Larotrectinib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Larotrectinib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Larotrectinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.171061
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0817204
VCL vinculin 0.0778778
IGFBP3 insulin-like growth factor binding protein 3 0.0739322
EGR1 early growth response 1 0.0711659
MYH9 myosin, heavy chain 9, non-muscle 0.0688052
NDRG1 N-myc downstream regulated 1 0.0626989
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0578854
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0485008
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0461923
FRMD4A FERM domain containing 4A 0.0456037
MSN moesin 0.0451624
VCAN versican 0.0436
CD44 CD44 molecule (Indian blood group) 0.0418744
HDAC9 histone deacetylase 9 0.0412143
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0389347
GPC6 glypican 6 0.0388286
LDHA lactate dehydrogenase A 0.0387788
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0376827
TGM2 transglutaminase 2 0.0361397
FTH1 ferritin, heavy polypeptide 1 0.0350184
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0347306
APLP2 amyloid beta (A4) precursor-like protein 2 0.034408
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.034097
COL6A3 collagen, type VI, alpha 3 0.0337554
SEPTIN9 septin 9 0.0325622
GOLGB1 golgin B1 0.0317846
VEGFA vascular endothelial growth factor A 0.0315911
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0308966
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0306298
ASPH aspartate beta-hydroxylase 0.0300723
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0288642
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0286922
NAV1 neuron navigator 1 0.0284084
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0279287
STC2 stanniocalcin 2 0.0259477
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0249318
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0248091
HLA-E major histocompatibility complex, class I, E 0.0246249
TRIM55 tripartite motif containing 55 0.0244643
SOX9 SRY (sex determining region Y)-box 9 0.0237357
RAB7A RAB7A, member RAS oncogene family 0.0234496
TLN1 talin 1 0.0228108
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.022786
PPARD peroxisome proliferator-activated receptor delta 0.0224006
ENO1 enolase 1, (alpha) 0.0222927
BCAR3 breast cancer anti-estrogen resistance 3 0.0217539
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0216841
PDE10A phosphodiesterase 10A 0.0216008
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0214887
WWTR1 WW domain containing transcription regulator 1 0.0210329
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0207435
TIMP2 TIMP metallopeptidase inhibitor 2 0.0206363
LOXL2 lysyl oxidase-like 2 0.0204424
EPAS1 endothelial PAS domain protein 1 0.0203365
VMP1 vacuole membrane protein 1 0.0201378
ERRFI1 ERBB receptor feedback inhibitor 1 0.0201281
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0197842
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0196999
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0191874
MYO1E myosin IE 0.01882
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0184482
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0183742
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0183718
PSD3 pleckstrin and Sec7 domain containing 3 0.0177464
LIMA1 LIM domain and actin binding 1 0.0175459
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0174928
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0173694
NCOR2 nuclear receptor corepressor 2 0.0169976
ZSWIM6 zinc finger, SWIM-type containing 6 0.0168482
PLIN2 perilipin 2 0.0165333
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.016444
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0162046
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0161417
ZMIZ1 zinc finger, MIZ-type containing 1 0.0160823
FBXL7 F-box and leucine-rich repeat protein 7 0.0159391
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0156919
IER2 immediate early response 2 0.0153136
PDLIM5 PDZ and LIM domain 5 0.0151331
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0148129
P3H2 prolyl 3-hydroxylase 2 0.0147589
RAD51B RAD51 paralog B 0.0146619
EVC Ellis van Creveld protein 0.014568
ZHX2 zinc fingers and homeoboxes 2 0.0145619
PRKCE protein kinase C, epsilon 0.0145538
ARFGEF3 ARFGEF family member 3 0.0143728
PDIA3 protein disulfide isomerase family A, member 3 0.0142321
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.014011
IRAK2 interleukin-1 receptor-associated kinase 2 0.0139234
RAB5B RAB5B, member RAS oncogene family 0.0138919
HSPA8 heat shock 70kDa protein 8 0.0137263
SHISA5 shisa family member 5 0.0137181
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0136107
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0136083
NTN4 netrin 4 0.0136082
ZNF608 zinc finger protein 608 0.0135144
