Lead Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
External Link http://ctdbase.org/detail.go?type=chem&acc=D007854
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Genes

135 genes/proteins interacting with the chemical Lead from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALAD aminolevulinate dehydratase
ALPI alkaline phosphatase, intestinal
ANXA1 annexin A1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ARNT aryl hydrocarbon receptor nuclear translocator
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BACE1 beta-site APP-cleaving enzyme 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAT catalase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CHUK conserved helix-loop-helix ubiquitous kinase
CLDN5 claudin 5
CP ceruloplasmin (ferroxidase)
CRYZ crystallin, zeta (quinone reductase)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSNK1E casein kinase 1, epsilon
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DRD2 dopamine receptor D2
EDN3 endothelin 3
EFNA2 ephrin-A2
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
FAS Fas cell surface death receptor
FOS FBJ murine osteosarcoma viral oncogene homolog
FSHB follicle stimulating hormone, beta polypeptide
FYN FYN proto-oncogene, Src family tyrosine kinase
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GLS glutaminase
GLUL glutamate-ammonia ligase
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIK4 glutamate receptor, ionotropic, kainate 4
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRM5 glutamate receptor, metabotropic 5
GSR glutathione reductase
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
HFE hemochromatosis
HMOX1 heme oxygenase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTT huntingtin
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IHH indian hedgehog
IL1B interleukin 1, beta
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LDLR low density lipoprotein receptor
LEP leptin
LHB luteinizing hormone beta polypeptide
LHX3 LIM homeobox 3
LIG4 ligase IV, DNA, ATP-dependent
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MECP2 methyl CpG binding protein 2
MET MET proto-oncogene, receptor tyrosine kinase
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MUTYH mutY homolog
NCAM1 neural cell adhesion molecule 1
NEUROG1 neurogenin 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFR nerve growth factor receptor
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NT5C3A 5'-nucleotidase, cytosolic IIIA
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OCLN occludin
OGG1 8-oxoguanine DNA glycosylase
ORAI1 ORAI calcium release-activated calcium modulator 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLXNA4 plexin A4
PON1 paraoxonase 1
POU2F2 POU class 2 homeobox 2
POU4F1 POU class 4 homeobox 1
POU5F1 POU class 5 homeobox 1
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCI protein kinase C, iota
PRL prolactin
PSEN1 presenilin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTK2 protein tyrosine kinase 2
RUNX2 runt-related transcription factor 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SOST sclerostin
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STIM1 stromal interaction molecule 1
SYN1 synapsin I
TF transferrin
TH tyrosine hydroxylase
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TRPC1 transient receptor potential cation channel, subfamily C, member 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4