| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0995499 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0666462 |
| LCN2 | lipocalin 2 | 0.066421 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0658812 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0602832 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0466018 |
| RUNX1 | runt-related transcription factor 1 | 0.0383985 |
| SMAD3 | SMAD family member 3 | 0.0370767 |
| VMP1 | vacuole membrane protein 1 | 0.0367261 |
| ATP11A | ATPase, class VI, type 11A | 0.0362491 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0361839 |
| MEIS2 | Meis homeobox 2 | 0.035718 |
| TRERF1 | transcriptional regulating factor 1 | 0.0331177 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0319633 |
| FAT1 | FAT atypical cadherin 1 | 0.0307473 |
| MYO1E | myosin IE | 0.0301016 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0297503 |
| RAD51B | RAD51 paralog B | 0.0294746 |
| IL20RA | interleukin 20 receptor, alpha | 0.0291411 |
| BMP4 | bone morphogenetic protein 4 | 0.0286339 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0284643 |
| TRIM2 | tripartite motif containing 2 | 0.0284599 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0282623 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0281701 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0281594 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0278455 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0274466 |
| PROX1 | prospero homeobox 1 | 0.0264925 |
| YAP1 | Yes-associated protein 1 | 0.0263983 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.02618 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0247246 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.023783 |
| VEGFA | vascular endothelial growth factor A | 0.0233518 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0223899 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0218653 |
| OCLN | occludin | 0.0212388 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0212005 |
| EFNB2 | ephrin-B2 | 0.0211265 |
| SEPTIN9 | septin 9 | 0.0210021 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0208432 |
| EHF | ets homologous factor | 0.0205555 |
| RNF43 | ring finger protein 43 | 0.0203011 |
| EREG | epiregulin | 0.0198186 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0197451 |
| IFNGR1 | interferon gamma receptor 1 | 0.0193754 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0192765 |
| ENO1 | enolase 1, (alpha) | 0.0188915 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0188706 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.018794 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0186696 |
| NCOR2 | nuclear receptor corepressor 2 | 0.018498 |
| KYNU | kynureninase | 0.018278 |
| TPM3 | tropomyosin 3 | 0.0182431 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0180022 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0178044 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0175209 |
| TXNRD1 | thioredoxin reductase 1 | 0.0174275 |
| ASPH | aspartate beta-hydroxylase | 0.017201 |
| TMC5 | transmembrane channel-like 5 | 0.0171215 |
| ATP10B | ATPase, class V, type 10B | 0.0168716 |
| AOPEP | aminopeptidase O (putative) | 0.016815 |
| FOXP1 | forkhead box P1 | 0.0166038 |
| ANXA1 | annexin A1 | 0.0165631 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0164817 |
| RBM26 | RNA binding motif protein 26 | 0.0163328 |
| CD68 | CD68 molecule | 0.0162886 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0160952 |
| ETV6 | ets variant 6 | 0.0160364 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0158453 |
| PDZD8 | PDZ domain containing 8 | 0.0155936 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0155407 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0155223 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0155181 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | 0.0153226 |
| TNS4 | tensin 4 | 0.015277 |
| PER2 | period circadian clock 2 | 0.0149808 |
| DST | dystonin | 0.014958 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0149368 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0149315 |
| ZNRF3 | zinc and ring finger 3 | 0.0146337 |
| SLK | STE20-like kinase | 0.0146284 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0145425 |
| JADE2 | jade family PHD finger 2 | 0.0143633 |
| FRK | fyn-related Src family tyrosine kinase | 0.0142984 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0142778 |
| WWOX | WW domain containing oxidoreductase | 0.0141837 |
| CCNL1 | cyclin L1 | 0.0140541 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0137839 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0136776 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0136603 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0133176 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0131852 |
| TOX3 | TOX high mobility group box family member 3 | 0.0129329 |
| UTRN | utrophin | 0.0128753 |
| LMO7 | LIM domain 7 | 0.0128172 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0127883 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0127822 |
| TMEM51 | transmembrane protein 51 | 0.0127583 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0127392 |
| RGS6 | regulator of G-protein signaling 6 | 0.012645 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.242604 |
| PTMA | prothymosin, alpha | -0.106592 |
| SQSTM1 | sequestosome 1 | -0.0942081 |
