Lenalidomide (hemihydrate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYOF myoferlin 0.0875892
MT2A metallothionein 2A 0.0642303
KTN1 kinectin 1 (kinesin receptor) 0.0630872
MBNL2 muscleblind-like splicing regulator 2 0.0610485
LMO7 LIM domain 7 0.059747
FNDC3B fibronectin type III domain containing 3B 0.0571182
RPS6 ribosomal protein S6 0.0524174
PDE4D phosphodiesterase 4D, cAMP-specific 0.0515062
TXNIP thioredoxin interacting protein 0.0508124
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0504462
ESYT2 extended synaptotagmin-like protein 2 0.0463381
KMT2E lysine (K)-specific methyltransferase 2E 0.0447734
EFHD2 EF-hand domain family, member D2 0.0443706
DOK5 docking protein 5 0.0439821
B2M beta-2-microglobulin 0.0436213
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0373704
TGM2 transglutaminase 2 0.0361824
APLP2 amyloid beta (A4) precursor-like protein 2 0.0340581
BARX2 BARX homeobox 2 0.0318322
MEF2A myocyte enhancer factor 2A 0.0316396
AOPEP aminopeptidase O (putative) 0.0304559
DST dystonin 0.0285544
ARHGAP21 Rho GTPase activating protein 21 0.0272317
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0265469
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0262264
MT1X metallothionein 1X 0.0259602
PCBP2 poly(rC) binding protein 2 0.0256391
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0251529
TTC3 tetratricopeptide repeat domain 3 0.0247836
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0247366
WWTR1 WW domain containing transcription regulator 1 0.0245772
ZNF292 zinc finger protein 292 0.0239132
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0237549
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0237359
ANKRD12 ankyrin repeat domain 12 0.0237333
RNF145 ring finger protein 145 0.0230871
SLC38A2 solute carrier family 38, member 2 0.0226366
ZNF638 zinc finger protein 638 0.0226036
CLU clusterin 0.0225644
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0222784
ARRDC3 arrestin domain containing 3 0.0221946
PTEN phosphatase and tensin homolog 0.0218423
N4BP2L2 NEDD4 binding protein 2-like 2 0.0217563
SMAD3 SMAD family member 3 0.0217133
TRAM1 translocation associated membrane protein 1 0.0209198
ZRANB2 zinc finger, RAN-binding domain containing 2 0.0208783
NOTCH2 notch 2 0.0208076
MT1E metallothionein 1E 0.0207838
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0207205
JAG1 jagged 1 0.020698
IFITM1 interferon induced transmembrane protein 1 0.020283
SIRT1 sirtuin 1 0.0202081
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0200025
TNRC6A trinucleotide repeat containing 6A 0.0199955
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0196984
GRAMD1B GRAM domain containing 1B 0.01968
VEGFC vascular endothelial growth factor C 0.01964
CMIP c-Maf inducing protein 0.019526
AKAP9 A kinase (PRKA) anchor protein 9 0.0193158
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0192089
SLK STE20-like kinase 0.0191501
ANKRD28 ankyrin repeat domain 28 0.0190536
SRSF11 serine/arginine-rich splicing factor 11 0.0188494
EPS8 epidermal growth factor receptor pathway substrate 8 0.0187453
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0186347
KIF16B kinesin family member 16B 0.0186134
MN1 meningioma (disrupted in balanced translocation) 1 0.0182705
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0182564
DPY19L1 dpy-19-like 1 (C. elegans) 0.0180512
UGCG UDP-glucose ceramide glucosyltransferase 0.0180162
METTL15 methyltransferase like 15 0.0179739
IFI44L interferon-induced protein 44-like 0.0178778
IRS2 insulin receptor substrate 2 0.017598
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0175929
ZCCHC7 zinc finger, CCHC domain containing 7 0.0172577
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0172476
CDK19 cyclin-dependent kinase 19 0.0171495
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0170581
TBC1D2 TBC1 domain family, member 2 0.0170508
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0169866
ELL2 elongation factor, RNA polymerase II, 2 0.0169282
PCDH1 protocadherin 1 0.0167303
JMJD1C jumonji domain containing 1C 0.0166057
GOLGA4 golgin A4 0.0164909
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0163484
ATM ATM serine/threonine kinase 0.016307
SLC35F5 solute carrier family 35, member F5 0.0162623
XPO1 exportin 1 0.01603
TMF1 TATA element modulatory factor 1 0.015884
SIK3 SIK family kinase 3 0.0158528
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0158474
RICTOR RPTOR independent companion of MTOR, complex 2 0.0157941
HAS2 hyaluronan synthase 2 0.0157413
SKAP2 src kinase associated phosphoprotein 2 0.0154073
KLF5 Kruppel-like factor 5 (intestinal) 0.0153666
FAM13A family with sequence similarity 13, member A 0.0153083
FTL ferritin, light polypeptide 0.0153079
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0151926
