Lenalidomide (hemihydrate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ADAM10 ADAM metallopeptidase domain 10 0.0527182
ARL4C ADP-ribosylation factor-like 4C 0.0491372
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0434518
PRELID2 PRELI domain containing 2 0.0396529
PGK1 phosphoglycerate kinase 1 0.0391286
MACROD2 MACRO domain containing 2 0.0344054
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0342989
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0341148
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0336987
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0323249
ESYT2 extended synaptotagmin-like protein 2 0.0314398
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0307821
TPM4 tropomyosin 4 0.0303419
APLP2 amyloid beta (A4) precursor-like protein 2 0.0301158
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0291924
NAMPT nicotinamide phosphoribosyltransferase 0.0278623
PKM pyruvate kinase, muscle 0.0263208
NAV2 neuron navigator 2 0.0255008
RSF1 remodeling and spacing factor 1 0.0243094
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0242219
FAT1 FAT atypical cadherin 1 0.024149
TXNIP thioredoxin interacting protein 0.0236163
SEPTIN7 septin 7 0.023413
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.0231385
NIPBL Nipped-B homolog (Drosophila) 0.022818
MATR3 matrin 3 0.0224639
FN1 fibronectin 1 0.0221353
USP34 ubiquitin specific peptidase 34 0.0216142
EZR ezrin 0.0214332
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0212602
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0212554
MACF1 microtubule-actin crosslinking factor 1 0.0211311
ATXN1 ataxin 1 0.0211267
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0207852
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0206237
ZNF638 zinc finger protein 638 0.020522
PPME1 protein phosphatase methylesterase 1 0.0204656
KIF5B kinesin family member 5B 0.0200991
UBA6 ubiquitin-like modifier activating enzyme 6 0.0200676
RPLP1 ribosomal protein, large, P1 0.0197631
KDM6A lysine (K)-specific demethylase 6A 0.0197218
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0196055
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0191832
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0191587
TLK1 tousled-like kinase 1 0.0191125
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0187626
RBM25 RNA binding motif protein 25 0.0183114
ANKRD36C ankyrin repeat domain 36C 0.0183059
STRN3 striatin, calmodulin binding protein 3 0.0183016
RLF rearranged L-myc fusion 0.0181414
RNF145 ring finger protein 145 0.0179116
AKAP12 A kinase (PRKA) anchor protein 12 0.0177626
RRM2 ribonucleotide reductase M2 0.0173701
ENO1 enolase 1, (alpha) 0.0173537
BARD1 BRCA1 associated RING domain 1 0.0172547
ANKRD12 ankyrin repeat domain 12 0.0172455
ATAD2 ATPase family, AAA domain containing 2 0.0171932
IGF2 insulin-like growth factor 2 0.0169905
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0168791
RPS12 ribosomal protein S12 0.0168468
CCDC88A coiled-coil domain containing 88A 0.016751
WSB1 WD repeat and SOCS box containing 1 0.0166969
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0166006
MXI1 MAX interactor 1, dimerization protein 0.0165433
WDFY1 WD repeat and FYVE domain containing 1 0.0165137
AFDN afadin, adherens junction formation factor 0.0163633
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0163549
CEP152 centrosomal protein 152kDa 0.0162024
STAG2 stromal antigen 2 0.0161903
SMC4 structural maintenance of chromosomes 4 0.0161777
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 0.0160306
ARHGAP5 Rho GTPase activating protein 5 0.016013
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0159654
NUMB numb homolog (Drosophila) 0.0159202
KDM3A lysine (K)-specific demethylase 3A 0.0158598
HDGFL3 HDGF like 3 0.0157886
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0157536
MORC3 MORC family CW-type zinc finger 3 0.0156247
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0155748
XPO1 exportin 1 0.0154987
RPL7 ribosomal protein L7 0.0154942
HELLS helicase, lymphoid-specific 0.0154673
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0154392
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0153711
GPC6 glypican 6 0.0153627
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.0153328
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0152238
HOOK2 hook microtubule-tethering protein 2 0.0151894
ANKRD36 ankyrin repeat domain 36 0.0151885
TENT4A terminal nucleotidyltransferase 4A 0.0151649
PTCH1 patched 1 0.0150888
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0150224
UBXN4 UBX domain protein 4 0.0150177
SET SET nuclear proto-oncogene 0.0150097
CAMTA1 calmodulin binding transcription activator 1 0.0150063
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.014946
KDM3B lysine (K)-specific demethylase 3B 0.0149103
FBLN2 fibulin 2 0.0148931
MYO1E myosin IE 0.0146978
HSPA4L heat shock 70kDa protein 4-like 0.0145283

decreased expression

Symbol Name Standardized Value
CPED1 cadherin-like and PC-esterase domain containing 1 -0.143678
