Lenalidomide (hemihydrate)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.117048
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0924672
RIMKLB ribosomal modification protein rimK-like family member B 0.0844312
RPS6 ribosomal protein S6 0.0816843
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0731766
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0677155
DUSP5 dual specificity phosphatase 5 0.0670904
EIF1 eukaryotic translation initiation factor 1 0.0653929
NRIP1 nuclear receptor interacting protein 1 0.0620352
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0613042
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0585167
RPS8 ribosomal protein S8 0.057231
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0521759
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0513898
KTN1 kinectin 1 (kinesin receptor) 0.0512454
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.049659
SLC38A2 solute carrier family 38, member 2 0.0496587
MYO1E myosin IE 0.049292
OXSR1 oxidative stress responsive 1 0.0481972
PCBP2 poly(rC) binding protein 2 0.0461965
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0455725
BCAR3 breast cancer anti-estrogen resistance 3 0.0451351
SMOC1 SPARC related modular calcium binding 1 0.0450992
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0442574
ESYT2 extended synaptotagmin-like protein 2 0.0438971
UBE2H ubiquitin-conjugating enzyme E2H 0.0435025
SOX9 SRY (sex determining region Y)-box 9 0.0430134
WWC1 WW and C2 domain containing 1 0.0425048
AREG amphiregulin 0.041944
ZBTB38 zinc finger and BTB domain containing 38 0.0401879
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0401712
ZSWIM6 zinc finger, SWIM-type containing 6 0.0398142
LATS2 large tumor suppressor kinase 2 0.0381014
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0375401
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0374398
TXNIP thioredoxin interacting protein 0.0371273
PCLO piccolo presynaptic cytomatrix protein 0.0370902
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0370764
FOXO1 forkhead box O1 0.0367481
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0354009
EIF4A2 eukaryotic translation initiation factor 4A2 0.0352943
EPS8 epidermal growth factor receptor pathway substrate 8 0.0351179
ARRDC3 arrestin domain containing 3 0.0346269
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0339502
RPL37A ribosomal protein L37a 0.0336452
B2M beta-2-microglobulin 0.0327926
SKAP2 src kinase associated phosphoprotein 2 0.0324502
HMGA1 high mobility group AT-hook 1 0.0324272
RPL30 ribosomal protein L30 0.0317679
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0315868
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.031415
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0313563
MBNL2 muscleblind-like splicing regulator 2 0.0312355
TC2N tandem C2 domains, nuclear 0.0310737
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.030959
RPS13 ribosomal protein S13 0.0309589
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0309064
IL1RAP interleukin 1 receptor accessory protein 0.0305698
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0299556
REEP3 receptor accessory protein 3 0.0292934
UGCG UDP-glucose ceramide glucosyltransferase 0.0291605
MED13 mediator complex subunit 13 0.0290553
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0290159
ZNF148 zinc finger protein 148 0.0287494
SNX9 sorting nexin 9 0.0282448
RPS12 ribosomal protein S12 0.0280676
TMF1 TATA element modulatory factor 1 0.0275
RPS29 ribosomal protein S29 0.0273027
SET SET nuclear proto-oncogene 0.0271982
RPLP0 ribosomal protein, large, P0 0.0269921
SIK3 SIK family kinase 3 0.0269361
RPS25 ribosomal protein S25 0.0269024
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0266227
KLF6 Kruppel-like factor 6 0.0264817
EFNA5 ephrin-A5 0.0260646
RPS10 ribosomal protein S10 0.0258449
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0258133
NIPBL Nipped-B homolog (Drosophila) 0.0257203
ZC3H12C zinc finger CCCH-type containing 12C 0.0256378
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0255949
ZCCHC7 zinc finger, CCHC domain containing 7 0.0253679
NPC1 Niemann-Pick disease, type C1 0.0253197
SMYD3 SET and MYND domain containing 3 0.0248411
WNK1 WNK lysine deficient protein kinase 1 0.0245669
BZW1 basic leucine zipper and W2 domains 1 0.0244701
KLF12 Kruppel-like factor 12 0.0243205
BPTF bromodomain PHD finger transcription factor 0.0242466
ANKRD12 ankyrin repeat domain 12 0.0241652
UBC ubiquitin C 0.0241594
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0240868
PLAUR plasminogen activator, urokinase receptor 0.0239767
CDCP1 CUB domain containing protein 1 0.0237697
DOCK5 dedicator of cytokinesis 5 0.0237091
RBM47 RNA binding motif protein 47 0.0236081
FOXO3 forkhead box O3 0.023407
UBL3 ubiquitin-like 3 0.0233427
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0231482
