| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0963376 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0771888 |
| TXNRD1 | thioredoxin reductase 1 | 0.0721234 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0708126 |
| PFN1 | profilin 1 | 0.0680118 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.063884 |
| PKM | pyruvate kinase, muscle | 0.0594859 |
| ZNF292 | zinc finger protein 292 | 0.0467435 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0454951 |
| PYGB | phosphorylase, glycogen; brain | 0.0437577 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0432394 |
| PDGFC | platelet derived growth factor C | 0.0421509 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0405287 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0400067 |
| FAM13A | family with sequence similarity 13, member A | 0.0391874 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0381431 |
| BMP2K | BMP2 inducible kinase | 0.0380618 |
| HMGA1 | high mobility group AT-hook 1 | 0.036658 |
| TXNIP | thioredoxin interacting protein | 0.0351868 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0349433 |
| GOLGA4 | golgin A4 | 0.0342424 |
| RNF145 | ring finger protein 145 | 0.0339961 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0330786 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | 0.032594 |
| MATR3 | matrin 3 | 0.0324598 |
| LOXL3 | lysyl oxidase-like 3 | 0.0319843 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0311395 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0308651 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0300383 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0299785 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0291327 |
| HDAC9 | histone deacetylase 9 | 0.0290838 |
| LDHA | lactate dehydrogenase A | 0.0287194 |
| DSTN | destrin (actin depolymerizing factor) | 0.0284498 |
| CDC73 | cell division cycle 73 | 0.0282635 |
| ITGA6 | integrin, alpha 6 | 0.0268261 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0266032 |
| CAVIN2 | caveolae associated protein 2 | 0.0265243 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0264811 |
| QKI | QKI, KH domain containing, RNA binding | 0.0264489 |
| GLI2 | GLI family zinc finger 2 | 0.026283 |
| PCGF5 | polycomb group ring finger 5 | 0.0259718 |
| KIF5B | kinesin family member 5B | 0.0255463 |
| CCDC68 | coiled-coil domain containing 68 | 0.0254462 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0253553 |
| PLK2 | polo-like kinase 2 | 0.0248207 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0242085 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0241225 |
| RPS2 | ribosomal protein S2 | 0.0238786 |
| NUP58 | nucleoporin 58 | 0.0236918 |
| TMSB4X | thymosin beta 4, X-linked | 0.0236882 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0235175 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0234275 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0233283 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0230974 |
| TPR | translocated promoter region, nuclear basket protein | 0.0229778 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0226338 |
| EZR | ezrin | 0.0225545 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.022101 |
| NCKAP1 | NCK-associated protein 1 | 0.0220138 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0219147 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | 0.0218126 |
| TJP1 | tight junction protein 1 | 0.0216863 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0216537 |
| TOB1 | transducer of ERBB2, 1 | 0.0214256 |
| RPL3 | ribosomal protein L3 | 0.0214221 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0213011 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.021271 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0211331 |
| CCNL1 | cyclin L1 | 0.021113 |
| GLI3 | GLI family zinc finger 3 | 0.020718 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.020629 |
| TMEM65 | transmembrane protein 65 | 0.0203012 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0201895 |
| YEATS2 | YEATS domain containing 2 | 0.0201767 |
| RPL18 | ribosomal protein L18 | 0.0201672 |
| HELZ | helicase with zinc finger | 0.0200224 |
| ZFR | zinc finger RNA binding protein | 0.0199603 |
| RCOR3 | REST corepressor 3 | 0.0198585 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0195548 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0194048 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.0193764 |
| PTMS | parathymosin | 0.0192017 |
| UBXN4 | UBX domain protein 4 | 0.0189377 |
| TPI1 | triosephosphate isomerase 1 | 0.0188981 |
| GPD2 | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.0184648 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0184614 |
| TRERF1 | transcriptional regulating factor 1 | 0.0184091 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0181378 |
| SPRY2 | sprouty homolog 2 (Drosophila) | 0.0180415 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0180361 |
| CLU | clusterin | 0.0178995 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0178209 |
| CHURC1 | churchill domain containing 1 | 0.0176689 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0174409 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0174317 |
| ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative) | 0.0173915 |
