| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.18778 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.128311 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.126229 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.117955 |
| FAT1 | FAT atypical cadherin 1 | 0.11346 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.100625 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0917567 |
| TNS4 | tensin 4 | 0.084755 |
| HSPA8 | heat shock 70kDa protein 8 | 0.083948 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0797585 |
| RPS6 | ribosomal protein S6 | 0.0789245 |
| DSPP | dentin sialophosphoprotein | 0.0778243 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0718172 |
| ENO1 | enolase 1, (alpha) | 0.0592187 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0590181 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.057204 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0550691 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.055011 |
| LDHA | lactate dehydrogenase A | 0.0526375 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0504472 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0500929 |
| RPS12 | ribosomal protein S12 | 0.0499399 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.048623 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.048382 |
| KIF5B | kinesin family member 5B | 0.0480887 |
| RPS2 | ribosomal protein S2 | 0.0449186 |
| BMP4 | bone morphogenetic protein 4 | 0.0431135 |
| MUC13 | mucin 13, cell surface associated | 0.042703 |
| CALR | calreticulin | 0.0421587 |
| KRT18 | keratin 18, type I | 0.040622 |
| TPM3 | tropomyosin 3 | 0.0398184 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.038976 |
| RNF217 | ring finger protein 217 | 0.0388207 |
| CENPF | centromere protein F, 350/400kDa | 0.0382347 |
| MUC17 | mucin 17, cell surface associated | 0.0370645 |
| MLEC | malectin | 0.0363337 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.035158 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0344275 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0330485 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0316023 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0315517 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0312736 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0299292 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0299142 |
| CALB1 | calbindin 1, 28kDa | 0.0297729 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0297114 |
| PAPOLA | poly(A) polymerase alpha | 0.0291379 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0291267 |
| DSG2 | desmoglein 2 | 0.0290671 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0281739 |
| HDLBP | high density lipoprotein binding protein | 0.0279118 |
| TMC5 | transmembrane channel-like 5 | 0.0273811 |
| SLK | STE20-like kinase | 0.0266665 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0264783 |
| EHF | ets homologous factor | 0.0259564 |
| TRIOBP | TRIO and F-actin binding protein | 0.0257879 |
| MT2A | metallothionein 2A | 0.0253168 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0252235 |
| ONECUT3 | one cut homeobox 3 | 0.0246581 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0239386 |
| RPL3 | ribosomal protein L3 | 0.0238512 |
| MXI1 | MAX interactor 1, dimerization protein | 0.022885 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.022788 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0225027 |
| GOLGB1 | golgin B1 | 0.0220194 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | 0.0219642 |
| YBX1 | Y box binding protein 1 | 0.0219327 |
| TMSB4X | thymosin beta 4, X-linked | 0.0217137 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.0216866 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.0213605 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0210945 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0210106 |
| RNF43 | ring finger protein 43 | 0.0209223 |
| MKI67 | marker of proliferation Ki-67 | 0.0208481 |
| TPD52 | tumor protein D52 | 0.0206569 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0205223 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0205107 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0204992 |
| MYO1E | myosin IE | 0.0203092 |
| FN1 | fibronectin 1 | 0.0201499 |
| CYP2S1 | cytochrome P450, family 2, subfamily S, polypeptide 1 | 0.0201183 |
| SON | SON DNA binding protein | 0.0200868 |
| NUCB2 | nucleobindin 2 | 0.0197765 |
| SET | SET nuclear proto-oncogene | 0.0197295 |
| TC2N | tandem C2 domains, nuclear | 0.0196726 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0196549 |
| KIF1B | kinesin family member 1B | 0.0196337 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0191699 |
| FOXP1 | forkhead box P1 | 0.019157 |
| RREB1 | ras responsive element binding protein 1 | 0.0188218 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0185383 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0185227 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0183655 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0183209 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0182976 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0182891 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0181944 |
| GPA33 | glycoprotein A33 (transmembrane) | 0.0181141 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0179529 |
| SLTM | SAFB-like, transcription modulator | 0.017896 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.319772 |
