Larotrectinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
APOB apolipoprotein B 0.175581
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.146045
AKAP12 A kinase (PRKA) anchor protein 12 0.133795
IGFBP1 insulin-like growth factor binding protein 1 0.115314
IGF2 insulin-like growth factor 2 0.114453
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.11358
SVIL supervillin 0.0892984
C3 complement component 3 0.0857216
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0742771
DSPP dentin sialophosphoprotein 0.0692994
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0667659
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0606567
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0580684
SAMD4A sterile alpha motif domain containing 4A 0.057054
MYH9 myosin, heavy chain 9, non-muscle 0.0534157
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0497897
RAI14 retinoic acid induced 14 0.0486096
NKD1 naked cuticle homolog 1 (Drosophila) 0.0479184
ERRFI1 ERBB receptor feedback inhibitor 1 0.0450948
MAML2 mastermind-like 2 (Drosophila) 0.0398156
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0397073
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0367283
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0354332
FAT1 FAT atypical cadherin 1 0.0349533
AFDN afadin, adherens junction formation factor 0.0336148
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0332192
TF transferrin 0.032669
BCL2L1 BCL2-like 1 0.0326504
NRIP1 nuclear receptor interacting protein 1 0.0323656
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0317917
VMP1 vacuole membrane protein 1 0.0317364
SMAD3 SMAD family member 3 0.03165
EEF2 eukaryotic translation elongation factor 2 0.0313381
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0303673
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0294244
WWTR1 WW domain containing transcription regulator 1 0.027811
KALRN kalirin, RhoGEF kinase 0.0271216
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0268342
LRMDA leucine rich melanocyte differentiation associated 0.026635
TPM1 tropomyosin 1 (alpha) 0.0263342
DNAH17 dynein, axonemal, heavy chain 17 0.0261234
MACF1 microtubule-actin crosslinking factor 1 0.0255869
FN1 fibronectin 1 0.0254061
YAP1 Yes-associated protein 1 0.0251927
CFB complement factor B 0.0247958
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0238257
ATP11A ATPase, class VI, type 11A 0.0235554
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0233143
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.023263
BAIAP2L1 BAI1-associated protein 2-like 1 0.0231904
EGR1 early growth response 1 0.02311
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0228304
ZMIZ1 zinc finger, MIZ-type containing 1 0.0225069
PTPRG protein tyrosine phosphatase, receptor type, G 0.0223998
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0223346
FOXO1 forkhead box O1 0.0222507
OSMR oncostatin M receptor 0.0221675
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0221344
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0218888
OSBPL10 oxysterol binding protein-like 10 0.0218278
ITGB5 integrin, beta 5 0.0208441
RPL3 ribosomal protein L3 0.0207867
UBASH3B ubiquitin associated and SH3 domain containing B 0.0205265
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0204091
ABTB3 ankyrin repeat and BTB domain containing 3 0.0195477
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0195272
ZFHX3 zinc finger homeobox 3 0.019286
A2M alpha-2-macroglobulin 0.0191407
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0190545
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0189025
RRBP1 ribosome binding protein 1 0.0188646
HSPA8 heat shock 70kDa protein 8 0.0188418
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0185162
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0183615
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0183608
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0180571
PEG10 paternally expressed 10 0.0180143
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.0179327
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0177543
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0175855
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0175531
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0172953
LRRC1 leucine rich repeat containing 1 0.0172169
EIF4B eukaryotic translation initiation factor 4B 0.0170478
AOPEP aminopeptidase O (putative) 0.0169807
MXRA7 matrix-remodelling associated 7 0.0169212
SCAF11 SR-related CTD-associated factor 11 0.016662
KIF5B kinesin family member 5B 0.0166207
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0163078
SRRM2 serine/arginine repetitive matrix 2 0.0162088
FNDC3A fibronectin type III domain containing 3A 0.0160779
DOCK5 dedicator of cytokinesis 5 0.0159687
CNKSR3 CNKSR family member 3 0.0157744
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0154552
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.0152514
