Leber congenital amaurosis_Retina_GSE3249 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE3249
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Genes

600 genes differentially expressed during Leber congenital amaurosis_Retina_GSE3249 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
ARL2BP ADP-ribosylation factor-like 2 binding protein 3.7366
REXO2 RNA exonuclease 2 3.25715
GSG1 germ cell associated 1 3.24983
ABHD14B abhydrolase domain containing 14B 3.11384
RTN3 reticulon 3 3.04758
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 3.03179
AGTPBP1 ATP/GTP binding protein 1 2.98735
SEC23IP SEC23 interacting protein 2.87349
SCGN secretagogin, EF-hand calcium binding protein 2.83166
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 2.80298
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 2.73136
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 2.66028
GPM6B glycoprotein M6B 2.64585
C18ORF32 chromosome 18 open reading frame 32 2.64012
MRPL24 mitochondrial ribosomal protein L24 2.59644
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 2.57022
C16ORF45 chromosome 16 open reading frame 45 2.55705
DOC2B double C2-like domains, beta 2.53099
GPRC5B G protein-coupled receptor, class C, group 5, member B 2.50974
RWDD4 RWD domain containing 4 2.48836
COA3 cytochrome c oxidase assembly factor 3 2.45652
PQBP1 polyglutamine binding protein 1 2.44479
GLUL glutamate-ammonia ligase 2.43313
SPAST spastin 2.42192
PCBP4 poly(rC) binding protein 4 2.40876
CCK cholecystokinin 2.36681
PPDPF pancreatic progenitor cell differentiation and proliferation factor 2.34175
CDC42SE2 CDC42 small effector 2 2.34042
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 2.33811
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 2.33411
PRKX protein kinase, X-linked 2.27651
PFN2 profilin 2 2.27493
ARMC9 armadillo repeat containing 9 2.26221
POLB polymerase (DNA directed), beta 2.25602
NPC1 Niemann-Pick disease, type C1 2.23972
CELF4 CUGBP, Elav-like family member 4 2.23703
TMEM147 transmembrane protein 147 2.21964
IFT46 intraflagellar transport 46 2.2191
ADSS adenylosuccinate synthase 2.21057
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 2.20418
PLRG1 pleiotropic regulator 1 2.18204
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.15912
EIF5A eukaryotic translation initiation factor 5A 2.15394
ADCY1 adenylate cyclase 1 (brain) 2.14622
CIB1 calcium and integrin binding 1 (calmyrin) 2.14468
PHF23 PHD finger protein 23 2.14358
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 2.12033
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 2.11165
ARMCX1 armadillo repeat containing, X-linked 1 2.11134
FLRT2 fibronectin leucine rich transmembrane protein 2 2.08713
GDAP1 ganglioside induced differentiation associated protein 1 2.06918
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit 2.0601
TAGLN3 transgelin 3 2.05673
BANF1 barrier to autointegration factor 1 2.05619
IGSF9 immunoglobulin superfamily, member 9 2.04294
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.0389
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.03523
OGFRL1 opioid growth factor receptor-like 1 2.01642
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 2.01386
NAP1L1 nucleosome assembly protein 1-like 1 2.0135
PRPF4B pre-mRNA processing factor 4B 2.01086
FERMT2 fermitin family member 2 1.99605
MTUS1 microtubule associated tumor suppressor 1 1.99408
SRPRB signal recognition particle receptor, B subunit 1.97812
NNAT neuronatin 1.9763
CCNG2 cyclin G2 1.96845
LECT1 leukocyte cell derived chemotaxin 1 1.96457
XRCC6BP1 XRCC6 binding protein 1 1.96451
CRYM crystallin, mu 1.94215
MSRA methionine sulfoxide reductase A 1.94004
GLO1 glyoxalase I 1.93823
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 1.93602
