Lenalidomide (hemihydrate)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.155988
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.141976
STC1 stanniocalcin 1 0.0866658
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0778166
ERRFI1 ERBB receptor feedback inhibitor 1 0.0748825
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0745273
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0633911
CD44 CD44 molecule (Indian blood group) 0.0593151
CXCL8 chemokine (C-X-C motif) ligand 8 0.0589718
MT2A metallothionein 2A 0.0587875
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0547828
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0511318
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0494778
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0484454
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0470112
CDCP1 CUB domain containing protein 1 0.0407475
GRAMD1B GRAM domain containing 1B 0.0393321
IGFBP3 insulin-like growth factor binding protein 3 0.037926
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0364231
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0347614
ELL2 elongation factor, RNA polymerase II, 2 0.0321646
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0307248
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0293567
RPS6 ribosomal protein S6 0.0288453
AKAP12 A kinase (PRKA) anchor protein 12 0.0282015
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0281091
TM4SF1 transmembrane 4 L six family member 1 0.0279493
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0273143
EIF1 eukaryotic translation initiation factor 1 0.0272484
MT1E metallothionein 1E 0.0265039
LDHA lactate dehydrogenase A 0.0263419
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0255184
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0249677
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.024654
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0230601
RND3 Rho family GTPase 3 0.0226286
RPLP1 ribosomal protein, large, P1 0.0218867
LOC112694756 uncharaterized LOC112694756 0.0218855
RPL7 ribosomal protein L7 0.0216356
HSPA8 heat shock 70kDa protein 8 0.0216165
PDIA3 protein disulfide isomerase family A, member 3 0.0215253
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0213447
NAMPT nicotinamide phosphoribosyltransferase 0.0205802
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0205671
ADM adrenomedullin 0.0201272
WWTR1 WW domain containing transcription regulator 1 0.020088
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0199402
JAG1 jagged 1 0.0199367
RNF24 ring finger protein 24 0.0199089
BHLHE40 basic helix-loop-helix family, member e40 0.0195427
NUMB numb homolog (Drosophila) 0.0194531
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0192575
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0192299
RPS20 ribosomal protein S20 0.0190532
GPC5 glypican 5 0.0187827
NGLY1 N-glycanase 1 0.0186318
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0185743
MINDY2 MINDY lysine 48 deubiquitinase 2 0.018329
RPLP0 ribosomal protein, large, P0 0.0183193
GOLGA4 golgin A4 0.0181105
ESYT2 extended synaptotagmin-like protein 2 0.0179021
SNAP25 synaptosomal-associated protein, 25kDa 0.0178091
ANGPTL4 angiopoietin-like 4 0.0176164
EPAS1 endothelial PAS domain protein 1 0.0173963
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0170359
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0169284
NPTN neuroplastin 0.0167151
ARFGEF3 ARFGEF family member 3 0.0164773
PKM pyruvate kinase, muscle 0.0163555
TAC4 tachykinin 4 (hemokinin) 0.0160434
TTC3 tetratricopeptide repeat domain 3 0.0158464
PHIP pleckstrin homology domain interacting protein 0.015591
KMT2E lysine (K)-specific methyltransferase 2E 0.0154431
CLEC1B C-type lectin domain family 1, member B 0.0152101
DUSP6 dual specificity phosphatase 6 0.0150866
TPR translocated promoter region, nuclear basket protein 0.0150061
DTNA dystrobrevin, alpha 0.0149998
TBX3 T-box 3 0.0148619
WDFY1 WD repeat and FYVE domain containing 1 0.0145214
BIRC3 baculoviral IAP repeat containing 3 0.0143788
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0143747
TOP2A topoisomerase (DNA) II alpha 170kDa 0.014335
CCND1 cyclin D1 0.0142675
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0141351
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.0140488
VEGFC vascular endothelial growth factor C 0.0138159
KYNU kynureninase 0.0135677
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0135271
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0134689
CTSB cathepsin B 0.0134641
KIAA1217 KIAA1217 0.013328
ZNF654 zinc finger protein 654 0.0133164
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0132715
LMAN1 lectin, mannose-binding, 1 0.0132391
GRID1 glutamate receptor, ionotropic, delta 1 0.0132223
BZW1 basic leucine zipper and W2 domains 1 0.0131471
ZNF331 zinc finger protein 331 0.0130165
