Lenalidomide (hemihydrate)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.110863
MYO1E myosin IE 0.101984
ONECUT3 one cut homeobox 3 0.0856449
MT2A metallothionein 2A 0.0854422
RPS6 ribosomal protein S6 0.0846256
ANTXR2 anthrax toxin receptor 2 0.0782338
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0727729
ABHD2 abhydrolase domain containing 2 0.0649609
B2M beta-2-microglobulin 0.0594223
N4BP2L2 NEDD4 binding protein 2-like 2 0.0564885
FTL ferritin, light polypeptide 0.0541824
SMYD3 SET and MYND domain containing 3 0.0496226
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0463398
FOXO1 forkhead box O1 0.0456739
PRSS3 protease, serine, 3 0.0415374
RPL35A ribosomal protein L35a 0.0413713
ISG15 ISG15 ubiquitin-like modifier 0.0409628
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0396374
AREG amphiregulin 0.0382572
TMEM165 transmembrane protein 165 0.0380927
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.037853
NEBL nebulette 0.0377126
TNS4 tensin 4 0.0362566
RPS8 ribosomal protein S8 0.0350306
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0346459
ZBTB20 zinc finger and BTB domain containing 20 0.0337728
FOXP1 forkhead box P1 0.0330734
RNF43 ring finger protein 43 0.0327677
MT1X metallothionein 1X 0.0317715
BACE2 beta-site APP-cleaving enzyme 2 0.0308033
EGFR epidermal growth factor receptor 0.0304497
MT1E metallothionein 1E 0.0292133
FAT1 FAT atypical cadherin 1 0.0289981
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0288476
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0284907
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0284499
ITPRID2 ITPR interacting domain containing 2 0.0275615
RPS27 ribosomal protein S27 0.0273738
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0273181
RPL11 ribosomal protein L11 0.0272755
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0264318
RAB10 RAB10, member RAS oncogene family 0.0262437
IFI27 interferon, alpha-inducible protein 27 0.0259592
RNF217 ring finger protein 217 0.0257193
EIF1 eukaryotic translation initiation factor 1 0.0254894
MED13 mediator complex subunit 13 0.0254527
RPS12 ribosomal protein S12 0.0253517
ESYT2 extended synaptotagmin-like protein 2 0.0251448
CCSER1 coiled-coil serine-rich protein 1 0.0250145
KLF3 Kruppel-like factor 3 (basic) 0.0247319
MACROD2 MACRO domain containing 2 0.0246659
ZNF638 zinc finger protein 638 0.0245246
RPLP1 ribosomal protein, large, P1 0.0244337
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0243671
PLS1 plastin 1 0.0243494
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0241999
TMEM45B transmembrane protein 45B 0.024101
INSR insulin receptor 0.0239699
FBXL17 F-box and leucine-rich repeat protein 17 0.0236388
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.0232208
SVIL supervillin 0.0232198
CADPS Ca++-dependent secretion activator 0.0231366
DUSP16 dual specificity phosphatase 16 0.0227659
FOXP2 forkhead box P2 0.0227454
PTBP3 polypyrimidine tract binding protein 3 0.022689
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0225437
REEP3 receptor accessory protein 3 0.0225034
PTPRK protein tyrosine phosphatase, receptor type, K 0.0224514
RPL28 ribosomal protein L28 0.0220132
PTPRR protein tyrosine phosphatase, receptor type, R 0.0220095
AHI1 Abelson helper integration site 1 0.0219323
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0217929
SLK STE20-like kinase 0.0215834
SERP1 stress-associated endoplasmic reticulum protein 1 0.0215601
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0213888
TFF1 trefoil factor 1 0.0211789
ANKRD12 ankyrin repeat domain 12 0.0211425
PARD3B par-3 family cell polarity regulator beta 0.0211162
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0204404
FOCAD focadhesin 0.0203496
PLAUR plasminogen activator, urokinase receptor 0.0203183
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0202273
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.020215
TSPAN8 tetraspanin 8 0.0202019
RPL31 ribosomal protein L31 0.0201225
FOXO3 forkhead box O3 0.0200422
ZFP36L2 ZFP36 ring finger protein-like 2 0.0199281
CDK13 cyclin-dependent kinase 13 0.019764
SAMD4A sterile alpha motif domain containing 4A 0.0197448
SRRM2 serine/arginine repetitive matrix 2 0.0196204
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0195907
UBN2 ubinuclein 2 0.019139
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0191349
TRAPPC9 trafficking protein particle complex 9 0.0190884
ICA1 islet cell autoantigen 1, 69kDa 0.0190343
PPARA peroxisome proliferator-activated receptor alpha 0.018967
PCDH9 protocadherin 9 0.01896
ALCAM activated leukocyte cell adhesion molecule 0.0189416
RPL15 ribosomal protein L15 0.0188998
METTL15 methyltransferase like 15 0.0187495

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.312168
