| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.117393 |
| TGM2 | transglutaminase 2 | 0.0959289 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0916585 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0696509 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0683207 |
| IGF2 | insulin-like growth factor 2 | 0.0668497 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0650154 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0623777 |
| MKI67 | marker of proliferation Ki-67 | 0.0599399 |
| IFI44L | interferon-induced protein 44-like | 0.058292 |
| MSN | moesin | 0.0577119 |
| SLK | STE20-like kinase | 0.0572555 |
| PODXL | podocalyxin-like | 0.0553337 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0536083 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.049172 |
| DST | dystonin | 0.0481161 |
| PCDH1 | protocadherin 1 | 0.04527 |
| GRAMD1B | GRAM domain containing 1B | 0.0434588 |
| EFNA5 | ephrin-A5 | 0.042727 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0426336 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0421606 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0409634 |
| FOXP1 | forkhead box P1 | 0.0406674 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0398988 |
| YBX1 | Y box binding protein 1 | 0.0392855 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0381137 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0375174 |
| HMGA1 | high mobility group AT-hook 1 | 0.0369075 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0361886 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0358942 |
| AOPEP | aminopeptidase O (putative) | 0.0358011 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0356332 |
| TPM3 | tropomyosin 3 | 0.0356048 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0351318 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0349974 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0344647 |
| HMGA2 | high mobility group AT-hook 2 | 0.033467 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0332554 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0327597 |
| ASPH | aspartate beta-hydroxylase | 0.0323798 |
| RPS6 | ribosomal protein S6 | 0.0322216 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0319978 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.031997 |
| ENO1 | enolase 1, (alpha) | 0.03016 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0301422 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.029173 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0287325 |
| TXNIP | thioredoxin interacting protein | 0.0285197 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0283281 |
| RPS12 | ribosomal protein S12 | 0.0279278 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0275943 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0265266 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0257887 |
| MX1 | MX dynamin-like GTPase 1 | 0.0256415 |
| FTL | ferritin, light polypeptide | 0.0256389 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0255203 |
| RASAL2 | RAS protein activator like 2 | 0.025254 |
| MT2A | metallothionein 2A | 0.0252428 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0250213 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0249781 |
| DOK5 | docking protein 5 | 0.024646 |
| RPS2 | ribosomal protein S2 | 0.0245525 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0244986 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0244177 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0243758 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0243754 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0243192 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0241312 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0241178 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0238538 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0238408 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0238307 |
| TNS4 | tensin 4 | 0.0237238 |
| RPS27 | ribosomal protein S27 | 0.0236098 |
| MXRA5 | matrix-remodelling associated 5 | 0.0234017 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0232634 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.0230367 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0228668 |
| TXNRD1 | thioredoxin reductase 1 | 0.0228309 |
| RPL21 | ribosomal protein L21 | 0.0225061 |
| PFN1 | profilin 1 | 0.0222639 |
| PCDH9 | protocadherin 9 | 0.0222191 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0221002 |
| SP100 | SP100 nuclear antigen | 0.0218232 |
| FAT1 | FAT atypical cadherin 1 | 0.0216258 |
| PALLD | palladin, cytoskeletal associated protein | 0.0211017 |
| SMC1A | structural maintenance of chromosomes 1A | 0.021014 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0210098 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0208575 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.02081 |
| RPS19 | ribosomal protein S19 | 0.0206949 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0203916 |
| RAD51B | RAD51 paralog B | 0.0203857 |
| BPTF | bromodomain PHD finger transcription factor | 0.0202377 |
| SET | SET nuclear proto-oncogene | 0.0202232 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | 0.0201718 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0200193 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0200037 |
| TGFB2 | transforming growth factor, beta 2 | 0.0199056 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0197879 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.139265 |
| AHNAK | AHNAK nucleoprotein | -0.119623 |
| FLNB | filamin B, beta | -0.114906 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.10172 |
| EMP1 | epithelial membrane protein 1 | -0.087557 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.078702 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0738891 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0669723 |
| CALU | calumenin | -0.0664349 |
| HM13 | histocompatibility (minor) 13 | -0.0655743 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0652058 |
| MTSS1 | metastasis suppressor 1 | -0.0621711 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0621562 |
| RPS21 | ribosomal protein S21 | -0.0621114 |
| SQLE | squalene epoxidase | -0.0590909 |
| GNAS | GNAS complex locus | -0.0587866 |
| TMSB4X | thymosin beta 4, X-linked | -0.0573549 |
| OGA | O-GlcNAcase | -0.0569047 |
| PTMA | prothymosin, alpha | -0.0567743 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0552928 |
| RBM39 | RNA binding motif protein 39 | -0.0552825 |
| MORF4L2 | mortality factor 4 like 2 | -0.0532153 |
| CANX | calnexin | -0.0520676 |
| S100A10 | S100 calcium binding protein A10 | -0.0520302 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0514767 |
| LMNA | lamin A/C | -0.0507748 |
| FOXO1 | forkhead box O1 | -0.0500543 |
| ANXA2 | annexin A2 | -0.0500454 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0483763 |
| RPS24 | ribosomal protein S24 | -0.0472788 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0462898 |
| SDCBP | syndecan binding protein (syntenin) | -0.0461996 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0458109 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0447547 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0447096 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0442006 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0440509 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0435434 |
| VCL | vinculin | -0.0426818 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0411371 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0409585 |
| RAB1A | RAB1A, member RAS oncogene family | -0.040599 |
| TMSB10 | thymosin beta 10 | -0.0405436 |
| H1-0 | H1.0 linker histone | -0.0382828 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0381935 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0380438 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0378758 |
| STC1 | stanniocalcin 1 | -0.0374678 |
| FSCN1 | fascin actin-bundling protein 1 | -0.037182 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0370268 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0369609 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0365992 |
| CAVIN1 | caveolae associated protein 1 | -0.0360664 |
| TPM4 | tropomyosin 4 | -0.0355692 |
| RTN4 | reticulon 4 | -0.0353963 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0353885 |
| CUL4B | cullin 4B | -0.0352869 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0346001 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0345443 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0340747 |
| KRT6A | keratin 6A, type II | -0.0339525 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0335736 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0327739 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0326231 |
| DUSP6 | dual specificity phosphatase 6 | -0.0317721 |
| ANXA1 | annexin A1 | -0.0316952 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0315235 |
| ARF4 | ADP-ribosylation factor 4 | -0.0315072 |
| LDLR | low density lipoprotein receptor | -0.0309218 |
| SRP54 | signal recognition particle 54kDa | -0.0308746 |
| OSBP | oxysterol binding protein | -0.0307981 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0305511 |
| COG5 | component of oligomeric golgi complex 5 | -0.030056 |
| SEC24D | SEC24 family member D | -0.0298369 |
| TMEM263 | transmembrane protein 263 | -0.0295943 |
| IER3 | immediate early response 3 | -0.0294371 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0293945 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.0293306 |
| NAV2 | neuron navigator 2 | -0.0293123 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0288917 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0288623 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0286305 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0286265 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0285387 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.028478 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0283919 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0283702 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0282138 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0280962 |
| RPL34 | ribosomal protein L34 | -0.0280492 |
| PMM2 | phosphomannomutase 2 | -0.0278048 |
| RLF | rearranged L-myc fusion | -0.0277313 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0273561 |
| THBD | thrombomodulin | -0.0273503 |
| CD99 | CD99 molecule | -0.0273178 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0271986 |
| IRF1 | interferon regulatory factor 1 | -0.0270902 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0270879 |
| COPA | coatomer protein complex, subunit alpha | -0.0270221 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0269049 |
