
| KLF6 | Kruppel-like factor 6 | 0.0242595 |
| TLN1 | talin 1 | 0.0241967 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0239708 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0237399 |
| DSPP | dentin sialophosphoprotein | 0.0236518 |
| RPS3 | ribosomal protein S3 | 0.0235941 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0233347 |
| VMP1 | vacuole membrane protein 1 | 0.0231834 |
| SYTL3 | synaptotagmin-like 3 | 0.0228683 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0226034 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0224961 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0219678 |
| ANO6 | anoctamin 6 | 0.021729 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0216382 |
| TXNIP | thioredoxin interacting protein | 0.0215072 |
| YBX1 | Y box binding protein 1 | 0.0213625 |
| DNMBP | dynamin binding protein | 0.0210977 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0208824 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0208239 |
| NMNAT2 | nicotinamide nucleotide adenylyltransferase 2 | 0.0208156 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0203835 |
| PLXNA2 | plexin A2 | 0.0203112 |
| TPR | translocated promoter region, nuclear basket protein | 0.0200246 |
| CEP170 | centrosomal protein 170kDa | 0.0199378 |
| FLNB | filamin B, beta | 0.0198135 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0197403 |
| ANLN | anillin, actin binding protein | 0.0197186 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0196758 |
| RPL23 | ribosomal protein L23 | 0.0195584 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0194581 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | 0.0193816 |
| ENAH | enabled homolog (Drosophila) | 0.019114 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0190857 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.185308 |
| AHNAK | AHNAK nucleoprotein | -0.141334 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.132735 |
| TMSB10 | thymosin beta 10 | -0.120245 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0869932 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0814602 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0805562 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0766695 |
| S100A6 | S100 calcium binding protein A6 | -0.0746468 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0652701 |
| S100A10 | S100 calcium binding protein A10 | -0.0642772 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0612272 |
| LMNA | lamin A/C | -0.0596476 |
| FBN1 | fibrillin 1 | -0.0590836 |
| COL1A2 | collagen, type I, alpha 2 | -0.0581756 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0565351 |
| AUTS2 | autism susceptibility candidate 2 | -0.0553909 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0553174 |
| CSTB | cystatin B (stefin B) | -0.0539014 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.052925 |
| MSI2 | musashi RNA-binding protein 2 | -0.0506382 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0503656 |
| SUCNR1 | succinate receptor 1 | -0.048807 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0487329 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0484848 |
| UBC | ubiquitin C | -0.0484799 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0466809 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.044099 |
| S100A4 | S100 calcium binding protein A4 | -0.0431169 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0424968 |
| CANX | calnexin | -0.0400904 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0398814 |
| COPA | coatomer protein complex, subunit alpha | -0.0394766 |
| KRT81 | keratin 81, type II | -0.0380501 |
| ACTG1 | actin gamma 1 | -0.0379449 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0374994 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0372839 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0365103 |
| COL3A1 | collagen, type III, alpha 1 | -0.0348152 |
| CDH13 | cadherin 13 | -0.0341848 |
| POTEF | POTE ankyrin domain family, member F | -0.034053 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0334886 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0334644 |
| COL1A1 | collagen, type I, alpha 1 | -0.0333794 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0333145 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0332081 |
| TMEM263 | transmembrane protein 263 | -0.0331755 |
| FSTL1 | follistatin-like 1 | -0.0330836 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0325274 |
| CAVIN1 | caveolae associated protein 1 | -0.0323107 |
| RPS24 | ribosomal protein S24 | -0.0318271 |
| VIM | vimentin | -0.0314543 |
| TAGLN2 | transgelin 2 | -0.0307966 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0307264 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0304427 |
| MAP1B | microtubule-associated protein 1B | -0.0303176 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0303134 |
| PRSS23 | protease, serine, 23 | -0.0293179 |
| PTMA | prothymosin, alpha | -0.0292149 |
| TMSB4X | thymosin beta 4, X-linked | -0.0282631 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0281138 |
| FNIP1 | folliculin interacting protein 1 | -0.0280652 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0277819 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0275865 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0275206 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0266758 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0260045 |
| CCND1 | cyclin D1 | -0.0259116 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0258726 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0257443 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0255851 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0250043 |
| TUBB | tubulin, beta class I | -0.0244465 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0240656 |
| CD109 | CD109 molecule | -0.0238369 |
| SPAG9 | sperm associated antigen 9 | -0.0236603 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0235441 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0233105 |
| INSIG1 | insulin induced gene 1 | -0.0231636 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.02316 |
| OGA | O-GlcNAcase | -0.0229801 |
| H3-3B | H3.3 histone B | -0.022288 |
| RND3 | Rho family GTPase 3 | -0.0222668 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0222297 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0220406 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0220201 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0217936 |
| TAOK1 | TAO kinase 1 | -0.0215088 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.0214041 |
| RASAL2 | RAS protein activator like 2 | -0.0213326 |
| CD99 | CD99 molecule | -0.0211869 |
| RPS15 | ribosomal protein S15 | -0.0210333 |
| MT1X | metallothionein 1X | -0.0210319 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0209302 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0205454 |
| INTS6 | integrator complex subunit 6 | -0.0205424 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0205377 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0203724 |
| SRPK2 | SRSF protein kinase 2 | -0.0202815 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.020068 |
