| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.156211 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0599434 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0584951 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0573946 |
| TMSB10 | thymosin beta 10 | 0.0452642 |
| PTMA | prothymosin, alpha | 0.0427011 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0420823 |
| ANGPTL4 | angiopoietin-like 4 | 0.041867 |
| RPLP1 | ribosomal protein, large, P1 | 0.0405909 |
| B2M | beta-2-microglobulin | 0.0382851 |
| RPL26 | ribosomal protein L26 | 0.0356767 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0356663 |
| NDRG1 | N-myc downstream regulated 1 | 0.0353822 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0340168 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.03313 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.032892 |
| ENO1 | enolase 1, (alpha) | 0.0327039 |
| LDHA | lactate dehydrogenase A | 0.0323933 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0313167 |
| VIM | vimentin | 0.030943 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0303211 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0300502 |
| FN1 | fibronectin 1 | 0.029046 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0276918 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0274019 |
| RPS12 | ribosomal protein S12 | 0.0273095 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0269292 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0267614 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.025437 |
| RPS8 | ribosomal protein S8 | 0.0249019 |
| RPL12 | ribosomal protein L12 | 0.0241442 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0237388 |
| PGK1 | phosphoglycerate kinase 1 | 0.0236128 |
| PFN1 | profilin 1 | 0.0229297 |
| MT2A | metallothionein 2A | 0.022772 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0221441 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0215188 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0213152 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0212909 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0210051 |
| ASPH | aspartate beta-hydroxylase | 0.0207711 |
| TMF1 | TATA element modulatory factor 1 | 0.0207491 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0207462 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0205412 |
| RPL36 | ribosomal protein L36 | 0.0202911 |
| RPL11 | ribosomal protein L11 | 0.0200707 |
| EGFR | epidermal growth factor receptor | 0.0199561 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0199483 |
| RPL32 | ribosomal protein L32 | 0.0195458 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0195036 |
| RPS29 | ribosomal protein S29 | 0.0190743 |
| SQSTM1 | sequestosome 1 | 0.0189393 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0186811 |
| RPS23 | ribosomal protein S23 | 0.0186428 |
| POMP | proteasome maturation protein | 0.0185829 |
| RPL23 | ribosomal protein L23 | 0.0185802 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.018556 |
| RIGI | RNA sensor RIG-I | 0.0185275 |
| RIOK3 | RIO kinase 3 | 0.0184349 |
| RPL9 | ribosomal protein L9 | 0.0183978 |
| ANKRD26 | ankyrin repeat domain 26 | 0.0183845 |
| YBX3 | Y box binding protein 3 | 0.0183415 |
| SET | SET nuclear proto-oncogene | 0.0183166 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0183162 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0181109 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0180975 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.0180821 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0179897 |
| FAM162A | family with sequence similarity 162, member A | 0.0179339 |
| CCND1 | cyclin D1 | 0.0176294 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0175478 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0174801 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0171572 |
| RPS3 | ribosomal protein S3 | 0.0171019 |
| WWOX | WW domain containing oxidoreductase | 0.0170302 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0169937 |
| IGF2 | insulin-like growth factor 2 | 0.0169789 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0169473 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0167176 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0167119 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0166495 |
| VMP1 | vacuole membrane protein 1 | 0.0166434 |
| RPL37 | ribosomal protein L37 | 0.016611 |
| PCED1B | PC-esterase domain containing 1B | 0.016499 |
| FTL | ferritin, light polypeptide | 0.0164067 |
| VEGFA | vascular endothelial growth factor A | 0.0163928 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0162527 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0162167 |
| RPL31 | ribosomal protein L31 | 0.0161834 |
| RPS17 | ribosomal protein S17 | 0.0161282 |
| PLEK2 | pleckstrin 2 | 0.0161002 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0160353 |
| RACK1 | receptor for activated C kinase 1 | 0.0160174 |
| TRAM2 | translocation associated membrane protein 2 | 0.0157679 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.015539 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0155265 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | 0.0154399 |
| HLA-B | major histocompatibility complex, class I, B | 0.0154385 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0154364 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0154049 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DSCAM | Down syndrome cell adhesion molecule | -0.0829599 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0503989 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0457666 |
