| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.229176 |
| MT2A | metallothionein 2A | 0.136728 |
| FN1 | fibronectin 1 | 0.103918 |
| VEGFA | vascular endothelial growth factor A | 0.0994423 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0936211 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0840964 |
| CD44 | CD44 molecule (Indian blood group) | 0.0825592 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0789596 |
| ENO1 | enolase 1, (alpha) | 0.0757821 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0691371 |
| TMSB10 | thymosin beta 10 | 0.0667053 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0560602 |
| CALR | calreticulin | 0.0558306 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0549728 |
| STC1 | stanniocalcin 1 | 0.0510361 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0492264 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0458216 |
| B2M | beta-2-microglobulin | 0.0451807 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0442613 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0425144 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0422429 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0409052 |
| S100A9 | S100 calcium binding protein A9 | 0.0404243 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0402243 |
| RIGI | RNA sensor RIG-I | 0.0398278 |
| YBX1 | Y box binding protein 1 | 0.0377895 |
| HLA-B | major histocompatibility complex, class I, B | 0.0371355 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0364869 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0358778 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0358636 |
| PFN1 | profilin 1 | 0.0354018 |
| MKI67 | marker of proliferation Ki-67 | 0.0346919 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.033538 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0334554 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0325381 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0322014 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0314591 |
| CFB | complement factor B | 0.0311153 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0309958 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0295716 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0293357 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0292284 |
| SP100 | SP100 nuclear antigen | 0.0290664 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0289606 |
| RPL23 | ribosomal protein L23 | 0.0287942 |
| VMP1 | vacuole membrane protein 1 | 0.0285982 |
| HAS2 | hyaluronan synthase 2 | 0.0285068 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0283868 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0282787 |
| MX2 | MX dynamin-like GTPase 2 | 0.0278693 |
| PLSCR1 | phospholipid scramblase 1 | 0.0268543 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0265595 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0262786 |
| CENPF | centromere protein F, 350/400kDa | 0.0262499 |
| SULF1 | sulfatase 1 | 0.0261854 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0260048 |
| HSPA8 | heat shock 70kDa protein 8 | 0.025994 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0249964 |
| HMGA1 | high mobility group AT-hook 1 | 0.024901 |
| IL6ST | interleukin 6 signal transducer | 0.0247254 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0244403 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0243626 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | 0.0241931 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0241311 |
| RPL36 | ribosomal protein L36 | 0.0239238 |
| RND3 | Rho family GTPase 3 | 0.0238337 |
| FOXP1 | forkhead box P1 | 0.0236222 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0232716 |
| SETBP1 | SET binding protein 1 | 0.0231009 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0230278 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0228633 |
| NRP1 | neuropilin 1 | 0.0227603 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0223825 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0223759 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0220625 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0214802 |
| OSMR | oncostatin M receptor | 0.0212851 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0212544 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0210568 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.020986 |
| IFI44L | interferon-induced protein 44-like | 0.0204587 |
| BRD2 | bromodomain containing 2 | 0.0203371 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 0.0200643 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0197283 |
| MSN | moesin | 0.019684 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0195416 |
| LDHA | lactate dehydrogenase A | 0.01947 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0193342 |
| EHBP1 | EH domain binding protein 1 | 0.0192417 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0192227 |
| SON | SON DNA binding protein | 0.0189828 |
| EFNA5 | ephrin-A5 | 0.0189221 |
| EGR1 | early growth response 1 | 0.0188075 |
| SMAD3 | SMAD family member 3 | 0.0185966 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0185578 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0185197 |
| ASPH | aspartate beta-hydroxylase | 0.0181502 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0180798 |
| STC2 | stanniocalcin 2 | 0.0180397 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0180305 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.195841 |
| COL1A2 | collagen, type I, alpha 2 | -0.0957201 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0907984 |
| TPM4 | tropomyosin 4 | -0.0858808 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0773287 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0715539 |
| IER3 | immediate early response 3 | -0.071341 |
| ATP13A3 | ATPase type 13A3 | -0.0646283 |
| LOX | lysyl oxidase | -0.0595535 |
| CALU | calumenin | -0.0591989 |
| AHNAK | AHNAK nucleoprotein | -0.048628 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0474872 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0468183 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0467121 |
| PDE10A | phosphodiesterase 10A | -0.0453312 |
| CAVIN1 | caveolae associated protein 1 | -0.0440725 |
| CLIC4 | chloride intracellular channel 4 | -0.0440688 |
| TMEM165 | transmembrane protein 165 | -0.0431423 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0420236 |
| CADM1 | cell adhesion molecule 1 | -0.0391691 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0383054 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0377436 |
| ANXA2 | annexin A2 | -0.0375748 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0359461 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0353509 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0350253 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0346401 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0340116 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0334835 |
| SBF2 | SET binding factor 2 | -0.0333709 |
| EXT1 | exostosin glycosyltransferase 1 | -0.031849 |
| NDRG1 | N-myc downstream regulated 1 | -0.0312229 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0309578 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0308322 |
| PRR16 | proline rich 16 | -0.0305418 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0302592 |
| RTN4 | reticulon 4 | -0.0295869 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0287005 |
| LOXL2 | lysyl oxidase-like 2 | -0.0286764 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0283304 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0282557 |
| CALD1 | caldesmon 1 | -0.027767 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0270421 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0270286 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0266853 |
| RLF | rearranged L-myc fusion | -0.0261548 |
| PRELID2 | PRELI domain containing 2 | -0.0259389 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0255756 |
| PRRC1 | proline-rich coiled-coil 1 | -0.025471 |
| FBN1 | fibrillin 1 | -0.0254678 |
| TMEM39A | transmembrane protein 39A | -0.0250365 |
| VCL | vinculin | -0.0250062 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0247364 |
| KIAA1217 | KIAA1217 | -0.0246557 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0245859 |
| SEC24D | SEC24 family member D | -0.0244179 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.024303 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0241798 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0240494 |
| COG5 | component of oligomeric golgi complex 5 | -0.0239022 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0237311 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0237306 |
| CLINT1 | clathrin interactor 1 | -0.0237045 |
| SEC24A | SEC24 family member A | -0.0236104 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.0235484 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0235223 |
| TMEM263 | transmembrane protein 263 | -0.0225595 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0223795 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0223307 |
| LMAN1 | lectin, mannose-binding, 1 | -0.022299 |
| CNTN5 | contactin 5 | -0.0222083 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0221894 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0221602 |
| GNAS | GNAS complex locus | -0.021951 |
| ITGAV | integrin, alpha V | -0.021679 |
| COL5A1 | collagen, type V, alpha 1 | -0.0215891 |
| TMEM41B | transmembrane protein 41B | -0.021491 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0214583 |
| UBC | ubiquitin C | -0.021401 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.021357 |
| MAP1B | microtubule-associated protein 1B | -0.0211992 |
| RRBP1 | ribosome binding protein 1 | -0.0210329 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0209965 |
| RHEB | Ras homolog enriched in brain | -0.0208224 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0206925 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0204391 |
| RNF121 | ring finger protein 121 | -0.0204175 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0203289 |
| TFG | TRK-fused gene | -0.0202993 |
| TMSB4X | thymosin beta 4, X-linked | -0.0200834 |
| CD109 | CD109 molecule | -0.0200529 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0200446 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0197922 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0197201 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.019712 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0195944 |
| USP3 | ubiquitin specific peptidase 3 | -0.0193921 |
| EVI5 | ecotropic viral integration site 5 | -0.0193149 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0188859 |
| RASA2 | RAS p21 protein activator 2 | -0.0186831 |