RPL31 ribosomal protein L31 0.0231283
USP9X ubiquitin specific peptidase 9, X-linked 0.0231183
RICTOR RPTOR independent companion of MTOR, complex 2 0.0229843

decreased expression

Symbol Name Standardized Value
LAMA4 laminin, alpha 4 -0.135065
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.132069
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.128606
PTMA prothymosin, alpha -0.105651
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.103689
FN1 fibronectin 1 -0.100818
ANXA2 annexin A2 -0.0941316
MAML2 mastermind-like 2 (Drosophila) -0.0869303
ASPH aspartate beta-hydroxylase -0.0782366
RNF213 ring finger protein 213 -0.0716638
EMP1 epithelial membrane protein 1 -0.0713209
DSG2 desmoglein 2 -0.0710647
MUC16 mucin 16, cell surface associated -0.0677495
TMSB10 thymosin beta 10 -0.0674563
IGFBP3 insulin-like growth factor binding protein 3 -0.0667106
AHNAK AHNAK nucleoprotein -0.0664629
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0653124
VCL vinculin -0.064582
PDLIM5 PDZ and LIM domain 5 -0.0612192
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0584872
EZR ezrin -0.0582574
ANLN anillin, actin binding protein -0.0566014
LAMC2 laminin, gamma 2 -0.0558403
ZBTB20 zinc finger and BTB domain containing 20 -0.052761
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0526231
ACTN4 actinin, alpha 4 -0.0508759
C3 complement component 3 -0.0456454
ANXA1 annexin A1 -0.0455764
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0454627
EGR1 early growth response 1 -0.0444331
TM4SF1 transmembrane 4 L six family member 1 -0.0443253
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0440561
TMSB4X thymosin beta 4, X-linked -0.043807
VMP1 vacuole membrane protein 1 -0.0432414
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0420507
KRT17 keratin 17, type I -0.0414325
CAV1 caveolin 1, caveolae protein, 22kDa -0.0410953
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.04081
NF1 neurofibromin 1 -0.040739
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0390552
C6ORF132 chromosome 6 open reading frame 132 -0.0387086
SULF2 sulfatase 2 -0.0387064
PLAU plasminogen activator, urokinase -0.0382682
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0379449
MKI67 marker of proliferation Ki-67 -0.0378444
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.0364792
KIAA1671 KIAA1671 -0.0364643
DAPK1 death-associated protein kinase 1 -0.0363816
MELTF melanotransferrin -0.0352992
SAMD4A sterile alpha motif domain containing 4A -0.0346962
RALY RALY heterogeneous nuclear ribonucleoprotein -0.034546
HLA-C major histocompatibility complex, class I, C -0.0344725
DOCK9 dedicator of cytokinesis 9 -0.0342949
CD2AP CD2-associated protein -0.0342923
MECOM MDS1 and EVI1 complex locus -0.0342623
EHF ets homologous factor -0.0339672
FTH1 ferritin, heavy polypeptide 1 -0.0337743
F3 coagulation factor III (thromboplastin, tissue factor) -0.0332188
H1-0 H1.0 linker histone -0.0331061
RAD51B RAD51 paralog B -0.032961
RIGI RNA sensor RIG-I -0.0325896
HMGA2 high mobility group AT-hook 2 -0.0322425
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0316244
SGMS2 sphingomyelin synthase 2 -0.0314679
WFDC2 WAP four-disulfide core domain 2 -0.0309763
RYBP RING1 and YY1 binding protein -0.0309235
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0305652
ARHGAP18 Rho GTPase activating protein 18 -0.0302659
DIAPH3 diaphanous-related formin 3 -0.0301867
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0300179
AHNAK2 AHNAK nucleoprotein 2 -0.0296866
ITGB4 integrin, beta 4 -0.0296419
ANKRD10 ankyrin repeat domain 10 -0.0296159
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0294714
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0293794
SORBS2 sorbin and SH3 domain containing 2 -0.0291918
ZNF217 zinc finger protein 217 -0.029147
RAB1A RAB1A, member RAS oncogene family -0.029104
PLEC plectin -0.0287869
NCOA7 nuclear receptor coactivator 7 -0.0285687
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0282754
BLZF1 basic leucine zipper nuclear factor 1 -0.0279749
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0277456
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0276448
HLA-B major histocompatibility complex, class I, B -0.0276234
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0276177
TCF12 transcription factor 12 -0.0275578
LPP LIM domain containing preferred translocation partner in lipoma -0.0274348
ARHGAP32 Rho GTPase activating protein 32 -0.027413
MYO18A myosin XVIIIA -0.0273059
SYT14 synaptotagmin XIV -0.0266812
MX1 MX dynamin-like GTPase 1 -0.026675
LAMA5 laminin, alpha 5 -0.0266158
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0265748
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.026474
SAV1 salvador family WW domain containing protein 1 -0.0264086
KRT8 keratin 8, type II -0.0264024
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0262322
TNS3 tensin 3 -0.0257686
PHF3 PHD finger protein 3 -0.0257296