Lenalidomide (hemihydrate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCBP2 poly(rC) binding protein 2 0.162693
CD44 CD44 molecule (Indian blood group) 0.131264
GLCCI1 glucocorticoid induced 1 0.0946396
UBC ubiquitin C 0.0907328
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.088454
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0878804
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0847756
VIM vimentin 0.0843459
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0783762
ARHGAP5 Rho GTPase activating protein 5 0.0754061
NTN4 netrin 4 0.0743758
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0683112
NRP1 neuropilin 1 0.0658817
ANTXR2 anthrax toxin receptor 2 0.065245
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0632541
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0620087
ZEB2 zinc finger E-box binding homeobox 2 0.0592889
TIMP1 TIMP metallopeptidase inhibitor 1 0.0572751
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0535078
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0533771
DOCK5 dedicator of cytokinesis 5 0.0511859
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0476263
NAV2 neuron navigator 2 0.0461239
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0460717
STK38L serine/threonine kinase 38 like 0.0441954
KSR1 kinase suppressor of ras 1 0.043334
HIPK2 homeodomain interacting protein kinase 2 0.0432224
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0431394
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0426659
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0409202
SIK3 SIK family kinase 3 0.0406119
FNDC3B fibronectin type III domain containing 3B 0.0405251
NAP1L1 nucleosome assembly protein 1-like 1 0.0403394
WLS wntless Wnt ligand secretion mediator 0.0396081
PKM pyruvate kinase, muscle 0.0392754
ANKRD28 ankyrin repeat domain 28 0.0388035
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0384272
EXT1 exostosin glycosyltransferase 1 0.0380452
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0375873
ATF7 activating transcription factor 7 0.0373501
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0370452
APLP2 amyloid beta (A4) precursor-like protein 2 0.0368329
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0360969
OXSR1 oxidative stress responsive 1 0.0357998
KYNU kynureninase 0.0353426
EEF2 eukaryotic translation elongation factor 2 0.034767
ITGAV integrin, alpha V 0.0341838
LOX lysyl oxidase 0.0341769
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0340801
ENO1 enolase 1, (alpha) 0.0338119
VEGFC vascular endothelial growth factor C 0.0335457
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0325562
B2M beta-2-microglobulin 0.0322651
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0318921
FHL2 four and a half LIM domains 2 0.0315078
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0312899
MAST4 microtubule associated serine/threonine kinase family member 4 0.0310335
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0306353
CDCP1 CUB domain containing protein 1 0.0295875
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0293748
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0291563
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0290504
ADD3 adducin 3 (gamma) 0.0287812
IL6ST interleukin 6 signal transducer 0.0285446
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0282095
MYO10 myosin X 0.0279586
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0279227
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0275849
ANGPTL4 angiopoietin-like 4 0.0275381
MBNL1 muscleblind-like splicing regulator 1 0.0275153
TGM2 transglutaminase 2 0.0274273
PTBP3 polypyrimidine tract binding protein 3 0.0272716
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0271043
GREB1L growth regulation by estrogen in breast cancer-like 0.0270443
MIPOL1 mirror-image polydactyly 1 0.0269976
LDHA lactate dehydrogenase A 0.0268628
IFI44L interferon-induced protein 44-like 0.0265438
EPS8 epidermal growth factor receptor pathway substrate 8 0.0264798
SLC38A2 solute carrier family 38, member 2 0.0264218
ARHGAP42 Rho GTPase activating protein 42 0.0262275
MEIS1 Meis homeobox 1 0.0261608
ITCH itchy E3 ubiquitin protein ligase 0.0261009
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0259127
SNX9 sorting nexin 9 0.0258926
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0258652
STRN3 striatin, calmodulin binding protein 3 0.0256668
FBXO11 F-box protein 11 0.0250714
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0250532
RAP1B RAP1B, member of RAS oncogene family 0.0249578
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0249057
GRB10 growth factor receptor-bound protein 10 0.0246684
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0246395
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0245574
TPST1 tyrosylprotein sulfotransferase 1 0.0244424
SH3RF1 SH3 domain containing ring finger 1 0.0239613
TTC3 tetratricopeptide repeat domain 3 0.0238785
HMGA2 high mobility group AT-hook 2 0.0236596
ECE1 endothelin converting enzyme 1 0.0236214
