Lenalidomide (hemihydrate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.174211
IGFBP3 insulin-like growth factor binding protein 3 0.145455
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.111825
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.102627
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0878335
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0651057
AKAP12 A kinase (PRKA) anchor protein 12 0.0544259
B2M beta-2-microglobulin 0.0521471
MT1X metallothionein 1X 0.0483901
BACE2 beta-site APP-cleaving enzyme 2 0.0480535
PTPRD protein tyrosine phosphatase, receptor type, D 0.0466785
HLA-B major histocompatibility complex, class I, B 0.0427022
FAM13A family with sequence similarity 13, member A 0.0403276
DTNA dystrobrevin, alpha 0.0397356
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.038653
PRELID2 PRELI domain containing 2 0.0371872
SDK1 sidekick cell adhesion molecule 1 0.0357098
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0327048
NDRG1 N-myc downstream regulated 1 0.0308188
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0303765
IGF2 insulin-like growth factor 2 0.0297194
GLRX glutaredoxin (thioltransferase) 0.0295788
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0294298
STC1 stanniocalcin 1 0.0288305
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0274924
HIP1 huntingtin interacting protein 1 0.0274399
CHD1L chromodomain helicase DNA binding protein 1-like 0.0271706
HLA-A major histocompatibility complex, class I, A 0.0270724
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0249589
PDIA3 protein disulfide isomerase family A, member 3 0.0248518
RUNX1 runt-related transcription factor 1 0.0245125
MMP12 matrix metallopeptidase 12 0.0243308
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0241304
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0230388
CLEC1B C-type lectin domain family 1, member B 0.0223355
RPL23 ribosomal protein L23 0.0222615
HDAC9 histone deacetylase 9 0.0219422
YEATS2 YEATS domain containing 2 0.0211965
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0207755
ARHGAP22 Rho GTPase activating protein 22 0.0207738
RPL28 ribosomal protein L28 0.0207205
PCBP2 poly(rC) binding protein 2 0.0206155
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0204091
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.020296
RPL37A ribosomal protein L37a 0.0201559
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0199467
GYS1 glycogen synthase 1 (muscle) 0.0199163
FAM219A family with sequence similarity 219, member A 0.0198685
TIMP1 TIMP metallopeptidase inhibitor 1 0.0197927
ESYT2 extended synaptotagmin-like protein 2 0.0195917
INSIG2 insulin induced gene 2 0.019394
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.019093
WWOX WW domain containing oxidoreductase 0.0189927
ENO2 enolase 2 (gamma, neuronal) 0.0188899
RPS19 ribosomal protein S19 0.0188075
SFXN1 sideroflexin 1 0.0185606
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0183423
C3 complement component 3 0.018212
KMT2E lysine (K)-specific methyltransferase 2E 0.0182053
ZNF638 zinc finger protein 638 0.0181713
ARFGEF3 ARFGEF family member 3 0.017729
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0174775
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0174339
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 0.017351
MYO1B myosin IB 0.0172554
FGF13 fibroblast growth factor 13 0.0171937
DOCK5 dedicator of cytokinesis 5 0.0171853
NGLY1 N-glycanase 1 0.0169912
NIBAN2 niban apoptosis regulator 2 0.0168561
APLP2 amyloid beta (A4) precursor-like protein 2 0.016637
CCL5 chemokine (C-C motif) ligand 5 0.0165428
ZSWIM5 zinc finger, SWIM-type containing 5 0.0164243
STXBP1 syntaxin binding protein 1 0.0163165
VEGFC vascular endothelial growth factor C 0.0162545
HELZ helicase with zinc finger 0.0162073
RPS8 ribosomal protein S8 0.0161653
PYGL phosphorylase, glycogen, liver 0.0161494
KTN1 kinectin 1 (kinesin receptor) 0.016127
RPS12 ribosomal protein S12 0.0161012
SRP54 signal recognition particle 54kDa 0.0159626
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.0156391
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.0156026
RPL34 ribosomal protein L34 0.015576
NCOR2 nuclear receptor corepressor 2 0.0155522
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0155203
POM121 POM121 transmembrane nucleoporin 0.0154629
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.0154066
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.01538
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0152752
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0152712
CFAP96 cilia and flagella associated protein 96 0.0152679
RPS20 ribosomal protein S20 0.0151307
OXR1 oxidation resistance 1 0.0151167
CUL4B cullin 4B 0.0150557
SYNE2 spectrin repeat containing, nuclear envelope 2 0.014856
HMGA2 high mobility group AT-hook 2 0.0147437
COL23A1 collagen, type XXIII, alpha 1 0.0145464
