| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | 0.13801 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.123562 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.112067 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.109007 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0986604 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0893933 |
| PFN1 | profilin 1 | 0.0736441 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.063955 |
| YBX3 | Y box binding protein 3 | 0.0635165 |
| PCDH7 | protocadherin 7 | 0.0622422 |
| DST | dystonin | 0.0589497 |
| MKI67 | marker of proliferation Ki-67 | 0.0579857 |
| EGR1 | early growth response 1 | 0.0579375 |
| PDGFC | platelet derived growth factor C | 0.0559194 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0515547 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0477059 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0434284 |
| MAP1B | microtubule-associated protein 1B | 0.0421229 |
| MMP12 | matrix metallopeptidase 12 | 0.0417011 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0411322 |
| HMGA2 | high mobility group AT-hook 2 | 0.0409828 |
| CENPF | centromere protein F, 350/400kDa | 0.0408158 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0397714 |
| HMGA1 | high mobility group AT-hook 1 | 0.0365687 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0361248 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0356691 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0351183 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0346658 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0341544 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0336436 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0332578 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0331943 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0324426 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0323331 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0322953 |
| KLF6 | Kruppel-like factor 6 | 0.0320375 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.030829 |
| TPM3 | tropomyosin 3 | 0.0299683 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0298425 |
| RPS6 | ribosomal protein S6 | 0.0290343 |
| RASAL2 | RAS protein activator like 2 | 0.0288609 |
| PTMS | parathymosin | 0.0287796 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0285179 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0283136 |
| TMEM41B | transmembrane protein 41B | 0.0279 |
| TPI1 | triosephosphate isomerase 1 | 0.0276184 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0274507 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0272034 |
| RPS2 | ribosomal protein S2 | 0.0270936 |
| BCHE | butyrylcholinesterase | 0.026778 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0265148 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.026085 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.0239321 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0238722 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0234589 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0234111 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0233868 |
| JMJD1C | jumonji domain containing 1C | 0.0233551 |
| EZR | ezrin | 0.0233544 |
| RPL12 | ribosomal protein L12 | 0.023147 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.022614 |
| MAP4 | microtubule-associated protein 4 | 0.0225959 |
| DSG2 | desmoglein 2 | 0.0222065 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0219401 |
| TMSB10 | thymosin beta 10 | 0.0217568 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | 0.0217296 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0217152 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0216571 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0215225 |
| CCDC88A | coiled-coil domain containing 88A | 0.0213493 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0213178 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0213097 |
| ANXA1 | annexin A1 | 0.020743 |
| RPS19 | ribosomal protein S19 | 0.0207284 |
| ETV6 | ets variant 6 | 0.0205577 |
| S100A11 | S100 calcium binding protein A11 | 0.0205454 |
| MYADM | myeloid-associated differentiation marker | 0.0203181 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0202274 |
| FASN | fatty acid synthase | 0.0202003 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0200133 |
| CALR | calreticulin | 0.0199945 |
| EXOC4 | exocyst complex component 4 | 0.0196934 |
| EGFR | epidermal growth factor receptor | 0.0190246 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0188925 |
| CMIP | c-Maf inducing protein | 0.0187764 |
| TXNRD1 | thioredoxin reductase 1 | 0.0186157 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.018554 |
| ANK2 | ankyrin 2, neuronal | 0.0183162 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0182771 |
| KIF18B | kinesin family member 18B | 0.0180932 |
| YBX1 | Y box binding protein 1 | 0.017844 |
| RPS26 | ribosomal protein S26 | 0.0177318 |
| IPO7 | importin 7 | 0.0175387 |
| PRDX1 | peroxiredoxin 1 | 0.0173042 |
| RPS12 | ribosomal protein S12 | 0.0171725 |
| EFNA5 | ephrin-A5 | 0.0171001 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0170443 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0169956 |
| PCBP1 | poly(rC) binding protein 1 | 0.0169952 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0168821 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.204344 |
| RPS27A | ribosomal protein S27a | -0.0810373 |
| AREG | amphiregulin | -0.080056 |
| VIM | vimentin | -0.0713691 |
| UBC | ubiquitin C | -0.0693401 |
| PTMA | prothymosin, alpha | -0.0564965 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.050782 |
| AHNAK | AHNAK nucleoprotein | -0.0498782 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0491716 |
| PCBP2 | poly(rC) binding protein 2 | -0.0469238 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0463115 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0435082 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0412109 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0410906 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0380208 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0377159 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0374539 |
| ACTG1 | actin gamma 1 | -0.0365612 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0344135 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0333306 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0326379 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0306587 |
| USP34 | ubiquitin specific peptidase 34 | -0.0303803 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0301173 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0299041 |
| FBXO11 | F-box protein 11 | -0.0298046 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0289783 |
| INTS6 | integrator complex subunit 6 | -0.0289134 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0289071 |
| LRRC23 | leucine rich repeat containing 23 | -0.0289028 |
| RPS24 | ribosomal protein S24 | -0.0284486 |
| RPL38 | ribosomal protein L38 | -0.0284315 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.028394 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0282947 |
| MED13 | mediator complex subunit 13 | -0.0280974 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0279456 |
| NF1 | neurofibromin 1 | -0.0279024 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0276818 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0274175 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0273757 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0256514 |
| CPOX | coproporphyrinogen oxidase | -0.0253629 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0252093 |
| RRM2 | ribonucleotide reductase M2 | -0.0250143 |
| VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) | -0.024699 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0246102 |
| RPS11 | ribosomal protein S11 | -0.0245616 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0245515 |
| RPS13 | ribosomal protein S13 | -0.0243359 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0242869 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0240948 |
| ASPH | aspartate beta-hydroxylase | -0.0238919 |
| MED13L | mediator complex subunit 13-like | -0.0233837 |
| FUS | FUS RNA binding protein | -0.0231409 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.022986 |
| ZNF292 | zinc finger protein 292 | -0.0227384 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.022696 |
| WDR45B | WD repeat domain 45B | -0.0226653 |
| ECT2 | epithelial cell transforming 2 | -0.0223013 |
| RPS29 | ribosomal protein S29 | -0.0220736 |
| TFG | TRK-fused gene | -0.0219977 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.021943 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0218628 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0216665 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0216013 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0214881 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0214059 |
| CEP192 | centrosomal protein 192kDa | -0.0201346 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0200352 |
| ZNF638 | zinc finger protein 638 | -0.0199698 |
| ADIPOR2 | adiponectin receptor 2 | -0.0197909 |
| WDR26 | WD repeat domain 26 | -0.0196579 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0194785 |
| NCOA1 | nuclear receptor coactivator 1 | -0.019441 |
| AXIN2 | axin 2 | -0.0194153 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0193347 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0193209 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0192959 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0190972 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.019 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0188594 |
| ZNF207 | zinc finger protein 207 | -0.0185106 |
| RYK | receptor-like tyrosine kinase | -0.0185016 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0184223 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0183902 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0180057 |
| SMC4 | structural maintenance of chromosomes 4 | -0.017986 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0179074 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0178594 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0178257 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0177338 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0177142 |
| CAVIN1 | caveolae associated protein 1 | -0.0175439 |
| RPS23 | ribosomal protein S23 | -0.0174967 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0174895 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0174619 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0174265 |
| RPS15 | ribosomal protein S15 | -0.0171465 |
| RPL31 | ribosomal protein L31 | -0.0171053 |
| ELP4 | elongator acetyltransferase complex subunit 4 | -0.0170852 |
