Lenalidomide (hemihydrate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.304705
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.192877
IGF2 insulin-like growth factor 2 0.11289
SAMD4A sterile alpha motif domain containing 4A 0.0991021
SLC38A2 solute carrier family 38, member 2 0.0791057
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0739799
DSPP dentin sialophosphoprotein 0.0729022
SVIL supervillin 0.069948
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0683779
PDLIM5 PDZ and LIM domain 5 0.0628152
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0626676
MT2A metallothionein 2A 0.0529792
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0529389
VCL vinculin 0.0499208
APLP2 amyloid beta (A4) precursor-like protein 2 0.0498329
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0475004
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0472642
FOXP1 forkhead box P1 0.0457562
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0437779
RUNX1 runt-related transcription factor 1 0.0428266
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0408685
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0394914
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.038539
CHIC2 cysteine-rich hydrophobic domain 2 0.0372683
FRMD5 FERM domain containing 5 0.0372424
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0367539
ZNF638 zinc finger protein 638 0.0365283
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0359611
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0342843
BPTF bromodomain PHD finger transcription factor 0.0340343
SOS1 son of sevenless homolog 1 (Drosophila) 0.0335543
ATXN1 ataxin 1 0.0333356
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.032539
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0317601
ITGB5 integrin, beta 5 0.0313627
RAD51B RAD51 paralog B 0.0312907
TIMP1 TIMP metallopeptidase inhibitor 1 0.0308757
FOXO1 forkhead box O1 0.0300452
PCBP2 poly(rC) binding protein 2 0.030045
DOCK4 dedicator of cytokinesis 4 0.0300043
FKTN fukutin 0.0295875
MACF1 microtubule-actin crosslinking factor 1 0.0295596
IGFBP1 insulin-like growth factor binding protein 1 0.0294076
ITGA6 integrin, alpha 6 0.029314
CORO1C coronin, actin binding protein, 1C 0.0286854
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0285912
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0284829
KYNU kynureninase 0.0283092
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0279617
ITCH itchy E3 ubiquitin protein ligase 0.0274461
GRB10 growth factor receptor-bound protein 10 0.0274268
TTC3 tetratricopeptide repeat domain 3 0.027401
RNF43 ring finger protein 43 0.0273134
MBNL2 muscleblind-like splicing regulator 2 0.0271372
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0266537
FAM135A family with sequence similarity 135, member A 0.0265034
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0263483
BCL2L1 BCL2-like 1 0.0260689
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.025945
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0252657
TRAM1 translocation associated membrane protein 1 0.0247478
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0247279
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.024586
SLC35F5 solute carrier family 35, member F5 0.0244627
CSNK1A1 casein kinase 1, alpha 1 0.0242291
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0239975
FNDC3A fibronectin type III domain containing 3A 0.0238997
GCLC glutamate-cysteine ligase, catalytic subunit 0.0238201
KIAA1217 KIAA1217 0.0234974
TXNRD1 thioredoxin reductase 1 0.0230738
RSU1 Ras suppressor protein 1 0.0225502
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.022549
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0224705
PDIA3 protein disulfide isomerase family A, member 3 0.0222904
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0222111
DENND4A DENN/MADD domain containing 4A 0.0219307
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.0217726
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0216531
TBCK TBC1 domain containing kinase 0.0215746
FAT1 FAT atypical cadherin 1 0.0215482
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0215436
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0214305
ZSWIM5 zinc finger, SWIM-type containing 5 0.0214274
DOCK5 dedicator of cytokinesis 5 0.0212957
TPM1 tropomyosin 1 (alpha) 0.0212221
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0212089
PKP4 plakophilin 4 0.021076
NABP1 nucleic acid binding protein 1 0.0209608
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0206716
NRP1 neuropilin 1 0.0205171
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.020515
SH3RF1 SH3 domain containing ring finger 1 0.0203305
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0202418
CEMIP2 cell migration inducing hyaluronidase 2 0.0202027
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.020189