POM121C POM121 transmembrane nucleoporin C 0.0145153
NPTN neuroplastin 0.014459
ANKH ANKH inorganic pyrophosphate transport regulator 0.0143057

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.226652
CXCL8 chemokine (C-X-C motif) ligand 8 -0.159933
COL6A3 collagen, type VI, alpha 3 -0.149058
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.114566
TPM4 tropomyosin 4 -0.0987705
DST dystonin -0.0950314
MAP1B microtubule-associated protein 1B -0.0928628
FN1 fibronectin 1 -0.0916084
EXT1 exostosin glycosyltransferase 1 -0.0881234
AHNAK AHNAK nucleoprotein -0.0847878
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0833412
FTL ferritin, light polypeptide -0.0773041
GARS1 glycyl-tRNA synthetase 1 -0.0770192
TMSB10 thymosin beta 10 -0.0741719
EGFR epidermal growth factor receptor -0.0738768
SBF2 SET binding factor 2 -0.0719221
TNNC1 troponin C type 1 (slow) -0.0715645
PTMA prothymosin, alpha -0.0660956
CANX calnexin -0.0650239
CADM1 cell adhesion molecule 1 -0.0649342
VIM vimentin -0.0644664
LDHA lactate dehydrogenase A -0.063552
CALR calreticulin -0.0628122
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0617326
FNDC3B fibronectin type III domain containing 3B -0.0614828
INHBA inhibin, beta A -0.0608135
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0584363
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0551528
TNS3 tensin 3 -0.053922
MAP4 microtubule-associated protein 4 -0.0523817
ANXA2 annexin A2 -0.0523584
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.0520377
ZFAND3 zinc finger, AN1-type domain 3 -0.0520296
PTPRG protein tyrosine phosphatase, receptor type, G -0.0520127
TENM3 teneurin transmembrane protein 3 -0.0517388
LOX lysyl oxidase -0.0512335
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0511007
GRB10 growth factor receptor-bound protein 10 -0.0492587
KYNU kynureninase -0.0468817
STK17A serine/threonine kinase 17a -0.0463728
HDLBP high density lipoprotein binding protein -0.0460968
LRRC49 leucine rich repeat containing 49 -0.0460126
VCL vinculin -0.0458444
TXNRD1 thioredoxin reductase 1 -0.0453325
VMP1 vacuole membrane protein 1 -0.0452887
RTN4 reticulon 4 -0.04308
IGFBP5 insulin-like growth factor binding protein 5 -0.0425916
COG5 component of oligomeric golgi complex 5 -0.0418174
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0416557
LYPD6B LY6/PLAUR domain containing 6B -0.0415168
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0413544
RRBP1 ribosome binding protein 1 -0.0411114
SCFD2 sec1 family domain containing 2 -0.0409039
ALCAM activated leukocyte cell adhesion molecule -0.0403941
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0403806
COPB1 coatomer protein complex, subunit beta 1 -0.0396585
TTC3 tetratricopeptide repeat domain 3 -0.0390054
CREB5 cAMP responsive element binding protein 5 -0.0377364
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0367467
SQSTM1 sequestosome 1 -0.0365983
BIRC6 baculoviral IAP repeat containing 6 -0.0364055
ANKRD11 ankyrin repeat domain 11 -0.0360597
SEC24D SEC24 family member D -0.0358019
NF1 neurofibromin 1 -0.0342109
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0340582
PDLIM5 PDZ and LIM domain 5 -0.0339053
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0337107
AFF4 AF4/FMR2 family, member 4 -0.0319743
FSTL1 follistatin-like 1 -0.031806
LCORL ligand dependent nuclear receptor corepressor-like -0.0316968
HIPK2 homeodomain interacting protein kinase 2 -0.0313946
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0313217
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.031025
JAZF1 JAZF zinc finger 1 -0.0309911
POTEF POTE ankyrin domain family, member F -0.0308475
CARS1 cysteinyl-tRNA synthetase 1 -0.0308319
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0303718
LMAN1 lectin, mannose-binding, 1 -0.0302381
COL5A2 collagen, type V, alpha 2 -0.0299467
CARD16 caspase recruitment domain family, member 16 -0.0297864
USP34 ubiquitin specific peptidase 34 -0.0293694
MBD5 methyl-CpG binding domain protein 5 -0.0292273
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0290758
CLIC4 chloride intracellular channel 4 -0.0287382
FAM20C family with sequence similarity 20, member C -0.0280634
GLIS3 GLIS family zinc finger 3 -0.0279153
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.027698
TPST1 tyrosylprotein sulfotransferase 1 -0.0276907
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0275762
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0275057
NABP1 nucleic acid binding protein 1 -0.0274084
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0271773
GOLGA3 golgin A3 -0.0269956
MBNL1 muscleblind-like splicing regulator 1 -0.0269824
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0269687
RAB1A RAB1A, member RAS oncogene family -0.0268427
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0268317
AHR aryl hydrocarbon receptor -0.026364
TRA2A transformer 2 alpha homolog (Drosophila) -0.0263508
TNPO1 transportin 1 -0.026105