GSR glutathione reductase 1.9342
MYO6 myosin VI 1.92947
FRZB frizzled-related protein 1.92682
UBE4B ubiquitination factor E4B 1.92089
TRUB2 TruB pseudouridine (psi) synthase family member 2 1.92058
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.91884
ZMYND11 zinc finger, MYND-type containing 11 1.91057
MZT2A mitotic spindle organizing protein 2A 1.90963
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 1.90607
RTN1 reticulon 1 1.90223
TYW5 tRNA-yW synthesizing protein 5 1.90112
MYO10 myosin X 1.89805
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 1.89781
MED21 mediator complex subunit 21 1.89769
CDK19 cyclin-dependent kinase 19 1.89529
METAP2 methionyl aminopeptidase 2 1.87924
C14ORF1 chromosome 14 open reading frame 1 1.87729
CFAP54 cilia and flagella associated 54 1.86243
TRIM37 tripartite motif containing 37 1.85872
IL18 interleukin 18 1.85343
PSENEN presenilin enhancer gamma secretase subunit 1.85304
DEDD death effector domain containing 1.84177
LOC729800 ZP domain-containing protein LOC729800-like 1.83442
SNAP47 synaptosomal-associated protein, 47kDa 1.83399
SPOP speckle-type POZ protein 1.83271
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 1.83041
ZNF778 zinc finger protein 778 1.82695
MYLIP myosin regulatory light chain interacting protein 1.82688
TFCP2 transcription factor CP2 1.79946
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 1.79882
MRPL3 mitochondrial ribosomal protein L3 1.79289
SULF2 sulfatase 2 1.79251
RTN4RL2 reticulon 4 receptor-like 2 1.79242
CETN2 centrin, EF-hand protein, 2 1.78627
C9ORF72 chromosome 9 open reading frame 72 1.78207
LSM11 LSM11, U7 small nuclear RNA associated 1.7786
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 1.76997
GUCY1B3 guanylate cyclase 1, soluble, beta 3 1.7657
DTNBP1 dystrobrevin binding protein 1 1.76084
LMAN2 lectin, mannose-binding 2 1.75047
RNF121 ring finger protein 121 1.7499
PLS1 plastin 1 1.74864
SDHAF2 succinate dehydrogenase complex assembly factor 2 1.743
RNF146 ring finger protein 146 1.73454
NCAPH2 non-SMC condensin II complex, subunit H2 1.72508
DAPK1 death-associated protein kinase 1 1.72435
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) 1.72404
CUEDC1 CUE domain containing 1 1.72218
PCDHB3 protocadherin beta 3 1.72117
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 1.72019
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 1.7197
HARS histidyl-tRNA synthetase 1.70941
UFC1 ubiquitin-fold modifier conjugating enzyme 1 1.70567
JTB jumping translocation breakpoint 1.70557
KLHL8 kelch-like family member 8 1.70254
PGP phosphoglycolate phosphatase 1.70109
TOLLIP toll interacting protein 1.69471
GPM6A glycoprotein M6A 1.68849
SNX24 sorting nexin 24 1.68684
PELI1 pellino E3 ubiquitin protein ligase 1 1.68076
IRS1 insulin receptor substrate 1 1.67701
SIRPA signal-regulatory protein alpha 1.6676
ELOF1 elongation factor 1 homolog (S. cerevisiae) 1.66633
ACYP2 acylphosphatase 2, muscle type 1.66531
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 1.66387
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 1.65818
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 1.65345
PRAF2 PRA1 domain family, member 2 1.65269
NPEPPS aminopeptidase puromycin sensitive 1.6498
MRPL43 mitochondrial ribosomal protein L43 1.6462
TTC13 tetratricopeptide repeat domain 13 1.64268
AKAP6 A kinase (PRKA) anchor protein 6 1.64069
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 1.6388
PGM2L1 phosphoglucomutase 2-like 1 1.6368
FAM160B1 family with sequence similarity 160, member B1 1.63241
MPHOSPH9 M-phase phosphoprotein 9 1.62872
PPP1R3C protein phosphatase 1, regulatory subunit 3C 1.62181
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.6208
