Leishmaniasis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Leishmaniasis is a disease caused by protozoan parasites that belong to the genus Leishmania and is transmitted by the bite of certain species of sand fly (subfamily Phlebotominae). (Experimental Factor Ontology, EFO_0005044)
External Link https://www.disgenet.org/browser/0/1/0/C0023281
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Genes

357 genes associated with the disease Leishmaniasis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
AADAC arylacetamide deacetylase
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ACSS2 acyl-CoA synthetase short-chain family member 2
ACTB actin, beta
ADA adenosine deaminase
AGMO alkylglycerol monooxygenase
AHCY adenosylhomocysteinase
AHR aryl hydrocarbon receptor
AIM2 absent in melanoma 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA1 annexin A1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOA1 apolipoprotein A-I
APRT adenine phosphoribosyltransferase
AQP1 aquaporin 1 (Colton blood group)
ARG1 arginase 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASPG asparaginase
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATR ATR serine/threonine kinase
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like
BID BH3 interacting domain death agonist
BRCA1 breast cancer 1, early onset
C1ORF228 chromosome 1 open reading frame 228
CAPN1 calpain 1, (mu/I) large subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL8 chemokine (C-C motif) ligand 8
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CD14 CD14 molecule
CD160 CD160 molecule
CD163 CD163 molecule
CD1A CD1a molecule
CD200 CD200 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CD274 CD274 molecule
CD28 CD28 molecule
CD34 CD34 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CD69 CD69 molecule
CD86 CD86 molecule
CDCA5 cell division cycle associated 5
CDK12 cyclin-dependent kinase 12
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CLEC4D C-type lectin domain family 4, member D
CLEC7A C-type lectin domain family 7, member A
COL1A1 collagen, type I, alpha 1
COX2
CPB1 carboxypeptidase B1 (tissue)
CPQ carboxypeptidase Q
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CST3 cystatin C
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSB cathepsin B
CTSL cathepsin L
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCLK3 doublecortin-like kinase 3
DCTN6 dynactin 6
DDT D-dopachrome tautomerase
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56
DHFR dihydrofolate reductase
DICER1 dicer 1, ribonuclease type III
DLL1 delta-like 1 (Drosophila)
DNAH8 dynein, axonemal, heavy chain 8
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
DPP4 dipeptidyl-peptidase 4
DSPP dentin sialophosphoprotein
DUSP4 dual specificity phosphatase 4
EBNA1BP2 EBNA1 binding protein 2
EEF1B2 eukaryotic translation elongation factor 1 beta 2
EEF2 eukaryotic translation elongation factor 2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ELF2 E74-like factor 2 (ets domain transcription factor)
EZR ezrin
F12 coagulation factor XII (Hageman factor)
F2R coagulation factor II (thrombin) receptor
F5 coagulation factor V (proaccelerin, labile factor)
FAM120B family with sequence similarity 120B
FAM20C family with sequence similarity 20, member C
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBLIM1 filamin binding LIM protein 1
FBXW4 F-box and WD repeat domain containing 4
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FDPS farnesyl diphosphate synthase
FECH ferrochelatase
FH fumarate hydratase
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOXO1 forkhead box O1
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GCHFR GTP cyclohydrolase I feedback regulator
GCK glucokinase (hexokinase 4)
GOPC golgi-associated PDZ and coiled-coil motif containing
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H1F0 H1 histone family, member 0
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HAMP hepcidin antimicrobial peptide
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HM13 histocompatibility (minor) 13
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA2 heat shock 70kDa protein 2
HSPA4 heat shock 70kDa protein 4
HSPB3 heat shock 27kDa protein 3
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL11 interleukin 11
IL12A interleukin 12A
IL12RB1 interleukin 12 receptor, beta 1
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL32 interleukin 32
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6 interleukin 6
IL9 interleukin 9
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF1 interferon regulatory factor 1
IRF5 interferon regulatory factor 5
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KLK3 kallikrein-related peptidase 3
