Lenalidomide (hemihydrate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.216498
MT2A metallothionein 2A 0.127347
TPT1 tumor protein, translationally-controlled 1 0.078408
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0630447
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0593882
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0542636
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0525543
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.049567
EGR1 early growth response 1 0.0470588
MCL1 myeloid cell leukemia 1 0.0438373
RPS6 ribosomal protein S6 0.0432698
WWC2 WW and C2 domain containing 2 0.0426428
TMSB10 thymosin beta 10 0.0404731
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.035786
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0352208
MIDN midnolin 0.0343951
PKM pyruvate kinase, muscle 0.034133
RPS8 ribosomal protein S8 0.0328641
S100A10 S100 calcium binding protein A10 0.0281892
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0278477
ANXA2 annexin A2 0.0272996
CDCP1 CUB domain containing protein 1 0.0270278
GPC5 glypican 5 0.0268078
SLC38A2 solute carrier family 38, member 2 0.0266196
RPL27 ribosomal protein L27 0.026384
PATJ PATJ crumbs cell polarity complex component 0.026143
ANKRD12 ankyrin repeat domain 12 0.0257367
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0257109
PCDH7 protocadherin 7 0.0251276
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0243288
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0241148
RPLP0 ribosomal protein, large, P0 0.0234138
HLA-B major histocompatibility complex, class I, B 0.0219621
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0217859
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0216188
RPLP1 ribosomal protein, large, P1 0.0216123
BACE2 beta-site APP-cleaving enzyme 2 0.0208765
MACROD2 MACRO domain containing 2 0.0207419
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0207415
SMYD3 SET and MYND domain containing 3 0.0205912
NABP1 nucleic acid binding protein 1 0.0205381
PFKP phosphofructokinase, platelet 0.0203906
DOCK5 dedicator of cytokinesis 5 0.0200954
CRYBG3 beta-gamma crystallin domain containing 3 0.0197715
WWOX WW domain containing oxidoreductase 0.0196243
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0194394
RPS20 ribosomal protein S20 0.0193293
RPL37A ribosomal protein L37a 0.0192717
RPS13 ribosomal protein S13 0.019241
LOC102724023 ES1 protein homolog, mitochondrial 0.0191957
EGFR epidermal growth factor receptor 0.0185877
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0185244
RPL36 ribosomal protein L36 0.018294
RPS27 ribosomal protein S27 0.0182396
SNX9 sorting nexin 9 0.0181265
MAP7 microtubule-associated protein 7 0.0181095
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0177047
RPL34 ribosomal protein L34 0.0175566
SLC35F5 solute carrier family 35, member F5 0.0175562
TGFB1 transforming growth factor, beta 1 0.0174639
ERRFI1 ERBB receptor feedback inhibitor 1 0.0174635
PDZD8 PDZ domain containing 8 0.0173915
ZBTB20 zinc finger and BTB domain containing 20 0.0173912
ZNF638 zinc finger protein 638 0.0173228
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0172936
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0171531
LIMCH1 LIM and calponin homology domains 1 0.0170104
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0166287
BIRC3 baculoviral IAP repeat containing 3 0.0165979
RPL11 ribosomal protein L11 0.016592
FOXP1 forkhead box P1 0.0165243
SDC4 syndecan 4 0.0163998
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0161827
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0161077
IER2 immediate early response 2 0.0161049
KIAA1217 KIAA1217 0.0159421
DST dystonin 0.0159264
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0158242
TRIO trio Rho guanine nucleotide exchange factor 0.0155119
SGMS2 sphingomyelin synthase 2 0.0154918
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0153695
AFF1 AF4/FMR2 family, member 1 0.0150782
N4BP2L2 NEDD4 binding protein 2-like 2 0.0150776
SKI SKI proto-oncogene 0.015056
FBXO11 F-box protein 11 0.0150238
ISG15 ISG15 ubiquitin-like modifier 0.0150099
RPLP2 ribosomal protein, large, P2 0.0149644
RPL31 ribosomal protein L31 0.0148863
RPL35A ribosomal protein L35a 0.0148414
RPL9 ribosomal protein L9 0.0148045
ANKRD36 ankyrin repeat domain 36 0.0147627
SEPTIN9 septin 9 0.0147439
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0147317
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.0147259
FHIT fragile histidine triad 0.0147157
SVIL supervillin 0.0147086
CTSB cathepsin B 0.0145768
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0145141
KLHL29 kelch-like family member 29 0.0144072
RASEF RAS and EF-hand domain containing 0.0143929

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.204523
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.198842
PTMA prothymosin, alpha -0.14121
P4HB prolyl 4-hydroxylase, beta polypeptide -0.139408
FAT1 FAT atypical cadherin 1 -0.132279
