| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.263207 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.103717 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0787246 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0773947 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0621155 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0557812 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0557808 |
| APP | amyloid beta (A4) precursor protein | 0.050426 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0498973 |
| MAP1B | microtubule-associated protein 1B | 0.0444927 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0437058 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0423035 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0414929 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0405979 |
| VEGFA | vascular endothelial growth factor A | 0.0400483 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0398518 |
| KLHL13 | kelch-like family member 13 | 0.0396493 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0394142 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0391629 |
| NDRG1 | N-myc downstream regulated 1 | 0.0386905 |
| RUNX1 | runt-related transcription factor 1 | 0.0378442 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0377749 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0375428 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0367971 |
| MEIS2 | Meis homeobox 2 | 0.0362184 |
| PHF21A | PHD finger protein 21A | 0.0359027 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0352956 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0338279 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | 0.033685 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0334095 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.0322494 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0321849 |
| PCDH7 | protocadherin 7 | 0.0320313 |
| DNMBP | dynamin binding protein | 0.0319179 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0315793 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | 0.0313688 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0312729 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.0311511 |
| ANO6 | anoctamin 6 | 0.0307584 |
| FLT1 | fms-related tyrosine kinase 1 | 0.0306147 |
| RPL23 | ribosomal protein L23 | 0.0305595 |
| ZNF521 | zinc finger protein 521 | 0.0301884 |
| TMF1 | TATA element modulatory factor 1 | 0.030103 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0295552 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0292883 |
| ASPH | aspartate beta-hydroxylase | 0.029053 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | 0.0289693 |
| SEPTIN9 | septin 9 | 0.0289499 |
| FAM13A | family with sequence similarity 13, member A | 0.0286646 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0280565 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0280097 |
| TXNRD1 | thioredoxin reductase 1 | 0.0276559 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.027534 |
| EFNA5 | ephrin-A5 | 0.0274711 |
| QKI | QKI, KH domain containing, RNA binding | 0.0273945 |
| RPS3 | ribosomal protein S3 | 0.0271116 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0269221 |
| DPH6 | diphthamine biosynthesis 6 | 0.0263546 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0256701 |
| GOLGB1 | golgin B1 | 0.0256491 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0254695 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0254019 |
| ATRNL1 | attractin-like 1 | 0.0254011 |
| TBC1D19 | TBC1 domain family, member 19 | 0.0253571 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.025196 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0251469 |
| PLAT | plasminogen activator, tissue | 0.0247792 |
| RPL36 | ribosomal protein L36 | 0.0247118 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0246184 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0245729 |
| RPL34 | ribosomal protein L34 | 0.0242938 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0242756 |
| CTBP2 | C-terminal binding protein 2 | 0.0242384 |
| POU2F1 | POU class 2 homeobox 1 | 0.0241863 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0241399 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0238589 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0238404 |
| GPC5 | glypican 5 | 0.0237193 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0236648 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0236174 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.023599 |
| TBC1D4 | TBC1 domain family, member 4 | 0.0235487 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0234865 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0234682 |
| HMGA1 | high mobility group AT-hook 1 | 0.0234099 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0228554 |
| GPHN | gephyrin | 0.0228527 |
| SYT1 | synaptotagmin I | 0.0228457 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0227293 |
| NEK1 | NIMA-related kinase 1 | 0.0227104 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0222361 |
| C14ORF132 | chromosome 14 open reading frame 132 | 0.0222184 |
| EMC10 | ER membrane protein complex subunit 10 | 0.0217892 |
| ANGPT1 | angiopoietin 1 | 0.0217148 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0217126 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0216948 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0216944 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.0215698 |
