Larotrectinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.263174
GRAMD1B GRAM domain containing 1B 0.138111
TXNRD1 thioredoxin reductase 1 0.116276
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0727217
IGF2 insulin-like growth factor 2 0.0709862
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0701494
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0535244
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0425353
EGR1 early growth response 1 0.0382529
ELL2 elongation factor, RNA polymerase II, 2 0.0381291
MMP12 matrix metallopeptidase 12 0.0373697
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0355646
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0347465
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0338628
MKI67 marker of proliferation Ki-67 0.0334774
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0326154
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0315129
CDK17 cyclin-dependent kinase 17 0.0310883
STC1 stanniocalcin 1 0.030169
ADAR adenosine deaminase, RNA-specific 0.0298165
RICTOR RPTOR independent companion of MTOR, complex 2 0.0297403
IL6ST interleukin 6 signal transducer 0.0293328
SNAP25 synaptosomal-associated protein, 25kDa 0.0292549
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0279847
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0266483
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0265425
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0264088
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0263147
PDE4B phosphodiesterase 4B, cAMP-specific 0.0262645
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0257544
CLIP1 CAP-GLY domain containing linker protein 1 0.0257059
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0254339
SRRM2 serine/arginine repetitive matrix 2 0.0252089
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.024891
BIRC2 baculoviral IAP repeat containing 2 0.0248524
DST dystonin 0.0247885
SIN3A SIN3 transcription regulator family member A 0.0245055
SNX9 sorting nexin 9 0.0243727
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0239035
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0232783
ZNFX1 zinc finger, NFX1-type containing 1 0.0230033
VMP1 vacuole membrane protein 1 0.0224922
ARID1A AT rich interactive domain 1A (SWI-like) 0.0223847
CHD1 chromodomain helicase DNA binding protein 1 0.0223255
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0222268
SENP6 SUMO1/sentrin specific peptidase 6 0.022108
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0219199
KLF6 Kruppel-like factor 6 0.0213006
DSPP dentin sialophosphoprotein 0.0209572
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0209198
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0208855
JMJD1C jumonji domain containing 1C 0.0208585
LATS2 large tumor suppressor kinase 2 0.0207408
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0205618
GOLGB1 golgin B1 0.020013
PLSCR1 phospholipid scramblase 1 0.0199853
TCF12 transcription factor 12 0.0197893
RIGI RNA sensor RIG-I 0.0196746
WDR43 WD repeat domain 43 0.019496
CDCP1 CUB domain containing protein 1 0.0194073
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0193944
BCAR3 breast cancer anti-estrogen resistance 3 0.0190745
MAP7 microtubule-associated protein 7 0.0189974
TMEM41B transmembrane protein 41B 0.0188971
BICD1 bicaudal D homolog 1 (Drosophila) 0.0188466
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0188279
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0187112
SINHCAF SIN3-HDAC complex associated factor 0.0185938
IFI6 interferon, alpha-inducible protein 6 0.0184318
IFIH1 interferon induced with helicase C domain 1 0.0183587
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0181328
ETV6 ets variant 6 0.0180849
CREB1 cAMP responsive element binding protein 1 0.0180653
BMAL2 basic helix-loop-helix ARNT like 2 0.0180198
XPO1 exportin 1 0.0179579
RNF145 ring finger protein 145 0.0179463
BHLHE40 basic helix-loop-helix family, member e40 0.0177521
RASAL2 RAS protein activator like 2 0.0176759
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0176689
THADA thyroid adenoma associated 0.017586
BMP5 bone morphogenetic protein 5 0.0175244
TNPO3 transportin 3 0.0174966
SCFD2 sec1 family domain containing 2 0.0174825
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0173744
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0172529
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0170446
CTTNBP2NL CTTNBP2 N-terminal like 0.0170371
SPPL3 signal peptide peptidase like 3 0.017004
BIRC3 baculoviral IAP repeat containing 3 0.0169685
CPNE8 copine VIII 0.0169584
ATXN7 ataxin 7 0.0167863
PMP22 peripheral myelin protein 22 0.0167359
ZFAND3 zinc finger, AN1-type domain 3 0.0165846
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.0163507
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0161964
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.016186