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.0150933
TBC1D5 TBC1 domain family, member 5 0.0150628

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.253216
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.197943
FLNB filamin B, beta -0.165438
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.109601
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.108798
AHNAK AHNAK nucleoprotein -0.108267
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0976638
PDLIM5 PDZ and LIM domain 5 -0.0939903
SULF1 sulfatase 1 -0.0881807
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0864337
SLC35F3 solute carrier family 35, member F3 -0.0803993
LAMC2 laminin, gamma 2 -0.0789735
TPT1 tumor protein, translationally-controlled 1 -0.0767812
VCL vinculin -0.0741052
PODXL podocalyxin-like -0.0726767
ANXA2 annexin A2 -0.0719422
ALCAM activated leukocyte cell adhesion molecule -0.0673463
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0672231
EMP1 epithelial membrane protein 1 -0.0668291
DPYD dihydropyrimidine dehydrogenase -0.0646146
MTSS1 metastasis suppressor 1 -0.0628107
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0608738
ZEB1 zinc finger E-box binding homeobox 1 -0.0570375
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0555213
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0514258
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0513169
KRT17 keratin 17, type I -0.050275
PLEC plectin -0.050141
PALLD palladin, cytoskeletal associated protein -0.0491358
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0490163
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0478421
RCOR1 REST corepressor 1 -0.0477337
PTMA prothymosin, alpha -0.0475249
SULF2 sulfatase 2 -0.0465543
S100A10 S100 calcium binding protein A10 -0.0464814
NDRG1 N-myc downstream regulated 1 -0.0462799
LDHA lactate dehydrogenase A -0.0460255
ACTN4 actinin, alpha 4 -0.0457031
THBD thrombomodulin -0.045126
PSD3 pleckstrin and Sec7 domain containing 3 -0.0446016
CLIC4 chloride intracellular channel 4 -0.0442091
ABI3BP ABI family, member 3 (NESH) binding protein -0.0438598
ANO1 anoctamin 1, calcium activated chloride channel -0.0437838
BCL2L1 BCL2-like 1 -0.042851
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0424076
CAPN2 calpain 2, (m/II) large subunit -0.0410937
SAMD9 sterile alpha motif domain containing 9 -0.0407789
CANX calnexin -0.0407784
KRT6A keratin 6A, type II -0.0397561
EGR1 early growth response 1 -0.0394445
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.039388
GRB10 growth factor receptor-bound protein 10 -0.0376489
ZNFX1 zinc finger, NFX1-type containing 1 -0.0374013
RPS24 ribosomal protein S24 -0.0371854
INTS6 integrator complex subunit 6 -0.0366594
TMSB4X thymosin beta 4, X-linked -0.0355019
CAVIN1 caveolae associated protein 1 -0.0353231
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0352923
STC1 stanniocalcin 1 -0.0347143
RAP1B RAP1B, member of RAS oncogene family -0.0342038
LMNA lamin A/C -0.0337649
OSMR oncostatin M receptor -0.0333902
LDLR low density lipoprotein receptor -0.0332428
EXT1 exostosin glycosyltransferase 1 -0.0325542
AMOTL1 angiomotin like 1 -0.0325311
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0315456
SQSTM1 sequestosome 1 -0.0311837
ANKRD33B ankyrin repeat domain 33B -0.0309069
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0306932
HLA-E major histocompatibility complex, class I, E -0.0303966
TPM4 tropomyosin 4 -0.0303524
CD9 CD9 molecule -0.0300501
H1-0 H1.0 linker histone -0.0299964
THSD4 thrombospondin, type I, domain containing 4 -0.0299923
DUSP6 dual specificity phosphatase 6 -0.0297634
NCOA3 nuclear receptor coactivator 3 -0.0297629
CDK6 cyclin-dependent kinase 6 -0.0297126
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0296965
TNS3 tensin 3 -0.0290557
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0290016
WASF2 WAS protein family, member 2 -0.028704
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0283484
LUZP1 leucine zipper protein 1 -0.027787
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0273383
FLNA filamin A, alpha -0.0272335
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0269051
CD59 CD59 molecule, complement regulatory protein -0.0267122
SOD2 superoxide dismutase 2, mitochondrial -0.026624
NAV2 neuron navigator 2 -0.0261275
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0259847
BCAR3 breast cancer anti-estrogen resistance 3 -0.0259319
ACTG1 actin gamma 1 -0.0257477
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0256641
MACF1 microtubule-actin crosslinking factor 1 -0.0256093
KRT14 keratin 14, type I -0.0255682
SQLE squalene epoxidase -0.0253324
CAPRIN2 caprin family member 2 -0.0251506
RPS21 ribosomal protein S21 -0.0248074
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0247521
RASAL2 RAS protein activator like 2 -0.024707