Lenalidomide (hemihydrate)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.173382
LMO7 LIM domain 7 0.172717
B2M beta-2-microglobulin 0.1192
LCN2 lipocalin 2 0.11471
RUNX1 runt-related transcription factor 1 0.0880169
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0868686
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0841627
PTBP3 polypyrimidine tract binding protein 3 0.0804018
C6ORF132 chromosome 6 open reading frame 132 0.0741835
SMAD3 SMAD family member 3 0.0720832
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0662097
RNF43 ring finger protein 43 0.0637404
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0603976
YAP1 Yes-associated protein 1 0.0591791
GCLC glutamate-cysteine ligase, catalytic subunit 0.0586824
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0580145
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.057249
NRIP1 nuclear receptor interacting protein 1 0.0548051
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0526678
SPTBN1 spectrin, beta, non-erythrocytic 1 0.050261
MYO1E myosin IE 0.0489377
ITGA6 integrin, alpha 6 0.0477521
LIMA1 LIM domain and actin binding 1 0.0475495
MEIS2 Meis homeobox 2 0.047533
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0457446
ASPH aspartate beta-hydroxylase 0.0456274
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0455523
MT2A metallothionein 2A 0.0446008
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0422067
IFNGR1 interferon gamma receptor 1 0.0418976
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0414556
AKAP13 A kinase (PRKA) anchor protein 13 0.041325
RBM47 RNA binding motif protein 47 0.0407034
PRSS3 protease, serine, 3 0.0405556
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0398993
ARGLU1 arginine and glutamate rich 1 0.0392556
DST dystonin 0.0391749
ADAM10 ADAM metallopeptidase domain 10 0.0389686
TOX3 TOX high mobility group box family member 3 0.038914
ETV6 ets variant 6 0.0382939
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0379756
SPRED1 sprouty-related, EVH1 domain containing 1 0.0378231
CATSPERB catsper channel auxiliary subunit beta 0.0371545
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0367439
LPP LIM domain containing preferred translocation partner in lipoma 0.036437
EXT1 exostosin glycosyltransferase 1 0.0355062
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0349864
FOXP1 forkhead box P1 0.0348327
TXNRD1 thioredoxin reductase 1 0.0348212
SLK STE20-like kinase 0.0347614
ATP10B ATPase, class V, type 10B 0.03466
TMC5 transmembrane channel-like 5 0.0345878
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0345429
BCL2L1 BCL2-like 1 0.0341521
PTK2 protein tyrosine kinase 2 0.0338369
PKM pyruvate kinase, muscle 0.0337961
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0335338
MACC1 metastasis associated in colon cancer 1 0.0333519
WWOX WW domain containing oxidoreductase 0.0332271
NCKAP5 NCK-associated protein 5 0.03301
MSI2 musashi RNA-binding protein 2 0.0328159
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0327693
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0323106
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.032195
ABHD2 abhydrolase domain containing 2 0.0318431
EHBP1 EH domain binding protein 1 0.0314909
DUSP16 dual specificity phosphatase 16 0.0311628
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0309962
KMT2E lysine (K)-specific methyltransferase 2E 0.0308553
ERBIN erbb2 interacting protein 0.0307945
MACF1 microtubule-actin crosslinking factor 1 0.0306939
MED13 mediator complex subunit 13 0.0304671
RPS6 ribosomal protein S6 0.0303799
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0302183
FAT1 FAT atypical cadherin 1 0.0302065
EFNB2 ephrin-B2 0.0297158
SORBS1 sorbin and SH3 domain containing 1 0.0295565
BICRAL BICRA like chromatin remodeling complex associated protein 0.0295429
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0295334
SPATS2L spermatogenesis associated, serine-rich 2-like 0.029456
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0284038
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0282291
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0282104
PRRC2C proline-rich coiled-coil 2C 0.0281969
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0280672
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0280233
PTGR1 prostaglandin reductase 1 0.0279801
TC2N tandem C2 domains, nuclear 0.0279719
FNDC3B fibronectin type III domain containing 3B 0.0275726
STK24 serine/threonine kinase 24 0.0275477
PDZD8 PDZ domain containing 8 0.0273307
ARHGAP26 Rho GTPase activating protein 26 0.0272096
APLP2 amyloid beta (A4) precursor-like protein 2 0.0271513
ALCAM activated leukocyte cell adhesion molecule 0.0271141
DIAPH1 diaphanous-related formin 1 0.0271016
SLTM SAFB-like, transcription modulator 0.0270083
LMTK2 lemur tyrosine kinase 2 0.0269838
AOPEP aminopeptidase O (putative) 0.0269637
UBE2H ubiquitin-conjugating enzyme E2H 0.0266939
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0262364

