Lenalidomide (hemihydrate)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.134749
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.134484
MT2A metallothionein 2A 0.133352
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.108582
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0850558
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0687422
MT1X metallothionein 1X 0.0660884
FAM3C family with sequence similarity 3, member C 0.0655694
APLP2 amyloid beta (A4) precursor-like protein 2 0.0653344
DOCK5 dedicator of cytokinesis 5 0.0644869
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0637033
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.063216
MYO1E myosin IE 0.0612925
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0593404
FNDC3B fibronectin type III domain containing 3B 0.0568439
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0550096
AREG amphiregulin 0.0534507
SAMD4A sterile alpha motif domain containing 4A 0.0530706
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0502273
ARHGAP5 Rho GTPase activating protein 5 0.0497144
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0496131
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0471018
NRIP1 nuclear receptor interacting protein 1 0.0464751
NAMPT nicotinamide phosphoribosyltransferase 0.0464234
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.042155
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0412595
RIMKLB ribosomal modification protein rimK-like family member B 0.0411406
TXNIP thioredoxin interacting protein 0.0400478
TMC5 transmembrane channel-like 5 0.0391592
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0389979
TMEM51 transmembrane protein 51 0.038582
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.038157
PDZD8 PDZ domain containing 8 0.0379412
MT1E metallothionein 1E 0.0371445
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0370997
TMCC3 transmembrane and coiled-coil domain family 3 0.036474
EPAS1 endothelial PAS domain protein 1 0.0360324
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0358935
NRP1 neuropilin 1 0.0351024
KYNU kynureninase 0.0346574
TGM2 transglutaminase 2 0.0346154
B2M beta-2-microglobulin 0.034234
ARHGAP42 Rho GTPase activating protein 42 0.0335106
PATJ PATJ crumbs cell polarity complex component 0.031834
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0305079
PHF3 PHD finger protein 3 0.030327
JMJD1C jumonji domain containing 1C 0.0299487
SVIL supervillin 0.0299254
MCL1 myeloid cell leukemia 1 0.0292348
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0289984
NOTCH2 notch 2 0.0288521
ZC3H12C zinc finger CCCH-type containing 12C 0.0288256
PCBP2 poly(rC) binding protein 2 0.028368
FOXP1 forkhead box P1 0.0282565
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0277161
BACE2 beta-site APP-cleaving enzyme 2 0.0277075
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0270413
RAB10 RAB10, member RAS oncogene family 0.0267518
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0264069
BARX2 BARX homeobox 2 0.0261899
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0261717
UBE2H ubiquitin-conjugating enzyme E2H 0.0258804
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0256209
BPTF bromodomain PHD finger transcription factor 0.025299
TC2N tandem C2 domains, nuclear 0.0252851
STRN3 striatin, calmodulin binding protein 3 0.0252098
SLC35F5 solute carrier family 35, member F5 0.0251428
RAP2B RAP2B, member of RAS oncogene family 0.0251354
ADAM28 ADAM metallopeptidase domain 28 0.0250205
BICC1 BicC family RNA binding protein 1 0.0250004
ESYT2 extended synaptotagmin-like protein 2 0.0249555
TESC tescalcin 0.0248882
FNIP1 folliculin interacting protein 1 0.0245058
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0243851
IFI27 interferon, alpha-inducible protein 27 0.0242834
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0240252
IL6ST interleukin 6 signal transducer 0.0237744
RBM47 RNA binding motif protein 47 0.0233924
SLC38A2 solute carrier family 38, member 2 0.0232846
HOMER2 homer scaffolding protein 2 0.02306
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0230347
C15ORF48 chromosome 15 open reading frame 48 0.0228785
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.0222747
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0218866
EIF1 eukaryotic translation initiation factor 1 0.0218788
FOSL2 FOS-like antigen 2 0.0217833
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0216749
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0212325
UGCG UDP-glucose ceramide glucosyltransferase 0.0211831
OSMR oncostatin M receptor 0.0211119
DUSP5 dual specificity phosphatase 5 0.0210711
PPARD peroxisome proliferator-activated receptor delta 0.0210456
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0208996
GPATCH2L G patch domain containing 2-like 0.0207458
ANKRD17 ankyrin repeat domain 17 0.0205436
RBPMS RNA binding protein with multiple splicing 0.0205162
