| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Larotrectinib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Larotrectinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.160155 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.133066 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.129615 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.11733 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.113423 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.10701 |
| STC2 | stanniocalcin 2 | 0.106139 |
| NDRG1 | N-myc downstream regulated 1 | 0.101757 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0946604 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0919143 |
| ITGA1 | integrin, alpha 1 | 0.0840218 |
| VIM | vimentin | 0.0785476 |
| HMGA2 | high mobility group AT-hook 2 | 0.0678972 |
| ENO1 | enolase 1, (alpha) | 0.0675877 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0672365 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0644821 |
| TMEM156 | transmembrane protein 156 | 0.0607975 |
| MT2A | metallothionein 2A | 0.0603797 |
| NRP1 | neuropilin 1 | 0.0588486 |
| DST | dystonin | 0.0583794 |
| SFTPA2 | surfactant protein A2 | 0.0543125 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0536841 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0531653 |
| PTK2 | protein tyrosine kinase 2 | 0.051654 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0512341 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0507908 |
| PKM | pyruvate kinase, muscle | 0.0505052 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0502985 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.049308 |
| B2M | beta-2-microglobulin | 0.0488348 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0484663 |
| DENND5B | DENN/MADD domain containing 5B | 0.0483476 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0483351 |
| EFNA5 | ephrin-A5 | 0.0478357 |
| ETV1 | ets variant 1 | 0.047253 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0466973 |
| FAM13A | family with sequence similarity 13, member A | 0.0462985 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0459285 |
| HLA-B | major histocompatibility complex, class I, B | 0.0449499 |
| FN1 | fibronectin 1 | 0.0436487 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0432397 |
| FNDC3B | fibronectin type III domain containing 3B | 0.041513 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0403586 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0395234 |
| AHR | aryl hydrocarbon receptor | 0.0364216 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0360335 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0357905 |
| RPS6 | ribosomal protein S6 | 0.0345499 |
| RPS12 | ribosomal protein S12 | 0.0344834 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0341095 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0339195 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0327545 |
| FOXP1 | forkhead box P1 | 0.0326955 |
| RPS3 | ribosomal protein S3 | 0.0319591 |
| TXNIP | thioredoxin interacting protein | 0.0319405 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0319271 |
| RPL23 | ribosomal protein L23 | 0.0315575 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0313959 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0313892 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0309665 |
| IFI44L | interferon-induced protein 44-like | 0.0308677 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0304616 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0304342 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0302264 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0300152 |
| VEGFC | vascular endothelial growth factor C | 0.0296479 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0290916 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0288065 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0286799 |
| PTMA | prothymosin, alpha | 0.0285136 |
| RPL26 | ribosomal protein L26 | 0.0284252 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.028415 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0282206 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0282062 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0281129 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.027921 |
| RACK1 | receptor for activated C kinase 1 | 0.0278656 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0274977 |
| OSMR | oncostatin M receptor | 0.0272716 |
| RNF145 | ring finger protein 145 | 0.0271341 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0270478 |
| RPS8 | ribosomal protein S8 | 0.0269701 |
| TXNRD1 | thioredoxin reductase 1 | 0.0268282 |
| RPL36 | ribosomal protein L36 | 0.0268103 |
| RPL35A | ribosomal protein L35a | 0.0262992 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0262791 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0262071 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.026206 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0260807 |
| SMYD3 | SET and MYND domain containing 3 | 0.0259462 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0259313 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0258352 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0257047 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.0256716 |
| CDCP1 | CUB domain containing protein 1 | 0.0254999 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0250865 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0250244 |
| RPS29 | ribosomal protein S29 | 0.0249483 |
| RAD51B | RAD51 paralog B | 0.0249146 |
