Leiomyomatosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

253 genes co-occuring with the disease Leiomyomatosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
FH fumarate hydratase 3.82
COL4A6 collagen, type IV, alpha 6 2.984
COL4A5 collagen, type IV, alpha 5 2.806
FLCN folliculin 2.711
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.657
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 2.555
TFE3 transcription factor binding to IGHM enhancer 3 2.448
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.444
MED12 mediator complex subunit 12 2.414
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.268
ELOC elongin C 2.246
SDHAF2 succinate dehydrogenase complex assembly factor 2 2.207
EPAS1 endothelial PAS domain protein 1 2.199
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 2.198
SETD2 SET domain containing 2 2.184
PBRM1 polybromo 1 2.175
KEAP1 kelch-like ECH-associated protein 1 2.158
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 2.153
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 2.125
TFEB transcription factor EB 2.12
CALD1 caldesmon 1 2.107
COL4A4 collagen, type IV, alpha 4 2.098
TSC2 tuberous sclerosis 2 2.043
HMGA2 high mobility group AT-hook 2 2.006
MTOR mechanistic target of rapamycin (serine/threonine kinase) 2.005
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.004
LDHA lactate dehydrogenase A 1.993
MITF microphthalmia-associated transcription factor 1.967
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 1.959
ACO2 aconitase 2, mitochondrial 1.954
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 1.922
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 1.918
ARMC5 armadillo repeat containing 5 1.91
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 1.901
MET MET proto-oncogene, receptor tyrosine kinase 1.896
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.887
EGLN1 egl-9 family hypoxia-inducible factor 1 1.885
AMACR alpha-methylacyl-CoA racemase 1.876
PTEN phosphatase and tensin homolog 1.865
TP53 tumor protein p53 1.855
NFE2L2 nuclear factor, erythroid 2-like 2 1.844
CA9 carbonic anhydrase IX 1.787
FNIP1 folliculin interacting protein 1 1.766
TMEM127 transmembrane protein 127 1.764
PDE11A phosphodiesterase 11A 1.761
MME membrane metallo-endopeptidase 1.754
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 1.753
PGR progesterone receptor 1.752
CDKN2A cyclin-dependent kinase inhibitor 2A 1.747
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.742
EIF5B eukaryotic translation initiation factor 5B 1.739
MEN1 multiple endocrine neoplasia I 1.731
ASL argininosuccinate lyase 1.714
CUL3 cullin 3 1.709
ANO1 anoctamin 1, calcium activated chloride channel 1.709
NF2 neurofibromin 2 (merlin) 1.7
PDE8B phosphodiesterase 8B 1.698
FNIP2 folliculin interacting protein 2 1.695
KDM5C lysine (K)-specific demethylase 5C 1.692
ACO1 aconitase 1, soluble 1.686
EGLN2 egl-9 family hypoxia-inducible factor 2 1.683
L2HGDH L-2-hydroxyglutarate dehydrogenase 1.678
KRT7 keratin 7, type II 1.677
KDM4B lysine (K)-specific demethylase 4B 1.666
ARNT aryl hydrocarbon receptor nuclear translocator 1.663
ALK anaplastic lymphoma receptor tyrosine kinase 1.651
PAX8 paired box 8 1.645
ESR1 estrogen receptor 1 1.627
ACLY ATP citrate lyase 1.619
PKM pyruvate kinase, muscle 1.602
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.601
KDM4A lysine (K)-specific demethylase 4A 1.6
CD34 CD34 molecule 1.598
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.597
TSC1 tuberous sclerosis 1 1.564
BET1L Bet1 golgi vesicular membrane trafficking protein-like 1.56
PLD5 phospholipase D family, member 5 1.56
CUL2 cullin 2 1.559
ELOB elongin B 1.558
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.554
CS citrate synthase 1.539
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.527
D2HGDH D-2-hydroxyglutarate dehydrogenase 1.518
EGLN3 egl-9 family hypoxia-inducible factor 3 1.516
PGD phosphogluconate dehydrogenase 1.512
ESPN espin 1.512
PDK1 pyruvate dehydrogenase kinase, isozyme 1 1.509
GLS glutaminase 1.509
TGFA transforming growth factor, alpha 1.507
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 1.5
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.481
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.478
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.476
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 1.473
RET ret proto-oncogene 1.465
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 1.459
STK11 serine/threonine kinase 11 1.455
RGS7 regulator of G-protein signaling 7 1.453
GLS2 glutaminase 2 (liver, mitochondrial) 1.443
KDM2B lysine (K)-specific demethylase 2B 1.443
ARID1A AT rich interactive domain 1A (SWI-like) 1.439
NF1 neurofibromin 1 1.439
BRCA1 breast cancer 1, early onset 1.418
KDM6A lysine (K)-specific demethylase 6A 1.407
SLC16A4 solute carrier family 16, member 4 1.401
EGFR epidermal growth factor receptor 1.392
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 1.39
CDH16 cadherin 16, KSP-cadherin 1.389
NQO1 NAD(P)H dehydrogenase, quinone 1 1.381
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 1.38
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 1.38
BRCA2 breast cancer 2, early onset 1.38
MSH2 mutS homolog 2 1.379
ASS1 argininosuccinate synthase 1 1.371
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 1.366
CDC73 cell division cycle 73 1.36
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.36
KRAS Kirsten rat sarcoma viral oncogene homolog 1.359
SDHAF1 succinate dehydrogenase complex assembly factor 1 1.357
PC pyruvate carboxylase 1.357
MSH6 mutS homolog 6 1.355
ATM ATM serine/threonine kinase 1.353
CD274 CD274 molecule 1.343
SUCNR1 succinate receptor 1 1.343
