Larotrectinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

191 genes differentially expressed following the Larotrectinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMTK2 lemur tyrosine kinase 2 0.245803
NAMPT nicotinamide phosphoribosyltransferase 0.174697
EPS8 epidermal growth factor receptor pathway substrate 8 0.116781
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.112947
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.111976
VIM vimentin 0.0998455
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0932573
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0916082
NDRG1 N-myc downstream regulated 1 0.0854336
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0755578
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0735364
B2M beta-2-microglobulin 0.0681853
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0671699
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0663802
STK24 serine/threonine kinase 24 0.0637476
SLC38A1 solute carrier family 38, member 1 0.0637022
ZBTB20 zinc finger and BTB domain containing 20 0.056479
CANX calnexin 0.053574
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0532645
MED13L mediator complex subunit 13-like 0.0501918
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0495779
PTMA prothymosin, alpha 0.0489157
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0475466
PGK1 phosphoglycerate kinase 1 0.0461746
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.045172
BAIAP2L1 BAI1-associated protein 2-like 1 0.0447045
CRY1 cryptochrome circadian clock 1 0.0436904
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0434449
AKAP12 A kinase (PRKA) anchor protein 12 0.0420382
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0415513
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0411142
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0399875
FRMD4A FERM domain containing 4A 0.0392259
LSAMP limbic system-associated membrane protein 0.0385736
QKI QKI, KH domain containing, RNA binding 0.0384678
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0362439
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0354731
RPS6 ribosomal protein S6 0.035251
DST dystonin 0.0350386
JMJD1C jumonji domain containing 1C 0.0346939
ERRFI1 ERBB receptor feedback inhibitor 1 0.0316044
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.031445
FBXO11 F-box protein 11 0.0312364
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.030921
GLS2 glutaminase 2 (liver, mitochondrial) 0.0295404
RLF rearranged L-myc fusion 0.0284675
IGFBP3 insulin-like growth factor binding protein 3 0.0280663
PDE4D phosphodiesterase 4D, cAMP-specific 0.0277529
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0268955
RIOK3 RIO kinase 3 0.0266462
ANXA2 annexin A2 0.0265891
RHOBTB3 Rho-related BTB domain containing 3 0.0257813
PICALM phosphatidylinositol binding clathrin assembly protein 0.025762
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0257095
AFDN afadin, adherens junction formation factor 0.0254878
TPT1 tumor protein, translationally-controlled 1 0.0247428
HIPK2 homeodomain interacting protein kinase 2 0.0243801
NCOR1 nuclear receptor corepressor 1 0.0237781
ANKHD1 ankyrin repeat and KH domain containing 1 0.0233793
PCCA propionyl CoA carboxylase, alpha polypeptide 0.023341
RPL23 ribosomal protein L23 0.0232879
IGF2 insulin-like growth factor 2 0.0229682
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.02245
AKAP13 A kinase (PRKA) anchor protein 13 0.0222229
CDH13 cadherin 13 0.0219906
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0219238
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0209496
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0207593
RBM39 RNA binding motif protein 39 0.020153
RBM33 RNA binding motif protein 33 0.0195175
CCNK cyclin K 0.0192209
MED13 mediator complex subunit 13 0.0190702
ZEB1 zinc finger E-box binding homeobox 1 0.0189632
PRKN parkin RBR E3 ubiquitin protein ligase 0.0178885
PRKG1 protein kinase, cGMP-dependent, type I 0.0174401
NALF1 NALCN channel auxiliary factor 1 0.0163738
TRA2A transformer 2 alpha homolog (Drosophila) 0.0158916
SFTPA2 surfactant protein A2 0.0157515
DENND4A DENN/MADD domain containing 4A 0.0156606
RPL31 ribosomal protein L31 0.0152574
RORA RAR-related orphan receptor A 0.0149775
TMSB10 thymosin beta 10 0.0143322
FAM13B family with sequence similarity 13, member B 0.0143035
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0141529
STAG2 stromal antigen 2 0.0138845
GPC6 glypican 6 0.0134688
RPLP1 ribosomal protein, large, P1 0.0133252
GOLIM4 golgi integral membrane protein 4 0.0133075
RAP1B RAP1B, member of RAS oncogene family 0.0130547
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0126321
RTN4 reticulon 4 0.0124062
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0114675
CERT1 ceramide transporter 1 0.0111921
