Lenalidomide (hemihydrate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.187732
TMEM41B transmembrane protein 41B 0.124485
RTN4 reticulon 4 0.0988597
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0943828
JMJD1C jumonji domain containing 1C 0.0942725
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0821012
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0801816
PCBP2 poly(rC) binding protein 2 0.0782391
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0693828
SMC4 structural maintenance of chromosomes 4 0.0643015
YAP1 Yes-associated protein 1 0.0606309
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0593505
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0561787
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0549296
WWOX WW domain containing oxidoreductase 0.054507
VMP1 vacuole membrane protein 1 0.052927
RRM2 ribonucleotide reductase M2 0.0513821
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0513191
AREG amphiregulin 0.0502785
ZNF638 zinc finger protein 638 0.0492789
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0466262
CCDC88A coiled-coil domain containing 88A 0.0453326
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0446508
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0434689
RCOR1 REST corepressor 1 0.0412891
ERBIN erbb2 interacting protein 0.040479
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0400957
DIAPH3 diaphanous-related formin 3 0.0398622
RANBP17 RAN binding protein 17 0.0388579
YBX3 Y box binding protein 3 0.0384749
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0378858
ANKRD17 ankyrin repeat domain 17 0.0378252
TRA2B transformer 2 beta homolog (Drosophila) 0.0375966
CEP192 centrosomal protein 192kDa 0.0367505
TJP1 tight junction protein 1 0.0365043
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0345579
TENM3 teneurin transmembrane protein 3 0.0334173
ECT2 epithelial cell transforming 2 0.0332825
ZNF148 zinc finger protein 148 0.0325948
DLC1 DLC1 Rho GTPase activating protein 0.0325498
SRPK2 SRSF protein kinase 2 0.0325118
EDARADD EDAR-associated death domain 0.0320659
KPNB1 karyopherin (importin) beta 1 0.0319468
KIF18B kinesin family member 18B 0.0314866
KCMF1 potassium channel modulatory factor 1 0.0309548
SLMAP sarcolemma associated protein 0.0309113
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0308576
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0306885
TBK1 TANK-binding kinase 1 0.0306271
CENPF centromere protein F, 350/400kDa 0.02982
RIMS2 regulating synaptic membrane exocytosis 2 0.0296791
TRIO trio Rho guanine nucleotide exchange factor 0.029587
CBX3 chromobox homolog 3 0.0292952
PHF14 PHD finger protein 14 0.0283876
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0282483
MARCHF4 membrane associated ring-CH-type finger 4 0.0281237
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0276037
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0275507
NEBL nebulette 0.0274206
MIS18BP1 MIS18 binding protein 1 0.0270126
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0266622
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0265612
FNDC3B fibronectin type III domain containing 3B 0.0264772
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0260533
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0259075
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0258778
APLP2 amyloid beta (A4) precursor-like protein 2 0.0258309
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0255678
NCAPD2 non-SMC condensin I complex, subunit D2 0.0254055
DDIT3 DNA-damage-inducible transcript 3 0.0253428
SFPQ splicing factor proline/glutamine-rich 0.0253412
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0252961
PCM1 pericentriolar material 1 0.0252753
UBXN4 UBX domain protein 4 0.0252248
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0251856
CARD16 caspase recruitment domain family, member 16 0.0251525
NALF1 NALCN channel auxiliary factor 1 0.0250604
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0249975
POTEF POTE ankyrin domain family, member F 0.0249893
MBNL1 muscleblind-like splicing regulator 1 0.0247557
VCL vinculin 0.024746
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0246207
LRP6 low density lipoprotein receptor-related protein 6 0.0246104
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0245709
TPX2 TPX2, microtubule-associated 0.0245492
SPATS2 spermatogenesis associated, serine-rich 2 0.0245303
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0243539
PRKCI protein kinase C, iota 0.024352
ATAD2 ATPase family, AAA domain containing 2 0.0241131
ETV6 ets variant 6 0.024066
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0240367
CIP2A cellular inhibitor of PP2A 0.0239549
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0238015
GREB1L growth regulation by estrogen in breast cancer-like 0.0237652
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0237581
MMP12 matrix metallopeptidase 12 0.0233606
LGALS12 lectin, galactoside-binding, soluble, 12 0.0232073