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0977345
LYZ lysozyme -0.0975956
INTS6 integrator complex subunit 6 -0.0936083
EZR ezrin -0.0918302
TPT1 tumor protein, translationally-controlled 1 -0.0883927
EGR1 early growth response 1 -0.0822001
SQSTM1 sequestosome 1 -0.0768529
PHF3 PHD finger protein 3 -0.0752594
MBNL2 muscleblind-like splicing regulator 2 -0.0743946
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0681512
GOLGB1 golgin B1 -0.0665493
NPSR1 neuropeptide S receptor 1 -0.0620294
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0526834
CANX calnexin -0.0524274
PLSCR2 phospholipid scramblase 2 -0.0501105
RAB7A RAB7A, member RAS oncogene family -0.0489992
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0489353
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0454595
IRF1 interferon regulatory factor 1 -0.0453558
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0446998
MORF4L2 mortality factor 4 like 2 -0.0441783
SEC31A SEC31 homolog A (S. cerevisiae) -0.0431943
NDRG1 N-myc downstream regulated 1 -0.0428788
SP100 SP100 nuclear antigen -0.0415826
HDLBP high density lipoprotein binding protein -0.0410511
UBC ubiquitin C -0.0406372
SDC4 syndecan 4 -0.0380069
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0380047
PTMA prothymosin, alpha -0.0373809
HLA-E major histocompatibility complex, class I, E -0.0373135
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0361426
POU2F2 POU class 2 homeobox 2 -0.0358763
JUN jun proto-oncogene -0.0354487
ANXA2 annexin A2 -0.0352409
H1-0 H1.0 linker histone -0.0346938
UGDH UDP-glucose 6-dehydrogenase -0.0341683
TM9SF2 transmembrane 9 superfamily member 2 -0.0339039
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0332126
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0324396
SDCBP2 syndecan binding protein (syntenin) 2 -0.0321481
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0321001
HM13 histocompatibility (minor) 13 -0.0311946
RAB1A RAB1A, member RAS oncogene family -0.030891
SPDYA speedy/RINGO cell cycle regulator family member A -0.0307328
MUC20 mucin 20, cell surface associated -0.0304622
TFRC transferrin receptor -0.0304226
TM4SF1 transmembrane 4 L six family member 1 -0.0298652
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0298174
BLZF1 basic leucine zipper nuclear factor 1 -0.0292737
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0291084
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0290193
TUFT1 tuftelin 1 -0.0289047
TM4SF19 transmembrane 4 L six family member 19 -0.0284843
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0282574
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0279848
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0275451
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.027432
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.027269
ZSWIM6 zinc finger, SWIM-type containing 6 -0.026473
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0262386
MCL1 myeloid cell leukemia 1 -0.0262349
FTH1 ferritin, heavy polypeptide 1 -0.026164
LCORL ligand dependent nuclear receptor corepressor-like -0.0258174
ADIPOR2 adiponectin receptor 2 -0.0256063
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0253902
ARF1 ADP-ribosylation factor 1 -0.0252286
NKD1 naked cuticle homolog 1 (Drosophila) -0.0249251
ARF4 ADP-ribosylation factor 4 -0.0248324
FBXO39 F-box protein 39 -0.0247511
MAML2 mastermind-like 2 (Drosophila) -0.0247338
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0245752
IGF1R insulin-like growth factor 1 receptor -0.0244083
MCTP1 multiple C2 domains, transmembrane 1 -0.0239205
STX5 syntaxin 5 -0.0239081
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0237454
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0236987
IGFBP3 insulin-like growth factor binding protein 3 -0.023665
LOC112694756 uncharaterized LOC112694756 -0.0232933
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0232834
GOLGA4 golgin A4 -0.0232754
ITPKC inositol-trisphosphate 3-kinase C -0.0232135
FDPS farnesyl diphosphate synthase -0.0231049
PIBF1 progesterone immunomodulatory binding factor 1 -0.0231016
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0230764
RIGI RNA sensor RIG-I -0.0226479
OASL 2'-5'-oligoadenylate synthetase-like -0.0224627
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0222854
FUS FUS RNA binding protein -0.0218402
RRBP1 ribosome binding protein 1 -0.0217651
ANXA1 annexin A1 -0.0217237
IFRD1 interferon-related developmental regulator 1 -0.0215398
CALU calumenin -0.0214545
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0213608
CDHR2 cadherin-related family member 2 -0.0212473
GOSR2 golgi SNAP receptor complex member 2 -0.0210212
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0208368
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0208194
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0207208
RORA RAR-related orphan receptor A -0.0206551
XAF1 XIAP associated factor 1 -0.0205885