Lenalidomide (hemihydrate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.188079
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.178354
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.158729
GPC6 glypican 6 0.133745
IGFBP3 insulin-like growth factor binding protein 3 0.126777
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.121692
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.114768
PRELID2 PRELI domain containing 2 0.0995764
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.097542
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0898186
ASPH aspartate beta-hydroxylase 0.0818907
NLGN1 neuroligin 1 0.0775573
ESYT2 extended synaptotagmin-like protein 2 0.0689704
PDIA4 protein disulfide isomerase family A, member 4 0.0658365
SETBP1 SET binding protein 1 0.0572102
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0556199
PCDH7 protocadherin 7 0.0548917
MT2A metallothionein 2A 0.0480427
ATXN1 ataxin 1 0.0434245
ZNF638 zinc finger protein 638 0.0421803
BACE2 beta-site APP-cleaving enzyme 2 0.0406516
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0398473
TPR translocated promoter region, nuclear basket protein 0.0377605
CTTNBP2 cortactin binding protein 2 0.0375936
SMYD3 SET and MYND domain containing 3 0.037058
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0366689
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0362417
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0356619
PTK2 protein tyrosine kinase 2 0.0352006
PDIA3 protein disulfide isomerase family A, member 3 0.0332088
AKAP12 A kinase (PRKA) anchor protein 12 0.0324807
LEF1 lymphoid enhancer-binding factor 1 0.0321431
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0318415
EXOC4 exocyst complex component 4 0.0316956
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0312068
SAMD4A sterile alpha motif domain containing 4A 0.0310344
WWTR1 WW domain containing transcription regulator 1 0.0304276
FMNL2 formin-like 2 0.0302335
NAV1 neuron navigator 1 0.029702
PTPRM protein tyrosine phosphatase, receptor type, M 0.0286919
TMEM178B transmembrane protein 178B 0.0286315
APLP2 amyloid beta (A4) precursor-like protein 2 0.0286114
MAML3 mastermind-like 3 (Drosophila) 0.028424
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.028117
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0280316
ZSWIM6 zinc finger, SWIM-type containing 6 0.0277766
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0276441
ZBTB20 zinc finger and BTB domain containing 20 0.0272988
ANK2 ankyrin 2, neuronal 0.0261199
PARVB parvin, beta 0.0258348
ZFYVE28 zinc finger, FYVE domain containing 28 0.0258041
FAM3C family with sequence similarity 3, member C 0.0257584
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0256956
SND1 staphylococcal nuclease and tudor domain containing 1 0.0254669
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0251068
TBC1D22A TBC1 domain family, member 22A 0.0247532
UBASH3B ubiquitin associated and SH3 domain containing B 0.0247495
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0244084
TMF1 TATA element modulatory factor 1 0.0241798
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0239541
CD109 CD109 molecule 0.02383
DOCK4 dedicator of cytokinesis 4 0.0235173
KTN1 kinectin 1 (kinesin receptor) 0.0234992
KDM4C lysine (K)-specific demethylase 4C 0.0234437
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0234211
GOLGB1 golgin B1 0.0231823
WNK1 WNK lysine deficient protein kinase 1 0.0230792
LINGO2 leucine rich repeat and Ig domain containing 2 0.0230343
SEC24A SEC24 family member A 0.0230248
RNF150 ring finger protein 150 0.022873
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0228362
CEMIP2 cell migration inducing hyaluronidase 2 0.022646
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0218337
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0218282
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0217942
FLNB filamin B, beta 0.0216945
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0214786
SOX13 SRY (sex determining region Y)-box 13 0.0214772
COPA coatomer protein complex, subunit alpha 0.02145
TRIO trio Rho guanine nucleotide exchange factor 0.0211655
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0210506
CANX calnexin 0.0208925
GOLGA4 golgin A4 0.0208871
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0207761
MEF2A myocyte enhancer factor 2A 0.0207001
LRMDA leucine rich melanocyte differentiation associated 0.0205422
RCAN1 regulator of calcineurin 1 0.0204563
PKP4 plakophilin 4 0.0204503
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0203138
POM121 POM121 transmembrane nucleoporin 0.0202712
MBD5 methyl-CpG binding domain protein 5 0.0201434
ARFGEF3 ARFGEF family member 3 0.0199364
ITGB8 integrin, beta 8 0.0198717
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0197215
GLS2 glutaminase 2 (liver, mitochondrial) 0.0197049
EFCAB13 EF-hand calcium binding domain 13 0.0197024
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0193866
