| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.174949 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.137203 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0882416 |
| EGFR | epidermal growth factor receptor | 0.0676635 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0628813 |
| NDRG1 | N-myc downstream regulated 1 | 0.0579156 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0578914 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.057274 |
| CDH13 | cadherin 13 | 0.0546084 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0542289 |
| SYNPO | synaptopodin | 0.0530123 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0465685 |
| VEGFA | vascular endothelial growth factor A | 0.0452215 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0451031 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0443669 |
| HMGA2 | high mobility group AT-hook 2 | 0.0442262 |
| RAI14 | retinoic acid induced 14 | 0.0431776 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0424632 |
| RUNX1 | runt-related transcription factor 1 | 0.0403768 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0401476 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0376106 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0355824 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0355561 |
| NRXN3 | neurexin 3 | 0.0347538 |
| EHBP1 | EH domain binding protein 1 | 0.0337219 |
| LAMB1 | laminin, beta 1 | 0.0337192 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0331242 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0329939 |
| CLMP | CXADR-like membrane protein | 0.031778 |
| MYLK | myosin light chain kinase | 0.0310081 |
| GLIS3 | GLIS family zinc finger 3 | 0.0308995 |
| VEGFC | vascular endothelial growth factor C | 0.0307376 |
| PFN1 | profilin 1 | 0.03065 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0303532 |
| SNX13 | sorting nexin 13 | 0.0301646 |
| MSN | moesin | 0.0297129 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0295627 |
| FRMD4A | FERM domain containing 4A | 0.0291729 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0290799 |
| TPM3 | tropomyosin 3 | 0.0289353 |
| KYNU | kynureninase | 0.0284258 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.0282551 |
| PRKCA | protein kinase C, alpha | 0.0280046 |
| HDAC9 | histone deacetylase 9 | 0.0276961 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.027627 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0275541 |
| EGR1 | early growth response 1 | 0.0273739 |
| COL5A1 | collagen, type V, alpha 1 | 0.0273702 |
| STC2 | stanniocalcin 2 | 0.0270198 |
| RNF145 | ring finger protein 145 | 0.026989 |
| MYO1E | myosin IE | 0.0268796 |
| OSMR | oncostatin M receptor | 0.0267184 |
| RPS6 | ribosomal protein S6 | 0.0264025 |
| IL6 | interleukin 6 | 0.0258784 |
| SETBP1 | SET binding protein 1 | 0.0256099 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0253841 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0251515 |
| FAM120A | family with sequence similarity 120A | 0.0250954 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0250369 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0249806 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0249638 |
| YBX1 | Y box binding protein 1 | 0.0249327 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0246676 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0246061 |
| FAF2 | Fas associated factor family member 2 | 0.0245658 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0245134 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.024136 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.02373 |
| TLN1 | talin 1 | 0.0237165 |
| UBXN4 | UBX domain protein 4 | 0.0237057 |
| SLTM | SAFB-like, transcription modulator | 0.0232945 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0230335 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.022896 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0228882 |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.0227725 |
| MAP4 | microtubule-associated protein 4 | 0.0223691 |
| HYOU1 | hypoxia up-regulated 1 | 0.0221398 |
| CUX1 | cut-like homeobox 1 | 0.0217886 |
| RPL11 | ribosomal protein L11 | 0.021522 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0211371 |
| RIN2 | Ras and Rab interactor 2 | 0.0210814 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | 0.0209321 |
| CSMD2 | CUB and Sushi multiple domains 2 | 0.02037 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0202361 |
| FRMD5 | FERM domain containing 5 | 0.0202002 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0201481 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0201046 |
| LAMB3 | laminin, beta 3 | 0.0200271 |
| LIMA1 | LIM domain and actin binding 1 | 0.0200155 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0199653 |
| SATB2 | SATB homeobox 2 | 0.0196934 |
| ZNF638 | zinc finger protein 638 | 0.0196712 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0196517 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.0195867 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.01953 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0194381 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0194084 |
| ATF4 | activating transcription factor 4 | 0.0194041 |
| SYAP1 | synapse associated protein 1 | 0.0192791 |
