Lenalidomide (hemihydrate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

110 genes differentially expressed following the Lenalidomide (hemihydrate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.362441
AKAP12 A kinase (PRKA) anchor protein 12 0.238958
GPC6 glypican 6 0.18948
EFNA5 ephrin-A5 0.178976
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.14404
NLGN1 neuroligin 1 0.138104
ASPH aspartate beta-hydroxylase 0.132236
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.110742
USP34 ubiquitin specific peptidase 34 0.108309
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.104526
LMO7 LIM domain 7 0.0971987
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0960952
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.094782
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.094209
PDE4D phosphodiesterase 4D, cAMP-specific 0.0821691
NAMPT nicotinamide phosphoribosyltransferase 0.0791891
VMP1 vacuole membrane protein 1 0.0728013
SBF2 SET binding factor 2 0.0710608
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0691374
MAP1B microtubule-associated protein 1B 0.0684785
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0683497
FNIP1 folliculin interacting protein 1 0.0662055
IGF2 insulin-like growth factor 2 0.0648322
ENO1 enolase 1, (alpha) 0.0622279
FNDC3B fibronectin type III domain containing 3B 0.060878
IFI16 interferon, gamma-inducible protein 16 0.0598945
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0578286
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0565863
CD44 CD44 molecule (Indian blood group) 0.0545104
ATXN1 ataxin 1 0.0529491
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0517541
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0443847
ACTG1 actin gamma 1 0.034061
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0339189
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0330292
SLTM SAFB-like, transcription modulator 0.0324736
MYO1E myosin IE 0.0295191
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0276512
PKM pyruvate kinase, muscle 0.0254171
RPS6 ribosomal protein S6 0.0243333
PSD3 pleckstrin and Sec7 domain containing 3 0.0240912
EXT1 exostosin glycosyltransferase 1 0.0228616
NPAS2 neuronal PAS domain protein 2 0.0165749
RPL35A ribosomal protein L35a 0.0164177
FTL ferritin, light polypeptide 0.0163697
RPL34 ribosomal protein L34 0.0153426
ZSWIM6 zinc finger, SWIM-type containing 6 0.014458
NALF1 NALCN channel auxiliary factor 1 0.0142923
LDHA lactate dehydrogenase A 0.0135168
GOLGB1 golgin B1 0.0133424
DST dystonin 0.0116344
SLC38A2 solute carrier family 38, member 2 0.0104419
CDH13 cadherin 13 0.00846947
GOLGA4 golgin A4 0.00740066
RLF rearranged L-myc fusion 0.00292857
RPLP1 ribosomal protein, large, P1 0.00231293
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00213989
JMJD1C jumonji domain containing 1C 0.00206661
RPL23 ribosomal protein L23 7.76538E-4

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.15644
HMGA2 high mobility group AT-hook 2 -0.148907
CADM2 cell adhesion molecule 2 -0.14657
PEG10 paternally expressed 10 -0.13515
PTMA prothymosin, alpha -0.12563
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.124344
ATP11A ATPase, class VI, type 11A -0.120645
TPM4 tropomyosin 4 -0.119319
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.117801
CXCL8 chemokine (C-X-C motif) ligand 8 -0.114953
ARRDC3 arrestin domain containing 3 -0.101785
TRIO trio Rho guanine nucleotide exchange factor -0.0977225
TPT1 tumor protein, translationally-controlled 1 -0.0951766
ANKRD17 ankyrin repeat domain 17 -0.087236
ANXA2 annexin A2 -0.0812469
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0794672
NDRG1 N-myc downstream regulated 1 -0.0761262
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.074679
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.065587
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0648786
RPS12 ribosomal protein S12 -0.0643752
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0636166
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0604227
EIF1 eukaryotic translation initiation factor 1 -0.0603411
RPL19 ribosomal protein L19 -0.0601921
KTN1 kinectin 1 (kinesin receptor) -0.0584946
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0580795
MT2A metallothionein 2A -0.0535865
RPS8 ribosomal protein S8 -0.0515202
RPS3 ribosomal protein S3 -0.0508801
RPS21 ribosomal protein S21 -0.0507319
EGFR epidermal growth factor receptor -0.0489202
RPS27A ribosomal protein S27a -0.0422657
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.041402
TMSB10 thymosin beta 10 -0.0407799
STC1 stanniocalcin 1 -0.0380467
POTEF POTE ankyrin domain family, member F -0.0322629
IGFBP3 insulin-like growth factor binding protein 3 -0.0313706
RPL26 ribosomal protein L26 -0.0309838
ZBTB20 zinc finger and BTB domain containing 20 -0.0261762
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0240373
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0236858
PTK2 protein tyrosine kinase 2 -0.0230683
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0227944
VCL vinculin -0.0218848
RPLP2 ribosomal protein, large, P2 -0.0195498
ELL2 elongation factor, RNA polymerase II, 2 -0.016962
RPS16 ribosomal protein S16 -0.0164952
PGK1 phosphoglycerate kinase 1 -0.0164878
VIM vimentin -0.0130388
MYO6 myosin VI -0.00999768