SNRPA1 small nuclear ribonucleoprotein polypeptide A' 1.61445
SLC7A4 solute carrier family 7, member 4 1.60893
TSPAN6 tetraspanin 6 1.60457
DPY19L3 dpy-19-like 3 (C. elegans) 1.60194
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 1.60187
IFRD1 interferon-related developmental regulator 1 1.6013
ACOT8 acyl-CoA thioesterase 8 1.60102
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 1.59984
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 1.59797
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 1.59335
TUSC2 tumor suppressor candidate 2 1.5902
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 1.58812
CA2 carbonic anhydrase II 1.58404
TBCD tubulin folding cofactor D 1.58368
C1ORF131 chromosome 1 open reading frame 131 1.57992
EBF3 early B-cell factor 3 1.57816
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 1.57226
SLC16A4 solute carrier family 16, member 4 1.57226
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 1.56711
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.56674
TRIM28 tripartite motif containing 28 1.56648
GNG3 guanine nucleotide binding protein (G protein), gamma 3 1.56558
IQGAP1 IQ motif containing GTPase activating protein 1 1.56555
FUOM fucose mutarotase 1.56038
RND2 Rho family GTPase 2 1.55307
C11ORF71 chromosome 11 open reading frame 71 1.55234
RBPMS RNA binding protein with multiple splicing 1.54715
CD9 CD9 molecule 1.53922
ZMYM2 zinc finger, MYM-type 2 1.53632
SPINT2 serine peptidase inhibitor, Kunitz type, 2 1.53546
RBBP4 retinoblastoma binding protein 4 1.53211
IMPG1 interphotoreceptor matrix proteoglycan 1 1.53068
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 1.52854
RASA1 RAS p21 protein activator (GTPase activating protein) 1 1.52679
AGFG1 ArfGAP with FG repeats 1 1.52146
RPS2 ribosomal protein S2 1.51763
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 1.51677
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 1.51275
WDR41 WD repeat domain 41 1.51139
SSR1 signal sequence receptor, alpha 1.51123
C8ORF48 chromosome 8 open reading frame 48 1.50921
SQLE squalene epoxidase 1.50826
C1QL1 complement component 1, q subcomponent-like 1 1.50804
TWF1 twinfilin actin binding protein 1 1.50373
GPATCH1 G patch domain containing 1 1.50145
B9D1 B9 protein domain 1 1.50129
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 1.49902
GCLM glutamate-cysteine ligase, modifier subunit 1.49857
SDF4 stromal cell derived factor 4 1.49693
CGGBP1 CGG triplet repeat binding protein 1 1.49561
CBLN1 cerebellin 1 precursor 1.49447
GCLC glutamate-cysteine ligase, catalytic subunit 1.49289
HAUS1 HAUS augmin-like complex, subunit 1 1.49264
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 1.48973
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 1.48352
LIMCH1 LIM and calponin homology domains 1 1.48285
C1QL2 complement component 1, q subcomponent-like 2 1.48105
PCCB propionyl CoA carboxylase, beta polypeptide 1.47908
PKD2 polycystic kidney disease 2 (autosomal dominant) 1.47743
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 1.47389
RAB24 RAB24, member RAS oncogene family 1.45933
ADGRA1 adhesion G protein-coupled receptor A1 1.45569
OTOR otoraplin 1.45283
NUP50 nucleoporin 50kDa 1.45197
SETDB2 SET domain, bifurcated 2 1.44645
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 1.44359
SLIT2 slit homolog 2 (Drosophila) 1.44224
KLHL29 kelch-like family member 29 1.44182
ITM2B integral membrane protein 2B 1.44051
NHLH2 nescient helix loop helix 2 1.4351
NIT2 nitrilase family, member 2 1.43327
MCMBP minichromosome maintenance complex binding protein 1.43253
EFNB1 ephrin-B1 1.42172
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 1.41797
RND3 Rho family GTPase 3 1.41634
LRP2 low density lipoprotein receptor-related protein 2 1.41484
