Laryngeal Squamous Cell Carcinoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A laryngeal carcinoma that has_material_basis_in squamous cells. (Human Disease Ontology, DOID_2876)
External Link https://www.disgenet.org/browser/0/1/0/C0280324
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Genes

399 genes associated with the disease Laryngeal Squamous Cell Carcinoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACHE acetylcholinesterase (Yt blood group)
ACTB actin, beta
ACYP2 acylphosphatase 2, muscle type
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGER advanced glycosylation end product-specific receptor
AHR aryl hydrocarbon receptor
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
ALG3 ALG3, alpha-1,3- mannosyltransferase
ALK anaplastic lymphoma receptor tyrosine kinase
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
ANXA5 annexin A5
APAF1 apoptotic peptidase activating factor 1
ARRB1 arrestin, beta 1
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASPG asparaginase
ATF3 activating transcription factor 3
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AVP arginine vasopressin
BAX BCL2-associated X protein
BCL10 B-cell CLL/lymphoma 10
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL2L12 BCL2-like 12 (proline rich)
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRCA2 breast cancer 2, early onset
CADM1 cell adhesion molecule 1
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAVIN2 caveolae associated protein 2
CBY1 chibby homolog 1 (Drosophila)
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNA1 cyclin A1
CCNB2 cyclin B2
CCND1 cyclin D1
CCND3 cyclin D3
CCNG2 cyclin G2
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD163 CD163 molecule
CD274 CD274 molecule
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD68 CD68 molecule
CD69 CD69 molecule
CD82 CD82 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDK8 cyclin-dependent kinase 8
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHD5 chromodomain helicase DNA binding protein 5
CHEK1 checkpoint kinase 1
CIB2 calcium and integrin binding family member 2
CKAP4 cytoskeleton-associated protein 4
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN11 claudin 11
CLDN7 claudin 7
CLPTM1L CLPTM1-like
CMTM3 CKLF-like MARVEL transmembrane domain containing 3
CNOT7 CCR4-NOT transcription complex, subunit 7
CNOT8 CCR4-NOT transcription complex, subunit 8
CNTNAP2 contactin associated protein-like 2
COX2
COX5A cytochrome c oxidase subunit Va
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CPOX coproporphyrinogen oxidase
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRP C-reactive protein, pentraxin-related
CRYAB crystallin, alpha B
CTCFL CCCTC-binding factor (zinc finger protein)-like
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CXCR2 chemokine (C-X-C motif) receptor 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DACH1 dachshund family transcription factor 1
DAPK1 death-associated protein kinase 1
DCTN6 dynactin 6
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5
DIAPH1 diaphanous-related formin 1
DIAPH2 diaphanous-related formin 2
DIAPH3 diaphanous-related formin 3
DIO1 deiodinase, iodothyronine, type I
DNLZ DNL-type zinc finger
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F1 E2F transcription factor 1
ECT2 epithelial cell transforming 2
EGFR epidermal growth factor receptor
EIF4E eukaryotic translation initiation factor 4E
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ENG endoglin
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EOMES eomesodermin
EPHA7 EPH receptor A7
EPHB6 EPH receptor B6
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERCC1 excision repair cross-complementation group 1
ESR1 estrogen receptor 1
ESRRG estrogen-related receptor gamma
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
FADD Fas (TNFRSF6)-associated via death domain
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM107A family with sequence similarity 107, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGF1 fibroblast growth factor 1 (acidic)
FGF2 fibroblast growth factor 2 (basic)
FGF3 fibroblast growth factor 3
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FHIT fragile histidine triad
FLNA filamin A, alpha
FN1 fibronectin 1
FOXC1 forkhead box C1
FOXD4L1 forkhead box D4-like 1
FOXJ1 forkhead box J1
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FOXP3 forkhead box P3
FSCN1 fascin actin-bundling protein 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA6 GATA binding protein 6
GBX2 gastrulation brain homeobox 2
GDE1 glycerophosphodiester phosphodiesterase 1
GJA1 gap junction protein, alpha 1, 43kDa
GMNN geminin, DNA replication inhibitor
GORASP1 golgi reassembly stacking protein 1, 65kDa
GPER1 G protein-coupled estrogen receptor 1
GPX1 glutathione peroxidase 1
GRN granulin
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTM3 glutathione S-transferase mu 3 (brain)
GSTT1 glutathione S-transferase theta 1
HDAC1 histone deacetylase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HK2 hexokinase 2
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HOXA9 homeobox A9
HOXB13 homeobox B13
HOXB9 homeobox B9
HOXD13 homeobox D13
HPGDS hematopoietic prostaglandin D synthase
HPSE heparanase
IFI27 interferon, alpha-inducible protein 27
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IL10 interleukin 10
IL17A interleukin 17A
IL1B interleukin 1, beta
IL2RA interleukin 2 receptor, alpha