| PAPOLA | poly(A) polymerase alpha | 0.0173676 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0172366 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0171999 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.237262 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.180239 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.124985 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0948962 |
| AHNAK | AHNAK nucleoprotein | -0.0847903 |
| RPS13 | ribosomal protein S13 | -0.0739095 |
| RPS27A | ribosomal protein S27a | -0.0710544 |
| RPL31 | ribosomal protein L31 | -0.064259 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0623019 |
| FOXP1 | forkhead box P1 | -0.0582529 |
| UBC | ubiquitin C | -0.0581528 |
| RPL35A | ribosomal protein L35a | -0.0563628 |
| RPL34 | ribosomal protein L34 | -0.0562907 |
| RPL37A | ribosomal protein L37a | -0.0552362 |
| RPLP1 | ribosomal protein, large, P1 | -0.0542419 |
| RPL9 | ribosomal protein L9 | -0.0534698 |
| RPS25 | ribosomal protein S25 | -0.0513713 |
| RPS3 | ribosomal protein S3 | -0.0512008 |
| RPS23 | ribosomal protein S23 | -0.0507595 |
| ACTG1 | actin gamma 1 | -0.0507025 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0503341 |
| RPL19 | ribosomal protein L19 | -0.0498567 |
| RPL26 | ribosomal protein L26 | -0.0493785 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0489705 |
| RPS8 | ribosomal protein S8 | -0.0467122 |
| INTS6 | integrator complex subunit 6 | -0.0465745 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0461361 |
| RPS24 | ribosomal protein S24 | -0.0459321 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0453277 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0453127 |
| VCL | vinculin | -0.0440513 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0433246 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0402375 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0398629 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0396307 |
| RPLP2 | ribosomal protein, large, P2 | -0.0393289 |
| RPL38 | ribosomal protein L38 | -0.0384659 |
| NAV2 | neuron navigator 2 | -0.0380145 |
| AEBP2 | AE binding protein 2 | -0.0373545 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.036472 |
| RPS21 | ribosomal protein S21 | -0.0362315 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0361467 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0354543 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0350843 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0349897 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0342949 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0340794 |
| FUS | FUS RNA binding protein | -0.0332879 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0326544 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0326321 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0324748 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0323104 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0319407 |
| S100A9 | S100 calcium binding protein A9 | -0.0314666 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.030067 |
| RPL8 | ribosomal protein L8 | -0.0297225 |
| FNIP1 | folliculin interacting protein 1 | -0.0294272 |
| RPL30 | ribosomal protein L30 | -0.0294074 |
| RPS29 | ribosomal protein S29 | -0.0294034 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.029041 |
| DIAPH3 | diaphanous-related formin 3 | -0.0284578 |
| RPL23 | ribosomal protein L23 | -0.0279426 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0278813 |
| CENPE | centromere protein E, 312kDa | -0.0278738 |
| AMOTL2 | angiomotin like 2 | -0.0274747 |
| FER1L6 | fer-1-like family member 6 | -0.02734 |
| CENPF | centromere protein F, 350/400kDa | -0.0272855 |
| TBCA | tubulin folding cofactor A | -0.0268648 |
| S100A6 | S100 calcium binding protein A6 | -0.0261514 |
| ADIPOR2 | adiponectin receptor 2 | -0.0261 |
| VIM | vimentin | -0.0255924 |
| CARS1 | cysteinyl-tRNA synthetase 1 | -0.0254105 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0252701 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0250462 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0250091 |
| RPS15 | ribosomal protein S15 | -0.0248885 |
| CREBBP | CREB binding protein | -0.0246361 |
| MCL1 | myeloid cell leukemia 1 | -0.0245855 |
| ATXN2 | ataxin 2 | -0.02457 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0245549 |
| RPL7A | ribosomal protein L7a | -0.0244789 |
| PPP4R2 | protein phosphatase 4, regulatory subunit 2 | -0.0241462 |
| COG5 | component of oligomeric golgi complex 5 | -0.0240563 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0240354 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.024019 |
| HLA-B | major histocompatibility complex, class I, B | -0.0240066 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0239683 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0238782 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.023856 |
| S100A10 | S100 calcium binding protein A10 | -0.0237119 |
| RPL36A | ribosomal protein L36a | -0.0236624 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0235796 |
| RPS16 | ribosomal protein S16 | -0.0234225 |
| CLIC4 | chloride intracellular channel 4 | -0.0232431 |
| CUX1 | cut-like homeobox 1 | -0.0232204 |
| NOP56 | NOP56 ribonucleoprotein | -0.0232012 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0231765 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0230006 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.022869 |
| RPL5 | ribosomal protein L5 | -0.0228172 |
