Lenalidomide (hemihydrate)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDLIM5 PDZ and LIM domain 5 0.0853465
ANKRD36C ankyrin repeat domain 36C 0.0777372
ITCH itchy E3 ubiquitin protein ligase 0.0755299
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0660934
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0651495
NRIP1 nuclear receptor interacting protein 1 0.0647169
FNDC3A fibronectin type III domain containing 3A 0.0588295
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0573436
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0524065
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.051542
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0512456
KIAA1217 KIAA1217 0.0491035
TSC22D2 TSC22 domain family, member 2 0.0469964
VCL vinculin 0.0468576
ZNFX1 zinc finger, NFX1-type containing 1 0.0447849
LIMCH1 LIM and calponin homology domains 1 0.0437861
SMYD3 SET and MYND domain containing 3 0.0434243
ADARB1 adenosine deaminase, RNA-specific, B1 0.0432403
FAM13A family with sequence similarity 13, member A 0.0418079
UBAP1 ubiquitin associated protein 1 0.0410949
IGF2 insulin-like growth factor 2 0.0404311
RTN4 reticulon 4 0.0401989
MT2A metallothionein 2A 0.0392269
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.038144
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0379056
WSB1 WD repeat and SOCS box containing 1 0.0372836
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0371513
FBXO11 F-box protein 11 0.0369895
DOCK5 dedicator of cytokinesis 5 0.0369551
TMEM165 transmembrane protein 165 0.0358245
FOXO3 forkhead box O3 0.0354943
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 0.0350675
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.034807
EXT1 exostosin glycosyltransferase 1 0.0346236
RAD51B RAD51 paralog B 0.03458
YAP1 Yes-associated protein 1 0.0341728
RPL30 ribosomal protein L30 0.0339599
MCL1 myeloid cell leukemia 1 0.0335583
KTN1 kinectin 1 (kinesin receptor) 0.0335297
ZBTB43 zinc finger and BTB domain containing 43 0.0334776
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0334616
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.033235
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.033091
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0322344
MED13 mediator complex subunit 13 0.0321795
PLSCR1 phospholipid scramblase 1 0.0319639
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0315231
CCNY cyclin Y 0.0314122
YEATS2 YEATS domain containing 2 0.0311378
PRELID2 PRELI domain containing 2 0.0301924
ESYT2 extended synaptotagmin-like protein 2 0.0301442
MYOF myoferlin 0.0300287
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0299628
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.029823
MYH9 myosin, heavy chain 9, non-muscle 0.0298045
RBM25 RNA binding motif protein 25 0.029527
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0294254
ITGB5 integrin, beta 5 0.0288477
TAOK3 TAO kinase 3 0.0278196
WDR45B WD repeat domain 45B 0.0275705
FGD4 FYVE, RhoGEF and PH domain containing 4 0.027555
RAB6A RAB6A, member RAS oncogene family 0.0273714
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0271815
HLA-B major histocompatibility complex, class I, B 0.0271408
ANKRD12 ankyrin repeat domain 12 0.0270566
USP53 ubiquitin specific peptidase 53 0.0269357
TRA2A transformer 2 alpha homolog (Drosophila) 0.0269078
EFNA5 ephrin-A5 0.0267158
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0262098
NPC1 Niemann-Pick disease, type C1 0.0260643
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0260422
FGB fibrinogen beta chain 0.0258287
IFI6 interferon, alpha-inducible protein 6 0.0257592
ZNF148 zinc finger protein 148 0.0255259
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0255093
LPP LIM domain containing preferred translocation partner in lipoma 0.025363
TRIO trio Rho guanine nucleotide exchange factor 0.0253611
PAWR PRKC, apoptosis, WT1, regulator 0.0253099
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0252363
CCNL1 cyclin L1 0.0250406
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0249359
SP100 SP100 nuclear antigen 0.0245782
BZW1 basic leucine zipper and W2 domains 1 0.0245503
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0245347
TPM4 tropomyosin 4 0.024517
SEPTIN7 septin 7 0.0245035
ZNF841 zinc finger protein 841 0.0244828
PARP14 poly (ADP-ribose) polymerase family, member 14 0.02434
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0243381
CSNK1A1 casein kinase 1, alpha 1 0.0241743
PHIP pleckstrin homology domain interacting protein 0.0241319
EGFR epidermal growth factor receptor 0.0241111
SLC38A2 solute carrier family 38, member 2 0.023875
CREB5 cAMP responsive element binding protein 5 0.0237902
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0236653
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.0236528
PPME1 protein phosphatase methylesterase 1 0.0230791
ARB2A ARB2 cotranscriptional regulator A 0.023066
B2M beta-2-microglobulin 0.0230366
TTC3 tetratricopeptide repeat domain 3 0.022971

decreased expression

Symbol Name Standardized Value
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.152076