MSN moesin 0.0161325
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0160916
PHF3 PHD finger protein 3 0.0160237
TRIO trio Rho guanine nucleotide exchange factor 0.0158561

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196469
MCL1 myeloid cell leukemia 1 -0.13016
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.11516
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.102704
PRELID2 PRELI domain containing 2 -0.099403
RAD51B RAD51 paralog B -0.0959544
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.09506
TMSB10 thymosin beta 10 -0.0879335
UBC ubiquitin C -0.0868749
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0824053
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0803836
YBX3 Y box binding protein 3 -0.0778164
PTMA prothymosin, alpha -0.0738829
RPS27A ribosomal protein S27a -0.0646111
ACTG1 actin gamma 1 -0.0643421
RPS3 ribosomal protein S3 -0.0599504
TPT1 tumor protein, translationally-controlled 1 -0.0581314
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0575123
AEBP2 AE binding protein 2 -0.0566835
RPL26 ribosomal protein L26 -0.0561748
VIM vimentin -0.0549489
RPL37A ribosomal protein L37a -0.0539763
RPL23 ribosomal protein L23 -0.0534126
TFPI2 tissue factor pathway inhibitor 2 -0.0515438
NAP1L1 nucleosome assembly protein 1-like 1 -0.0500835
RPS21 ribosomal protein S21 -0.0450751
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0445697
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0443623
RPS12 ribosomal protein S12 -0.0439507
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0420603
RPS8 ribosomal protein S8 -0.0419113
SDK1 sidekick cell adhesion molecule 1 -0.0395289
RYR3 ryanodine receptor 3 -0.0392822
MT2A metallothionein 2A -0.039198
CAMTA1 calmodulin binding transcription activator 1 -0.0388531
RPS24 ribosomal protein S24 -0.0386658
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.038475
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0383276
RPL12 ribosomal protein L12 -0.0381777
RRM2 ribonucleotide reductase M2 -0.0375138
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0372441
VCP valosin containing protein -0.0371752
WWOX WW domain containing oxidoreductase -0.0367575
PRH1 proline-rich protein HaeIII subfamily 1 -0.036615
ATXN1 ataxin 1 -0.0359502
OGA O-GlcNAcase -0.0358842
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0356797
RPL31 ribosomal protein L31 -0.0354908
KDM4B lysine (K)-specific demethylase 4B -0.0351643
RPL9 ribosomal protein L9 -0.0340598
SPDYA speedy/RINGO cell cycle regulator family member A -0.03385
HDAC4 histone deacetylase 4 -0.0338153
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0337035
PCBP2 poly(rC) binding protein 2 -0.0333041
STYK1 serine/threonine/tyrosine kinase 1 -0.0327037
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0323966
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0323239
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0323146
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0322208
RPL34 ribosomal protein L34 -0.0319132
ZNF638 zinc finger protein 638 -0.0318967
RPLP1 ribosomal protein, large, P1 -0.0310331
AFF3 AF4/FMR2 family, member 3 -0.030978
FUS FUS RNA binding protein -0.030274
RPS15 ribosomal protein S15 -0.0302664
RPL37 ribosomal protein L37 -0.0301806
WNT2B wingless-type MMTV integration site family, member 2B -0.030099
MYL12B myosin, light chain 12B, regulatory -0.0296523
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0293467
RPS19 ribosomal protein S19 -0.0288545
WDPCP WD repeat containing planar cell polarity effector -0.0286365
INTS6 integrator complex subunit 6 -0.0285766
EXT1 exostosin glycosyltransferase 1 -0.0285422
AHNAK AHNAK nucleoprotein -0.0284685
BRWD1 bromodomain and WD repeat domain containing 1 -0.0281546
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0280676
NEK10 NIMA-related kinase 10 -0.0277791
SEPTIN7 septin 7 -0.0277136
RPL27 ribosomal protein L27 -0.027697
RPL5 ribosomal protein L5 -0.0274324
RPLP2 ribosomal protein, large, P2 -0.0274036
RPS10 ribosomal protein S10 -0.0273627
RSF1 remodeling and spacing factor 1 -0.0270463
RPS4X ribosomal protein S4, X-linked -0.0269391
SAMD4A sterile alpha motif domain containing 4A -0.0268822
RPS29 ribosomal protein S29 -0.0263642
DIAPH2 diaphanous-related formin 2 -0.0262598
TPM2 tropomyosin 2 (beta) -0.025983
SMC4 structural maintenance of chromosomes 4 -0.025631
SET SET nuclear proto-oncogene -0.0253495
RPL11 ribosomal protein L11 -0.0253253
POTEF POTE ankyrin domain family, member F -0.0252425
PKM pyruvate kinase, muscle -0.0251647
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0249936
RYK receptor-like tyrosine kinase -0.0247516
ATP11A ATPase, class VI, type 11A -0.0243422
ENO1 enolase 1, (alpha) -0.0242516
DENND1A DENN/MADD domain containing 1A -0.024182
EEF2 eukaryotic translation elongation factor 2 -0.0241685
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0240823