PLAG1 pleiomorphic adenoma gene 1 1.34
CHEK2 checkpoint kinase 2 1.34
RBX1 ring-box 1, E3 ubiquitin protein ligase 1.339
IREB2 iron-responsive element binding protein 2 1.337
ACSS2 acyl-CoA synthetase short-chain family member 2 1.331
ATRX alpha thalassemia/mental retardation syndrome X-linked 1.324
CTSK cathepsin K 1.32
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.32
H3-3B H3.3 histone B 1.312
ACSS1 acyl-CoA synthetase short-chain family member 1 1.309
TERT telomerase reverse transcriptase 1.309
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 1.308
MLH1 mutL homolog 1 1.3
VHLL von Hippel-Lindau tumor suppressor-like 1.295
PFKM phosphofructokinase, muscle 1.292
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.288
ADSL adenylosuccinate lyase 1.288
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.287
WDR64 WD repeat domain 64 1.282
HMOX1 heme oxygenase 1 1.281
WT1 Wilms tumor 1 1.277
COL4A2 collagen, type IV, alpha 2 1.257
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.248
FASN fatty acid synthase 1.246
PARP1 poly (ADP-ribose) polymerase 1 1.244
TET2 tet methylcytosine dioxygenase 2 1.241
IRS4 insulin receptor substrate 4 1.239
H3-4 H3.4 histone, cluster member 1.235
H3C13 H3 clustered histone 13 1.215
H3-5 H3.5 histone 1.215
H3C12 H3 clustered histone 12 1.213
KRT20 keratin 20, type I 1.211
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1.206
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1.204
RAD51B RAD51 paralog B 1.203
TNRC6B trinucleotide repeat containing 6B 1.203
SLC49A4 solute carrier family 49 member 4 1.2
TIGAR TP53 induced glycolysis regulatory phosphatase 1.197
G6PD glucose-6-phosphate dehydrogenase 1.197
CCND1 cyclin D1 1.196
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 1.19
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 1.19
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.189
GPX4 glutathione peroxidase 4 1.187
TALDO1 transaldolase 1 1.186
KDR kinase insert domain receptor 1.183
ZEB1 zinc finger E-box binding homeobox 1 1.181
FBP1 fructose-1,6-bisphosphatase 1 1.18
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 1.174
KIF1B kinesin family member 1B 1.172
TFAM transcription factor A, mitochondrial 1.17
CSDE1 cold shock domain containing E1, RNA-binding 1.166
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 1.166
HIF3A hypoxia inducible factor 3, alpha subunit 1.162
HRAS Harvey rat sarcoma viral oncogene homolog 1.162
HOOK2 hook microtubule-tethering protein 2 1.155
COL4A1 collagen, type IV, alpha 1 1.152
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 1.15
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 1.146
HK2 hexokinase 2 1.146
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.142
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.139
NEIL2 nei endonuclease VIII-like 2 (E. coli) 1.139
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.133
PECAM1 platelet/endothelial cell adhesion molecule 1 1.131
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.13
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.129
H2AZ1 H2A.Z variant histone 1 1.122
AXL AXL receptor tyrosine kinase 1.121
NFU1 NFU1 iron-sulfur cluster scaffold 1.115
SIRT3 sirtuin 3 1.112
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.111
PALB2 partner and localizer of BRCA2 1.109
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.108
GLRX2 glutaredoxin 2 1.107
EPO erythropoietin 1.106
SIRT5 sirtuin 5 1.104
BCL2 B-cell CLL/lymphoma 2 1.099
SFPQ splicing factor proline/glutamine-rich 1.09
TKTL2 transketolase-like 2 1.089
RPTOR regulatory associated protein of MTOR, complex 1 1.087
MAX MYC associated factor X 1.086
CALB2 calbindin 2 1.085
NONO non-POU domain containing, octamer-binding 1.08
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.079
TKTL1 transketolase-like 1 1.076
VSTM2A V-set and transmembrane domain containing 2A 1.075
TGFB1 transforming growth factor, beta 1 1.074
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.064
STRN striatin, calmodulin binding protein 1.063
TKT transketolase 1.061
SIRT4 sirtuin 4 1.057
HHATL hedgehog acyltransferase-like 1.057
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 1.056
TET1 tet methylcytosine dioxygenase 1 1.055
CDK8 cyclin-dependent kinase 8 1.049
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 1.048
TXN thioredoxin 1.046
HOOK1 hook microtubule-tethering protein 1 1.045
FANCM Fanconi anemia, complementation group M 1.045
KMT2D lysine (K)-specific methyltransferase 2D 1.042
HELLS helicase, lymphoid-specific 1.04
CARMIL2 capping protein regulator and myosin 1 linker 2 1.04
NFE2 nuclear factor, erythroid 2 1.039
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.038
EXO1 exonuclease 1 1.037
CYCS cytochrome c, somatic 1.037
GNAS GNAS complex locus 1.037
CDK4 cyclin-dependent kinase 4 1.036
IFNA1 interferon, alpha 1 1.032
YEATS4 YEATS domain containing 4 1.03
PHGDH phosphoglycerate dehydrogenase 1.029
IL2 interleukin 2 1.027
PAX2 paired box 2 1.027
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 1.023
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 1.022
GRIPAP1 GRIP1 associated protein 1 1.021
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 1.02
MUTYH mutY homolog 1.019
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 1.019
MITD1 MIT, microtubule interacting and transport, domain containing 1 1.015
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.013
RHEB Ras homolog enriched in brain 1.013
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.011
PDC phosducin 1.01
GATA3 GATA binding protein 3 1.009
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 1.007
BARD1 BRCA1 associated RING domain 1 1.005
FTL ferritin, light polypeptide 1.001