DST dystonin 0.0193422
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0190278
MRPS6 mitochondrial ribosomal protein S6 0.0188892

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.206281
VGF VGF nerve growth factor inducible -0.155443
FN1 fibronectin 1 -0.108954
FMN1 formin 1 -0.0931422
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0716396
VIM vimentin -0.0696218
DCT dopachrome tautomerase -0.0681646
GDF15 growth differentiation factor 15 -0.0663868
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0565582
HMCN1 hemicentin 1 -0.0550734
CDC73 cell division cycle 73 -0.053967
NDRG1 N-myc downstream regulated 1 -0.0524438
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.045933
RHEB Ras homolog enriched in brain -0.0441538
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0434233
IFRD1 interferon-related developmental regulator 1 -0.041766
S100A6 S100 calcium binding protein A6 -0.0402974
RNF145 ring finger protein 145 -0.0395389
CALD1 caldesmon 1 -0.0379071
TMSB10 thymosin beta 10 -0.0367329
APP amyloid beta (A4) precursor protein -0.0363264
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0358607
NPR2 natriuretic peptide receptor 2 -0.0355613
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0354116
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0350572
TMEM123 transmembrane protein 123 -0.0348036
HELZ helicase with zinc finger -0.0344211
ZNF292 zinc finger protein 292 -0.0337185
MTPN myotrophin -0.0334622
RLF rearranged L-myc fusion -0.0332847
HILPDA hypoxia inducible lipid droplet-associated -0.0330639
RAB7A RAB7A, member RAS oncogene family -0.0327842
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0327726
POTEF POTE ankyrin domain family, member F -0.0322988
PGK1 phosphoglycerate kinase 1 -0.0318926
NAMPT nicotinamide phosphoribosyltransferase -0.0310961
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.030335
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0296752
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0295207
KMT2E lysine (K)-specific methyltransferase 2E -0.0293182
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0289797
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0283936
TPI1 triosephosphate isomerase 1 -0.028292
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0281456
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0278892
DDIT4 DNA-damage-inducible transcript 4 -0.0265908
FTL ferritin, light polypeptide -0.0265758
RBM39 RNA binding motif protein 39 -0.0265617
PTMA prothymosin, alpha -0.0260835
RAD21 RAD21 homolog (S. pombe) -0.0256766
HLA-B major histocompatibility complex, class I, B -0.0254304
NOP58 NOP58 ribonucleoprotein -0.0252996
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0250045
RBM33 RNA binding motif protein 33 -0.0248805
YBX1 Y box binding protein 1 -0.0247556
BHLHE40 basic helix-loop-helix family, member e40 -0.0241588
NAV3 neuron navigator 3 -0.0239825
ANXA2 annexin A2 -0.0239507
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0239124
NUP58 nucleoporin 58 -0.0238534
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0232791
RPLP0 ribosomal protein, large, P0 -0.0228954
KDM5B lysine (K)-specific demethylase 5B -0.0224224
COLEC11 collectin sub-family member 11 -0.022188
HBP1 HMG-box transcription factor 1 -0.0221608
GNAS GNAS complex locus -0.0219171
LOC102724023 ES1 protein homolog, mitochondrial -0.021613
FRMD5 FERM domain containing 5 -0.0215353
ANKRD28 ankyrin repeat domain 28 -0.0214984
ACTG1 actin gamma 1 -0.0214363
PDE4B phosphodiesterase 4B, cAMP-specific -0.0210794
ANKRD11 ankyrin repeat domain 11 -0.020976
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0203024
C10ORF90 chromosome 10 open reading frame 90 -0.0202643
PUM1 pumilio RNA-binding family member 1 -0.0201353
TPD52 tumor protein D52 -0.0200559
NEK7 NIMA-related kinase 7 -0.0200038
PXMP2 peroxisomal membrane protein 2, 22kDa -0.0196397
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0191641
FTH1 ferritin, heavy polypeptide 1 -0.0191374
WDR45B WD repeat domain 45B -0.0189222
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0187911
WDR43 WD repeat domain 43 -0.0187369
CCNL1 cyclin L1 -0.0186892
MOXD1 monooxygenase, DBH-like 1 -0.0185086
NCOA7 nuclear receptor coactivator 7 -0.0182469
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0181973
PNLIPRP3 pancreatic lipase-related protein 3 -0.0179421
A2M alpha-2-macroglobulin -0.0177442
GHR growth hormone receptor -0.0176976
KDM3A lysine (K)-specific demethylase 3A -0.0176686
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0174991
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0174614
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0174113
CTSD cathepsin D -0.0174011
STRN3 striatin, calmodulin binding protein 3 -0.0173325
CYB5R3 cytochrome b5 reductase 3 -0.0172852
SYPL1 synaptophysin-like 1 -0.017126
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0171179
DENND1A DENN/MADD domain containing 1A -0.0170751