| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0649832 |
| SMYD3 | SET and MYND domain containing 3 | 0.0567618 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0563212 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0554928 |
| NTM | neurotrimin | 0.0545118 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0467378 |
| RAD51B | RAD51 paralog B | 0.0459834 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0446807 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0420554 |
| MTDH | metadherin | 0.0420146 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0400908 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0389807 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.036573 |
| NFIA | nuclear factor I/A | 0.0351398 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0349837 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0342195 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | 0.0331629 |
| SESN2 | sestrin 2 | 0.0327477 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0320581 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0318075 |
| DSPP | dentin sialophosphoprotein | 0.0314668 |
| SPIDR | scaffolding protein involved in DNA repair | 0.030002 |
| DST | dystonin | 0.0298318 |
| RPS6 | ribosomal protein S6 | 0.0288097 |
| GSPT1 | G1 to S phase transition 1 | 0.028701 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0284817 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0280619 |
| YBX1 | Y box binding protein 1 | 0.0279925 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0278483 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0275558 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0275452 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0273324 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0272846 |
| GLI3 | GLI family zinc finger 3 | 0.0272422 |
| WWC2 | WW and C2 domain containing 2 | 0.0269979 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0267849 |
| MKI67 | marker of proliferation Ki-67 | 0.0265184 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0263492 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0261414 |
| C7ORF57 | chromosome 7 open reading frame 57 | 0.0260719 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0258128 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0255112 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0254703 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0253907 |
| PCBP2 | poly(rC) binding protein 2 | 0.0252635 |
| REST | RE1-silencing transcription factor | 0.0248605 |
| NGFR | nerve growth factor receptor | 0.0245393 |
| HYOU1 | hypoxia up-regulated 1 | 0.0245128 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0240666 |
| TLN1 | talin 1 | 0.0240487 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 0.0240405 |
| TMF1 | TATA element modulatory factor 1 | 0.0239908 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.023762 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0237506 |
| PRTG | protogenin | 0.0235782 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0234728 |
| SET | SET nuclear proto-oncogene | 0.0234573 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0232665 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0231397 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0230782 |
| RGL3 | ral guanine nucleotide dissociation stimulator-like 3 | 0.023006 |
| PDS5B | PDS5 cohesin associated factor B | 0.0228847 |
| PEG10 | paternally expressed 10 | 0.02286 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0227658 |
| IRF2BPL | interferon regulatory factor 2 binding protein-like | 0.0226696 |
| METAP2 | methionyl aminopeptidase 2 | 0.0223026 |
| RPS2 | ribosomal protein S2 | 0.0222979 |
| RABGAP1 | RAB GTPase activating protein 1 | 0.0219852 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0219016 |
| RPL4 | ribosomal protein L4 | 0.0218389 |
| ZNF609 | zinc finger protein 609 | 0.0216916 |
| DMD | dystrophin | 0.0215449 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.021478 |
| PLPP1 | phospholipid phosphatase 1 | 0.0213165 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0213088 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0213062 |
| NRDC | nardilysin convertase | 0.021168 |
| LPIN2 | lipin 2 | 0.0210856 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0209849 |
| TMEM165 | transmembrane protein 165 | 0.0208485 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0208254 |
| SEC24B | SEC24 family member B | 0.0208097 |
| NOP58 | NOP58 ribonucleoprotein | 0.0207435 |
| FAT1 | FAT atypical cadherin 1 | 0.0207153 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0206219 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0205259 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0204737 |
| PCBP1 | poly(rC) binding protein 1 | 0.0204666 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0204612 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0202577 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0202294 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0200752 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0199555 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0199495 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0199119 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0199108 |
| ZFP30 | ZFP30 zinc finger protein | 0.0198859 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0198656 |
| TBCD | tubulin folding cofactor D | 0.019843 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0197423 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.162369 |
| COL5A2 | collagen, type V, alpha 2 | -0.139324 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.121573 |
| COL3A1 | collagen, type III, alpha 1 | -0.103563 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0939824 |
| VIM | vimentin | -0.0903276 |
| PHIP | pleckstrin homology domain interacting protein | -0.0883251 |
| PCDH9 | protocadherin 9 | -0.0793487 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.078174 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0768764 |
| PTMA | prothymosin, alpha | -0.0763396 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0750775 |
| LRRC4C | leucine rich repeat containing 4C | -0.0746276 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0732493 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0711088 |
| COL1A2 | collagen, type I, alpha 2 | -0.0688371 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0682535 |
| RASAL2 | RAS protein activator like 2 | -0.0667401 |
| ITGAV | integrin, alpha V | -0.0637402 |
| GPC3 | glypican 3 | -0.0622562 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0595147 |
| ZNF292 | zinc finger protein 292 | -0.0578021 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0573218 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0534719 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.049765 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.048971 |
| HMCN1 | hemicentin 1 | -0.0479485 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0478411 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0463227 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0457305 |
| PRELID2 | PRELI domain containing 2 | -0.0455466 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0454026 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0449198 |
| ZNF217 | zinc finger protein 217 | -0.0436971 |
| B2M | beta-2-microglobulin | -0.0432566 |
| TENM3 | teneurin transmembrane protein 3 | -0.0405009 |
| MED12L | mediator complex subunit 12-like | -0.0400608 |
| ACTG1 | actin gamma 1 | -0.0398411 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0397611 |
| MYL12B | myosin, light chain 12B, regulatory | -0.038805 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0379703 |
| RAB31 | RAB31, member RAS oncogene family | -0.0372367 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0370972 |
| VCL | vinculin | -0.0364276 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0355389 |
| FUS | FUS RNA binding protein | -0.0351939 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.035102 |
| RPL5 | ribosomal protein L5 | -0.0347878 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0347307 |
| S100A10 | S100 calcium binding protein A10 | -0.0341685 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0340687 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0338154 |
| PUM2 | pumilio RNA-binding family member 2 | -0.033249 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0328958 |
| ZNF207 | zinc finger protein 207 | -0.032856 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0327096 |
| JMJD1C | jumonji domain containing 1C | -0.032494 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0321986 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0317358 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0314262 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0313412 |
| GNAS | GNAS complex locus | -0.0310783 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0310593 |
| SPAG9 | sperm associated antigen 9 | -0.0308372 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.030762 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0306714 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0305453 |
| SYT1 | synaptotagmin I | -0.0302095 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0301901 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0301408 |
| INTS6 | integrator complex subunit 6 | -0.0301335 |
| ANXA2 | annexin A2 | -0.0292075 |
| HMGB1 | high mobility group box 1 | -0.0291655 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0289912 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0289729 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0286429 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0285188 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0283076 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0282693 |
| DIAPH3 | diaphanous-related formin 3 | -0.0281239 |
| KHSRP | KH-type splicing regulatory protein | -0.0281012 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0280792 |
| KIF13A | kinesin family member 13A | -0.0277931 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0276291 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0274177 |
| TMSB4X | thymosin beta 4, X-linked | -0.0273803 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.027334 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0272148 |
| RPL9 | ribosomal protein L9 | -0.027026 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0269779 |
| MAP4 | microtubule-associated protein 4 | -0.0269079 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0268659 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0268267 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0267592 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0265707 |
| MB21D2 | Mab-21 domain containing 2 | -0.0265113 |
| CTSB | cathepsin B | -0.0263853 |
| USP25 | ubiquitin specific peptidase 25 | -0.0263485 |
| CLIC4 | chloride intracellular channel 4 | -0.0262487 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0261679 |
