Lenalidomide (hemihydrate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.129709
EXT1 exostosin glycosyltransferase 1 0.0818498
NAP1L1 nucleosome assembly protein 1-like 1 0.059159
CD44 CD44 molecule (Indian blood group) 0.0559124
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0552101
PABPC1 poly(A) binding protein, cytoplasmic 1 0.05155
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0469197
AKAP12 A kinase (PRKA) anchor protein 12 0.0420414
ITGA6 integrin, alpha 6 0.0398149
DST dystonin 0.0396496
TXNRD1 thioredoxin reductase 1 0.0377867
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0361053
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0360144
KYNU kynureninase 0.0360102
VCL vinculin 0.0355849
HAS2 hyaluronan synthase 2 0.0352201
BCAR3 breast cancer anti-estrogen resistance 3 0.0346999
RPS12 ribosomal protein S12 0.0343062
MAML2 mastermind-like 2 (Drosophila) 0.0341539
CALD1 caldesmon 1 0.03402
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0339807
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0333343
ERRFI1 ERBB receptor feedback inhibitor 1 0.0328773
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0313113
MYO10 myosin X 0.0311559
ADAM19 ADAM metallopeptidase domain 19 0.0310837
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0307725
KTN1 kinectin 1 (kinesin receptor) 0.0304169
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0299054
RPL37A ribosomal protein L37a 0.0294362
ANKRD28 ankyrin repeat domain 28 0.0294102
RND3 Rho family GTPase 3 0.029186
BPTF bromodomain PHD finger transcription factor 0.0290516
DLC1 DLC1 Rho GTPase activating protein 0.028752
UGCG UDP-glucose ceramide glucosyltransferase 0.0281553
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0280155
ATP13A3 ATPase type 13A3 0.0279428
RTN4 reticulon 4 0.0275436
MED13 mediator complex subunit 13 0.0271942
ZNF638 zinc finger protein 638 0.0269735
NAMPT nicotinamide phosphoribosyltransferase 0.0269379
MCL1 myeloid cell leukemia 1 0.0268947
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0259276
SPAG9 sperm associated antigen 9 0.0259116
FRMD6 FERM domain containing 6 0.0256653
SLC38A2 solute carrier family 38, member 2 0.0252493
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.024427
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0238351
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0236834
TXNIP thioredoxin interacting protein 0.0236291
NAV3 neuron navigator 3 0.0235279
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0234115
RIGI RNA sensor RIG-I 0.023377
SCAF11 SR-related CTD-associated factor 11 0.0233265
ELL2 elongation factor, RNA polymerase II, 2 0.0227226
PCBP2 poly(rC) binding protein 2 0.0217572
CDK17 cyclin-dependent kinase 17 0.0216092
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0215804
RPLP1 ribosomal protein, large, P1 0.0213913
MSN moesin 0.0213417
RPS20 ribosomal protein S20 0.0212899
RUNX1 runt-related transcription factor 1 0.0211781
ENKUR enkurin, TRPC channel interacting protein 0.0211655
LIMA1 LIM domain and actin binding 1 0.0210435
TSC22D2 TSC22 domain family, member 2 0.0210003
CORO1C coronin, actin binding protein, 1C 0.0205739
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0203063
JMJD1C jumonji domain containing 1C 0.0201887
FNDC3B fibronectin type III domain containing 3B 0.0193957
LIMS1 LIM and senescent cell antigen-like domains 1 0.0193878
WNK1 WNK lysine deficient protein kinase 1 0.0193255
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.019172
KLF6 Kruppel-like factor 6 0.0187082
CXCL8 chemokine (C-X-C motif) ligand 8 0.0185746
SIK3 SIK family kinase 3 0.0183999
ERBIN erbb2 interacting protein 0.0182903
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0182834
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0182444
TPR translocated promoter region, nuclear basket protein 0.0182053
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0182052
SPRED2 sprouty-related, EVH1 domain containing 2 0.0178552
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0178279
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0176043
WWTR1 WW domain containing transcription regulator 1 0.0175675
SMAD3 SMAD family member 3 0.0174146
SH3RF1 SH3 domain containing ring finger 1 0.0172472
ZFAND3 zinc finger, AN1-type domain 3 0.017089
EIF5B eukaryotic translation initiation factor 5B 0.0168755
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0168448
MYH9 myosin, heavy chain 9, non-muscle 0.016827
MALT1 MALT1 paracaspase 0.0167863
PHF14 PHD finger protein 14 0.0167794
ITGAV integrin, alpha V 0.0165708
SLMAP sarcolemma associated protein 0.0164353
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0164071
WDR43 WD repeat domain 43 0.0161999
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0160911
FLNB filamin B, beta 0.0160876
MYO1E myosin IE 0.0160379