CASC4 cancer susceptibility candidate 4 1.41345
UBASH3B ubiquitin associated and SH3 domain containing B 1.41243
KIF3A kinesin family member 3A 1.40806
SAR1A secretion associated, Ras related GTPase 1A 1.40391
SFXN1 sideroflexin 1 1.40352
SRI sorcin 1.40279
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 1.40101
PTPRG protein tyrosine phosphatase, receptor type, G 1.39827
PRMT5 protein arginine methyltransferase 5 1.39561
TSG101 tumor susceptibility 101 1.39209
FAM69B family with sequence similarity 69, member B 1.38898
CRAMP1L Crm, cramped-like (Drosophila) 1.38727
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 1.38645
MLF1 myeloid leukemia factor 1 1.38537
RAB4A RAB4A, member RAS oncogene family 1.38336
NIPSNAP1 nipsnap homolog 1 (C. elegans) 1.38312
FAM76B family with sequence similarity 76, member B 1.38184
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 1.38046
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 1.37875
ENY2 enhancer of yellow 2 homolog (Drosophila) 1.37703
STXBP4 syntaxin binding protein 4 1.37673
PEA15 phosphoprotein enriched in astrocytes 15 1.37486
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 1.36991
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 1.36745
HDGFRP3 hepatoma-derived growth factor, related protein 3 1.36522
HEATR1 HEAT repeat containing 1 1.36227
RAB2B RAB2B, member RAS oncogene family 1.36096
PPP1R17 protein phosphatase 1, regulatory subunit 17 1.35965
ANKRD11 ankyrin repeat domain 11 1.35833
RAB10 RAB10, member RAS oncogene family 1.35789
FN1 fibronectin 1 1.35068
LRRC2 leucine rich repeat containing 2 1.34692
FBXO33 F-box protein 33 1.34448
UNC5C unc-5 homolog C (C. elegans) 1.33732
WDR35 WD repeat domain 35 1.33503
MPZL1 myelin protein zero-like 1 1.3329
CAPN7 calpain 7 1.32927
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 1.32923
PTER phosphotriesterase related 1.32862
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 1.32266
OTX2 orthodenticle homeobox 2 1.32172
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 1.32125
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.32017
MEST mesoderm specific transcript 1.31777
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 1.31773
EPHA5 EPH receptor A5 1.31544
CPEB2 cytoplasmic polyadenylation element binding protein 2 1.31164
POGK pogo transposable element with KRAB domain 1.30865
HBEGF heparin-binding EGF-like growth factor 1.30689
IL6ST interleukin 6 signal transducer 1.30537
GPR155 G protein-coupled receptor 155 1.30426
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 1.3029
PCDH10 protocadherin 10 1.30256
NRCAM neuronal cell adhesion molecule 1.30213
MRPL48 mitochondrial ribosomal protein L48 1.30197
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 1.29944
CNOT8 CCR4-NOT transcription complex, subunit 8 1.29686
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 1.2953
GLRX5 glutaredoxin 5 1.29502
NRSN1 neurensin 1 1.29453
PRMT1 protein arginine methyltransferase 1 1.29417
BCL7C B-cell CLL/lymphoma 7C 1.2931
PPP4C protein phosphatase 4, catalytic subunit 1.29203
IPO4 importin 4 1.29185
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1.2916
ZNF24 zinc finger protein 24 1.28907
EMC3 ER membrane protein complex subunit 3 1.28454
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 1.2844
SLC48A1 solute carrier family 48 (heme transporter), member 1 1.28298
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 1.28238
MAGED1 melanoma antigen family D1 1.2819
EXTL2 exostosin-like glycosyltransferase 2 1.28049
LIN7A lin-7 homolog A (C. elegans) 1.27946
TMTC2 transmembrane and tetratricopeptide repeat containing 2 1.27763

decreased expression

Symbol Name Standardized Value
ABHD14A abhydrolase domain containing 14A -4.0928