BPTF bromodomain PHD finger transcription factor 0.0230522
PTBP3 polypyrimidine tract binding protein 3 0.0230293
AKAP9 A kinase (PRKA) anchor protein 9 0.0229804

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.137409
TMSB10 thymosin beta 10 -0.0995876
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0909527
PTMA prothymosin, alpha -0.0846147
CLDN1 claudin 1 -0.0726814
ANXA1 annexin A1 -0.0656189
SYT1 synaptotagmin I -0.0647763
IFIH1 interferon induced with helicase C domain 1 -0.064609
EEF2 eukaryotic translation elongation factor 2 -0.0636007
EHBP1 EH domain binding protein 1 -0.0626519
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0611663
AHNAK AHNAK nucleoprotein -0.0585946
CANX calnexin -0.0564827
VIM vimentin -0.0561765
CXADR coxsackie virus and adenovirus receptor -0.0549091
H1-0 H1.0 linker histone -0.0541438
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0531048
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0527566
ASPH aspartate beta-hydroxylase -0.0513251
HDLBP high density lipoprotein binding protein -0.0496235
ERRFI1 ERBB receptor feedback inhibitor 1 -0.049613
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0482935
LMO7 LIM domain 7 -0.0471427
MGAT4C MGAT4 family, member C -0.0466344
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0445494
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0445129
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0429776
RPL23 ribosomal protein L23 -0.0412121
SPDYA speedy/RINGO cell cycle regulator family member A -0.0405815
ZNF804A zinc finger protein 804A -0.0403173
RPS24 ribosomal protein S24 -0.039798
RPL34 ribosomal protein L34 -0.0397091
RPL12 ribosomal protein L12 -0.0396314
TPT1 tumor protein, translationally-controlled 1 -0.0381434
FSTL5 follistatin-like 5 -0.0376448
MYL12B myosin, light chain 12B, regulatory -0.0376144
CALR calreticulin -0.0369834
HSPA8 heat shock 70kDa protein 8 -0.0360849
RPS8 ribosomal protein S8 -0.0353783
KDM3A lysine (K)-specific demethylase 3A -0.0350887
EEF1G eukaryotic translation elongation factor 1 gamma -0.0350351
EIF1 eukaryotic translation initiation factor 1 -0.0350237
RPL19 ribosomal protein L19 -0.0347061
RPL35A ribosomal protein L35a -0.0343014
ZNF217 zinc finger protein 217 -0.0340339
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0335218
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0331208
LOC112694756 uncharaterized LOC112694756 -0.0330194
RPL32 ribosomal protein L32 -0.0326658
MTAP methylthioadenosine phosphorylase -0.032366
RACK1 receptor for activated C kinase 1 -0.0322538
CNRIP1 cannabinoid receptor interacting protein 1 -0.0321496
TM4SF1 transmembrane 4 L six family member 1 -0.0316941
CLNS1A chloride channel, nucleotide-sensitive, 1A -0.0315923
HSPA4 heat shock 70kDa protein 4 -0.0312645
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0305687
GASK1B golgi associated kinase 1B -0.0304906
TMEM123 transmembrane protein 123 -0.030266
RPL6 ribosomal protein L6 -0.0301517
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0300194
CCDC47 coiled-coil domain containing 47 -0.0294926
RPL36 ribosomal protein L36 -0.02766
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -0.0274216
DPYD dihydropyrimidine dehydrogenase -0.0273403
SRP72 signal recognition particle 72kDa -0.0272999
NACA nascent polypeptide-associated complex alpha subunit -0.0269311
RPS23 ribosomal protein S23 -0.0266644
STIP1 stress-induced phosphoprotein 1 -0.0264166
RPS27A ribosomal protein S27a -0.0264045
LRRC23 leucine rich repeat containing 23 -0.026401
RPS25 ribosomal protein S25 -0.026281
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.026088
AXIN2 axin 2 -0.0258996
HMGB1 high mobility group box 1 -0.025852
BLTP2 bridge-like lipid transfer protein family member 2 -0.0257616
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0256952
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0250103
RASAL2 RAS protein activator like 2 -0.0249813
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0249788
RSL1D1 ribosomal L1 domain containing 1 -0.0243023
KLF6 Kruppel-like factor 6 -0.0241271
PDIA4 protein disulfide isomerase family A, member 4 -0.0239118
PCDH9 protocadherin 9 -0.0237035
FGFR1 fibroblast growth factor receptor 1 -0.0236154
RPL4 ribosomal protein L4 -0.0235102
CSDE1 cold shock domain containing E1, RNA-binding -0.0234851
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0234029
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0232317
RAD21 RAD21 homolog (S. pombe) -0.023093
PHF3 PHD finger protein 3 -0.0230722
RPL26 ribosomal protein L26 -0.0229783
RPS14 ribosomal protein S14 -0.0227468
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0223054
RPLP2 ribosomal protein, large, P2 -0.0222566
RPL31 ribosomal protein L31 -0.022255
YBX1 Y box binding protein 1 -0.0221969
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0221302
RPL11 ribosomal protein L11 -0.0220431
RPL38 ribosomal protein L38 -0.0219643
RPL13A ribosomal protein L13a -0.0219334