| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Larotrectinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.130563 |
| CES1 | carboxylesterase 1 | 0.121607 |
| GRAMD1B | GRAM domain containing 1B | 0.119122 |
| LAMA4 | laminin, alpha 4 | 0.107376 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.102223 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0907745 |
| SLTM | SAFB-like, transcription modulator | 0.0874316 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0865963 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0821447 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0700941 |
| MT2A | metallothionein 2A | 0.0634548 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0567505 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.056692 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0513211 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0488549 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.045892 |
| STC1 | stanniocalcin 1 | 0.0457437 |
| TOP1 | topoisomerase (DNA) I | 0.0446021 |
| EGR1 | early growth response 1 | 0.0434073 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0432591 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.041174 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0406069 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0390872 |
| NTN4 | netrin 4 | 0.0372184 |
| SP100 | SP100 nuclear antigen | 0.0371026 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0369696 |
| RNF213 | ring finger protein 213 | 0.0362946 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0359037 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0353124 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0331416 |
| AREG | amphiregulin | 0.0328079 |
| TRIM56 | tripartite motif containing 56 | 0.032765 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0327567 |
| OSMR | oncostatin M receptor | 0.0321557 |
| SMYD3 | SET and MYND domain containing 3 | 0.0317294 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0314783 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0310292 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0305171 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0304666 |
| RPS12 | ribosomal protein S12 | 0.029517 |
| RPS3 | ribosomal protein S3 | 0.0294934 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0290123 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0281194 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0277807 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0270622 |
| TBC1D22A | TBC1 domain family, member 22A | 0.02695 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0263723 |
| ATP11A | ATPase, class VI, type 11A | 0.025313 |
| HLA-B | major histocompatibility complex, class I, B | 0.0249984 |
| AGO2 | argonaute RISC catalytic component 2 | 0.024845 |
| PAPOLA | poly(A) polymerase alpha | 0.0246397 |
| EFNA5 | ephrin-A5 | 0.0244389 |
| YBX3 | Y box binding protein 3 | 0.0243783 |
| IFI44 | interferon-induced protein 44 | 0.0240254 |
| RPL23 | ribosomal protein L23 | 0.0239505 |
| IGF2 | insulin-like growth factor 2 | 0.0238134 |
| LAMC2 | laminin, gamma 2 | 0.0235082 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0234258 |
| MKI67 | marker of proliferation Ki-67 | 0.0233133 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0224994 |
| VIM | vimentin | 0.0224607 |
| KIF5B | kinesin family member 5B | 0.0217837 |
| IFI44L | interferon-induced protein 44-like | 0.021629 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0216248 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0214709 |
| PMP22 | peripheral myelin protein 22 | 0.0211964 |
| MYO1E | myosin IE | 0.0211468 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0207865 |
| BMP6 | bone morphogenetic protein 6 | 0.0207829 |
| KIAA1217 | KIAA1217 | 0.0207267 |
| STC2 | stanniocalcin 2 | 0.0205855 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.020492 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.020444 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0203447 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.0200763 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.019829 |
| PRKCE | protein kinase C, epsilon | 0.0193569 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0190871 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0190229 |
| RPS2 | ribosomal protein S2 | 0.0189708 |
| WWOX | WW domain containing oxidoreductase | 0.0187442 |
| ATXN1 | ataxin 1 | 0.0186611 |
| ABHD17C | abhydrolase domain containing 17C | 0.0183287 |
| EPAS1 | endothelial PAS domain protein 1 | 0.018303 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0179257 |
| RACK1 | receptor for activated C kinase 1 | 0.0176161 |
| OXSR1 | oxidative stress responsive 1 | 0.0174453 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0172956 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0171037 |
| FOXP1 | forkhead box P1 | 0.0171006 |
| RAD51B | RAD51 paralog B | 0.0170542 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0169864 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0169352 |
| RPLP1 | ribosomal protein, large, P1 | 0.0168925 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0168394 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0167398 |
| PCBP1 | poly(rC) binding protein 1 | 0.0164668 |
| TMEM45B | transmembrane protein 45B | 0.0164094 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0163513 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0163085 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.291568 |