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -3.49917
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 -3.38904
TUSC3 tumor suppressor candidate 3 -3.36332
RGS5 regulator of G-protein signaling 5 -3.30257
ZDHHC14 zinc finger, DHHC-type containing 14 -3.24202
RGS9BP regulator of G protein signaling 9 binding protein -3.2293
PGAM1 phosphoglycerate mutase 1 (brain) -3.17439
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -3.10647
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -3.07917
SCARB1 scavenger receptor class B, member 1 -2.9652
TSPAN3 tetraspanin 3 -2.9601
SLC38A6 solute carrier family 38, member 6 -2.95555
TOMM40L translocase of outer mitochondrial membrane 40 homolog (yeast)-like -2.93304
GLUD1 glutamate dehydrogenase 1 -2.85971
REEP6 receptor accessory protein 6 -2.8123
TMLHE trimethyllysine hydroxylase, epsilon -2.79474
UBE2J2 ubiquitin-conjugating enzyme E2, J2 -2.77476
CRX cone-rod homeobox -2.76878
FAM169A family with sequence similarity 169, member A -2.73343
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -2.72118
SC5D sterol-C5-desaturase -2.71384
TJP2 tight junction protein 2 -2.69673
UNC119 unc-119 homolog (C. elegans) -2.68748
TAC3 tachykinin 3 -2.64707
HEATR5A HEAT repeat containing 5A -2.64383
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -2.63249
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 -2.62812
RPL21 ribosomal protein L21 -2.62343
GPSM1 G-protein signaling modulator 1 -2.61484
RPL22 ribosomal protein L22 -2.61314
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.59677
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -2.59359
NARS asparaginyl-tRNA synthetase -2.5806
ERP29 endoplasmic reticulum protein 29 -2.56353
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.55036
AQP1 aquaporin 1 (Colton blood group) -2.54899
ROM1 retinal outer segment membrane protein 1 -2.54799
FAM168B family with sequence similarity 168, member B -2.52058
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta -2.48049
ARL3 ADP-ribosylation factor-like 3 -2.46406
UQCRB ubiquinol-cytochrome c reductase binding protein -2.43844
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 -2.43055
SPATA1 spermatogenesis associated 1 -2.4114
HK2 hexokinase 2 -2.40385
SCAF8 SR-related CTD-associated factor 8 -2.3929
OSBPL1A oxysterol binding protein-like 1A -2.37838
RIOK2 RIO kinase 2 -2.36547
FHOD3 formin homology 2 domain containing 3 -2.35357
NUCB2 nucleobindin 2 -2.35023
CCDC127 coiled-coil domain containing 127 -2.34297
DDIT4 DNA-damage-inducible transcript 4 -2.34246
LPIN1 lipin 1 -2.32223
CRLF3 cytokine receptor-like factor 3 -2.31236
OPTN optineurin -2.30987
FMN2 formin 2 -2.30336
WDR82 WD repeat domain 82 -2.3
FRMPD2 FERM and PDZ domain containing 2 -2.29559
HSPB6 heat shock protein, alpha-crystallin-related, B6 -2.29345
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.2906
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -2.28907
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J -2.28048
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 -2.26592
ZNF280D zinc finger protein 280D -2.26557
AP4S1 adaptor-related protein complex 4, sigma 1 subunit -2.26459
SCG2 secretogranin II -2.25809
MFGE8 milk fat globule-EGF factor 8 protein -2.25372
ACTG1 actin gamma 1 -2.22715
PCNP PEST proteolytic signal containing nuclear protein -2.22593
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.21007
MAB21L2 mab-21-like 2 (C. elegans) -2.20972
RBP3 retinol binding protein 3, interstitial -2.20965
HSPA4L heat shock 70kDa protein 4-like -2.20794
RPS8 ribosomal protein S8 -2.20263
NRL neural retina leucine zipper -2.20155
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.19619
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma -2.19344