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0134647
C6ORF62 chromosome 6 open reading frame 62 0.0132222
MYO10 myosin X 0.0131876
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0129301

decreased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial -0.222726
NAMPT nicotinamide phosphoribosyltransferase -0.110897
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101225
TPT1 tumor protein, translationally-controlled 1 -0.0972167
TMSB10 thymosin beta 10 -0.0915817
IER3 immediate early response 3 -0.0885696
AHNAK AHNAK nucleoprotein -0.0834661
FN1 fibronectin 1 -0.0817652
UGCG UDP-glucose ceramide glucosyltransferase -0.0798939
VIM vimentin -0.076975
KYNU kynureninase -0.0646053
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0633446
RPS24 ribosomal protein S24 -0.0617429
PGK1 phosphoglycerate kinase 1 -0.0567341
NAP1L1 nucleosome assembly protein 1-like 1 -0.0543937
FNDC3B fibronectin type III domain containing 3B -0.0535925
WSB1 WD repeat and SOCS box containing 1 -0.0507784
HLA-B major histocompatibility complex, class I, B -0.05073
CADM1 cell adhesion molecule 1 -0.0501334
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0499892
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0495133
BASP1 brain abundant, membrane attached signal protein 1 -0.048573
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0476179
WTAP Wilms tumor 1 associated protein -0.0461983
ZFAND3 zinc finger, AN1-type domain 3 -0.0456822
PTMA prothymosin, alpha -0.0449871
RBM39 RNA binding motif protein 39 -0.0438089
FTL ferritin, light polypeptide -0.0424232
MT2A metallothionein 2A -0.0421387
TUBB tubulin, beta class I -0.0417667
ATP13A3 ATPase type 13A3 -0.0415478
UBC ubiquitin C -0.0410474
ACTG1 actin gamma 1 -0.0403363
RPS21 ribosomal protein S21 -0.0396353
ZMYND8 zinc finger, MYND-type containing 8 -0.0396075
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.037806
TMSB4X thymosin beta 4, X-linked -0.0367976
GNAS GNAS complex locus -0.0365251
RPLP0 ribosomal protein, large, P0 -0.0353075
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0350763
COL1A1 collagen, type I, alpha 1 -0.0343424
HLA-A major histocompatibility complex, class I, A -0.0342312
THBS1 thrombospondin 1 -0.0341995
RPL36A ribosomal protein L36a -0.0341344
RPS4X ribosomal protein S4, X-linked -0.0339434
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0335066
EIF1 eukaryotic translation initiation factor 1 -0.0330787
KDM3A lysine (K)-specific demethylase 3A -0.0322233
PNISR PNN-interacting serine/arginine-rich protein -0.0315154
TMEM123 transmembrane protein 123 -0.0312082
RPL35A ribosomal protein L35a -0.0309427
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0303467
RPS8 ribosomal protein S8 -0.0302233
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0300549
RPS23 ribosomal protein S23 -0.0298915
RPL23 ribosomal protein L23 -0.0296345
RPL32 ribosomal protein L32 -0.0295221
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.029431
ADM adrenomedullin -0.0291731
RPLP2 ribosomal protein, large, P2 -0.0290365
NPEPPS aminopeptidase puromycin sensitive -0.0289011
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0288756
RPL9 ribosomal protein L9 -0.0286242
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0284948
RPL19 ribosomal protein L19 -0.0284911
SNX9 sorting nexin 9 -0.0284583
RPL12 ribosomal protein L12 -0.0280677
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0277891
SRGN serglycin -0.0273629
RAB1A RAB1A, member RAS oncogene family -0.0270166
RPS3 ribosomal protein S3 -0.0269995
PTBP3 polypyrimidine tract binding protein 3 -0.0267812
ANKRD28 ankyrin repeat domain 28 -0.026749
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0266499
RPL26 ribosomal protein L26 -0.026531
INHBA inhibin, beta A -0.0265274
CANX calnexin -0.0263934
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0263179
RPL37A ribosomal protein L37a -0.0260616
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0258065
RPS19 ribosomal protein S19 -0.0253272
DEK DEK proto-oncogene -0.0249244
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0244854
OGA O-GlcNAcase -0.0244362
RPS10 ribosomal protein S10 -0.0241537
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0237088
ELL2 elongation factor, RNA polymerase II, 2 -0.0236317
COL1A2 collagen, type I, alpha 2 -0.0236162
SPAG9 sperm associated antigen 9 -0.0234561
TFG TRK-fused gene -0.0231313
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0230501
NT5C2 5'-nucleotidase, cytosolic II -0.0230046
USP9X ubiquitin specific peptidase 9, X-linked -0.0228965
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0228856
TKT transketolase -0.022845
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0226439
MARCHF6 membrane associated ring-CH-type finger 6 -0.0224454
NRP1 neuropilin 1 -0.0223079
GOLGA4 golgin A4 -0.0219763
LAMP2 lysosomal-associated membrane protein 2 -0.0218525