LAMP1 lysosomal-associated membrane protein 1
LAMP3 lysosomal-associated membrane protein 3
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LCK LCK proto-oncogene, Src family tyrosine kinase
LECT2 leukocyte cell-derived chemotaxin 2
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LMLN leishmanolysin-like (metallopeptidase M8 family)
LOC101929726 uncharacterized LOC101929726
LOC102724560 cystathionine beta-synthase
LOC105375355 uroplakin-3b
LPL lipoprotein lipase
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LSAMP limbic system-associated membrane protein
LTA lymphotoxin alpha
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MAPK4 mitogen-activated protein kinase 4
MATK megakaryocyte-associated tyrosine kinase
MBL2 mannose-binding lectin (protein C) 2, soluble
MCL1 myeloid cell leukemia 1
MFAP1 microfibrillar-associated protein 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MNAT1 MNAT CDK-activating kinase assembly factor 1
MON2 MON2 homolog (S. cerevisiae)
MPG N-methylpurine-DNA glycosylase
MPL MPL proto-oncogene, thrombopoietin receptor
MPST mercaptopyruvate sulfurtransferase
MRC1 mannose receptor, C type 1
MSMB microseminoprotein, beta-
MST1 macrophage stimulating 1
MSTO1 misato 1, mitochondrial distribution and morphology regulator
MT-CYB cytochrome b
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYD88 myeloid differentiation primary response 88
NCAM1 neural cell adhesion molecule 1
NELFCD negative elongation factor complex member C/D
NFE2L2 nuclear factor, erythroid 2-like 2
NLRP10 NLR family, pyrin domain containing 10
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOTCH3 notch 3
NOX1 NADPH oxidase 1
NPEPPS aminopeptidase puromycin sensitive
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NT5C2 5'-nucleotidase, cytosolic II
NUP93 nucleoporin 93kDa
ODC1 ornithine decarboxylase 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P4HB prolyl 4-hydroxylase, beta polypeptide
PABPC1 poly(A) binding protein, cytoplasmic 1
PADI1 peptidyl arginine deiminase, type I
PAEP progestagen-associated endometrial protein
PDCD1LG2 programmed cell death 1 ligand 2
PDIA2 protein disulfide isomerase family A, member 2
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase
PGD phosphogluconate dehydrogenase
PHB prohibitin
PHGDH phosphoglycerate dehydrogenase
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PKD2L1 polycystic kidney disease 2-like 1
PLAG1 pleiomorphic adenoma gene 1
PLP1 proteolipid protein 1
PNOC prepronociceptin
PNP purine nucleoside phosphorylase
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POPDC3 popeye domain containing 3
PPARA peroxisome proliferator-activated receptor alpha
PRDM1 PR domain containing 1, with ZNF domain
PRDX2 peroxiredoxin 2
PRDX5 peroxiredoxin 5
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PROS1 protein S (alpha)
PRRT2 proline-rich transmembrane protein 2
PSAT1 phosphoserine aminotransferase 1
PSG5 pregnancy specific beta-1-glycoprotein 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTHLH parathyroid hormone-like hormone
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB6A RAB6A, member RAS oncogene family
RABEPK Rab9 effector protein with kelch motifs
RBM45 RNA binding motif protein 45
RCE1 Ras converting CAAX endopeptidase 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPA1 replication protein A1, 70kDa
RPS6 ribosomal protein S6
RPSA ribosomal protein SA
SGSM3 small G protein signaling modulator 3
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIRT1 sirtuin 1
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNAP25 synaptosomal-associated protein, 25kDa
SOAT1 sterol O-acyltransferase 1
SOCS1 suppressor of cytokine signaling 1
SPAG1 sperm associated antigen 1
SPHK1 sphingosine kinase 1
SPP1 secreted phosphoprotein 1
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TARS threonyl-tRNA synthetase
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TARSL2 threonyl-tRNA synthetase-like 2
TBP TATA box binding protein
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TICAM2 toll-like receptor adaptor molecule 2
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TMED7 transmembrane emp24 protein transport domain containing 7
TMED7-TICAM2 TMED7-TICAM2 readthrough
TMPRSS13 transmembrane protease, serine 13
TNF tumor necrosis factor
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TOLLIP toll interacting protein
TP53 tumor protein p53
TP63 tumor protein p63
TREM1 triggering receptor expressed on myeloid cells 1
UNC13D unc-13 homolog D (C. elegans)
UNG uracil-DNA glycosylase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
YY1 YY1 transcription factor
ZNF469 zinc finger protein 469