SFPQ splicing factor proline/glutamine-rich 0.0234507
PICALM phosphatidylinositol binding clathrin assembly protein 0.0232323

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.167756
FN1 fibronectin 1 -0.114287
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.10123
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.090502
RBM39 RNA binding motif protein 39 -0.084952
SDK1 sidekick cell adhesion molecule 1 -0.0785789
PDE4D phosphodiesterase 4D, cAMP-specific -0.0736289
MT2A metallothionein 2A -0.0684506
IER3 immediate early response 3 -0.0683826
FTL ferritin, light polypeptide -0.0663029
TMSB10 thymosin beta 10 -0.0634955
PTMA prothymosin, alpha -0.0623739
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0617215
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0615808
USP34 ubiquitin specific peptidase 34 -0.0558616
FAM20C family with sequence similarity 20, member C -0.0555294
RPLP1 ribosomal protein, large, P1 -0.0527745
ELL2 elongation factor, RNA polymerase II, 2 -0.0508723
FAM13A family with sequence similarity 13, member A -0.0508594
GPC6 glypican 6 -0.0500432
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0484123
PSD3 pleckstrin and Sec7 domain containing 3 -0.0483423
DLG1 discs, large homolog 1 (Drosophila) -0.0481114
KMT2C lysine (K)-specific methyltransferase 2C -0.0481084
C15ORF48 chromosome 15 open reading frame 48 -0.046258
TAS2R14 taste receptor, type 2, member 14 -0.0452585
GOLGA4 golgin A4 -0.0446695
NCOA7 nuclear receptor coactivator 7 -0.0443387
PRELID2 PRELI domain containing 2 -0.0430005
RPL35A ribosomal protein L35a -0.0419743
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0417977
ZMYND8 zinc finger, MYND-type containing 8 -0.0417752
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0416452
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0410637
FTH1 ferritin, heavy polypeptide 1 -0.0407659
RAB1A RAB1A, member RAS oncogene family -0.0405679
CDH13 cadherin 13 -0.040251
OSMR oncostatin M receptor -0.0394383
MORF4L2 mortality factor 4 like 2 -0.0390831
DDIT3 DNA-damage-inducible transcript 3 -0.0390582
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.038778
SLC38A1 solute carrier family 38, member 1 -0.0377623
KDM2A lysine (K)-specific demethylase 2A -0.0369073
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0364022
SBF2 SET binding factor 2 -0.0359329
EGR1 early growth response 1 -0.0358217
KDM3A lysine (K)-specific demethylase 3A -0.034472
UBE2O ubiquitin-conjugating enzyme E2O -0.0339254
H1-0 H1.0 linker histone -0.0325055
ZNF292 zinc finger protein 292 -0.0322699
BIRC6 baculoviral IAP repeat containing 6 -0.0316366
KPNB1 karyopherin (importin) beta 1 -0.0315913
DPYD dihydropyrimidine dehydrogenase -0.0307995
OGA O-GlcNAcase -0.0306631
COL12A1 collagen, type XII, alpha 1 -0.0304038
GNAS GNAS complex locus -0.0301052
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0295869
ARF4 ADP-ribosylation factor 4 -0.0293872
MAP4 microtubule-associated protein 4 -0.0293249
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0288761
GCC2 GRIP and coiled-coil domain containing 2 -0.0285955
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0285029
RPS24 ribosomal protein S24 -0.0277973
CHD6 chromodomain helicase DNA binding protein 6 -0.0272562
MYOF myoferlin -0.0271193
HDLBP high density lipoprotein binding protein -0.0271024
RPL34 ribosomal protein L34 -0.0269405
ACTG1 actin gamma 1 -0.0265378
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0265182
RPL32 ribosomal protein L32 -0.0259391
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0259032
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0257897
KLF6 Kruppel-like factor 6 -0.0257024
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0254884
ZFR zinc finger RNA binding protein -0.0253893
TMSB4X thymosin beta 4, X-linked -0.0252009
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0250084
PTPRR protein tyrosine phosphatase, receptor type, R -0.0247438
RPL13A ribosomal protein L13a -0.0247312
AKAP12 A kinase (PRKA) anchor protein 12 -0.0247163
ESYT2 extended synaptotagmin-like protein 2 -0.0246715
NPC1 Niemann-Pick disease, type C1 -0.0246588
KDM5B lysine (K)-specific demethylase 5B -0.0246413
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0242714
RPL36 ribosomal protein L36 -0.0242695
BLZF1 basic leucine zipper nuclear factor 1 -0.0241518
ZBTB20 zinc finger and BTB domain containing 20 -0.0239658
PHF21A PHD finger protein 21A -0.0239511
TBC1D22A TBC1 domain family, member 22A -0.0237979
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.023753
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0235243
RAD51B RAD51 paralog B -0.0234614
MECOM MDS1 and EVI1 complex locus -0.0234124
WDR45B WD repeat domain 45B -0.0234054
LRMDA leucine rich melanocyte differentiation associated -0.0231437
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0229708
ATG7 autophagy related 7 -0.0229338
RSF1 remodeling and spacing factor 1 -0.0227277
RPS19 ribosomal protein S19 -0.0224687
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0222652