PTMA prothymosin, alpha -0.251333
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0952558
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0917137
KRT18 keratin 18, type I -0.080083
EZR ezrin -0.0754467
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0739958
RBM39 RNA binding motif protein 39 -0.0737475
DSCAM Down syndrome cell adhesion molecule -0.0666969
KRT8 keratin 8, type II -0.0628729
FAM13A family with sequence similarity 13, member A -0.0622913
FTH1 ferritin, heavy polypeptide 1 -0.059795
H1-0 H1.0 linker histone -0.0557167
NPSR1 neuropeptide S receptor 1 -0.0541146
KDM3A lysine (K)-specific demethylase 3A -0.0535252
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.052463
ANXA1 annexin A1 -0.0523726
MED13L mediator complex subunit 13-like -0.0522129
GPHN gephyrin -0.0500338
WDR45B WD repeat domain 45B -0.0494403
RRBP1 ribosome binding protein 1 -0.0478382
EREG epiregulin -0.0453777
PIGR polymeric immunoglobulin receptor -0.0453522
RAB1A RAB1A, member RAS oncogene family -0.0448446
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0435784
SERINC5 serine incorporator 5 -0.0434787
YBX1 Y box binding protein 1 -0.0424267
TFRC transferrin receptor -0.0422202
EMP1 epithelial membrane protein 1 -0.0417501
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0415744
OGA O-GlcNAcase -0.0413779
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0410885
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0410301
AHNAK AHNAK nucleoprotein -0.0409812
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0404384
LMNA lamin A/C -0.0399544
DSPP dentin sialophosphoprotein -0.0396952
GARS1 glycyl-tRNA synthetase 1 -0.0382106
CCNY cyclin Y -0.0375138
CANX calnexin -0.0366182
ZFAND3 zinc finger, AN1-type domain 3 -0.0352126
CALR calreticulin -0.035163
NOP58 NOP58 ribonucleoprotein -0.0348987
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0345544
ANKRD11 ankyrin repeat domain 11 -0.0344402
FNDC3B fibronectin type III domain containing 3B -0.0340482
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0339544
GCC2 GRIP and coiled-coil domain containing 2 -0.0338809
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0337196
ANXA2 annexin A2 -0.0335879
TM9SF3 transmembrane 9 superfamily member 3 -0.0330844
STK17A serine/threonine kinase 17a -0.0329293
MBNL2 muscleblind-like splicing regulator 2 -0.0329162
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.032718
FOSL1 FOS-like antigen 1 -0.0326901
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.032495
NDRG1 N-myc downstream regulated 1 -0.0320086
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0319849
TXNIP thioredoxin interacting protein -0.0316207
MARCHF6 membrane associated ring-CH-type finger 6 -0.030591
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.030392
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0302394
TRA2A transformer 2 alpha homolog (Drosophila) -0.0299364
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0295414
ACTN4 actinin, alpha 4 -0.0295068
SEC31A SEC31 homolog A (S. cerevisiae) -0.0290299
MUC17 mucin 17, cell surface associated -0.0288077
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0287719
FNBP1L formin binding protein 1-like -0.0286309
KIF5B kinesin family member 5B -0.0285741
PDIA4 protein disulfide isomerase family A, member 4 -0.0284615
PUM2 pumilio RNA-binding family member 2 -0.0283014
TOP1 topoisomerase (DNA) I -0.02814
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0280151
WASF2 WAS protein family, member 2 -0.0279149
IARS1 isoleucyl-tRNA synthetase 1 -0.027579
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0273883
ZNF292 zinc finger protein 292 -0.0268833
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0265348
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0263228
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0262475
NRN1 neuritin 1 -0.026191
VDAC1 voltage-dependent anion channel 1 -0.026108
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0260964
YBX3 Y box binding protein 3 -0.0260243
LRRC1 leucine rich repeat containing 1 -0.0259406
TFG TRK-fused gene -0.0259173
MORF4L2 mortality factor 4 like 2 -0.0258393
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0258314
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0258262
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.025763
CTBP2 C-terminal binding protein 2 -0.0257483
CDC42SE2 CDC42 small effector 2 -0.025372
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0252744
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.025203
RYBP RING1 and YY1 binding protein -0.0248872
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0247958
KITLG KIT ligand -0.0246108
IFRD1 interferon-related developmental regulator 1 -0.0245348
ITGA6 integrin, alpha 6 -0.0243678