| LYZ | lysozyme | -0.0892574 |
| B2M | beta-2-microglobulin | -0.0833835 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0735313 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0729768 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0684886 |
| PERP | PERP, TP53 apoptosis effector | -0.067789 |
| RNF213 | ring finger protein 213 | -0.0657594 |
| ACTG1 | actin gamma 1 | -0.0571764 |
| ANXA2 | annexin A2 | -0.0557212 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0551723 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0525503 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0517502 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0511184 |
| FTL | ferritin, light polypeptide | -0.0501291 |
| AHI1 | Abelson helper integration site 1 | -0.0500724 |
| UBC | ubiquitin C | -0.0494742 |
| RIGI | RNA sensor RIG-I | -0.0487553 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.047771 |
| HLA-B | major histocompatibility complex, class I, B | -0.0477274 |
| MUC20 | mucin 20, cell surface associated | -0.045765 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0456297 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0456239 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0440732 |
| PHF3 | PHD finger protein 3 | -0.0430654 |
| XAF1 | XIAP associated factor 1 | -0.0425905 |
| RRBP1 | ribosome binding protein 1 | -0.0424527 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0423281 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0421437 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0415464 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0413215 |
| S100A6 | S100 calcium binding protein A6 | -0.0404175 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.040336 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0402151 |
| NPSR1 | neuropeptide S receptor 1 | -0.0397685 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0397222 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0393392 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0384703 |
| RPL34 | ribosomal protein L34 | -0.0378636 |
| SP100 | SP100 nuclear antigen | -0.0373858 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0372518 |
| EZR | ezrin | -0.0364582 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0364039 |
| SSH2 | slingshot protein phosphatase 2 | -0.035663 |
| IRS2 | insulin receptor substrate 2 | -0.0353758 |
| TFRC | transferrin receptor | -0.034686 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.034485 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0344563 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0342794 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0334149 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.033376 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | -0.0333532 |
| HLA-E | major histocompatibility complex, class I, E | -0.0333391 |
| EPCAM | epithelial cell adhesion molecule | -0.0330555 |
| RPL35A | ribosomal protein L35a | -0.0326066 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0321862 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0321205 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.031638 |
| FNIP1 | folliculin interacting protein 1 | -0.0313865 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0312376 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0311613 |
| AHNAK | AHNAK nucleoprotein | -0.030723 |
| RPL31 | ribosomal protein L31 | -0.0306584 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0306568 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0300013 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0298656 |
| SPATA13 | spermatogenesis associated 13 | -0.029808 |
| HLA-C | major histocompatibility complex, class I, C | -0.0292009 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0291773 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0291177 |
| IER3 | immediate early response 3 | -0.0290625 |
| CANX | calnexin | -0.0290097 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | -0.0288693 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0286994 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0286794 |
| GOLGB1 | golgin B1 | -0.0286733 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0285723 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0285407 |
| RPL37A | ribosomal protein L37a | -0.028278 |
| HLA-A | major histocompatibility complex, class I, A | -0.0279099 |
| RPS24 | ribosomal protein S24 | -0.0278501 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0275528 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0275028 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0272992 |
| HDLBP | high density lipoprotein binding protein | -0.0270115 |
| PLSCR1 | phospholipid scramblase 1 | -0.0269175 |
| VCL | vinculin | -0.0268775 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0268007 |
| TMEM87A | transmembrane protein 87A | -0.0265617 |
| PGK1 | phosphoglycerate kinase 1 | -0.0265546 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0264148 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0263507 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.02608 |
| H3-3B | H3.3 histone B | -0.0259985 |
| USP53 | ubiquitin specific peptidase 53 | -0.0259455 |
| RBM39 | RNA binding motif protein 39 | -0.0256523 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0256225 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0254364 |