| STXBP1 | syntaxin binding protein 1 | 0.0192664 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.228074 |
| COL6A3 | collagen, type VI, alpha 3 | -0.192668 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.165199 |
| COL1A2 | collagen, type I, alpha 2 | -0.136167 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.124738 |
| COL1A1 | collagen, type I, alpha 1 | -0.120619 |
| TMSB10 | thymosin beta 10 | -0.114829 |
| CALU | calumenin | -0.106253 |
| UBC | ubiquitin C | -0.102498 |
| AHNAK | AHNAK nucleoprotein | -0.0924641 |
| SDC4 | syndecan 4 | -0.0860902 |
| OGA | O-GlcNAcase | -0.0767341 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0751248 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0719658 |
| MT2A | metallothionein 2A | -0.0714441 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0705471 |
| LOXL2 | lysyl oxidase-like 2 | -0.0689281 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0659072 |
| RAB1A | RAB1A, member RAS oncogene family | -0.064909 |
| ANXA2 | annexin A2 | -0.0632984 |
| CANX | calnexin | -0.0608291 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0572937 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0571677 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0570933 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0562773 |
| SRP54 | signal recognition particle 54kDa | -0.053226 |
| CCNI | cyclin I | -0.0514969 |
| TXNIP | thioredoxin interacting protein | -0.0497246 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0493437 |
| CAVIN1 | caveolae associated protein 1 | -0.0483685 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0483186 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0481329 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0461646 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0460178 |
| B2M | beta-2-microglobulin | -0.0459737 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0451048 |
| RTN4 | reticulon 4 | -0.0447999 |
| HDLBP | high density lipoprotein binding protein | -0.0445112 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.044434 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0443949 |
| EMP1 | epithelial membrane protein 1 | -0.0438707 |
| RLF | rearranged L-myc fusion | -0.0431383 |
| RHEB | Ras homolog enriched in brain | -0.0429795 |
| MYOF | myoferlin | -0.0427157 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0421059 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0414496 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0407635 |
| SEPTIN7 | septin 7 | -0.0405905 |
| HBP1 | HMG-box transcription factor 1 | -0.0404772 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0394684 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0394473 |
| COG5 | component of oligomeric golgi complex 5 | -0.0394381 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0389217 |
| MT1X | metallothionein 1X | -0.0379745 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0375722 |
| GNAS | GNAS complex locus | -0.0372719 |
| H3-3B | H3.3 histone B | -0.0372248 |
| ENO1 | enolase 1, (alpha) | -0.0364577 |
| MATR3 | matrin 3 | -0.036119 |
| COL5A2 | collagen, type V, alpha 2 | -0.0361182 |
| ANO6 | anoctamin 6 | -0.0360448 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0359345 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0358539 |
| PTMA | prothymosin, alpha | -0.0355592 |
| SEC24D | SEC24 family member D | -0.0354469 |
| TPM4 | tropomyosin 4 | -0.0353296 |
| SPAG9 | sperm associated antigen 9 | -0.0347415 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0343868 |
| PTGES2 | prostaglandin E synthase 2 | -0.034263 |
| TFG | TRK-fused gene | -0.0328662 |
| ARRDC3 | arrestin domain containing 3 | -0.0328127 |
| ZNF207 | zinc finger protein 207 | -0.0326421 |
| ARF4 | ADP-ribosylation factor 4 | -0.0325891 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0325601 |
| TBC1D23 | TBC1 domain family, member 23 | -0.032534 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0324119 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0322901 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.0322538 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.031844 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0318028 |
| FTL | ferritin, light polypeptide | -0.0318001 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0315753 |
| CD109 | CD109 molecule | -0.0304057 |
| FAM13A | family with sequence similarity 13, member A | -0.0302839 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0302542 |
| RHOA | ras homolog family member A | -0.0302155 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.0299571 |
| VCL | vinculin | -0.0299243 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0296578 |
| CFDP1 | craniofacial development protein 1 | -0.0294269 |
| MTPN | myotrophin | -0.0292192 |
| TUBB | tubulin, beta class I | -0.0291942 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0287494 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0286947 |
| TPM2 | tropomyosin 2 (beta) | -0.0286431 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0286093 |
| LONP2 | lon peptidase 2, peroxisomal | -0.0283473 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0282672 |
| LOX | lysyl oxidase | -0.028192 |
| ADM | adrenomedullin | -0.0281118 |