RTN4 reticulon 4 0.0197741
TBC1D22A TBC1 domain family, member 22A 0.0193893
KDM4C lysine (K)-specific demethylase 4C 0.0192847
IARS1 isoleucyl-tRNA synthetase 1 0.0192488
RASA2 RAS p21 protein activator 2 0.0192387

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.171692
GPC3 glypican 3 -0.141918
C3 complement component 3 -0.120499
APOA2 apolipoprotein A-II -0.116249
ERRFI1 ERBB receptor feedback inhibitor 1 -0.11185
CP ceruloplasmin (ferroxidase) -0.105517
FN1 fibronectin 1 -0.105205
RPS24 ribosomal protein S24 -0.104142
AKAP12 A kinase (PRKA) anchor protein 12 -0.103273
GPC6 glypican 6 -0.102683
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0963668
SDC4 syndecan 4 -0.083784
FNDC3B fibronectin type III domain containing 3B -0.0801559
TM4SF1 transmembrane 4 L six family member 1 -0.0710851
RPS8 ribosomal protein S8 -0.0687194
NPAS2 neuronal PAS domain protein 2 -0.0680635
AHSG alpha-2-HS-glycoprotein -0.0666702
TRIM26 tripartite motif containing 26 -0.0636015
RPL11 ribosomal protein L11 -0.0623568
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0622234
RPS27A ribosomal protein S27a -0.0615816
GNAS GNAS complex locus -0.0580866
TMSB10 thymosin beta 10 -0.0575563
EHBP1 EH domain binding protein 1 -0.0575265
RPL26 ribosomal protein L26 -0.0571437
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.056409
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0552184
RPL35A ribosomal protein L35a -0.0537229
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0531636
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0523266
RACK1 receptor for activated C kinase 1 -0.0521165
A2M alpha-2-macroglobulin -0.0514669
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0505032
RPS3 ribosomal protein S3 -0.050253
RPL23 ribosomal protein L23 -0.0499547
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0489208
RPL9 ribosomal protein L9 -0.0479866
LYZ lysozyme -0.0470472
PTPRM protein tyrosine phosphatase, receptor type, M -0.0467066
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0466776
PEG3 paternally expressed 3 -0.0459889
GMDS GDP-mannose 4,6-dehydratase -0.0457969
SOD2 superoxide dismutase 2, mitochondrial -0.0451111
CCL20 chemokine (C-C motif) ligand 20 -0.0449325
PTMA prothymosin, alpha -0.04307
RPS25 ribosomal protein S25 -0.0425887
RPS12 ribosomal protein S12 -0.0425505
FTL ferritin, light polypeptide -0.0423257
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0422488
ELL2 elongation factor, RNA polymerase II, 2 -0.0422075
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0413205
ENO1 enolase 1, (alpha) -0.0412309
AMBP alpha-1-microglobulin/bikunin precursor -0.0410805
RPS13 ribosomal protein S13 -0.0409838
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0409745
APOB apolipoprotein B -0.040844
APOE apolipoprotein E -0.0407263
RPL31 ribosomal protein L31 -0.0406726
NPR2 natriuretic peptide receptor 2 -0.04041
LRMDA leucine rich melanocyte differentiation associated -0.0398314
RPL37A ribosomal protein L37a -0.0381267
RPL34 ribosomal protein L34 -0.0374207
STK17A serine/threonine kinase 17a -0.0363779
FBF1 Fas (TNFRSF6) binding factor 1 -0.0357606
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.035654
RPS10 ribosomal protein S10 -0.0354386
RPL5 ribosomal protein L5 -0.0349378
TF transferrin -0.0349078
RPLP0 ribosomal protein, large, P0 -0.0344389
RPL12 ribosomal protein L12 -0.0341873
PTPRF protein tyrosine phosphatase, receptor type, F -0.0340865
RBM39 RNA binding motif protein 39 -0.0338924
FMNL2 formin-like 2 -0.0337927
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0334115
EML4 echinoderm microtubule associated protein like 4 -0.0329315
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0327924
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0317014
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0312872
KDM3A lysine (K)-specific demethylase 3A -0.0312408
RYBP RING1 and YY1 binding protein -0.0311188
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0309983
H1-0 H1.0 linker histone -0.0307059
TMEM123 transmembrane protein 123 -0.03039
RNF213 ring finger protein 213 -0.0299482
KLF6 Kruppel-like factor 6 -0.0296153
TPM4 tropomyosin 4 -0.0295917
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0295391
H3-3B H3.3 histone B -0.0287264
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0283378
SOX5 SRY (sex determining region Y)-box 5 -0.0283345
ZHX2 zinc fingers and homeoboxes 2 -0.0282694
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0281936
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.027975
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0277157
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0276897
PLIN2 perilipin 2 -0.0276027
IER3 immediate early response 3 -0.0274479
CALR calreticulin -0.0273622
RPS23 ribosomal protein S23 -0.027057
ISG15 ISG15 ubiquitin-like modifier -0.0270097