Lasmiditan Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/11610526
Similar Terms
Downloads & Tools

Genes

200 proteins with high or low expression in Lasmiditan relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
NR1D2 nuclear receptor subfamily 1, group D, member 2 2.35
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.15
RNASEH1 ribonuclease H1 0.75
TSPAN3 tetraspanin 3 0.62
ZNF518B zinc finger protein 518B 0.55
RHBDD2 rhomboid domain containing 2 0.54
AOC1 amine oxidase, copper containing 1 0.52
MAP1A microtubule-associated protein 1A 0.52
TOMM40L translocase of outer mitochondrial membrane 40 homolog (yeast)-like 0.52
RPL31 ribosomal protein L31 0.51
FRMPD1 FERM and PDZ domain containing 1 0.5
DES desmin 0.5
MISO1 mitochondrial inner membrane subdomain organizer 1 0.47
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 0.46
MOCS1 molybdenum cofactor synthesis 1 0.44
ITGA1 integrin, alpha 1 0.44
CA8 carbonic anhydrase VIII 0.44
RTN2 reticulon 2 0.43
CKM creatine kinase, muscle 0.43
MED30 mediator complex subunit 30 0.41
VIM vimentin 0.41
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.41
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.39
ATG2B autophagy related 2B 0.39
GPN2 GPN-loop GTPase 2 0.39
KMT2B lysine (K)-specific methyltransferase 2B 0.39
TTC27 tetratricopeptide repeat domain 27 0.39
DCAF12 DDB1 and CUL4 associated factor 12 0.38
COMMD5 COMM domain containing 5 0.38
NUCB2 nucleobindin 2 0.38
MCTP2 multiple C2 domains, transmembrane 2 0.37
AUNIP aurora kinase A and ninein interacting protein 0.37
ARG2 arginase 2 0.36
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.36
TGFBR3 transforming growth factor, beta receptor III 0.36
RAB11FIP4 RAB11 family interacting protein 4 (class II) 0.36
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.36
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.36
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.35
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 0.35
TOX2 TOX high mobility group box family member 2 0.35
ITGB8 integrin, beta 8 0.35
MPND MPN domain containing 0.35
MPV17L2 MPV17 mitochondrial membrane protein-like 2 0.35
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 0.35
DCLRE1B DNA cross-link repair 1B 0.34
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.34
ATXN1L ataxin 1-like 0.34
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 0.34
MTSS1 metastasis suppressor 1 0.34
TRIM11 tripartite motif containing 11 0.33
CD82 CD82 molecule 0.33
TTYH3 tweety family member 3 0.33
PLXND1 plexin D1 0.33
TMEM14C transmembrane protein 14C 0.33
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.33
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.32
ZNF805 zinc finger protein 805 0.32
CCDC32 coiled-coil domain containing 32 0.31
EPOP elongin BC and polycomb repressive complex 2 associated protein 0.31
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.31
PDGFC platelet derived growth factor C 0.31
FGFR1OP2 FGFR1 oncogene partner 2 0.31
F8A1 coagulation factor VIII-associated 1 0.31
PALB2 partner and localizer of BRCA2 0.3
IGFBP3 insulin-like growth factor binding protein 3 0.3
TXNDC16 thioredoxin domain containing 16 0.3
TNK2 tyrosine kinase, non-receptor, 2 0.29
TAPT1 transmembrane anterior posterior transformation 1 0.29
CDC25B cell division cycle 25B 0.29
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase 0.29
MSLN mesothelin 0.28
LAD1 ladinin 1 0.28
DCAF5 DDB1 and CUL4 associated factor 5 0.28
MBP myelin basic protein 0.28
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.28
NFIA nuclear factor I/A 0.28
PLPP6 phospholipid phosphatase 6 0.28
NKAPD1 NKAP domain containing 1 0.28
SAMD4A sterile alpha motif domain containing 4A 0.28
PTPRU protein tyrosine phosphatase, receptor type, U 0.28
TMEM9B TMEM9 domain family, member B 0.28
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 0.28
C17ORF53 chromosome 17 open reading frame 53 0.28
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.27
AGTRAP angiotensin II receptor-associated protein 0.27
HAS3 hyaluronan synthase 3 0.27
L1CAM L1 cell adhesion molecule 0.27
PI4K2B phosphatidylinositol 4-kinase type 2 beta 0.27
ADAM21 ADAM metallopeptidase domain 21 0.27
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 0.26
NLGN2 neuroligin 2 0.26
COBL cordon-bleu WH2 repeat protein 0.26
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.26
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 0.26
CCNE1 cyclin E1 0.26
FAM110A family with sequence similarity 110, member A 0.26
GLMP glycosylated lysosomal membrane protein 0.26
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 0.26
KLHL20 kelch-like family member 20 0.26

