Leiomyosarcoma Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)|A malignant smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.|An uncommon, aggressive malignant smooth muscle neoplasm, usually occurring in post-menopausal women. It is characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid, granular cell, inflammatory and myxoid leimyosarcomas. (Experimental Factor Ontology, EFO_0000564)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D007890
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Genes

160 genes/proteins associated with the disease Leiomyosarcoma from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
CSF3 colony stimulating factor 3 (granulocyte) 2.88009
HMGA1 high mobility group AT-hook 1 2.88009
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.88009
DMD dystrophin 2.88009
GSTP1 glutathione S-transferase pi 1 1.70244
BCL2 B-cell CLL/lymphoma 2 1.68782
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.66964
TYMP thymidine phosphorylase 1.66425
BAK1 BCL2-antagonist/killer 1 1.65467
ERBB2 erb-b2 receptor tyrosine kinase 2 1.64235
GADD45A growth arrest and DNA-damage-inducible, alpha 1.59685
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.59427
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.59172
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.58467
MCL1 myeloid cell leukemia 1 1.56558
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.5555
IL6 interleukin 6 1.54159
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.53651
VEGFA vascular endothelial growth factor A 1.5254
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.5254
BAX BCL2-associated X protein 1.52161
PARP1 poly (ADP-ribose) polymerase 1 1.51305
MGMT O-6-methylguanine-DNA methyltransferase 1.50624
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.50448
TNF tumor necrosis factor 1.50043
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.48813
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.48556
BCL2L1 BCL2-like 1 1.48505
CD274 CD274 molecule 1.47193
VCAM1 vascular cell adhesion molecule 1 1.45777
TOP2A topoisomerase (DNA) II alpha 170kDa 1.44544
FASLG Fas ligand (TNF superfamily, member 6) 1.43564
FAS Fas cell surface death receptor 1.43428
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.42535
TP53 tumor protein p53 1.42183
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.41559
JUN jun proto-oncogene 1.40732
EPO erythropoietin 1.40486
SOD2 superoxide dismutase 2, mitochondrial 1.39924
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.39394
BIRC2 baculoviral IAP repeat containing 2 1.39394
AXL AXL receptor tyrosine kinase 1.39254
CFLAR CASP8 and FADD-like apoptosis regulator 1.39114
BRCA1 breast cancer 1, early onset 1.3793
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.37103
IL1B interleukin 1, beta 1.34983
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.34869
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 1.33791
TYMS thymidylate synthetase 1.33257
CCNB1 cyclin B1 1.32667
EGR1 early growth response 1 1.30177
GDF15 growth differentiation factor 15 1.30056
H2AFX H2A histone family, member X 1.30056
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.29843
STAT1 signal transducer and activator of transcription 1, 91kDa 1.29502
AURKA aurora kinase A 1.28734
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.2772
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.2744
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.27162
EGFR epidermal growth factor receptor 1.26607
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.25838
APAF1 apoptotic peptidase activating factor 1 1.24591
CDK2 cyclin-dependent kinase 2 1.2456
BBC3 BCL2 binding component 3 1.24433
MAPK14 mitogen-activated protein kinase 14 1.24118
IER3 immediate early response 3 1.23233
PROCR protein C receptor, endothelial 1.23137
MCAM melanoma cell adhesion molecule 1.22599
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.21984
MAPK3 mitogen-activated protein kinase 3 1.21239
BTG2 BTG family, member 2 1.20295
CAV1 caveolin 1, caveolae protein, 22kDa 1.19802
CD44 CD44 molecule (Indian blood group) 1.19542
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.19279
FOSL1 FOS-like antigen 1 1.18915
RBM17 RNA binding motif protein 17 1.18456
PRC1 protein regulator of cytokinesis 1 1.18359
PRKCD protein kinase C, delta 1.18293
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.1786
HMMR hyaluronan-mediated motility receptor (RHAMM) 1.17662
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.17399
CAT catalase 1.17333
GSTM1 glutathione S-transferase mu 1 1.17
CYCS cytochrome c, somatic 1.16933
EMP1 epithelial membrane protein 1 1.16799
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.16799
BIRC3 baculoviral IAP repeat containing 3 1.16533
BUB3 BUB3 mitotic checkpoint protein 1.16137
SAT1 spermidine/spermine N1-acetyltransferase 1 1.15256
BAD BCL2-associated agonist of cell death 1.142
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 1.1403
HRAS Harvey rat sarcoma viral oncogene homolog 1.13177
WIF1 WNT inhibitory factor 1 1.13177
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.12973
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 1.12703
BTG1 B-cell translocation gene 1, anti-proliferative 1.12495
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.12391
IFNG interferon, gamma 1.11639
NRP1 neuropilin 1 1.11606
MAP3K12 mitogen-activated protein kinase kinase kinase 12 1.11501
DPYD dihydropyrimidine dehydrogenase 1.11431
HSPA1A heat shock 70kDa protein 1A 1.11431
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.11116
POR P450 (cytochrome) oxidoreductase 1.11046
GPR137B G protein-coupled receptor 137B 1.10631
FLT1 fms-related tyrosine kinase 1 1.10388
BID BH3 interacting domain death agonist 1.10317
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.09927
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.09506
CCL2 chemokine (C-C motif) ligand 2 1.0919
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.09083
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.09083
PRNP prion protein 1.09047
CXCL8 chemokine (C-X-C motif) ligand 8 1.08797
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.08619
MAPK1 mitogen-activated protein kinase 1 1.07983
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.07804
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.07804
BIN1 bridging integrator 1 1.0766
RUNX3 runt-related transcription factor 3 1.07625
IL10 interleukin 10 1.07625
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.07447
E2F3 E2F transcription factor 3 1.07269
GPX1 glutathione peroxidase 1 1.07093
ERBB4 erb-b2 receptor tyrosine kinase 4 1.07057
THBS1 thrombospondin 1 1.07057
STK39 serine threonine kinase 39 1.07022
ICAM1 intercellular adhesion molecule 1 1.06917
EMP3 epithelial membrane protein 3 1.06044
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.05936
RPS27L ribosomal protein S27-like 1.05936
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.05793
TP53I3 tumor protein p53 inducible protein 3 1.0561
CEL carboxyl ester lipase 1.05461
EDNRB endothelin receptor type B 1.04941
GPX3 glutathione peroxidase 3 1.04904
CHEK2 checkpoint kinase 2 1.04904
TMSB4X thymosin beta 4, X-linked 1.04757
BIRC5 baculoviral IAP repeat containing 5 1.04684
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.04684
IER5 immediate early response 5 1.04427
TUBA4A tubulin, alpha 4a 1.04201
SGK1 serum/glucocorticoid regulated kinase 1 1.03939
CXCL11 chemokine (C-X-C motif) ligand 11 1.03864
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.03827
BTG3 BTG family, member 3 1.03827
ACKR3 atypical chemokine receptor 3 1.03789
F3 coagulation factor III (thromboplastin, tissue factor) 1.03678
NOS2 nitric oxide synthase 2, inducible 1.03308
TUBB tubulin, beta class I 1.03271
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.02783
ATM ATM serine/threonine kinase 1.02671
BAG1 BCL2-associated athanogene 1.02671
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.0241
HMGA2 high mobility group AT-hook 2 1.02373
RB1 retinoblastoma 1 1.02114
SQSTM1 sequestosome 1 1.01701
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.01437
TNNI3 troponin I type 3 (cardiac) 1.01361
PCNA proliferating cell nuclear antigen 1.01025