| TDRD3 | tudor domain containing 3 | 0.0214747 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0214402 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | -0.17505 |
| NRG1 | neuregulin 1 | -0.115602 |
| LSAMP | limbic system-associated membrane protein | -0.0881616 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0767258 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0614776 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0613748 |
| TPM1 | tropomyosin 1 (alpha) | -0.0562746 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0471991 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0470243 |
| COL1A1 | collagen, type I, alpha 1 | -0.0457334 |
| STK38L | serine/threonine kinase 38 like | -0.0448778 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0417853 |
| ACTG1 | actin gamma 1 | -0.0417548 |
| EGR1 | early growth response 1 | -0.0405889 |
| CENPF | centromere protein F, 350/400kDa | -0.0404501 |
| FMN1 | formin 1 | -0.0367887 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0367065 |
| TLE4 | transducin-like enhancer of split 4 | -0.0358804 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0352433 |
| RPL38 | ribosomal protein L38 | -0.0352293 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0352052 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0346155 |
| FRMD4A | FERM domain containing 4A | -0.034573 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0333918 |
| TPM4 | tropomyosin 4 | -0.0329945 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0311057 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0299822 |
| CUX1 | cut-like homeobox 1 | -0.0283906 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0271631 |
| FNBP4 | formin binding protein 4 | -0.0270281 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0268953 |
| CCDC47 | coiled-coil domain containing 47 | -0.0267985 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0266703 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0265921 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0262406 |
| PCDH9 | protocadherin 9 | -0.0252513 |
| CADM1 | cell adhesion molecule 1 | -0.0251919 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | -0.0248437 |
| SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | -0.0243491 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0243065 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0239735 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0238099 |
| MED13 | mediator complex subunit 13 | -0.02363 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0235098 |
| SEM1 | SEM1 26S proteasome subunit | -0.0235067 |
| TRIB2 | tribbles pseudokinase 2 | -0.0234271 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.0233443 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.023321 |
| ADAR | adenosine deaminase, RNA-specific | -0.0229862 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0227337 |
| ANKRD50 | ankyrin repeat domain 50 | -0.0224953 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0224659 |
| RNF213 | ring finger protein 213 | -0.0221603 |
| RPS23 | ribosomal protein S23 | -0.0221343 |
| IER3 | immediate early response 3 | -0.0220483 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0220396 |
| ASL | argininosuccinate lyase | -0.0220182 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0219689 |
| RGS5 | regulator of G-protein signaling 5 | -0.0218365 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0216599 |
| FERMT2 | fermitin family member 2 | -0.0216497 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0215292 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.0212799 |
| KIF5B | kinesin family member 5B | -0.0212396 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0208897 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0205397 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0203902 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0201237 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0200224 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0199396 |
| CDK19 | cyclin-dependent kinase 19 | -0.0199282 |
| ARF4 | ADP-ribosylation factor 4 | -0.0198936 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0198451 |
| SQSTM1 | sequestosome 1 | -0.0197587 |
| CREB1 | cAMP responsive element binding protein 1 | -0.019758 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0196962 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0194759 |
| RPL13A | ribosomal protein L13a | -0.0194746 |
| ZNF33B | zinc finger protein 33B | -0.0192959 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0192709 |
| ATE1 | arginyltransferase 1 | -0.0192576 |
| SP100 | SP100 nuclear antigen | -0.0191601 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.0190185 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0188399 |
| CNTN4 | contactin 4 | -0.0188318 |
| SPAG9 | sperm associated antigen 9 | -0.0187905 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0187574 |
| RAD51B | RAD51 paralog B | -0.0185939 |
| RCOR3 | REST corepressor 3 | -0.018468 |
| RAB21 | RAB21, member RAS oncogene family | -0.0183873 |
| SEC24D | SEC24 family member D | -0.0183861 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.0183629 |
| CUL3 | cullin 3 | -0.0183611 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0183492 |
| MT2A | metallothionein 2A | -0.0181388 |
| SDCBP | syndecan binding protein (syntenin) | -0.0180871 |
| DNM1L | dynamin 1-like | -0.0180837 |
| S100A9 | S100 calcium binding protein A9 | -0.0180294 |
| CDK14 | cyclin-dependent kinase 14 | -0.0179144 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.0178717 |