| RBM39 | RNA binding motif protein 39 | -0.0451759 |
| NAV2 | neuron navigator 2 | -0.0427734 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0408656 |
| DNER | delta/notch-like EGF repeat containing | -0.0374442 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0350854 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0349074 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0336869 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0331294 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0326451 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.031877 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0308572 |
| ATXN1 | ataxin 1 | -0.0305758 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0301355 |
| ZNF609 | zinc finger protein 609 | -0.0297317 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0296014 |
| AHNAK | AHNAK nucleoprotein | -0.0292083 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0288697 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0286952 |
| SMYD3 | SET and MYND domain containing 3 | -0.0281721 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0280244 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0278702 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0271869 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.026051 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0257544 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0257438 |
| RAD51B | RAD51 paralog B | -0.0256946 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0255419 |
| FER | fer (fps/fes related) tyrosine kinase | -0.025166 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0249722 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0249251 |
| MAP1B | microtubule-associated protein 1B | -0.0248763 |
| TBC1D5 | TBC1 domain family, member 5 | -0.024859 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0248281 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0248219 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0246276 |
| FNIP1 | folliculin interacting protein 1 | -0.0241109 |
| PTK2 | protein tyrosine kinase 2 | -0.024087 |
| NUP98 | nucleoporin 98kDa | -0.0232241 |
| HDLBP | high density lipoprotein binding protein | -0.0231926 |
| VCL | vinculin | -0.0231576 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0228633 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0228389 |
| EFNA5 | ephrin-A5 | -0.0228121 |
| CEP95 | centrosomal protein 95kDa | -0.0223642 |
| SETD5 | SET domain containing 5 | -0.0222733 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0221921 |
| TPM4 | tropomyosin 4 | -0.0221429 |
| YAP1 | Yes-associated protein 1 | -0.0220041 |
| WDR33 | WD repeat domain 33 | -0.0219375 |
| RABGAP1 | RAB GTPase activating protein 1 | -0.0217955 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0217688 |
| ATM | ATM serine/threonine kinase | -0.0216794 |
| HDAC9 | histone deacetylase 9 | -0.0216169 |
| RFX7 | regulatory factor X, 7 | -0.0215081 |
| OGA | O-GlcNAcase | -0.0213254 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0213158 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0211785 |
| DERA | deoxyribose-phosphate aldolase (putative) | -0.0211716 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0211665 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0211011 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0209913 |
| ATG7 | autophagy related 7 | -0.0209342 |
| NUP58 | nucleoporin 58 | -0.0208583 |
| KIAA1328 | KIAA1328 | -0.020596 |
| ETNK1 | ethanolamine kinase 1 | -0.020489 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0202072 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0201992 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0201961 |
| PARD3 | par-3 family cell polarity regulator | -0.0200828 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0200637 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0200568 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | -0.0200494 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0200347 |
| NALCN | sodium leak channel, non selective | -0.0199374 |
| NBEAL1 | neurobeachin-like 1 | -0.0198616 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0197721 |
| GNAS | GNAS complex locus | -0.0196838 |
| DIAPH3 | diaphanous-related formin 3 | -0.019629 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0193803 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0192844 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0191249 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0191197 |
| GOLGA3 | golgin A3 | -0.0190312 |
| GPC6 | glypican 6 | -0.019005 |
| SNX14 | sorting nexin 14 | -0.0189981 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0189926 |
| KIAA1958 | KIAA1958 | -0.0188837 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0188115 |
| SMAD3 | SMAD family member 3 | -0.0185419 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0185239 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0183098 |
| USP34 | ubiquitin specific peptidase 34 | -0.0181517 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0181284 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0180723 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0180345 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0178898 |
| USP12 | ubiquitin specific peptidase 12 | -0.017863 |