FAM114A2 family with sequence similarity 114, member A2 -2.177
IARS isoleucyl-tRNA synthetase -2.17422
RIOK3 RIO kinase 3 -2.17167
DESI1 desumoylating isopeptidase 1 -2.16699
DGKE diacylglycerol kinase, epsilon 64kDa -2.15395
TMX1 thioredoxin-related transmembrane protein 1 -2.15186
C2ORF49 chromosome 2 open reading frame 49 -2.14894
SERBP1 SERPINE1 mRNA binding protein 1 -2.1436
FAM57B family with sequence similarity 57, member B -2.14023
AURKAIP1 aurora kinase A interacting protein 1 -2.13913
OAZ1 ornithine decarboxylase antizyme 1 -2.13575
PDC phosducin -2.1286
TSPYL4 TSPY-like 4 -2.12446
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.11516
CNGA1 cyclic nucleotide gated channel alpha 1 -2.10591
RNF10 ring finger protein 10 -2.10441
SUCLG1 succinate-CoA ligase, alpha subunit -2.09482
PPA1 pyrophosphatase (inorganic) 1 -2.09026
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -2.09001
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 -2.08746
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 -2.07376
RNPS1 RNA binding protein S1, serine-rich domain -2.07279
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -2.06635
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -2.05997
BACE1 beta-site APP-cleaving enzyme 1 -2.05822
RAP1GAP2 RAP1 GTPase activating protein 2 -2.05264
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime -2.04462
SON SON DNA binding protein -2.03382
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma -2.00999
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.00762
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 -2.00118
RHO rhodopsin -1.99392
DNLZ DNL-type zinc finger -1.99039
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -1.98321
DCTN6 dynactin 6 -1.96907
PPCDC phosphopantothenoylcysteine decarboxylase -1.95721
TFG TRK-fused gene -1.95312
FAM161A family with sequence similarity 161, member A -1.95123
CCDC64 coiled-coil domain containing 64 -1.94694
ODC1 ornithine decarboxylase 1 -1.94403
FXYD6 FXYD domain containing ion transport regulator 6 -1.94167
DPY30 dpy-30 homolog (C. elegans) -1.90349
NDFIP1 Nedd4 family interacting protein 1 -1.89925
SYNJ2BP synaptojanin 2 binding protein -1.897
NME1 NME/NM23 nucleoside diphosphate kinase 1 -1.89539
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma -1.8924
ITSN2 intersectin 2 -1.8918
GLB1L2 galactosidase, beta 1-like 2 -1.89115
FBXL20 F-box and leucine-rich repeat protein 20 -1.88773
TRIM2 tripartite motif containing 2 -1.88299
STK35 serine/threonine kinase 35 -1.88018
PAIP2B poly(A) binding protein interacting protein 2B -1.87498
DIABLO diablo, IAP-binding mitochondrial protein -1.87485
EML3 echinoderm microtubule associated protein like 3 -1.86959
CNTLN centlein, centrosomal protein -1.86827
FAM3C family with sequence similarity 3, member C -1.86734
ZC3H4 zinc finger CCCH-type containing 4 -1.86157
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 -1.86119
PPP5C protein phosphatase 5, catalytic subunit -1.85772
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa -1.857
LMAN1 lectin, mannose-binding, 1 -1.84546
JKAMP JNK1/MAPK8-associated membrane protein -1.83558
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -1.83556
LCLAT1 lysocardiolipin acyltransferase 1 -1.83228
COX5A cytochrome c oxidase subunit Va -1.82345
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 -1.81871
PER3 period circadian clock 3 -1.81752
MEF2C myocyte enhancer factor 2C -1.81507
CPLX4 complexin 4 -1.81277
GPSM2 G-protein signaling modulator 2 -1.803
UCKL1 uridine-cytidine kinase 1-like 1 -1.79775
CCNDBP1 cyclin D-type binding-protein 1 -1.79601
ABHD10 abhydrolase domain containing 10 -1.79586
PDIA5 protein disulfide isomerase family A, member 5 -1.78936