ATXN7 ataxin 7 0.0152354
SLK STE20-like kinase 0.0148923
RNF43 ring finger protein 43 0.0148736
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.01487
BRD7 bromodomain containing 7 0.0147081

decreased expression

Symbol Name Standardized Value
APOA2 apolipoprotein A-II -0.210899
TPT1 tumor protein, translationally-controlled 1 -0.191027
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.139919
TMSB10 thymosin beta 10 -0.1038
RPS24 ribosomal protein S24 -0.0943914
TM4SF1 transmembrane 4 L six family member 1 -0.0874989
SLC38A2 solute carrier family 38, member 2 -0.0871981
GMDS GDP-mannose 4,6-dehydratase -0.0865337
VCL vinculin -0.085545
ASPH aspartate beta-hydroxylase -0.0835544
GPC3 glypican 3 -0.0726938
FNDC3B fibronectin type III domain containing 3B -0.0695288
AHSG alpha-2-HS-glycoprotein -0.0672569
CP ceruloplasmin (ferroxidase) -0.0646451
NDRG1 N-myc downstream regulated 1 -0.0616328
AMBP alpha-1-microglobulin/bikunin precursor -0.061236
EXT1 exostosin glycosyltransferase 1 -0.0609786
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0601546
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.059214
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0587935
MT2A metallothionein 2A -0.0574877
ENO1 enolase 1, (alpha) -0.0567427
HMGA1 high mobility group AT-hook 1 -0.0564037
PLIN2 perilipin 2 -0.053719
STAU1 staufen double-stranded RNA binding protein 1 -0.053463
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0516731
GPC6 glypican 6 -0.0516236
RPLP0 ribosomal protein, large, P0 -0.051117
UBC ubiquitin C -0.0511123
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0503055
RPS21 ribosomal protein S21 -0.0498454
RPL31 ribosomal protein L31 -0.0496647
RPS8 ribosomal protein S8 -0.0495801
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.049392
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0491138
NPR2 natriuretic peptide receptor 2 -0.0477873
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0473827
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0458439
APOE apolipoprotein E -0.0455433
RPL11 ribosomal protein L11 -0.045432
PERP PERP, TP53 apoptosis effector -0.044773
RPL37A ribosomal protein L37a -0.0445831
CPE carboxypeptidase E -0.0434789
RPL35A ribosomal protein L35a -0.0428469
RPL9 ribosomal protein L9 -0.0426776
TPM4 tropomyosin 4 -0.0419856
RPL34 ribosomal protein L34 -0.0418763
GNAS GNAS complex locus -0.0413547
ITGAV integrin, alpha V -0.0401814
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0398748
RPLP1 ribosomal protein, large, P1 -0.0395648
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0387936
FMNL2 formin-like 2 -0.0384538
RAB1A RAB1A, member RAS oncogene family -0.0378104
DSCAM Down syndrome cell adhesion molecule -0.037126
TMEM123 transmembrane protein 123 -0.0370643
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0369163
HLA-A major histocompatibility complex, class I, A -0.0368921
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0363009
ACTG1 actin gamma 1 -0.0359978
TMEM263 transmembrane protein 263 -0.0350841
FTL ferritin, light polypeptide -0.0347205
FAM107B family with sequence similarity 107, member B -0.0342114
EIF1 eukaryotic translation initiation factor 1 -0.033753
SESTD1 SEC14 and spectrin domains 1 -0.0330565
IFITM1 interferon induced transmembrane protein 1 -0.0328285
PTPRF protein tyrosine phosphatase, receptor type, F -0.0321958
RPS5 ribosomal protein S5 -0.0321605
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0320528
RPL26 ribosomal protein L26 -0.0319957
SEC31A SEC31 homolog A (S. cerevisiae) -0.0318054
RPS23 ribosomal protein S23 -0.0317394
ZBTB20 zinc finger and BTB domain containing 20 -0.0316918
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.031663
MAP1B microtubule-associated protein 1B -0.0316496
RPS27A ribosomal protein S27a -0.031605
H3-3B H3.3 histone B -0.0314321
B2M beta-2-microglobulin -0.031217
NABP1 nucleic acid binding protein 1 -0.0311313
STK17A serine/threonine kinase 17a -0.0306709
RPS10 ribosomal protein S10 -0.030427
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.030354
BRD2 bromodomain containing 2 -0.0301929
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0299826
RPL27A ribosomal protein L27a -0.0297233
DEK DEK proto-oncogene -0.0296798
RPS25 ribosomal protein S25 -0.0291406
RPLP2 ribosomal protein, large, P2 -0.0291308
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0289381
WSB1 WD repeat and SOCS box containing 1 -0.0289163
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0284577
RAB7A RAB7A, member RAS oncogene family -0.0282898
PKM pyruvate kinase, muscle -0.0282888
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0282204
LPP LIM domain containing preferred translocation partner in lipoma -0.0281179
RPS13 ribosomal protein S13 -0.0280813
ZMYND8 zinc finger, MYND-type containing 8 -0.0279523
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0279407
KDM3A lysine (K)-specific demethylase 3A -0.0278751
KIF21A kinesin family member 21A -0.0274284