ILK integrin-linked kinase
ING1 inhibitor of growth family, member 1
INPPL1 inositol polyphosphate phosphatase-like 1
INTS2 integrator complex subunit 2
IQGAP1 IQ motif containing GTPase activating protein 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KLK11 kallikrein-related peptidase 11
KLK4 kallikrein-related peptidase 4
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT7 keratin 7, type II
LAT linker for activation of T cells
LGALS1 lectin, galactoside-binding, soluble, 1
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LMX1B LIM homeobox transcription factor 1, beta
LOXL4 lysyl oxidase-like 4
LTA4H leukotriene A4 hydrolase
LZTS2 leucine zipper, putative tumor suppressor 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP2K4 mitogen-activated protein kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MIB1 mindbomb E3 ubiquitin protein ligase 1
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP20 matrix metallopeptidase 20
MMP25 matrix metallopeptidase 25
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MMUT methylmalonyl-CoA mutase
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSN moesin
MST1R macrophage stimulating 1 receptor
MT1A metallothionein 1A
MT1B metallothionein 1B
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
MTA1 metastasis associated 1
MTAP methylthioadenosine phosphorylase
MTDH metadherin
MTNR1A melatonin receptor 1A
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCT1 myc target 1
MYLK myosin light chain kinase
MYO5A myosin VA (heavy chain 12, myoxin)
NABP1 nucleic acid binding protein 1
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NLRP3 NLR family, pyrin domain containing 3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOTCH1 notch 1
NOTCH2 notch 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OCLN occludin
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PCDH17 protocadherin 17
PCNA proliferating cell nuclear antigen
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDCD5 programmed cell death 5
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLAGL2 pleiomorphic adenoma gene-like 2
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLXNB1 plexin B1
POMC proopiomelanocortin
POSTN periostin, osteoblast specific factor
POTEF POTE ankyrin domain family, member F
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PRDX3 peroxiredoxin 3
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRLR prolactin receptor
PROM1 prominin 1
PRPF31 pre-mRNA processing factor 31
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTOV1 prostate tumor overexpressed 1
PTPA protein phosphatase 2 phosphatase activator
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRD protein tyrosine phosphatase, receptor type, D
PXN paxillin
PYCARD PYD and CARD domain containing
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RARA retinoic acid receptor, alpha
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPE65 retinal pigment epithelium-specific protein 65kDa
RUNX3 runt-related transcription factor 3
S100A11 S100 calcium binding protein A11
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100B S100 calcium binding protein B
SATB2 SATB homeobox 2
SCLY selenocysteine lyase
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3GL2 SH3-domain GRB2-like 2
SIRT1 sirtuin 1
SLC22A23 solute carrier family 22, member 23
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SLPI secretory leukocyte peptidase inhibitor
SMAD2 SMAD family member 2
SNAI1 snail family zinc finger 1
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOX1 SRY (sex determining region Y)-box 1
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
SRY sex determining region Y
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
SSTR2 somatostatin receptor 2
SSTR5 somatostatin receptor 5
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STK11 serine/threonine kinase 11
STS steroid sulfatase (microsomal), isozyme S
SYK spleen tyrosine kinase
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TAL1 T-cell acute lymphocytic leukemia 1
TENM1 teneurin transmembrane protein 1
TERT telomerase reverse transcriptase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TICAM2 toll-like receptor adaptor molecule 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TMED7 transmembrane emp24 protein transport domain containing 7
TMED7-TICAM2 TMED7-TICAM2 readthrough
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TRA2B transformer 2 beta homolog (Drosophila)
TRAPPC10 trafficking protein particle complex 10
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
TUG1 taurine up-regulated 1 (non-protein coding)
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UVRAG UV radiation resistance associated
VCAN versican
VEGFA vascular endothelial growth factor A
VIM vimentin
WEE1 WEE1 G2 checkpoint kinase
WISP1 WNT1 inducible signaling pathway protein 1
WNK1 WNK lysine deficient protein kinase 1
WNT1 wingless-type MMTV integration site family, member 1
WNT3A wingless-type MMTV integration site family, member 3A
WNT5A wingless-type MMTV integration site family, member 5A
WRAP53 WD repeat containing, antisense to TP53
WT1 Wilms tumor 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YAP1 Yes-associated protein 1
YBX1 Y box binding protein 1
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2
ZFX zinc finger protein, X-linked
ZNF107 zinc finger protein 107
ZNF654 zinc finger protein 654
ZNF667 zinc finger protein 667