| VCL | vinculin | -0.163355 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.135161 |
| TMSB10 | thymosin beta 10 | -0.0877875 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0688521 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.06862 |
| RPL35A | ribosomal protein L35a | -0.065179 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0638031 |
| S100A6 | S100 calcium binding protein A6 | -0.0612567 |
| ACTG1 | actin gamma 1 | -0.0595292 |
| LAMA4 | laminin, alpha 4 | -0.0593778 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0590141 |
| RPS24 | ribosomal protein S24 | -0.0571938 |
| MED13L | mediator complex subunit 13-like | -0.0557958 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0547025 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0536575 |
| AHNAK | AHNAK nucleoprotein | -0.0531713 |
| IER3 | immediate early response 3 | -0.0488685 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0483338 |
| POTEF | POTE ankyrin domain family, member F | -0.0481193 |
| ACTN4 | actinin, alpha 4 | -0.0478355 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0477414 |
| ANXA2 | annexin A2 | -0.0471999 |
| RPS21 | ribosomal protein S21 | -0.0440691 |
| SLC38A2 | solute carrier family 38, member 2 | -0.042752 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.042641 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0424104 |
| RPLP0 | ribosomal protein, large, P0 | -0.0407673 |
| SPAG9 | sperm associated antigen 9 | -0.0401619 |
| ITGA6 | integrin, alpha 6 | -0.0400602 |
| MED13 | mediator complex subunit 13 | -0.0381268 |
| RPL8 | ribosomal protein L8 | -0.0377978 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0371954 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0371897 |
| USP53 | ubiquitin specific peptidase 53 | -0.0371695 |
| RPL34 | ribosomal protein L34 | -0.0367627 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0366745 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.035656 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.035405 |
| RPS11 | ribosomal protein S11 | -0.0353538 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0351316 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0348458 |
| LMNA | lamin A/C | -0.0348004 |
| LMO7 | LIM domain 7 | -0.0347188 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0344278 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0342062 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0341367 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0335163 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0332659 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0326741 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0322885 |
| RBM39 | RNA binding motif protein 39 | -0.0316512 |
| KRT8 | keratin 8, type II | -0.0316336 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0314801 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0314789 |
| RPL19 | ribosomal protein L19 | -0.0313071 |
| RPL7A | ribosomal protein L7a | -0.0312085 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0305793 |
| NFIA | nuclear factor I/A | -0.0305328 |
| RPL27A | ribosomal protein L27a | -0.0301514 |
| COG5 | component of oligomeric golgi complex 5 | -0.0299939 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0298063 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.029753 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0294291 |
| S100A10 | S100 calcium binding protein A10 | -0.0293337 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0291655 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0289409 |
| RPL11 | ribosomal protein L11 | -0.028756 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.028582 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0285712 |
| PIGR | polymeric immunoglobulin receptor | -0.0283241 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0283018 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0283007 |
| HEPH | hephaestin | -0.0281486 |
| RCOR1 | REST corepressor 1 | -0.0280588 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0278513 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0276397 |
| THOC2 | THO complex 2 | -0.027614 |
| RPS15 | ribosomal protein S15 | -0.0275448 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.027242 |
| RPLP2 | ribosomal protein, large, P2 | -0.0271282 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0270408 |
| H3-3B | H3.3 histone B | -0.0270156 |
| RAB10 | RAB10, member RAS oncogene family | -0.0269823 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0269247 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0266358 |
| DIAPH2 | diaphanous-related formin 2 | -0.0266007 |
| CD2AP | CD2-associated protein | -0.0264602 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0264056 |
| INSIG1 | insulin induced gene 1 | -0.0261304 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0260838 |
| S100P | S100 calcium binding protein P | -0.0259876 |
| RPS23 | ribosomal protein S23 | -0.0258821 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0258235 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0255576 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0255424 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0254801 |
| RPLP1 | ribosomal protein, large, P1 | -0.0254677 |
| TMEM87A | transmembrane protein 87A | -0.0254268 |
| JUN | jun proto-oncogene | -0.0252929 |
