| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Larotrectinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.133903 |
| SMAD3 | SMAD family member 3 | 0.0938109 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0929038 |
| VIM | vimentin | 0.0865652 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0856852 |
| PCBP2 | poly(rC) binding protein 2 | 0.0853169 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0787744 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0772249 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0721884 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0716395 |
| TGM2 | transglutaminase 2 | 0.0625245 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0620063 |
| CD44 | CD44 molecule (Indian blood group) | 0.0608628 |
| NDRG1 | N-myc downstream regulated 1 | 0.0586047 |
| HMGA1 | high mobility group AT-hook 1 | 0.0557081 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0551134 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0522896 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0464915 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.045978 |
| FTL | ferritin, light polypeptide | 0.0458432 |
| KSR1 | kinase suppressor of ras 1 | 0.045771 |
| CDCP1 | CUB domain containing protein 1 | 0.0448915 |
| NRP1 | neuropilin 1 | 0.0444764 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0442296 |
| VMP1 | vacuole membrane protein 1 | 0.043826 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0437543 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0429158 |
| MYO10 | myosin X | 0.042308 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0422798 |
| TMSB10 | thymosin beta 10 | 0.0412425 |
| TXNRD1 | thioredoxin reductase 1 | 0.0407612 |
| KYNU | kynureninase | 0.0407316 |
| RAB27B | RAB27B, member RAS oncogene family | 0.040533 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0404402 |
| GLCCI1 | glucocorticoid induced 1 | 0.0400625 |
| VEGFA | vascular endothelial growth factor A | 0.0396397 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0395909 |
| RPS6 | ribosomal protein S6 | 0.0395068 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.039407 |
| SFTPA2 | surfactant protein A2 | 0.0391017 |
| VRK2 | vaccinia related kinase 2 | 0.039081 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0390032 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0389591 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0386376 |
| ATP13A3 | ATPase type 13A3 | 0.0384659 |
| MEIS1 | Meis homeobox 1 | 0.0384487 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0382533 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0381367 |
| LDHA | lactate dehydrogenase A | 0.0372585 |
| POTEF | POTE ankyrin domain family, member F | 0.0372023 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0368364 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0364686 |
| PKM | pyruvate kinase, muscle | 0.0357159 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0354583 |
| NTN4 | netrin 4 | 0.0353876 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.034961 |
| GRAMD1B | GRAM domain containing 1B | 0.0349435 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0341571 |
| IL1R1 | interleukin 1 receptor, type I | 0.0339591 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0338038 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.032266 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0321768 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.0320937 |
| IFI44L | interferon-induced protein 44-like | 0.0319252 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0316672 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0316176 |
| GOLGA4 | golgin A4 | 0.0305841 |
| CALR | calreticulin | 0.0300124 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0299438 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0295618 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0294752 |
| HMGA2 | high mobility group AT-hook 2 | 0.0294046 |
| PDE8A | phosphodiesterase 8A | 0.0290766 |
| VEGFC | vascular endothelial growth factor C | 0.0290683 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0289726 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0288986 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.0288506 |
| ACTN4 | actinin, alpha 4 | 0.0280729 |
| ZFP91 | ZFP91 zinc finger protein | 0.0280063 |
| SYAP1 | synapse associated protein 1 | 0.0277157 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0276266 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0275178 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0273811 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0273584 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0273037 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0272916 |
| FAM120A | family with sequence similarity 120A | 0.02698 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0267186 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0267032 |
| TMEM131 | transmembrane protein 131 | 0.0266968 |
| UBC | ubiquitin C | 0.0266267 |
| ECE1 | endothelin converting enzyme 1 | 0.0265687 |
| RBM39 | RNA binding motif protein 39 | 0.026072 |
| RUNX2 | runt-related transcription factor 2 | 0.0258329 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0258169 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0257457 |
| MYO1E | myosin IE | 0.0254895 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0254094 |
| GPHN | gephyrin | 0.0253671 |
| USP47 | ubiquitin specific peptidase 47 | 0.0253234 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SDK1 | sidekick cell adhesion molecule 1 | -0.171348 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.17038 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.142671 |
| CDH13 | cadherin 13 | -0.136495 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0865523 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0805626 |
| MTSS1 | metastasis suppressor 1 | -0.0759307 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0641204 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0621913 |
| FAM20C | family with sequence similarity 20, member C | -0.0598649 |
| RAI14 | retinoic acid induced 14 | -0.0537298 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0512425 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0452055 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0447098 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0444959 |
| GPC6 | glypican 6 | -0.0430528 |
| CFAP20DC | CFAP20 domain containing | -0.0429667 |
| CDK14 | cyclin-dependent kinase 14 | -0.0410764 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0409239 |
| DIAPH2 | diaphanous-related formin 2 | -0.0401701 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0401422 |
| EFNA5 | ephrin-A5 | -0.0395355 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0392987 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0386161 |
| AHNAK | AHNAK nucleoprotein | -0.0381083 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0378764 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0369555 |
| PYGL | phosphorylase, glycogen, liver | -0.0367978 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0367921 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0365091 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0359609 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0356637 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0339202 |
| EGR1 | early growth response 1 | -0.0326292 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0319911 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0309357 |
| HDAC4 | histone deacetylase 4 | -0.0304034 |
| SUMF1 | sulfatase modifying factor 1 | -0.0303086 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0301263 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0299267 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0287571 |
| SLC44A5 | solute carrier family 44, member 5 | -0.0286253 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0285566 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0284548 |
| PRR16 | proline rich 16 | -0.0280221 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0279695 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0272772 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0272497 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0265536 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0264084 |
| FBN1 | fibrillin 1 | -0.0251784 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.025089 |
| FN1 | fibronectin 1 | -0.0248023 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0247832 |
| FBXO11 | F-box protein 11 | -0.0245381 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0236453 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0236194 |
| ETV6 | ets variant 6 | -0.0235248 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0232434 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0231954 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0230511 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0230471 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0225488 |
| TNNC1 | troponin C type 1 (slow) | -0.022423 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0221957 |
| ATG7 | autophagy related 7 | -0.0219228 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0216724 |
| LRRC8C | leucine rich repeat containing 8 family, member C | -0.0216135 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0215823 |
| VCL | vinculin | -0.0215107 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0214522 |
| BMERB1 | bMERB domain containing 1 | -0.0213094 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0212541 |
| NLK | nemo-like kinase | -0.0211158 |
| STC1 | stanniocalcin 1 | -0.0209277 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0208748 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0208128 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | -0.020633 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0205699 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0205613 |
| CDK13 | cyclin-dependent kinase 13 | -0.0204685 |
| CFDP1 | craniofacial development protein 1 | -0.0204666 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0203803 |
| PRRX1 | paired related homeobox 1 | -0.02018 |
| PRELID2 | PRELI domain containing 2 | -0.0201035 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | -0.0200415 |
| ANXA2 | annexin A2 | -0.019842 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0197664 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0195176 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0191208 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0188999 |
| DENND1A | DENN/MADD domain containing 1A | -0.0188049 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0187713 |
| LOX | lysyl oxidase | -0.0187654 |
| SH3RF3 | SH3 domain containing ring finger 3 | -0.0186437 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0186275 |
| MCL1 | myeloid cell leukemia 1 | -0.0186142 |
| ABCA9 | ATP-binding cassette, sub-family A (ABC1), member 9 | -0.0185956 |
| AK1 | adenylate kinase 1 | -0.0184659 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0183622 |
