| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.273743 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.229321 |
| LAMC2 | laminin, gamma 2 | 0.122938 |
| FTL | ferritin, light polypeptide | 0.119918 |
| LAMB3 | laminin, beta 3 | 0.11122 |
| SQSTM1 | sequestosome 1 | 0.108394 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0984452 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0811331 |
| DSPP | dentin sialophosphoprotein | 0.0720599 |
| ENO1 | enolase 1, (alpha) | 0.0697626 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0641266 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0633174 |
| LMO7 | LIM domain 7 | 0.0623572 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0617324 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0614081 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0610874 |
| LDHA | lactate dehydrogenase A | 0.0603944 |
| HMGA1 | high mobility group AT-hook 1 | 0.06015 |
| DSG2 | desmoglein 2 | 0.0598747 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0576446 |
| RPS3 | ribosomal protein S3 | 0.0563057 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0520949 |
| RACK1 | receptor for activated C kinase 1 | 0.0519191 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0519138 |
| ANXA2 | annexin A2 | 0.0514733 |
| RNF213 | ring finger protein 213 | 0.0503452 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0498989 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0491263 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0487861 |
| TPM3 | tropomyosin 3 | 0.0471253 |
| RPS8 | ribosomal protein S8 | 0.0466345 |
| FHIT | fragile histidine triad | 0.0456261 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0450708 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0447972 |
| RPL35A | ribosomal protein L35a | 0.0446972 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0442128 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0442022 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0439965 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0430545 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0430481 |
| KRT7 | keratin 7, type II | 0.042553 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0424094 |
| CCND1 | cyclin D1 | 0.0423123 |
| PGK1 | phosphoglycerate kinase 1 | 0.0413845 |
| DST | dystonin | 0.0411276 |
| CTSS | cathepsin S | 0.0401556 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0388331 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0384759 |
| RPL23 | ribosomal protein L23 | 0.0377814 |
| NAV2 | neuron navigator 2 | 0.0375328 |
| RPL37A | ribosomal protein L37a | 0.0372781 |
| PTMA | prothymosin, alpha | 0.0368538 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0362025 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0358392 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0355453 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0353564 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0352973 |
| ASPH | aspartate beta-hydroxylase | 0.0346184 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0343714 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0341372 |
| PLEC | plectin | 0.0331956 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0329544 |
| CD44 | CD44 molecule (Indian blood group) | 0.0323251 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0322455 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0319537 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0319156 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0314228 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0309844 |
| RPL37 | ribosomal protein L37 | 0.0308723 |
| TXNRD1 | thioredoxin reductase 1 | 0.0304867 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0299335 |
| KRT19 | keratin 19, type I | 0.0299332 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0296818 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0296508 |
| HLA-E | major histocompatibility complex, class I, E | 0.0296174 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0295515 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0294953 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0294497 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0292885 |
| YBX1 | Y box binding protein 1 | 0.0291423 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.029115 |
| EFNA5 | ephrin-A5 | 0.0289361 |
| RPS6 | ribosomal protein S6 | 0.028936 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0286888 |
| CANX | calnexin | 0.028635 |
| VIM | vimentin | 0.0281145 |
| ARF1 | ADP-ribosylation factor 1 | 0.02783 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.027567 |
| KLHL5 | kelch-like family member 5 | 0.0275322 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.027345 |
| MYOF | myoferlin | 0.0273083 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0272304 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0271983 |
| RPL12 | ribosomal protein L12 | 0.027187 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0271171 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0268506 |
| MKI67 | marker of proliferation Ki-67 | 0.026823 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0267461 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0267234 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0266835 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0906905 |
| S100A6 | S100 calcium binding protein A6 | -0.0770806 |
| RCOR1 | REST corepressor 1 | -0.0715649 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0694281 |
| FAM3C | family with sequence similarity 3, member C | -0.0684035 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0633552 |
| TMEM165 | transmembrane protein 165 | -0.0600177 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0590128 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0533668 |
| UBC | ubiquitin C | -0.0520968 |
| COPA | coatomer protein complex, subunit alpha | -0.049442 |
| RBM25 | RNA binding motif protein 25 | -0.0472309 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0469487 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0456607 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0449165 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0446766 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.043912 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0438335 |
| POTEF | POTE ankyrin domain family, member F | -0.0436794 |
| GOLGA4 | golgin A4 | -0.0429723 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0426002 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0414535 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0404543 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.040187 |
| TFG | TRK-fused gene | -0.0400842 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0399424 |
| ARF4 | ADP-ribosylation factor 4 | -0.0397279 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.039164 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0388423 |
| ERBIN | erbb2 interacting protein | -0.0382231 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0369488 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0343982 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0335948 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0331981 |
| FNDC3B | fibronectin type III domain containing 3B | -0.033063 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0327912 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0325485 |
| RNF145 | ring finger protein 145 | -0.0321317 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0320727 |
| CALU | calumenin | -0.0319534 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0313651 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0311409 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0310646 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0303359 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0297394 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0295498 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0293526 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0286686 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0286464 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | -0.0284657 |
| FBXO34 | F-box protein 34 | -0.0284266 |
| TOP1 | topoisomerase (DNA) I | -0.0284069 |
| ZNF207 | zinc finger protein 207 | -0.0283422 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0282775 |
| PCBP2 | poly(rC) binding protein 2 | -0.027647 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0275577 |
| CCNL1 | cyclin L1 | -0.027161 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0270658 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0268754 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0266333 |
| TMEM263 | transmembrane protein 263 | -0.0266144 |
| RPS21 | ribosomal protein S21 | -0.0265839 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0265561 |
| WASF2 | WAS protein family, member 2 | -0.026375 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.026159 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0256355 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.025551 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0255395 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0253208 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0246998 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0246562 |
| PDS5A | PDS5 cohesin associated factor A | -0.0246377 |
| PTK2 | protein tyrosine kinase 2 | -0.0242312 |
| NEMF | nuclear export mediator factor | -0.0241335 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0239443 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0238799 |
| AHNAK | AHNAK nucleoprotein | -0.023603 |
| SEC24D | SEC24 family member D | -0.023569 |
| TJP1 | tight junction protein 1 | -0.0234988 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0234982 |
| NF1 | neurofibromin 1 | -0.0234858 |
| CDK7 | cyclin-dependent kinase 7 | -0.0232347 |
| CBX3 | chromobox homolog 3 | -0.023171 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0231188 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0228947 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0228441 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0227676 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0227223 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.022631 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0225033 |
| MSI2 | musashi RNA-binding protein 2 | -0.0222118 |
| SRPK2 | SRSF protein kinase 2 | -0.0220509 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0220454 |
| CDCP1 | CUB domain containing protein 1 | -0.0219644 |
| RPL8 | ribosomal protein L8 | -0.0216251 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0214288 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0211486 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.020999 |
| BBX | bobby sox homolog (Drosophila) | -0.0209332 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0207856 |
