| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Larotrectinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.0885655 |
| DST | dystonin | 0.0778399 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0662983 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0645846 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.059266 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0591784 |
| RUNX1 | runt-related transcription factor 1 | 0.056386 |
| PDE10A | phosphodiesterase 10A | 0.0548504 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0546374 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0502441 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0491976 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.048827 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0488228 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0472449 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0470822 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0467112 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0465812 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0457116 |
| RIGI | RNA sensor RIG-I | 0.0452017 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0425511 |
| AK1 | adenylate kinase 1 | 0.0421815 |
| INHBA | inhibin, beta A | 0.0416142 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0413927 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.040876 |
| LAMA4 | laminin, alpha 4 | 0.0405546 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.04 |
| PRKCE | protein kinase C, epsilon | 0.0394392 |
| GLCCI1 | glucocorticoid induced 1 | 0.0393675 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0386845 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0382763 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0377189 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0375571 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0367678 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0349756 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0349 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0348772 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0347261 |
| RPL26 | ribosomal protein L26 | 0.0345074 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0341476 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0341252 |
| SMAD2 | SMAD family member 2 | 0.034022 |
| SVIL | supervillin | 0.0333827 |
| EFNA5 | ephrin-A5 | 0.0333461 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0327474 |
| GOLGA4 | golgin A4 | 0.032403 |
| CNKSR3 | CNKSR family member 3 | 0.0323428 |
| HMGA2 | high mobility group AT-hook 2 | 0.0319835 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0318814 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0317029 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0313853 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0311022 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0310977 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0310852 |
| KIF5B | kinesin family member 5B | 0.0308901 |
| CD44 | CD44 molecule (Indian blood group) | 0.0305455 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0303653 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0303305 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0303207 |
| URI1 | URI1, prefoldin-like chaperone | 0.0301337 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0298633 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0297015 |
| RAD51B | RAD51 paralog B | 0.0296373 |
| GLG1 | golgi glycoprotein 1 | 0.0295945 |
| RPS20 | ribosomal protein S20 | 0.029324 |
| GPHN | gephyrin | 0.0291799 |
| FAM168A | family with sequence similarity 168, member A | 0.0290421 |
| PRKCA | protein kinase C, alpha | 0.0289823 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0289328 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0287461 |
| ACTN4 | actinin, alpha 4 | 0.028718 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0287074 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0283455 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0280509 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0273987 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0273838 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0273825 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0272261 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0271776 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0269598 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0267539 |
| RPS27A | ribosomal protein S27a | 0.026478 |
| KDM5A | lysine (K)-specific demethylase 5A | 0.0262622 |
| CUL4A | cullin 4A | 0.0261803 |
| TPM3 | tropomyosin 3 | 0.0260239 |
| CDH13 | cadherin 13 | 0.0258308 |
| EXOC6B | exocyst complex component 6B | 0.0258239 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0256332 |
| SCFD1 | sec1 family domain containing 1 | 0.0251007 |
| NBEA | neurobeachin | 0.0250729 |
| MAP1B | microtubule-associated protein 1B | 0.0248043 |
| DENND4C | DENN/MADD domain containing 4C | 0.0247592 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0247419 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0247058 |
| AREG | amphiregulin | 0.0246354 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0246051 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0246013 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0245048 |
| WAPL | WAPL cohesin release factor | 0.0241365 |
| SLTM | SAFB-like, transcription modulator | 0.0241065 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0239826 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.189833 |
| FTL | ferritin, light polypeptide | -0.122925 |
| VIM | vimentin | -0.0994625 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0877207 |
| KRT17 | keratin 17, type I | -0.0759233 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.073048 |
| NDRG1 | N-myc downstream regulated 1 | -0.0628528 |
| S100A9 | S100 calcium binding protein A9 | -0.0609046 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0600234 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0585775 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0563387 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0551794 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0538505 |
| RPL23 | ribosomal protein L23 | -0.0537749 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0527598 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0512993 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0510215 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0499668 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.049931 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0498495 |
| SQSTM1 | sequestosome 1 | -0.0493663 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0493164 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0487149 |
| PKM | pyruvate kinase, muscle | -0.0484306 |
| PGK1 | phosphoglycerate kinase 1 | -0.0473939 |
| PARD3 | par-3 family cell polarity regulator | -0.0467889 |
| TXNIP | thioredoxin interacting protein | -0.0466442 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0458541 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0449197 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0448798 |
| TMSB10 | thymosin beta 10 | -0.044866 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0433181 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0429511 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0428827 |
| ANXA1 | annexin A1 | -0.0424382 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.041913 |
| TMEM123 | transmembrane protein 123 | -0.0416461 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0399562 |
| PHF21A | PHD finger protein 21A | -0.0382625 |
| SLMAP | sarcolemma associated protein | -0.0381386 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0379907 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0377422 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0374913 |
| CUL3 | cullin 3 | -0.037401 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0373766 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0370742 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0368944 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0364238 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0364224 |
| ATOSA | atos homolog A | -0.0362609 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.036203 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0359624 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.0355939 |
| MYO1E | myosin IE | -0.0353668 |
| RPL19 | ribosomal protein L19 | -0.0352861 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0351558 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0348604 |
| CALU | calumenin | -0.0346691 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.033628 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0331746 |
| RPL32 | ribosomal protein L32 | -0.0330398 |
| WASF2 | WAS protein family, member 2 | -0.0329724 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0326888 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0326319 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0322867 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0321732 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0318595 |
| ACTG1 | actin gamma 1 | -0.0313351 |
| ATXN1 | ataxin 1 | -0.0309571 |
| RBM39 | RNA binding motif protein 39 | -0.0307725 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0304032 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0303562 |
| AMBRA1 | autophagy/beclin-1 regulator 1 | -0.0303381 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0302769 |
| MATR3 | matrin 3 | -0.0300028 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0298802 |
| CCNI | cyclin I | -0.029775 |
| COPA | coatomer protein complex, subunit alpha | -0.0295522 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0295107 |
| TPR | translocated promoter region, nuclear basket protein | -0.0293692 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0290848 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0287633 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0284066 |
| H3-3B | H3.3 histone B | -0.0284018 |
| CLTC | clathrin, heavy chain (Hc) | -0.0282774 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.02784 |
| CANX | calnexin | -0.0277607 |
| CUL1 | cullin 1 | -0.0275524 |
| RPL7A | ribosomal protein L7a | -0.0274056 |
| STEAP4 | STEAP family member 4 | -0.0270632 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0269457 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0266454 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0263179 |
| UBAP1 | ubiquitin associated protein 1 | -0.0262857 |
| S100A10 | S100 calcium binding protein A10 | -0.0262842 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.02625 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0261521 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0261255 |
| RPS11 | ribosomal protein S11 | -0.0260828 |
| SIK3 | SIK family kinase 3 | -0.0260375 |
