Lenalidomide (hemihydrate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.269982
MT1X metallothionein 1X 0.087723
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0796586
MT1E metallothionein 1E 0.0792107
CAPRIN2 caprin family member 2 0.0720062
TXNRD1 thioredoxin reductase 1 0.0699795
KMT2E lysine (K)-specific methyltransferase 2E 0.0691007
WWTR1 WW domain containing transcription regulator 1 0.0667511
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0637541
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0584944
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0539105
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0535828
RPL35A ribosomal protein L35a 0.0470372
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0461097
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0454184
AREG amphiregulin 0.0410679
RPS6 ribosomal protein S6 0.0405309
BIRC3 baculoviral IAP repeat containing 3 0.038845
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0374493
TMEM41B transmembrane protein 41B 0.0350092
BCAR3 breast cancer anti-estrogen resistance 3 0.032994
RPL36 ribosomal protein L36 0.0324958
PSD3 pleckstrin and Sec7 domain containing 3 0.0323363
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0322019
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0320377
RPS19 ribosomal protein S19 0.0319844
PCBP2 poly(rC) binding protein 2 0.0316469
FERMT1 fermitin family member 1 0.0314902
TUBB6 tubulin, beta 6 class V 0.0304227
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0299851
ANKRD12 ankyrin repeat domain 12 0.0287679
NPAS2 neuronal PAS domain protein 2 0.0277903
F2R coagulation factor II (thrombin) receptor 0.0275155
ANGPTL4 angiopoietin-like 4 0.0265998
SEC24A SEC24 family member A 0.0260816
EZR ezrin 0.0260798
ANTXR2 anthrax toxin receptor 2 0.0259806
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0258592
PDE10A phosphodiesterase 10A 0.0256493
FOSL1 FOS-like antigen 1 0.0252226
RTTN rotatin 0.0251244
ERBIN erbb2 interacting protein 0.024586
ARL4C ADP-ribosylation factor-like 4C 0.0245206
SOCS6 suppressor of cytokine signaling 6 0.0242261
RUNX1 runt-related transcription factor 1 0.0241107
USP12 ubiquitin specific peptidase 12 0.0236369
KTN1 kinectin 1 (kinesin receptor) 0.0236016
SRSF11 serine/arginine-rich splicing factor 11 0.0233636
RPS8 ribosomal protein S8 0.0226827
EMP1 epithelial membrane protein 1 0.0226767
RPS23 ribosomal protein S23 0.0225069
BARX2 BARX homeobox 2 0.0224647
SPRED2 sprouty-related, EVH1 domain containing 2 0.0224599
DIAPH1 diaphanous-related formin 1 0.0220975
RPL37A ribosomal protein L37a 0.0218434
PMEPA1 prostate transmembrane protein, androgen induced 1 0.021514
RTN4 reticulon 4 0.021392
JMJD1C jumonji domain containing 1C 0.0212587
EIF5B eukaryotic translation initiation factor 5B 0.0212183
CSNK1A1 casein kinase 1, alpha 1 0.0208973
VEGFC vascular endothelial growth factor C 0.0204306
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0203597
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0200573
ZEB1 zinc finger E-box binding homeobox 1 0.0200391
CXCL8 chemokine (C-X-C motif) ligand 8 0.0199665
NIBAN2 niban apoptosis regulator 2 0.0199035
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0197659
S100A6 S100 calcium binding protein A6 0.0197187
CDCP1 CUB domain containing protein 1 0.0193248
KPNB1 karyopherin (importin) beta 1 0.0192884
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0192123
RPS13 ribosomal protein S13 0.0191961
SRPK2 SRSF protein kinase 2 0.0188176
ETNK1 ethanolamine kinase 1 0.0187926
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0185148
SLC38A2 solute carrier family 38, member 2 0.0181947
TRIP12 thyroid hormone receptor interactor 12 0.018049
ADAM17 ADAM metallopeptidase domain 17 0.0180456
PNISR PNN-interacting serine/arginine-rich protein 0.0180005
CCDC88A coiled-coil domain containing 88A 0.0179187
PRKCI protein kinase C, iota 0.0177915
TPM4 tropomyosin 4 0.017791
RPL31 ribosomal protein L31 0.0176802
UBXN4 UBX domain protein 4 0.0175061
USP11 ubiquitin specific peptidase 11 0.0172109
TSC22D1 TSC22 domain family, member 1 0.0171608
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0170578
HMGA1 high mobility group AT-hook 1 0.0169831
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0168951
ECPAS Ecm29 proteasome adaptor and scaffold 0.0167523
PCM1 pericentriolar material 1 0.0165945
NBDY negative regulator of P-body association 0.0164896
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0164418
DPYSL2 dihydropyrimidinase-like 2 0.0162796
TRA2B transformer 2 beta homolog (Drosophila) 0.0161487
RPL35 ribosomal protein L35 0.015994
RPS27 ribosomal protein S27 0.0158621
RAD50 RAD50 homolog (S. cerevisiae) 0.0157497
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.0156987
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0156762

decreased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) -0.152206