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.113796
CANX calnexin -0.0859068
DLG1 discs, large homolog 1 (Drosophila) -0.0602353
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0596386
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0569987
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0553883
GOLGA4 golgin A4 -0.054842
HDLBP high density lipoprotein binding protein -0.0520636
IARS1 isoleucyl-tRNA synthetase 1 -0.0507837
CSDE1 cold shock domain containing E1, RNA-binding -0.050144
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.049022
MKI67 marker of proliferation Ki-67 -0.0487565
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0486613
CENPF centromere protein F, 350/400kDa -0.0485716
FTH1 ferritin, heavy polypeptide 1 -0.0480575
YBX1 Y box binding protein 1 -0.0461625
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0422329
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.042061
RAD51B RAD51 paralog B -0.0416712
NF1 neurofibromin 1 -0.0414741
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0412245
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0407177
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0397535
AHNAK AHNAK nucleoprotein -0.0383118
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0380601
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0373478
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0368241
SUCO SUN domain containing ossification factor -0.0367079
ARF4 ADP-ribosylation factor 4 -0.0365095
TAS2R14 taste receptor, type 2, member 14 -0.0364539
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0363995
NOP58 NOP58 ribonucleoprotein -0.0360375
MED13L mediator complex subunit 13-like -0.0351682
BIRC6 baculoviral IAP repeat containing 6 -0.0346813
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0344945
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0342944
ANKRD11 ankyrin repeat domain 11 -0.0342379
RPS24 ribosomal protein S24 -0.0333885
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0331934
LCORL ligand dependent nuclear receptor corepressor-like -0.0326923
KDM2A lysine (K)-specific demethylase 2A -0.0316603
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0314253
GARS1 glycyl-tRNA synthetase 1 -0.0309017
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0308047
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0303788
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.0297718
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.029671
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0295165
TCF12 transcription factor 12 -0.0288637
TBC1D22A TBC1 domain family, member 22A -0.0287106
MAP4 microtubule-associated protein 4 -0.0282745
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0280701
SHROOM3 shroom family member 3 -0.0280551
WDR45B WD repeat domain 45B -0.0278656
NSD3 nuclear receptor binding SET domain protein 3 -0.027839
RAD21 RAD21 homolog (S. pombe) -0.0276071
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0275862
MORC4 MORC family CW-type zinc finger 4 -0.0275608
RPS2 ribosomal protein S2 -0.0274018
GOLGA2 golgin A2 -0.0271726
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0269652
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0269375
NCOR1 nuclear receptor corepressor 1 -0.0267469
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0264451
NFIA nuclear factor I/A -0.0262467
CALR calreticulin -0.0261723
SSR1 signal sequence receptor, alpha -0.0259896
SRP72 signal recognition particle 72kDa -0.0258576
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0258187
RHOBTB3 Rho-related BTB domain containing 3 -0.0257131
PDIA4 protein disulfide isomerase family A, member 4 -0.0256307
PARD3 par-3 family cell polarity regulator -0.0255744
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0255109
CEP350 centrosomal protein 350kDa -0.025299
RBM26 RNA binding motif protein 26 -0.0252414
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.025134
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0250821
WASF2 WAS protein family, member 2 -0.025004
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0249724
TFRC transferrin receptor -0.0248103
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0246058
EXOC4 exocyst complex component 4 -0.0245947
CCDC47 coiled-coil domain containing 47 -0.0245721
KMT2A lysine (K)-specific methyltransferase 2A -0.0245281
FNDC3B fibronectin type III domain containing 3B -0.0244886
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0244142
HOOK2 hook microtubule-tethering protein 2 -0.0243733
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0243681
OSBP oxysterol binding protein -0.0243633
COPB1 coatomer protein complex, subunit beta 1 -0.024336
MORF4L2 mortality factor 4 like 2 -0.0243342
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0242759
RBM39 RNA binding motif protein 39 -0.0242653
SPDYA speedy/RINGO cell cycle regulator family member A -0.0241266
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0241039