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0104544
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.010425
KMT2E lysine (K)-specific methyltransferase 2E 0.0104089
MYO10 myosin X 0.0100848
KTN1 kinectin 1 (kinesin receptor) 0.00943068
SH3KBP1 SH3-domain kinase binding protein 1 0.00939287
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00884413

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.170495
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.109338
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.108653
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.104619
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.1005
EFNA5 ephrin-A5 -0.097653
DOCK4 dedicator of cytokinesis 4 -0.0948374
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0940652
ITCH itchy E3 ubiquitin protein ligase -0.0906206
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0869348
EXT1 exostosin glycosyltransferase 1 -0.0816268
TNS3 tensin 3 -0.0761462
PKM pyruvate kinase, muscle -0.0726104
TBC1D5 TBC1 domain family, member 5 -0.0714324
ALCAM activated leukocyte cell adhesion molecule -0.0707513
VCL vinculin -0.07025
FNDC3A fibronectin type III domain containing 3A -0.0689021
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0646339
PRRC2C proline-rich coiled-coil 2C -0.0633999
PDLIM5 PDZ and LIM domain 5 -0.0604402
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0585015
LMO7 LIM domain 7 -0.0557276
ZNF292 zinc finger protein 292 -0.0545201
FN1 fibronectin 1 -0.0534623
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0532626
USP34 ubiquitin specific peptidase 34 -0.0510996
SLTM SAFB-like, transcription modulator -0.0492656
TPM4 tropomyosin 4 -0.0470081
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0448391
TRIO trio Rho guanine nucleotide exchange factor -0.0434697
GCC2 GRIP and coiled-coil domain containing 2 -0.043014
ACTG1 actin gamma 1 -0.0400593
NBAS neuroblastoma amplified sequence -0.0398959
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0384577
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0360602
GOLGA4 golgin A4 -0.0339733
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0335151
SMYD3 SET and MYND domain containing 3 -0.0325801
EEF2 eukaryotic translation elongation factor 2 -0.0317238
STC1 stanniocalcin 1 -0.0316577
FLNB filamin B, beta -0.0314051
MAML3 mastermind-like 3 (Drosophila) -0.0311991
RPL35A ribosomal protein L35a -0.0298845
BIRC6 baculoviral IAP repeat containing 6 -0.029431
RPS19 ribosomal protein S19 -0.0225877
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0208084
PSD3 pleckstrin and Sec7 domain containing 3 -0.0186775
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0186609
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0184735
RASAL2 RAS protein activator like 2 -0.0162196
DOCK5 dedicator of cytokinesis 5 -0.0151682
TRIP12 thyroid hormone receptor interactor 12 -0.0150619
ANKRD11 ankyrin repeat domain 11 -0.0149567
FNDC3B fibronectin type III domain containing 3B -0.0147427
ASPH aspartate beta-hydroxylase -0.014482
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0138286
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0136954
MYO1E myosin IE -0.0135717
PUM2 pumilio RNA-binding family member 2 -0.0134941
SPAG9 sperm associated antigen 9 -0.0128225
VMP1 vacuole membrane protein 1 -0.0126186
CD44 CD44 molecule (Indian blood group) -0.0113686
ANKRD12 ankyrin repeat domain 12 -0.0110604
MYOF myoferlin -0.0107763
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0105986
JAK1 Janus kinase 1 -0.010221
ZFAND3 zinc finger, AN1-type domain 3 -0.0102179
RPS8 ribosomal protein S8 -0.00950639
RAD51B RAD51 paralog B -0.00926605
ZSWIM6 zinc finger, SWIM-type containing 6 -0.00861463
PTPRM protein tyrosine phosphatase, receptor type, M -0.00696363
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0065565
KLF5 Kruppel-like factor 5 (intestinal) -0.00645439
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.00610131
INTS6 integrator complex subunit 6 -0.00536987
EGFR epidermal growth factor receptor -0.00455357
AGO2 argonaute RISC catalytic component 2 -0.0044979
MACF1 microtubule-actin crosslinking factor 1 -0.00441421
SYAP1 synapse associated protein 1 -0.00412707
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0038809
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00324807
KIF5B kinesin family member 5B -0.00235872
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.00218549
FNIP1 folliculin interacting protein 1 -0.0020677
RCOR1 REST corepressor 1 -0.00199691
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.00158524
PTK2 protein tyrosine kinase 2 -0.00143351
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -7.1386E-4
RNF213 ring finger protein 213 -1.30753E-4
DSCAM Down syndrome cell adhesion molecule -1.0945E-4
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -6.14803E-5