| TMSB10 | thymosin beta 10 | -0.209588 |
| EGFR | epidermal growth factor receptor | -0.20541 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.114982 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.108793 |
| S100A10 | S100 calcium binding protein A10 | -0.0917274 |
| ACTG1 | actin gamma 1 | -0.0899871 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0809721 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0742917 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0693622 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.068549 |
| PKM | pyruvate kinase, muscle | -0.0651572 |
| KRT7 | keratin 7, type II | -0.0648106 |
| LMO7 | LIM domain 7 | -0.0628673 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0610229 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0604549 |
| ASPH | aspartate beta-hydroxylase | -0.0584807 |
| POTEF | POTE ankyrin domain family, member F | -0.0579981 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0525904 |
| KRT8 | keratin 8, type II | -0.0515533 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0510254 |
| UBC | ubiquitin C | -0.0503768 |
| CST3 | cystatin C | -0.0500302 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0494913 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0489372 |
| AHNAK | AHNAK nucleoprotein | -0.0476705 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0465048 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0461858 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0438055 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0429268 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0415294 |
| TMEM165 | transmembrane protein 165 | -0.0410379 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0409564 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.040373 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0401938 |
| GPC6 | glypican 6 | -0.0396585 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0392282 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0391874 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0380928 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.037997 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0376025 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0370165 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0369543 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0366299 |
| ANXA2 | annexin A2 | -0.0365514 |
| S100A6 | S100 calcium binding protein A6 | -0.0361466 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0356947 |
| SBF2 | SET binding factor 2 | -0.0350308 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0347144 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0341872 |
| USP34 | ubiquitin specific peptidase 34 | -0.0339395 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0332896 |
| INTS6 | integrator complex subunit 6 | -0.0332749 |
| MORF4L2 | mortality factor 4 like 2 | -0.0328429 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0322548 |
| PTMA | prothymosin, alpha | -0.0318533 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0314701 |
| H1-0 | H1.0 linker histone | -0.0314648 |
| PDE8A | phosphodiesterase 8A | -0.0312669 |
| NABP1 | nucleic acid binding protein 1 | -0.0311164 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0309568 |
| MYO1D | myosin ID | -0.0307773 |
| CD163L1 | CD163 molecule-like 1 | -0.0305478 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0300359 |
| PERP | PERP, TP53 apoptosis effector | -0.0299373 |
| WASF2 | WAS protein family, member 2 | -0.0298141 |
| CAV2 | caveolin 2 | -0.0295109 |
| TPD52 | tumor protein D52 | -0.0292209 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0292055 |
| GNAS | GNAS complex locus | -0.0292041 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0290656 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0285453 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0278988 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0278888 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0278293 |
| CCNL1 | cyclin L1 | -0.0277242 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0272866 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0272232 |
| RPS25 | ribosomal protein S25 | -0.0271731 |
| NDRG1 | N-myc downstream regulated 1 | -0.0271243 |
| RYBP | RING1 and YY1 binding protein | -0.0271125 |
| MCU | mitochondrial calcium uniporter | -0.0270756 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0270556 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0268234 |
| S100A9 | S100 calcium binding protein A9 | -0.026809 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0266668 |
| FBXO11 | F-box protein 11 | -0.0266492 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.02655 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0265467 |
| RNF145 | ring finger protein 145 | -0.02642 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0262806 |
| NF1 | neurofibromin 1 | -0.0260772 |
| PCBP2 | poly(rC) binding protein 2 | -0.0260577 |
| SEC61G | Sec61 gamma subunit | -0.0256308 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0252714 |
| NBEAL1 | neurobeachin-like 1 | -0.0248702 |
| FNIP1 | folliculin interacting protein 1 | -0.0247229 |
| IER3 | immediate early response 3 | -0.0246138 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0243292 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0242906 |
