Lenalidomide (hemihydrate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.155987
VIM vimentin 0.114788
PDE10A phosphodiesterase 10A 0.0908968
TSHZ2 teashirt zinc finger homeobox 2 0.0855957
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.07273
RPS6 ribosomal protein S6 0.0677155
LINGO2 leucine rich repeat and Ig domain containing 2 0.0677107
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0587984
MT2A metallothionein 2A 0.0582434
RPL23 ribosomal protein L23 0.0504809
ITGAV integrin, alpha V 0.0486315
MYOF myoferlin 0.0463162
GSE1 Gse1 coiled-coil protein 0.044359
SLC38A2 solute carrier family 38, member 2 0.0441235
VEGFA vascular endothelial growth factor A 0.0428635
PHIP pleckstrin homology domain interacting protein 0.0406754
FNDC3B fibronectin type III domain containing 3B 0.040573
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0403774
ASPH aspartate beta-hydroxylase 0.0398931
PRELID2 PRELI domain containing 2 0.0376338
KMT2E lysine (K)-specific methyltransferase 2E 0.0364463
ANKRD17 ankyrin repeat domain 17 0.0354736
EGFR epidermal growth factor receptor 0.0353591
TRIO trio Rho guanine nucleotide exchange factor 0.0353141
PGK1 phosphoglycerate kinase 1 0.0352394
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0348978
YEATS2 YEATS domain containing 2 0.0345128
APLP2 amyloid beta (A4) precursor-like protein 2 0.03374
RPL35A ribosomal protein L35a 0.0328635
ATP11A ATPase, class VI, type 11A 0.0324119
SFPQ splicing factor proline/glutamine-rich 0.0323643
HMGA1 high mobility group AT-hook 1 0.0321331
PHF14 PHD finger protein 14 0.0321008
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0319489
ZNF638 zinc finger protein 638 0.0314175
ANKRD12 ankyrin repeat domain 12 0.0307147
KTN1 kinectin 1 (kinesin receptor) 0.0306805
PCBP2 poly(rC) binding protein 2 0.030432
GPC6 glypican 6 0.030311
ITCH itchy E3 ubiquitin protein ligase 0.0302726
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0302699
ECT2 epithelial cell transforming 2 0.0298497
ARHGAP21 Rho GTPase activating protein 21 0.0297235
EXOC6B exocyst complex component 6B 0.0293207
ATG10 autophagy related 10 0.0284327
TXNRD1 thioredoxin reductase 1 0.0282092
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0276691
FNIP1 folliculin interacting protein 1 0.0273483
FBXL7 F-box and leucine-rich repeat protein 7 0.0269798
ZFHX3 zinc finger homeobox 3 0.0269185
RAD51B RAD51 paralog B 0.0268949
PTMS parathymosin 0.0267324
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.026509
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0259987
PTBP2 polypyrimidine tract binding protein 2 0.0258627
BBX bobby sox homolog (Drosophila) 0.0258246
MYO9A myosin IXA 0.0257317
GPM6B glycoprotein M6B 0.0255541
CBX3 chromobox homolog 3 0.0254142
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0253424
CDK19 cyclin-dependent kinase 19 0.0253346
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0252993
RPS14 ribosomal protein S14 0.0250403
IGF2 insulin-like growth factor 2 0.0248762
RPS19 ribosomal protein S19 0.0242565
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0241356
ZFP36L1 ZFP36 ring finger protein-like 1 0.0239508
WWOX WW domain containing oxidoreductase 0.0238378
TBX2 T-box 2 0.0237178
MIS18BP1 MIS18 binding protein 1 0.0235447
VMP1 vacuole membrane protein 1 0.0235368
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.023392
THOC2 THO complex 2 0.0233099
BICD1 bicaudal D homolog 1 (Drosophila) 0.0232705
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0230325
C11ORF58 chromosome 11 open reading frame 58 0.0227143
YTHDC1 YTH domain containing 1 0.0220071
RABGAP1L RAB GTPase activating protein 1-like 0.0219835
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.0218997
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 0.0217843
TBC1D5 TBC1 domain family, member 5 0.0214602
HOXC10 homeobox C10 0.0212681
FOXP1 forkhead box P1 0.0211899
PBX3 pre-B-cell leukemia homeobox 3 0.0211811
UBE3A ubiquitin protein ligase E3A 0.0211794
RPL37A ribosomal protein L37a 0.0210764
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0209421
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0208892
FAF2 Fas associated factor family member 2 0.0207451
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0207293
RNF150 ring finger protein 150 0.0206948
MAP2K5 mitogen-activated protein kinase kinase 5 0.0204976
RPLP1 ribosomal protein, large, P1 0.0203722
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0203648
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0201532
RIC1 RAB6A GEF complex partner 1 0.0200999
RPS21 ribosomal protein S21 0.0200973
GPHN gephyrin 0.0200321
CSNK1A1 casein kinase 1, alpha 1 0.0200249
COL1A2 collagen, type I, alpha 2 0.0198794

decreased expression

Symbol Name Standardized Value
PEG10 paternally expressed 10 -0.228524
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.17412
