| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.257367 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.176991 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.117398 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.114487 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.110549 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.10202 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0999329 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0978705 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0920315 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0846408 |
| TPM3 | tropomyosin 3 | 0.0753795 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0626275 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0614749 |
| KIF5B | kinesin family member 5B | 0.0603185 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0577745 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.056731 |
| PYGL | phosphorylase, glycogen, liver | 0.0564136 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0530067 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0510015 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0489934 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0484914 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0470689 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0465527 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0462443 |
| FMNL2 | formin-like 2 | 0.0431095 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0412551 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0400221 |
| FGB | fibrinogen beta chain | 0.0396233 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.039443 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.038425 |
| WWOX | WW domain containing oxidoreductase | 0.0374824 |
| YBX1 | Y box binding protein 1 | 0.0371654 |
| RPS6 | ribosomal protein S6 | 0.0368905 |
| FGA | fibrinogen alpha chain | 0.0354338 |
| MKI67 | marker of proliferation Ki-67 | 0.0354076 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0332867 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0326225 |
| MYOF | myoferlin | 0.0314496 |
| APP | amyloid beta (A4) precursor protein | 0.0314143 |
| ATP11A | ATPase, class VI, type 11A | 0.0313131 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0310907 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0310569 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0304563 |
| CLU | clusterin | 0.0296865 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0290209 |
| ZNF292 | zinc finger protein 292 | 0.028883 |
| TGFB2 | transforming growth factor, beta 2 | 0.0286746 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0282977 |
| TLN1 | talin 1 | 0.028025 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0278572 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.027161 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0268321 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0267514 |
| LDHA | lactate dehydrogenase A | 0.0267293 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0264277 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0263852 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0263773 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0263519 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0261078 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0259359 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0253277 |
| HYOU1 | hypoxia up-regulated 1 | 0.025322 |
| TPD52 | tumor protein D52 | 0.0250366 |
| EZR | ezrin | 0.0245142 |
| AHR | aryl hydrocarbon receptor | 0.0241782 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0239993 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0234004 |
| RNF145 | ring finger protein 145 | 0.0233793 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0233444 |
| FNBP1L | formin binding protein 1-like | 0.022695 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0226302 |
| NCKAP1 | NCK-associated protein 1 | 0.0219877 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0219766 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0216955 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.0216068 |
| RPL3 | ribosomal protein L3 | 0.0215858 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0214887 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.021442 |
| AXL | AXL receptor tyrosine kinase | 0.020912 |
| TCIM | transcriptional and immune response regulator | 0.0207721 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0207592 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0206677 |
| GAN | gigaxonin | 0.0206385 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0206332 |
| TLK1 | tousled-like kinase 1 | 0.0203762 |
| RSPO3 | R-spondin 3 | 0.0202284 |
| KLC1 | kinesin light chain 1 | 0.0201768 |
| PCBP1 | poly(rC) binding protein 1 | 0.0200211 |
| PRELID2 | PRELI domain containing 2 | 0.0199296 |
| RPL37A | ribosomal protein L37a | 0.0199264 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0199088 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.019776 |
| RPS12 | ribosomal protein S12 | 0.0197076 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0196483 |
| OPTN | optineurin | 0.0193738 |
| ENO1 | enolase 1, (alpha) | 0.0190881 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0190868 |
| ANXA1 | annexin A1 | 0.0190398 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.018934 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0189245 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.291025 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.197284 |
| ACTG1 | actin gamma 1 | -0.106772 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.103112 |
| IER3 | immediate early response 3 | -0.092066 |
| TXNRD1 | thioredoxin reductase 1 | -0.0846061 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0782901 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0708232 |
| POTEF | POTE ankyrin domain family, member F | -0.0619181 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0572404 |
| TMSB10 | thymosin beta 10 | -0.0564718 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0555492 |
| MCL1 | myeloid cell leukemia 1 | -0.0547012 |
| S100A6 | S100 calcium binding protein A6 | -0.0531998 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0509946 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0476717 |
| RPS21 | ribosomal protein S21 | -0.0465437 |
| EGR1 | early growth response 1 | -0.0465408 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0455407 |
| AK1 | adenylate kinase 1 | -0.0435206 |
| RPS24 | ribosomal protein S24 | -0.0427322 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0387715 |
| BICC1 | BicC family RNA binding protein 1 | -0.0382184 |
| VCL | vinculin | -0.0380225 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0374639 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0371831 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0366515 |
| AHNAK | AHNAK nucleoprotein | -0.0355735 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0353332 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0346631 |
| RPLP0 | ribosomal protein, large, P0 | -0.0343214 |
| USP34 | ubiquitin specific peptidase 34 | -0.0340995 |
| RPL35A | ribosomal protein L35a | -0.0332182 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0332024 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0322274 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0315016 |
| PTMA | prothymosin, alpha | -0.0310572 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0310564 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0301286 |
| KYNU | kynureninase | -0.0294922 |
| NF1 | neurofibromin 1 | -0.0288909 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0286072 |
| S100A10 | S100 calcium binding protein A10 | -0.0279455 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0278196 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0274989 |
| CAVIN1 | caveolae associated protein 1 | -0.027377 |
| NEGR1 | neuronal growth regulator 1 | -0.0269249 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0269071 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0267091 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0266002 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0261822 |
| DENND4A | DENN/MADD domain containing 4A | -0.0257671 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0253457 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0249817 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0247048 |
| CDK12 | cyclin-dependent kinase 12 | -0.0243459 |
| RPS25 | ribosomal protein S25 | -0.0242404 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0241096 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0240822 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0240636 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0236693 |
| NAV3 | neuron navigator 3 | -0.0236163 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0233333 |
| GLIS3 | GLIS family zinc finger 3 | -0.0231707 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0230544 |
| CALU | calumenin | -0.0229367 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0228316 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.022783 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0226288 |
| TMEM263 | transmembrane protein 263 | -0.0225415 |
| RASAL2 | RAS protein activator like 2 | -0.0223587 |
| RPL9 | ribosomal protein L9 | -0.0223571 |
| SERF2 | small EDRK-rich factor 2 | -0.0220236 |
| RPS15 | ribosomal protein S15 | -0.0220073 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0218067 |
| ZNF644 | zinc finger protein 644 | -0.0217738 |
| RPS23 | ribosomal protein S23 | -0.0217516 |
| MORF4L2 | mortality factor 4 like 2 | -0.0215695 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0215574 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.021362 |
| NDUFB3 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa | -0.020948 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0208834 |
| RAB10 | RAB10, member RAS oncogene family | -0.0208766 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0206962 |
| NABP1 | nucleic acid binding protein 1 | -0.0205937 |
| RPL31 | ribosomal protein L31 | -0.0201599 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0201407 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0200693 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0200321 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0198649 |
| DSCAM | Down syndrome cell adhesion molecule | -0.019685 |
| COPA | coatomer protein complex, subunit alpha | -0.0194585 |
| INO80 | INO80 complex subunit | -0.0192265 |
| NNMT | nicotinamide N-methyltransferase | -0.0191442 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0190933 |
| SQSTM1 | sequestosome 1 | -0.0189444 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0187324 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0187043 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0186778 |
| RPS10 | ribosomal protein S10 | -0.0186349 |