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase -1.78761
RGS7 regulator of G-protein signaling 7 -1.78653
BMPR1A bone morphogenetic protein receptor, type IA -1.78576
RPS9 ribosomal protein S9 -1.78246
CCDC58 coiled-coil domain containing 58 -1.76648
SNTG2 syntrophin, gamma 2 -1.76541
COG3 component of oligomeric golgi complex 3 -1.7629
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 -1.75578
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -1.75301
USP34 ubiquitin specific peptidase 34 -1.74516
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -1.74421
EFR3A EFR3 homolog A (S. cerevisiae) -1.74357
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -1.73845
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) -1.73839
MEIS2 Meis homeobox 2 -1.73388
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -1.72958
EGLN1 egl-9 family hypoxia-inducible factor 1 -1.72489
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -1.72233
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 -1.71925
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -1.71613
WISP1 WNT1 inducible signaling pathway protein 1 -1.71536
IMPACT impact RWD domain protein -1.71486
ANKDD1B ankyrin repeat and death domain containing 1B -1.71164
CKB creatine kinase, brain -1.70976
ADCY6 adenylate cyclase 6 -1.69678
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -1.69552
KIF13A kinesin family member 13A -1.69213
RPS25 ribosomal protein S25 -1.68365
SVIL supervillin -1.68338
C4ORF47 chromosome 4 open reading frame 47 -1.68245
RBM20 RNA binding motif protein 20 -1.67754
TBC1D24 TBC1 domain family, member 24 -1.66822
UQCRHL ubiquinol-cytochrome c reductase hinge protein-like -1.66016
SLC38A3 solute carrier family 38, member 3 -1.65971
EMG1 EMG1 N1-specific pseudouridine methyltransferase -1.65163
RORB RAR-related orphan receptor B -1.65082
CRIPT cysteine-rich PDZ-binding protein -1.64531
USPL1 ubiquitin specific peptidase like 1 -1.64086
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 -1.63857
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -1.63666
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -1.63452
HNRNPF heterogeneous nuclear ribonucleoprotein F -1.63095
AKAP11 A kinase (PRKA) anchor protein 11 -1.63026
RPS19 ribosomal protein S19 -1.62522
KIAA1024L KIAA1024-like -1.61955
RPS28 ribosomal protein S28 -1.61928
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -1.61864
CLSTN1 calsyntenin 1 -1.61
H2AFX H2A histone family, member X -1.60938
TAOK3 TAO kinase 3 -1.6028
MSI2 musashi RNA-binding protein 2 -1.60047
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 -1.59192
GUCY1A3 guanylate cyclase 1, soluble, alpha 3 -1.5844
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -1.58371
HPRT1 hypoxanthine phosphoribosyltransferase 1 -1.58265
MFAP3 microfibrillar-associated protein 3 -1.57442
PTPN2 protein tyrosine phosphatase, non-receptor type 2 -1.57423
SAMD11 sterile alpha motif domain containing 11 -1.56766
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -1.56459
FILIP1L filamin A interacting protein 1-like -1.56131
CHGB chromogranin B -1.55768
PVALB parvalbumin -1.55613
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -1.55534
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle -1.55335
CAMTA2 calmodulin binding transcription activator 2 -1.55253
ARR3 arrestin 3, retinal (X-arrestin) -1.55165
RDM1 RAD52 motif containing 1 -1.55164
MTMR7 myotubularin related protein 7 -1.55128
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) -1.55095
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 -1.54817
LYNX1 Ly6/neurotoxin 1 -1.5471
NLK nemo-like kinase -1.54628
JCHAIN joining chain of multimeric IgA and IgM -1.54396
PDE8B phosphodiesterase 8B -1.54275
