| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.228935 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0925242 |
| HLA-B | major histocompatibility complex, class I, B | 0.0871438 |
| CAPRIN2 | caprin family member 2 | 0.0707601 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0632681 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0596978 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0541031 |
| RPS6 | ribosomal protein S6 | 0.0529001 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0527264 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0525698 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.05237 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0493274 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0488119 |
| PDE10A | phosphodiesterase 10A | 0.0474142 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0431658 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0420201 |
| RPL35A | ribosomal protein L35a | 0.041708 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0409628 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0395802 |
| HMGA1 | high mobility group AT-hook 1 | 0.038621 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0380113 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0367748 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0343168 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0333436 |
| RIGI | RNA sensor RIG-I | 0.0329642 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0316381 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0314734 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0311593 |
| VEGFC | vascular endothelial growth factor C | 0.0306202 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.030383 |
| JUN | jun proto-oncogene | 0.0301644 |
| HOMER1 | homer scaffolding protein 1 | 0.0294274 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0291626 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0291065 |
| EZR | ezrin | 0.0285856 |
| RPLP1 | ribosomal protein, large, P1 | 0.0277575 |
| B2M | beta-2-microglobulin | 0.0277244 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0275792 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.026971 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0265196 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0261733 |
| SP100 | SP100 nuclear antigen | 0.0260975 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0259041 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0256448 |
| RPL36 | ribosomal protein L36 | 0.0252913 |
| RPL7L1 | ribosomal protein L7-like 1 | 0.0248713 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0238542 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0237344 |
| HLA-E | major histocompatibility complex, class I, E | 0.0236658 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0232953 |
| TMSB10 | thymosin beta 10 | 0.0231641 |
| FTL | ferritin, light polypeptide | 0.023063 |
| RPS19 | ribosomal protein S19 | 0.0226917 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0226797 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0225489 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0224967 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0224169 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0223949 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0223455 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0215549 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0213338 |
| AHI1 | Abelson helper integration site 1 | 0.0209818 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.020912 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0208886 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0207158 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 0.0202302 |
| RPLP2 | ribosomal protein, large, P2 | 0.0199656 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0198705 |
| PLK2 | polo-like kinase 2 | 0.0198365 |
| RPL37A | ribosomal protein L37a | 0.0190705 |
| VMP1 | vacuole membrane protein 1 | 0.0189062 |
| RPS23 | ribosomal protein S23 | 0.0188143 |
| PYGB | phosphorylase, glycogen; brain | 0.0188106 |
| RPL31 | ribosomal protein L31 | 0.0184308 |
| FN1 | fibronectin 1 | 0.0182633 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0181936 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0178372 |
| AREG | amphiregulin | 0.0177397 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0176013 |
| CCNL1 | cyclin L1 | 0.0173436 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.0173131 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.0171318 |
| GPATCH2 | G patch domain containing 2 | 0.0171114 |
| RPS8 | ribosomal protein S8 | 0.0170602 |
| RPL37 | ribosomal protein L37 | 0.0170302 |
| USP36 | ubiquitin specific peptidase 36 | 0.0169702 |
| VEGFA | vascular endothelial growth factor A | 0.0169264 |
| TBCA | tubulin folding cofactor A | 0.0169099 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0167444 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0166886 |
| PODXL | podocalyxin-like | 0.0166698 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0165625 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.016542 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0164866 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0162557 |
| SKIL | SKI-like proto-oncogene | 0.0161919 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0160599 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0160479 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0158506 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0158221 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.111111 |
| RAD51B | RAD51 paralog B | -0.103725 |
| TP63 | tumor protein p63 | -0.0921112 |
| PRELID2 | PRELI domain containing 2 | -0.0839795 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0786043 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0780277 |
| VCL | vinculin | -0.0735813 |
| FMNL2 | formin-like 2 | -0.0636845 |
| SBF2 | SET binding factor 2 | -0.0585895 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0565347 |
| MT2A | metallothionein 2A | -0.0556272 |
| EXOC4 | exocyst complex component 4 | -0.0543795 |
| NEK10 | NIMA-related kinase 10 | -0.0529306 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0519658 |
| SPAG9 | sperm associated antigen 9 | -0.0519597 |
| DST | dystonin | -0.0516533 |
| USP34 | ubiquitin specific peptidase 34 | -0.0516044 |
| PGK1 | phosphoglycerate kinase 1 | -0.0513417 |
| ZNF292 | zinc finger protein 292 | -0.0504885 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.049193 |
| TNS3 | tensin 3 | -0.0490172 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0479551 |
| SRPK2 | SRSF protein kinase 2 | -0.0468812 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.046559 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0458251 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0458009 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0453069 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0439755 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0429614 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0416737 |
| DIAPH3 | diaphanous-related formin 3 | -0.0403911 |
| ZNF217 | zinc finger protein 217 | -0.0403323 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0399806 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0397734 |
| HPCAL1 | hippocalcin-like 1 | -0.0388517 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0388035 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0386187 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0374952 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0373788 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0367956 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.036728 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0364832 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0364738 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0362872 |
| FNIP1 | folliculin interacting protein 1 | -0.0357099 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.03525 |
| DENND1A | DENN/MADD domain containing 1A | -0.034908 |
| DPH6 | diphthamine biosynthesis 6 | -0.0346806 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0346552 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0345428 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0344318 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0337151 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0333682 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0331172 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0329927 |
| SMAD3 | SMAD family member 3 | -0.032914 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0327231 |
| MYOF | myoferlin | -0.0325354 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0324717 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0324694 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0322889 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0322845 |
| NF1 | neurofibromin 1 | -0.03219 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0320635 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.031853 |
| NUP58 | nucleoporin 58 | -0.0308456 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0307907 |
| BMERB1 | bMERB domain containing 1 | -0.0305001 |
| DYM | dymeclin | -0.0303924 |
| POU2F1 | POU class 2 homeobox 1 | -0.0301953 |
| LRRC49 | leucine rich repeat containing 49 | -0.0298669 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0298082 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0297736 |
| CENPF | centromere protein F, 350/400kDa | -0.0296755 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0293036 |
| ATP9B | ATPase, class II, type 9B | -0.0292777 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0292731 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0292529 |
| CCDC91 | coiled-coil domain containing 91 | -0.0291964 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0291862 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.029077 |
| RTTN | rotatin | -0.0290721 |
| TXNRD1 | thioredoxin reductase 1 | -0.0290015 |
| EFNA5 | ephrin-A5 | -0.0286655 |
| TBC1D22A | TBC1 domain family, member 22A | -0.028472 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0282264 |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase | -0.0281656 |
| CEP192 | centrosomal protein 192kDa | -0.0279117 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0277688 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0277087 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0276967 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0274513 |
| COG5 | component of oligomeric golgi complex 5 | -0.0274109 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.027372 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0271528 |
| ACTN4 | actinin, alpha 4 | -0.0269785 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0269312 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0266315 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0264891 |
| EXOC6B | exocyst complex component 6B | -0.0263397 |