low expression

Symbol Name Standardized Value
ALG10B ALG10B, alpha-1,2-glucosyltransferase -0.62
CADPS Ca++-dependent secretion activator -0.61
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.55
RIN3 Ras and Rab interactor 3 -0.5
HNF4A hepatocyte nuclear factor 4, alpha -0.45
KIZ kizuna centrosomal protein -0.44
RETREG2 reticulophagy regulator family member 2 -0.43
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.43
CRY2 cryptochrome circadian clock 2 -0.43
MKRN3 makorin ring finger protein 3 -0.42
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 -0.39
GRK3 G protein-coupled receptor kinase 3 -0.38
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.38
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -0.37
PMF1 polyamine-modulated factor 1 -0.36
ATE1 arginyltransferase 1 -0.36
RNF115 ring finger protein 115 -0.35
CGRRF1 cell growth regulator with ring finger domain 1 -0.34
ZBTB38 zinc finger and BTB domain containing 38 -0.34
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -0.34
STK36 serine/threonine kinase 36 -0.33
ZNF711 zinc finger protein 711 -0.33
MFSD8 major facilitator superfamily domain containing 8 -0.32
MOB3A MOB kinase activator 3A -0.32
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.31
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -0.31
GFOD2 glucose-fructose oxidoreductase domain containing 2 -0.31
USP53 ubiquitin specific peptidase 53 -0.3
MAGEA6 melanoma antigen family A6 -0.3
UBQLN1 ubiquilin 1 -0.3
RAB19 RAB19, member RAS oncogene family -0.3
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.3
ATG101 autophagy related 101 -0.29
DOHH deoxyhypusine hydroxylase/monooxygenase -0.28
ADGRL1 adhesion G protein-coupled receptor L1 -0.28
FBXO34 F-box protein 34 -0.28
ACVR1B activin A receptor, type IB -0.28
NR1H2 nuclear receptor subfamily 1, group H, member 2 -0.27
SERINC1 serine incorporator 1 -0.27
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -0.27
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.26
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -0.26
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa -0.26
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -0.26
BBS1 Bardet-Biedl syndrome 1 -0.26
ANKRD10 ankyrin repeat domain 10 -0.26
MT-ND5 NADH dehydrogenase, subunit 5 (complex I) -0.25
ATXN7L3B ataxin 7-like 3B -0.25
AREG amphiregulin -0.25
SH3YL1 SH3 and SYLF domain containing 1 -0.25
CREBZF CREB/ATF bZIP transcription factor -0.24
MITD1 MIT, microtubule interacting and transport, domain containing 1 -0.24
ZNF28 zinc finger protein 28 -0.24
KCTD5 potassium channel tetramerization domain containing 5 -0.24
ABHD3 abhydrolase domain containing 3 -0.24
RBM23 RNA binding motif protein 23 -0.23
ZDHHC18 zinc finger, DHHC-type containing 18 -0.23
DTWD2 DTW domain containing 2 -0.23
GNB5 guanine nucleotide binding protein (G protein), beta 5 -0.23
GTF2A2 general transcription factor IIA, 2, 12kDa -0.22
TWISTNB TWIST neighbor -0.22
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa -0.22
HSPG2 heparan sulfate proteoglycan 2 -0.22
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -0.22
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.22
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.21
TULP3 tubby like protein 3 -0.21
GPR179 G protein-coupled receptor 179 -0.21
TCF19 transcription factor 19 -0.21
SINHCAF SIN3-HDAC complex associated factor -0.21
ZNF721 zinc finger protein 721 -0.21
AFG1L AFG1 like ATPase -0.21
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.21
ANKRD20A4 ankyrin repeat domain 20 family, member A4 -0.2
FAM120C family with sequence similarity 120C -0.2
RP9 retinitis pigmentosa 9 (autosomal dominant) -0.2
ZNF587 zinc finger protein 587 -0.2
RPL36A ribosomal protein L36a -0.2
ZNF696 zinc finger protein 696 -0.2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -0.2
C18ORF32 chromosome 18 open reading frame 32 -0.2
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -0.2
HMGB2 high mobility group box 2 -0.2
TAPBP TAP binding protein (tapasin) -0.19
SREBF1 sterol regulatory element binding transcription factor 1 -0.19
FAM241A family with sequence similarity 241 member A -0.19
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 -0.19
MRPL51 mitochondrial ribosomal protein L51 -0.19
C2ORF42 chromosome 2 open reading frame 42 -0.19
HAUS7 HAUS augmin-like complex, subunit 7 -0.19
NR1D1 nuclear receptor subfamily 1, group D, member 1 -0.19
ZIC5 Zic family member 5 -0.19
GLT8D1 glycosyltransferase 8 domain containing 1 -0.18
C9ORF40 chromosome 9 open reading frame 40 -0.18
PEX5 peroxisomal biogenesis factor 5 -0.18
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.18
ADAT2 adenosine deaminase, tRNA-specific 2 -0.18
SLC38A7 solute carrier family 38, member 7 -0.18
TRAM2 translocation associated membrane protein 2 -0.18
PIM1 Pim-1 proto-oncogene, serine/threonine kinase -0.18