PRKG1 protein kinase, cGMP-dependent, type I -0.132121
CADM2 cell adhesion molecule 2 -0.11892
TPK1 thiamin pyrophosphokinase 1 -0.114747
CANX calnexin -0.111703
FGFR1 fibroblast growth factor receptor 1 -0.105761
RLF rearranged L-myc fusion -0.0892308
PTMA prothymosin, alpha -0.0837951
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0772329
QKI QKI, KH domain containing, RNA binding -0.0771326
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0741748
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0728002
MGP matrix Gla protein -0.0693906
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0656863
MEOX2 mesenchyme homeobox 2 -0.0654395
MEST mesoderm specific transcript -0.061733
IGF2R insulin-like growth factor 2 receptor -0.0586606
TMSB4X thymosin beta 4, X-linked -0.0576517
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0547939
GOLGA4 golgin A4 -0.0546771
AFF4 AF4/FMR2 family, member 4 -0.0518572
RHEB Ras homolog enriched in brain -0.0512988
NFIA nuclear factor I/A -0.0502355
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0485819
KDM5B lysine (K)-specific demethylase 5B -0.0474737
LDHA lactate dehydrogenase A -0.0461418
MED13L mediator complex subunit 13-like -0.0459227
IFRD1 interferon-related developmental regulator 1 -0.0447078
HDLBP high density lipoprotein binding protein -0.0441009
HMGB1 high mobility group box 1 -0.042745
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0423337
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0410624
TULP4 tubby like protein 4 -0.0408854
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0406086
KMT2C lysine (K)-specific methyltransferase 2C -0.0405208
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0399227
CALD1 caldesmon 1 -0.0398682
ZEB1 zinc finger E-box binding homeobox 1 -0.0393565
APP amyloid beta (A4) precursor protein -0.0392628
CALR calreticulin -0.0391832
MXI1 MAX interactor 1, dimerization protein -0.0391663
VDAC1 voltage-dependent anion channel 1 -0.0373099
KAZN kazrin, periplakin interacting protein -0.0367296
SOD2 superoxide dismutase 2, mitochondrial -0.0359558
NFIB nuclear factor I/B -0.0356768
RPS24 ribosomal protein S24 -0.0354136
COTL1 coactosin-like F-actin binding protein 1 -0.0353609
SKP1 S-phase kinase-associated protein 1 -0.0352639
RAB7A RAB7A, member RAS oncogene family -0.0349001
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0348587
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0346856
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0343921
KAT6A K(lysine) acetyltransferase 6A -0.0340616
TPM4 tropomyosin 4 -0.0338071
NOP58 NOP58 ribonucleoprotein -0.0334061
RPS2 ribosomal protein S2 -0.0332306
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.033136
ZNF292 zinc finger protein 292 -0.0331208
NCOA1 nuclear receptor coactivator 1 -0.0328531
TPT1 tumor protein, translationally-controlled 1 -0.032842
DENND4C DENN/MADD domain containing 4C -0.0327361
NAP1L1 nucleosome assembly protein 1-like 1 -0.0327329
SSBP2 single-stranded DNA binding protein 2 -0.0326888
CSDE1 cold shock domain containing E1, RNA-binding -0.032651
NPR2 natriuretic peptide receptor 2 -0.0326341
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B -0.0322837
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0322205
YBX1 Y box binding protein 1 -0.0321326
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0320036
FGFR2 fibroblast growth factor receptor 2 -0.0319573
IER3 immediate early response 3 -0.0315312
SEC31A SEC31 homolog A (S. cerevisiae) -0.031233
SFTPA2 surfactant protein A2 -0.0311703
ABI1 abl-interactor 1 -0.0308456
ELOVL5 ELOVL fatty acid elongase 5 -0.0306572
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.030567
RSL1D1 ribosomal L1 domain containing 1 -0.0304902
LPP LIM domain containing preferred translocation partner in lipoma -0.0304777
PTK2 protein tyrosine kinase 2 -0.0303228
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -0.0295977
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.0294675
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0293966
DEK DEK proto-oncogene -0.0293234
AHNAK AHNAK nucleoprotein -0.02932
KDM3A lysine (K)-specific demethylase 3A -0.0292039
PHF3 PHD finger protein 3 -0.0290943
DUSP6 dual specificity phosphatase 6 -0.0288624
RFX7 regulatory factor X, 7 -0.0287415
SPAG9 sperm associated antigen 9 -0.0287
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0284539
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0281102
TPST1 tyrosylprotein sulfotransferase 1 -0.0276225
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0275093
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0273554
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0272983
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0272788
FN1 fibronectin 1 -0.0272077
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0269913
BCOR BCL6 corepressor -0.0269046