ZMYND8 zinc finger, MYND-type containing 8 -0.146148
RPL23 ribosomal protein L23 -0.122186
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.106264
CATSPERB catsper channel auxiliary subunit beta -0.100752
IGFBP5 insulin-like growth factor binding protein 5 -0.0977179
TRPS1 trichorhinophalangeal syndrome I -0.0976313
LASP1 LIM and SH3 protein 1 -0.0907113
PTMA prothymosin, alpha -0.089533
ACACA acetyl-CoA carboxylase alpha -0.0852799
PBX1 pre-B-cell leukemia homeobox 1 -0.0750514
TMEM123 transmembrane protein 123 -0.0704736
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0648447
CDK12 cyclin-dependent kinase 12 -0.0616741
THSD4 thrombospondin, type I, domain containing 4 -0.0614695
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0603513
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0571106
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0541384
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0498618
TC2N tandem C2 domains, nuclear -0.0494352
ASPH aspartate beta-hydroxylase -0.0484986
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0451992
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0445063
ELOVL5 ELOVL fatty acid elongase 5 -0.0441351
FTH1 ferritin, heavy polypeptide 1 -0.0436815
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.042918
CEP250 centrosomal protein 250kDa -0.0423512
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0408313
VCP valosin containing protein -0.0389997
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0386181
RPL19 ribosomal protein L19 -0.0382111
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -0.0374082
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0373386
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.0372453
YPEL2 yippee-like 2 (Drosophila) -0.0366189
NCAM2 neural cell adhesion molecule 2 -0.0359998
TMSB4X thymosin beta 4, X-linked -0.0353797
KAZN kazrin, periplakin interacting protein -0.0338525
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0336523
FASN fatty acid synthase -0.0329088
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0323545
KRT18 keratin 18, type I -0.0319513
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0318793
EXOC4 exocyst complex component 4 -0.0316245
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0316205
DENND1A DENN/MADD domain containing 1A -0.0314484
ZNF217 zinc finger protein 217 -0.0314179
RIMS2 regulating synaptic membrane exocytosis 2 -0.0309346
RAD21 RAD21 homolog (S. pombe) -0.0306139
LRP1B low density lipoprotein receptor-related protein 1B -0.0303121
ZC3H11A zinc finger CCCH-type containing 11A -0.0300687
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0297659
BCAS1 breast carcinoma amplified sequence 1 -0.0292638
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0291868
GMDS GDP-mannose 4,6-dehydratase -0.0291625
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.029105
AUTS2 autism susceptibility candidate 2 -0.0289999
KIF1A kinesin family member 1A -0.0289517
ALCAM activated leukocyte cell adhesion molecule -0.0289336
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0280374
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0279207
TRAPPC9 trafficking protein particle complex 9 -0.027888
BRWD1 bromodomain and WD repeat domain containing 1 -0.0275253
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0274256
CD164 CD164 molecule, sialomucin -0.0269095
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0264632
SEPTIN11 septin 11 -0.0264479
SOD2 superoxide dismutase 2, mitochondrial -0.0261246
TTC6 tetratricopeptide repeat domain 6 -0.0257885
SMIM14 small integral membrane protein 14 -0.0257619
ZFAND3 zinc finger, AN1-type domain 3 -0.0257479
POTEF POTE ankyrin domain family, member F -0.0257093
PRLR prolactin receptor -0.0256429
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0251271
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -0.024886
SQSTM1 sequestosome 1 -0.0245249
GPC5 glypican 5 -0.0245172
NFIA nuclear factor I/A -0.0243705
TENM2 teneurin transmembrane protein 2 -0.0243399
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.0241374
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0239822
HMGB1 high mobility group box 1 -0.0237197
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.02268
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0222675
APP amyloid beta (A4) precursor protein -0.0222646
MUCL1 mucin-like 1 -0.022004
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.021659
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -0.0214007
SRSF1 serine/arginine-rich splicing factor 1 -0.0212931
PLCB4 phospholipase C, beta 4 -0.0212295
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0211418
IPO7 importin 7 -0.0209741
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0209147
NRCAM neuronal cell adhesion molecule -0.0206637
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0206291
MBD4 methyl-CpG binding domain protein 4 -0.0205223
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0204102
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0203152
MACROD2 MACRO domain containing 2 -0.0202749
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0202391