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.145603
VIM vimentin -0.123556
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123513
TP63 tumor protein p63 -0.110662
DLG1 discs, large homolog 1 (Drosophila) -0.100832
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0941559
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.093104
PTMA prothymosin, alpha -0.0920535
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0910065
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0858516
CANX calnexin -0.0807294
APP amyloid beta (A4) precursor protein -0.0797653
EHBP1 EH domain binding protein 1 -0.0789791
MYOF myoferlin -0.0765535
TNS3 tensin 3 -0.0733486
AHNAK AHNAK nucleoprotein -0.0712531
EEF2 eukaryotic translation elongation factor 2 -0.0671966
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0614354
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0613601
EPHA4 EPH receptor A4 -0.0605897
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0604739
DOCK11 dedicator of cytokinesis 11 -0.0603786
TMSB4X thymosin beta 4, X-linked -0.058815
SOD2 superoxide dismutase 2, mitochondrial -0.0570474
CADM2 cell adhesion molecule 2 -0.0560169
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0559949
PTPRF protein tyrosine phosphatase, receptor type, F -0.0527085
SP100 SP100 nuclear antigen -0.0516388
LDHA lactate dehydrogenase A -0.0510565
TMEM123 transmembrane protein 123 -0.0506244
ZNF217 zinc finger protein 217 -0.049957
MACF1 microtubule-actin crosslinking factor 1 -0.0496218
HDAC9 histone deacetylase 9 -0.0487674
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0487523
FTH1 ferritin, heavy polypeptide 1 -0.0477545
HLA-B major histocompatibility complex, class I, B -0.0457476
CLIP2 CAP-GLY domain containing linker protein 2 -0.0438484
ACTG1 actin gamma 1 -0.0437072
EGFR epidermal growth factor receptor -0.0433091
RIGI RNA sensor RIG-I -0.0425766
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0423057
LRRC49 leucine rich repeat containing 49 -0.0416973
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0406451
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0406174
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0400825
HDLBP high density lipoprotein binding protein -0.0394813
RAB7A RAB7A, member RAS oncogene family -0.0391221
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0389316
PODXL podocalyxin-like -0.0384457
CFAP299 cilia and flagella associated protein 299 -0.0383572
DENND1A DENN/MADD domain containing 1A -0.0383098
RNF213 ring finger protein 213 -0.0365816
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.036483
PLK2 polo-like kinase 2 -0.036448
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0353812
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0352366
KDM3A lysine (K)-specific demethylase 3A -0.0348178
RPS24 ribosomal protein S24 -0.0347716
CSMD3 CUB and Sushi multiple domains 3 -0.0347538
EFNA5 ephrin-A5 -0.0346297
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0345903
ANXA1 annexin A1 -0.0345314
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0344993
ANXA2 annexin A2 -0.0336387
NEK10 NIMA-related kinase 10 -0.0331071
SRGN serglycin -0.0330392
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.032997
ADAR adenosine deaminase, RNA-specific -0.0320321
CALR calreticulin -0.0317473
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0315778
AHNAK2 AHNAK nucleoprotein 2 -0.0312514
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0303265
POTEF POTE ankyrin domain family, member F -0.0302075
EXOC4 exocyst complex component 4 -0.0301235
ZMYND8 zinc finger, MYND-type containing 8 -0.0298436
LOC112694756 uncharaterized LOC112694756 -0.0296927
SQSTM1 sequestosome 1 -0.0296542
ENO1 enolase 1, (alpha) -0.0293466
VDAC1 voltage-dependent anion channel 1 -0.0288968
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0285299
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0282151
STK17A serine/threonine kinase 17a -0.0276167
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0270998
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0269194
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0266934
SPDYA speedy/RINGO cell cycle regulator family member A -0.0266568
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0264323
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0260385
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0259752
EPB41 erythrocyte membrane protein band 4.1 -0.0255631
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0253921
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0250626
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0249048
NAV2 neuron navigator 2 -0.0244982
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0243809
PHF3 PHD finger protein 3 -0.0243556
FNIP1 folliculin interacting protein 1 -0.0241288
AEBP2 AE binding protein 2 -0.0241145
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0238723