PAWR PRKC, apoptosis, WT1, regulator 0.015996

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.273264
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.166017
PHACTR1 phosphatase and actin regulator 1 -0.135673
PRKG1 protein kinase, cGMP-dependent, type I -0.125378
LSAMP limbic system-associated membrane protein -0.120018
GPC6 glypican 6 -0.116427
EFNA5 ephrin-A5 -0.116045
CDH13 cadherin 13 -0.0891173
ASPH aspartate beta-hydroxylase -0.084723
SAMD3 sterile alpha motif domain containing 3 -0.0762203
TMSB10 thymosin beta 10 -0.0760118
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0753197
KIAA1549L KIAA1549-like -0.0616303
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0582512
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0548389
LDHA lactate dehydrogenase A -0.0534774
NAV1 neuron navigator 1 -0.0498481
VIM vimentin -0.0473662
MMP12 matrix metallopeptidase 12 -0.0466319
KIAA1217 KIAA1217 -0.0462741
FTL ferritin, light polypeptide -0.045539
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0450992
ACTG1 actin gamma 1 -0.0427892
ZNF804A zinc finger protein 804A -0.0403622
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0391347
NDRG1 N-myc downstream regulated 1 -0.038936
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.038612
PTPRG protein tyrosine phosphatase, receptor type, G -0.0384778
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0376447
EGR1 early growth response 1 -0.0351259
RPL12 ribosomal protein L12 -0.0349382
POTEF POTE ankyrin domain family, member F -0.0341177
AHNAK AHNAK nucleoprotein -0.0339088
ENO1 enolase 1, (alpha) -0.032423
NTM neurotrimin -0.0312385
MACF1 microtubule-actin crosslinking factor 1 -0.0310036
CDK14 cyclin-dependent kinase 14 -0.0302104
TPT1 tumor protein, translationally-controlled 1 -0.0299324
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0298752
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0293008
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.028195
TAS2R14 taste receptor, type 2, member 14 -0.0279325
MBD5 methyl-CpG binding domain protein 5 -0.0278486
DTNA dystrobrevin, alpha -0.0277396
FLNA filamin A, alpha -0.0269389
KDM4C lysine (K)-specific demethylase 4C -0.0266378
DGKI diacylglycerol kinase, iota -0.0263755
ADAM32 ADAM metallopeptidase domain 32 -0.0263147
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0260904
HMGA2 high mobility group AT-hook 2 -0.0255902
ANXA2 annexin A2 -0.0255665
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0254523
LOC112694756 uncharaterized LOC112694756 -0.0253096
PTCHD4 patched domain containing 4 -0.0251733
C2CD2 C2 calcium-dependent domain containing 2 -0.0246451
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0244287
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0243361
DPYD dihydropyrimidine dehydrogenase -0.0243161
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0231624
FER fer (fps/fes related) tyrosine kinase -0.023089
SOX5 SRY (sex determining region Y)-box 5 -0.0229823
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0226705
RPL32 ribosomal protein L32 -0.0226523
RPS5 ribosomal protein S5 -0.0226306
DSCAM Down syndrome cell adhesion molecule -0.022588
PTPRD protein tyrosine phosphatase, receptor type, D -0.0225426
ARHGAP18 Rho GTPase activating protein 18 -0.0225208
VCAN versican -0.0224305
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0214777
PLEC plectin -0.0214211
AEBP2 AE binding protein 2 -0.0213495
SBF2 SET binding factor 2 -0.0212189
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0211109
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0207759
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0207171
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0204355
CANX calnexin -0.0202222
PKM pyruvate kinase, muscle -0.0201777
RPL5 ribosomal protein L5 -0.0201557
RPL19 ribosomal protein L19 -0.0201518
KDM4B lysine (K)-specific demethylase 4B -0.0200396
TPI1 triosephosphate isomerase 1 -0.020029
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0199831
SYT9 synaptotagmin IX -0.0199644
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0193792
TRPS1 trichorhinophalangeal syndrome I -0.0192844
CENPF centromere protein F, 350/400kDa -0.0190587
DIAPH2 diaphanous-related formin 2 -0.0190573
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0190439
PHF3 PHD finger protein 3 -0.0190418
PRR11 proline rich 11 -0.0189055
PTPRF protein tyrosine phosphatase, receptor type, F -0.0188044
CD109 CD109 molecule -0.0187511
RASA3 RAS p21 protein activator 3 -0.0185865
RPL30 ribosomal protein L30 -0.0183454
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0182934
DIAPH3 diaphanous-related formin 3 -0.0180794
MSR1 macrophage scavenger receptor 1 -0.0178841
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0177482
PTK2 protein tyrosine kinase 2 -0.0176377