CD2AP CD2-associated protein 0.0204124
SP140L SP140 nuclear body protein-like 0.0203133
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0202423
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0201237

decreased expression

Symbol Name Standardized Value
MMP7 matrix metallopeptidase 7 -0.201324
PTMA prothymosin, alpha -0.154279
LAMC2 laminin, gamma 2 -0.150505
ASPH aspartate beta-hydroxylase -0.145854
ANXA2 annexin A2 -0.103452
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.101893
PARD3 par-3 family cell polarity regulator -0.0940763
POTEF POTE ankyrin domain family, member F -0.0922727
ACTG1 actin gamma 1 -0.0833008
IGFBP3 insulin-like growth factor binding protein 3 -0.0823639
MAML2 mastermind-like 2 (Drosophila) -0.0797987
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0779067
TMSB10 thymosin beta 10 -0.0773844
AHNAK AHNAK nucleoprotein -0.062813
AHNAK2 AHNAK nucleoprotein 2 -0.0626231
FLNB filamin B, beta -0.0583714
ARHGAP26 Rho GTPase activating protein 26 -0.0581246
F3 coagulation factor III (thromboplastin, tissue factor) -0.0566843
LAMA4 laminin, alpha 4 -0.0542691
FTH1 ferritin, heavy polypeptide 1 -0.0530616
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0530161
KDM5B lysine (K)-specific demethylase 5B -0.0522638
PDLIM5 PDZ and LIM domain 5 -0.0521167
ARHGAP32 Rho GTPase activating protein 32 -0.0493052
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0492734
IER3 immediate early response 3 -0.0491244
PLAT plasminogen activator, tissue -0.048061
TPM4 tropomyosin 4 -0.0478175
PLAU plasminogen activator, urokinase -0.047557
EZR ezrin -0.0473154
TMSB4X thymosin beta 4, X-linked -0.0471776
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0467217
DTNA dystrobrevin, alpha -0.0456037
PICALM phosphatidylinositol binding clathrin assembly protein -0.0454319
FTL ferritin, light polypeptide -0.0453551
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0450292
DST dystonin -0.0450155
CCNY cyclin Y -0.0442625
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0439725
NDRG1 N-myc downstream regulated 1 -0.0435016
IGF1R insulin-like growth factor 1 receptor -0.0424843
MEF2A myocyte enhancer factor 2A -0.0421048
S100A6 S100 calcium binding protein A6 -0.0413343
LPP LIM domain containing preferred translocation partner in lipoma -0.0412039
MAP1B microtubule-associated protein 1B -0.0411747
TPM1 tropomyosin 1 (alpha) -0.0410972
RAB7A RAB7A, member RAS oncogene family -0.0410951
MCU mitochondrial calcium uniporter -0.0403899
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0400195
ACTN4 actinin, alpha 4 -0.0396786
GNAS GNAS complex locus -0.0392904
TSC22D2 TSC22 domain family, member 2 -0.0390781
VCL vinculin -0.0381431
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0380338
PLEC plectin -0.0376105
PCDH7 protocadherin 7 -0.0375424
NCKAP5 NCK-associated protein 5 -0.0363204
PRKCA protein kinase C, alpha -0.0363176
CP ceruloplasmin (ferroxidase) -0.0361366
GRB10 growth factor receptor-bound protein 10 -0.0358944
KRT8 keratin 8, type II -0.0358599
FLNA filamin A, alpha -0.0357296
S100A10 S100 calcium binding protein A10 -0.035554
TPT1 tumor protein, translationally-controlled 1 -0.035543
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0354561
ITGB4 integrin, beta 4 -0.03446
MYH9 myosin, heavy chain 9, non-muscle -0.0344078
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0338396
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0333648
WSB1 WD repeat and SOCS box containing 1 -0.0330072
CLIC4 chloride intracellular channel 4 -0.032852
LMNA lamin A/C -0.0327286
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0321025
HMGA1 high mobility group AT-hook 1 -0.0319399
TRIO trio Rho guanine nucleotide exchange factor -0.03153
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0313575
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0312999
H1-0 H1.0 linker histone -0.0312805
YBX1 Y box binding protein 1 -0.0310408
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0307409
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0306863
FOSL1 FOS-like antigen 1 -0.0305344
RAB1A RAB1A, member RAS oncogene family -0.030403
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0299373
ANKRD11 ankyrin repeat domain 11 -0.02969
VIM vimentin -0.0291098
FMNL2 formin-like 2 -0.0290334
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0285798
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0284639
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.028125
HSPG2 heparan sulfate proteoglycan 2 -0.0279363
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0277814
KMT2C lysine (K)-specific methyltransferase 2C -0.0274931
VEGFA vascular endothelial growth factor A -0.0273209
ENO1 enolase 1, (alpha) -0.0272399
SPAG9 sperm associated antigen 9 -0.0268563
PKM pyruvate kinase, muscle -0.0268399
GSK3B glycogen synthase kinase 3 beta -0.026815
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0266314
INSIG1 insulin induced gene 1 -0.0265625