BACE2 beta-site APP-cleaving enzyme 2 0.0129945
SEPTIN10 septin 10 0.0129824
RPL39 ribosomal protein L39 0.01296

decreased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.234601
CDH13 cadherin 13 -0.216439
COL5A1 collagen, type V, alpha 1 -0.211435
TMSB10 thymosin beta 10 -0.16067
FN1 fibronectin 1 -0.14411
COL6A1 collagen, type VI, alpha 1 -0.118066
MYO10 myosin X -0.0922317
IGF2 insulin-like growth factor 2 -0.0904614
ASPH aspartate beta-hydroxylase -0.086842
COL6A2 collagen, type VI, alpha 2 -0.0804925
MAML3 mastermind-like 3 (Drosophila) -0.0785926
COL7A1 collagen, type VII, alpha 1 -0.0661945
COL6A3 collagen, type VI, alpha 3 -0.0647094
DST dystonin -0.0632955
EXT1 exostosin glycosyltransferase 1 -0.0609588
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0565702
NAV1 neuron navigator 1 -0.0534239
TENM2 teneurin transmembrane protein 2 -0.0525171
FMN1 formin 1 -0.0507961
ACTG1 actin gamma 1 -0.049862
IGF1R insulin-like growth factor 1 receptor -0.0495865
PTMA prothymosin, alpha -0.0484052
NALF1 NALCN channel auxiliary factor 1 -0.0478257
COL1A1 collagen, type I, alpha 1 -0.0450503
PLEC plectin -0.0443687
EGR1 early growth response 1 -0.0438911
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0432624
AFF3 AF4/FMR2 family, member 3 -0.0422874
FLNA filamin A, alpha -0.0417708
ATXN1 ataxin 1 -0.0413702
DIAPH2 diaphanous-related formin 2 -0.0412997
CALD1 caldesmon 1 -0.0411214
TAS2R14 taste receptor, type 2, member 14 -0.0410219
VCL vinculin -0.040793
ANKRD11 ankyrin repeat domain 11 -0.0407363
GRB10 growth factor receptor-bound protein 10 -0.0406779
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0405875
LPP LIM domain containing preferred translocation partner in lipoma -0.040548
ANKRD12 ankyrin repeat domain 12 -0.0390309
POTEF POTE ankyrin domain family, member F -0.0388231
PRSS23 protease, serine, 23 -0.0386199
KIAA1549L KIAA1549-like -0.0385255
RAI14 retinoic acid induced 14 -0.0384247
CUX1 cut-like homeobox 1 -0.0383938
RAD51B RAD51 paralog B -0.0382865
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0381572
SOX5 SRY (sex determining region Y)-box 5 -0.0367532
TPM1 tropomyosin 1 (alpha) -0.0366591
SDK1 sidekick cell adhesion molecule 1 -0.0366061
PRKCA protein kinase C, alpha -0.0363427
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0354124
RUNX1 runt-related transcription factor 1 -0.0353385
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0352571
PTPRG protein tyrosine phosphatase, receptor type, G -0.0351375
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0347863
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0347389
GLIS3 GLIS family zinc finger 3 -0.0346932
RPTOR regulatory associated protein of MTOR, complex 1 -0.0334291
TGFBI transforming growth factor, beta-induced, 68kDa -0.0330862
MYH9 myosin, heavy chain 9, non-muscle -0.0329809
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0321483
ZFAND3 zinc finger, AN1-type domain 3 -0.0319461
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0319053
TNS1 tensin 1 -0.0316259
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0315145
ENO2 enolase 2 (gamma, neuronal) -0.0313671
CCDC91 coiled-coil domain containing 91 -0.03111
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0306359
LIMCH1 LIM and calponin homology domains 1 -0.0303717
FNDC3B fibronectin type III domain containing 3B -0.0302839
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0298976
RRBP1 ribosome binding protein 1 -0.0295037
PCBP3 poly(rC) binding protein 3 -0.0294822
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0294293
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0287518
SBF2 SET binding factor 2 -0.0286704
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0281259
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0279766
CALR calreticulin -0.0279745
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0279677
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.027924
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.027825
LMNA lamin A/C -0.0277821
TNNC1 troponin C type 1 (slow) -0.0273986
ZBTB20 zinc finger and BTB domain containing 20 -0.0273867
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0271822
MPRIP myosin phosphatase Rho interacting protein -0.0268525
TRPS1 trichorhinophalangeal syndrome I -0.0268382
ANTXR1 anthrax toxin receptor 1 -0.026643
IGFBP4 insulin-like growth factor binding protein 4 -0.0266255
NCOR2 nuclear receptor corepressor 2 -0.0265742
VMP1 vacuole membrane protein 1 -0.0265476
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0264067
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0262911
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0254204
ATG7 autophagy related 7 -0.0252759
GSE1 Gse1 coiled-coil protein -0.0252266
ARHGAP22 Rho GTPase activating protein 22 -0.0250974
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0249126
CDK14 cyclin-dependent kinase 14 -0.0247192