| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.118841 |
| GRAMD1B | GRAM domain containing 1B | 0.114809 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.109386 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.106523 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0873759 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0855915 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0834773 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0828781 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0728107 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0666419 |
| DST | dystonin | 0.0649647 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0568886 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0516845 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0513233 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0503952 |
| ANTXR1 | anthrax toxin receptor 1 | 0.047675 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0472802 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.046578 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0446846 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0445154 |
| CENPF | centromere protein F, 350/400kDa | 0.0444723 |
| KYNU | kynureninase | 0.043925 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0437193 |
| TPM3 | tropomyosin 3 | 0.0433759 |
| TXNRD1 | thioredoxin reductase 1 | 0.042331 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0421461 |
| RPS6 | ribosomal protein S6 | 0.042043 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0410568 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0400363 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0381729 |
| EGR1 | early growth response 1 | 0.0365069 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0358553 |
| MSN | moesin | 0.0357338 |
| PCBP2 | poly(rC) binding protein 2 | 0.0353475 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0340564 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0339013 |
| GPRIN3 | GPRIN family member 3 | 0.0338375 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0333817 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0325494 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0316381 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0305699 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0299768 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0299139 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0295596 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0293282 |
| NEK7 | NIMA-related kinase 7 | 0.0292431 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0291533 |
| COL5A2 | collagen, type V, alpha 2 | 0.0277306 |
| YBX1 | Y box binding protein 1 | 0.0271918 |
| RPL3 | ribosomal protein L3 | 0.0271684 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0270242 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0267482 |
| MYO10 | myosin X | 0.0266829 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0262993 |
| NRG1 | neuregulin 1 | 0.025809 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.025483 |
| EZR | ezrin | 0.0252292 |
| NUP58 | nucleoporin 58 | 0.0249417 |
| CSRP1 | cysteine and glycine-rich protein 1 | 0.0247699 |
| LSAMP | limbic system-associated membrane protein | 0.0244479 |
| SET | SET nuclear proto-oncogene | 0.0240668 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0238611 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0235876 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0234572 |
| MKI67 | marker of proliferation Ki-67 | 0.0230501 |
| PKM | pyruvate kinase, muscle | 0.0227953 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0227923 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.0223585 |
| PFN1 | profilin 1 | 0.0223303 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0222879 |
| RPS2 | ribosomal protein S2 | 0.0218413 |
| LDHA | lactate dehydrogenase A | 0.021774 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0217721 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0217096 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0214847 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0213578 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0212202 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0211787 |
| RPL23 | ribosomal protein L23 | 0.0211333 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0209216 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.0207095 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0204811 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0204354 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0201569 |
| CHL1 | cell adhesion molecule L1-like | 0.0200119 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0198885 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0198636 |
| CLU | clusterin | 0.0198371 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.019449 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0190427 |
| PAPOLA | poly(A) polymerase alpha | 0.0190139 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0187063 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0186349 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0181041 |
| ENO1 | enolase 1, (alpha) | 0.0179239 |
| HSPE1 | heat shock 10kDa protein 1 | 0.0177816 |
| VMP1 | vacuole membrane protein 1 | 0.0177093 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0174818 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0173042 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.017301 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.167552 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.142516 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.107035 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.103942 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0986275 |
| FN1 | fibronectin 1 | -0.0947203 |
| RPS24 | ribosomal protein S24 | -0.0869951 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0848832 |
| EFNA5 | ephrin-A5 | -0.0785824 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0701506 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0687823 |
| VIM | vimentin | -0.0683511 |
| CDH13 | cadherin 13 | -0.0647913 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0614697 |
| PCBP3 | poly(rC) binding protein 3 | -0.0542326 |
| SMYD3 | SET and MYND domain containing 3 | -0.0499138 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0488599 |
| S100A6 | S100 calcium binding protein A6 | -0.0473171 |
| RPLP0 | ribosomal protein, large, P0 | -0.0455583 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0440079 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0434794 |
| RPL38 | ribosomal protein L38 | -0.0432662 |
| NPAS2 | neuronal PAS domain protein 2 | -0.043133 |
| RPL31 | ribosomal protein L31 | -0.0428658 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0428145 |
| RPLP1 | ribosomal protein, large, P1 | -0.0428099 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0426098 |
| CANX | calnexin | -0.0422633 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0399717 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0395971 |
| TMSB10 | thymosin beta 10 | -0.0388273 |
| RPL35A | ribosomal protein L35a | -0.0385547 |
| RPS27A | ribosomal protein S27a | -0.0382918 |
| AUTS2 | autism susceptibility candidate 2 | -0.0377378 |
| ACTG1 | actin gamma 1 | -0.0376857 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0374723 |
| S100A10 | S100 calcium binding protein A10 | -0.0372575 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.037028 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0365801 |
| RPL7A | ribosomal protein L7a | -0.0363666 |
| RPL36A | ribosomal protein L36a | -0.0361159 |
| AHNAK | AHNAK nucleoprotein | -0.0358672 |
| RPS21 | ribosomal protein S21 | -0.0346508 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0338174 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0336946 |
| RPL26 | ribosomal protein L26 | -0.0336914 |
| VCL | vinculin | -0.0336878 |
| NCKAP5 | NCK-associated protein 5 | -0.0328157 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.032627 |
| GDA | guanine deaminase | -0.0321694 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.031702 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0312726 |
| IER3 | immediate early response 3 | -0.0311918 |
| PGK1 | phosphoglycerate kinase 1 | -0.0307024 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0304653 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0301132 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0291271 |
| PTMA | prothymosin, alpha | -0.0289696 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0289416 |
| RPL9 | ribosomal protein L9 | -0.028607 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0284475 |
| ANXA2 | annexin A2 | -0.0278076 |
| HDAC8 | histone deacetylase 8 | -0.0277418 |
| RPL34 | ribosomal protein L34 | -0.0276007 |
| RPS16 | ribosomal protein S16 | -0.02748 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0272938 |
| RPS25 | ribosomal protein S25 | -0.0270788 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0270591 |
| LMNA | lamin A/C | -0.0269664 |
| RANBP17 | RAN binding protein 17 | -0.0269533 |
| TMSB4X | thymosin beta 4, X-linked | -0.0269214 |
| SMAD2 | SMAD family member 2 | -0.0269125 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0264592 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0264321 |
| GNAS | GNAS complex locus | -0.0254679 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0253686 |
| FNIP1 | folliculin interacting protein 1 | -0.0253656 |
| TBXT | T-box transcription factor T | -0.0250306 |
| SRGN | serglycin | -0.0248403 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.024833 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0248026 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0245839 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.024497 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0244881 |
| RPL12 | ribosomal protein L12 | -0.0244005 |
| DENND1A | DENN/MADD domain containing 1A | -0.0243126 |
| RPS29 | ribosomal protein S29 | -0.0239722 |
| UBC | ubiquitin C | -0.0237252 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0236828 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0235131 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0234729 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0234236 |
| RPL19 | ribosomal protein L19 | -0.0230948 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0229941 |
| DIAPH2 | diaphanous-related formin 2 | -0.0229847 |
| RAB31 | RAB31, member RAS oncogene family | -0.0227277 |
| SBF2 | SET binding factor 2 | -0.0226617 |
| ABLIM1 | actin binding LIM protein 1 | -0.0226285 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0226025 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0224928 |