GTPBP2 GTP binding protein 2 -1.54247
PCM1 pericentriolar material 1 -1.53642
LCMT2 leucine carboxyl methyltransferase 2 -1.53203
STK17B serine/threonine kinase 17b -1.53121
GUCA1A guanylate cyclase activator 1A (retina) -1.52721
IRF3 interferon regulatory factor 3 -1.52134
SGK1 serum/glucocorticoid regulated kinase 1 -1.51868
RPL31 ribosomal protein L31 -1.51706
RPL30 ribosomal protein L30 -1.51682
PRNP prion protein -1.51567
C2ORF71 chromosome 2 open reading frame 71 -1.51535
L3HYPDH L-3-hydroxyproline dehydratase (trans-) -1.51253
ALPL alkaline phosphatase, liver/bone/kidney -1.50877
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1 -1.50633
GREB1L growth regulation by estrogen in breast cancer-like -1.50598
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -1.50251
LARS leucyl-tRNA synthetase -1.50198
IFT122 intraflagellar transport 122 -1.49447
YPEL3 yippee-like 3 (Drosophila) -1.49437
FSCN2 fascin actin-bundling protein 2, retinal -1.49194
MINOS1 mitochondrial inner membrane organizing system 1 -1.4903
CCDC107 coiled-coil domain containing 107 -1.49006
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide -1.48667
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -1.48626
ATM ATM serine/threonine kinase -1.48534
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -1.48026
NRD1 nardilysin (N-arginine dibasic convertase) -1.47616
ADRB1 adrenoceptor beta 1 -1.47491
UNC80 unc-80 homolog (C. elegans) -1.47397
RBM22 RNA binding motif protein 22 -1.47321
SLC35F5 solute carrier family 35, member F5 -1.47111
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -1.47104
CERK ceramide kinase -1.4657
LDHA lactate dehydrogenase A -1.4621
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase -1.4615
ACAT1 acetyl-CoA acetyltransferase 1 -1.46039
PDCL3 phosducin-like 3 -1.45445
TSN translin -1.45353
TMEM87B transmembrane protein 87B -1.45249
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -1.44506
CLDND1 claudin domain containing 1 -1.44475
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 -1.44186
LPIN2 lipin 2 -1.44118
RPS21 ribosomal protein S21 -1.43303
RPL9 ribosomal protein L9 -1.43132
PANK4 pantothenate kinase 4 -1.4295
SLC16A6 solute carrier family 16, member 6 -1.42856
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 -1.42591
CAMSAP1 calmodulin regulated spectrin-associated protein 1 -1.42587
ARFRP1 ADP-ribosylation factor related protein 1 -1.42158
NICN1 nicolin 1 -1.4199
TRIB3 tribbles pseudokinase 3 -1.41625
YARS tyrosyl-tRNA synthetase -1.41549
MDM1 Mdm1 nuclear protein homolog (mouse) -1.414
HIST3H2A histone cluster 3, H2a -1.41208
RPL37 ribosomal protein L37 -1.41049
MRPL55 mitochondrial ribosomal protein L55 -1.40891
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -1.40736
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 -1.40557
HDAC9 histone deacetylase 9 -1.40364
NAF1 nuclear assembly factor 1 ribonucleoprotein -1.40047
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 -1.40018
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -1.40001
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -1.39575
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -1.39482
UROD uroporphyrinogen decarboxylase -1.39278
KLHDC8A kelch domain containing 8A -1.3918
STARD7 StAR-related lipid transfer (START) domain containing 7 -1.39028
C16ORF58 chromosome 16 open reading frame 58 -1.38896
FRMPD1 FERM and PDZ domain containing 1 -1.38737
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -1.38736
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -1.38626
CEP192 centrosomal protein 192kDa -1.38626
TRRAP transformation/transcription domain-associated protein -1.38015
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -1.38009
Funding