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.112525
PDE4B phosphodiesterase 4B, cAMP-specific -0.0992003
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0929047
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0894944
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0872165
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0771998
EGFR epidermal growth factor receptor -0.0753508
NBEA neurobeachin -0.070089
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0672134
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0598031
ANKRD11 ankyrin repeat domain 11 -0.0590182
TJP1 tight junction protein 1 -0.0586493
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0558494
EFNA5 ephrin-A5 -0.0557716
VCL vinculin -0.0553887
PDE4D phosphodiesterase 4D, cAMP-specific -0.0543368
FOXP1 forkhead box P1 -0.0522837
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0522043
GOLGA4 golgin A4 -0.0505332
SLC38A2 solute carrier family 38, member 2 -0.0494764
IARS1 isoleucyl-tRNA synthetase 1 -0.0483459
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0465363
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0461337
PTMA prothymosin, alpha -0.0460766
DLG1 discs, large homolog 1 (Drosophila) -0.0457316
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0455031
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0454714
TTC3 tetratricopeptide repeat domain 3 -0.044109
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0438401
ZFAND3 zinc finger, AN1-type domain 3 -0.0437425
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0424776
VMP1 vacuole membrane protein 1 -0.0409172
DOCK3 dedicator of cytokinesis 3 -0.0406282
SSBP2 single-stranded DNA binding protein 2 -0.0386981
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0384872
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0384592
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0368623
SEC31A SEC31 homolog A (S. cerevisiae) -0.0368164
MBNL1 muscleblind-like splicing regulator 1 -0.0360855
NT5C2 5'-nucleotidase, cytosolic II -0.0359668
CLIC4 chloride intracellular channel 4 -0.035334
ZBTB20 zinc finger and BTB domain containing 20 -0.0352434
TXNRD1 thioredoxin reductase 1 -0.0351752
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0351526
HDLBP high density lipoprotein binding protein -0.0346763
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0344694
CDK13 cyclin-dependent kinase 13 -0.0343046
ZMYND8 zinc finger, MYND-type containing 8 -0.0340566
ZNF438 zinc finger protein 438 -0.034039
LDHA lactate dehydrogenase A -0.0340383
NCEH1 neutral cholesterol ester hydrolase 1 -0.0339431
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0334841
FLNB filamin B, beta -0.0333999
AK1 adenylate kinase 1 -0.0331342
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0328482
PDE7B phosphodiesterase 7B -0.0328052
MSI2 musashi RNA-binding protein 2 -0.0326982
TPT1 tumor protein, translationally-controlled 1 -0.0324003
ANK2 ankyrin 2, neuronal -0.0320808
TTC17 tetratricopeptide repeat domain 17 -0.0316679
CTIF CBP80/20-dependent translation initiation factor -0.0312814
SAMD4A sterile alpha motif domain containing 4A -0.030566
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0305147
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0302757
ANKRD17 ankyrin repeat domain 17 -0.0301701
TBC1D22A TBC1 domain family, member 22A -0.0299931
GARS1 glycyl-tRNA synthetase 1 -0.0298345
EEF2 eukaryotic translation elongation factor 2 -0.0294153
EIF1 eukaryotic translation initiation factor 1 -0.0290518
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0289563
ENO2 enolase 2 (gamma, neuronal) -0.0283647
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0283463
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0283118
CLIP1 CAP-GLY domain containing linker protein 1 -0.0282828
GDI2 GDP dissociation inhibitor 2 -0.0278965
AHI1 Abelson helper integration site 1 -0.0277049
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0274142
ETNK1 ethanolamine kinase 1 -0.0270912
ACTN4 actinin, alpha 4 -0.0269263
PDGFC platelet derived growth factor C -0.026819
PLXNA1 plexin A1 -0.0267296
RPL26 ribosomal protein L26 -0.0265191
KLF3 Kruppel-like factor 3 (basic) -0.0263272
GPHN gephyrin -0.0262241
MLIP muscular LMNA-interacting protein -0.0262142
PICALM phosphatidylinositol binding clathrin assembly protein -0.0260684
RPL13A ribosomal protein L13a -0.0260203
MBNL2 muscleblind-like splicing regulator 2 -0.0259768
PHF3 PHD finger protein 3 -0.025855
LPP LIM domain containing preferred translocation partner in lipoma -0.025817
PARD3 par-3 family cell polarity regulator -0.0257929
ASXL1 additional sex combs like transcriptional regulator 1 -0.0255891
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0253288
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0252138
PTPRG protein tyrosine phosphatase, receptor type, G -0.0251589
SENP6 SUMO1/sentrin specific peptidase 6 -0.0250504
HM13 histocompatibility (minor) 13 -0.0249097
TTC28 tetratricopeptide repeat domain 28 -0.0246795
DOCK1 dedicator of cytokinesis 1 -0.0245472