| FHIT | fragile histidine triad | 0.024848 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.215426 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.17601 |
| VCL | vinculin | -0.164352 |
| EXT1 | exostosin glycosyltransferase 1 | -0.126471 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0852656 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0618422 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0553612 |
| AEBP2 | AE binding protein 2 | -0.0542122 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.052731 |
| NTN4 | netrin 4 | -0.0521436 |
| EGR1 | early growth response 1 | -0.0500237 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0455239 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0447389 |
| NRG1 | neuregulin 1 | -0.0427856 |
| INTS6 | integrator complex subunit 6 | -0.0413421 |
| SQSTM1 | sequestosome 1 | -0.0410884 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0402897 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0396553 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0386858 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0372711 |
| KSR1 | kinase suppressor of ras 1 | -0.0354242 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0351695 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0348773 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0336591 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0334705 |
| VMP1 | vacuole membrane protein 1 | -0.0328235 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0328223 |
| CCDC138 | coiled-coil domain containing 138 | -0.032452 |
| FNDC3A | fibronectin type III domain containing 3A | -0.031548 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0314531 |
| PALLD | palladin, cytoskeletal associated protein | -0.0311873 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0302342 |
| ADIPOR2 | adiponectin receptor 2 | -0.0300546 |
| RAB31 | RAB31, member RAS oncogene family | -0.0297492 |
| COPA | coatomer protein complex, subunit alpha | -0.0291427 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0283573 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0283475 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0282855 |
| CLIC4 | chloride intracellular channel 4 | -0.0281351 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | -0.0277686 |
| CALU | calumenin | -0.0275135 |
| HDLBP | high density lipoprotein binding protein | -0.0267663 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0265791 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0264283 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0260682 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0258173 |
| TMEM263 | transmembrane protein 263 | -0.0256006 |
| SDC2 | syndecan 2 | -0.025203 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0248432 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0246398 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0245136 |
| CDK13 | cyclin-dependent kinase 13 | -0.0242736 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.024192 |
| SEC24A | SEC24 family member A | -0.0238491 |
| ACOXL | acyl-CoA oxidase-like | -0.0238314 |
| ZNF644 | zinc finger protein 644 | -0.0234458 |
| LRRC23 | leucine rich repeat containing 23 | -0.023416 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.023317 |
| TUFT1 | tuftelin 1 | -0.0226699 |
| ACTG1 | actin gamma 1 | -0.0226393 |
| GLCCI1 | glucocorticoid induced 1 | -0.0226359 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0225747 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | -0.0225235 |
| RCOR1 | REST corepressor 1 | -0.0224711 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0221621 |
| GPATCH2L | G patch domain containing 2-like | -0.0221192 |
| TPM4 | tropomyosin 4 | -0.0219156 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0216104 |
| MORF4L2 | mortality factor 4 like 2 | -0.0214132 |
| PCBP3 | poly(rC) binding protein 3 | -0.0210772 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0210401 |
| ATF6 | activating transcription factor 6 | -0.0209612 |
| CRY1 | cryptochrome circadian clock 1 | -0.0208081 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0206434 |
| SMOX | spermine oxidase | -0.0206085 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0205756 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0205043 |
| EPN2 | epsin 2 | -0.020348 |
| CCNL1 | cyclin L1 | -0.0202277 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0201637 |
| PTGES2 | prostaglandin E synthase 2 | -0.0201256 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0198724 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0197926 |
| UBAP2 | ubiquitin associated protein 2 | -0.01948 |
| ARF4 | ADP-ribosylation factor 4 | -0.0193955 |
| SCFD1 | sec1 family domain containing 1 | -0.0193854 |
| MCL1 | myeloid cell leukemia 1 | -0.0192364 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0191541 |
| IL1R1 | interleukin 1 receptor, type I | -0.0190651 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0189477 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0187149 |
| PRPF3 | pre-mRNA processing factor 3 | -0.0187141 |
| WDR59 | WD repeat domain 59 | -0.0186443 |
| SPAG9 | sperm associated antigen 9 | -0.0184643 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0184331 |
| ACTN1 | actinin, alpha 1 | -0.018278 |
| FAM20C | family with sequence similarity 20, member C | -0.0179308 |
| GON4L | gon-4-like (C. elegans) | -0.017211 |
| TGFB1 | transforming growth factor, beta 1 | -0.0171955 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0170329 |
