Left Ventricular Noncompaction Cardiomyopathy Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Left ventricular non-compaction (LVNC) is characterized by prominent left ventricular trabeculae and deep inter-trabecular recesses. The myocardial wall is often thickened with a thin, compacted epicardial layer and a thickened endocardial layer. In some patients, LVNC is associated with left ventricular dilatation and systolic dysfunction, which can be transient in neonates. (Human Phenotype Ontology, HP_0011664)
External Link https://www.disgenet.org/browser/0/1/0/C4021133
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Genes

38 genes associated with the disease Left Ventricular Noncompaction Cardiomyopathy in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
CASZ1 castor zinc finger 1
COX3
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DSP desmoplakin
DTNA dystrobrevin, alpha
FBN1 fibrillin 1
GATA4 GATA binding protein 4
GJA1 gap junction protein, alpha 1, 43kDa
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
LDB3 LIM domain binding 3
MIB1 mindbomb E3 ubiquitin protein ligase 1
MIPEP mitochondrial intermediate peptidase
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYH7B myosin, heavy chain 7B, cardiac muscle, beta
NKX2-5 NK2 homeobox 5
NNT nicotinamide nucleotide transhydrogenase
NONO non-POU domain containing, octamer-binding
NOTCH1 notch 1
NUBPL nucleotide binding protein-like
PARK2 parkin RBR E3 ubiquitin protein ligase
PLEC plectin
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PRDM16 PR domain containing 16
RBM20 RNA binding motif protein 20
RYR2 ryanodine receptor 2 (cardiac)
SCN5A sodium channel, voltage gated, type V alpha subunit
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
TAZ tafazzin
TBX20 T-box 20
TNNT2 troponin T type 2 (cardiac)
TPM1 tropomyosin 1 (alpha)
TTN titin
XIRP1 xin actin binding repeat containing 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF645 zinc finger protein 645