Lenalidomide (hemihydrate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lenalidomide (hemihydrate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lenalidomide (hemihydrate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ATXN1 ataxin 1 0.0675214
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0667638
PKM pyruvate kinase, muscle 0.066276
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0528223
ZSWIM6 zinc finger, SWIM-type containing 6 0.0521875
SLC38A2 solute carrier family 38, member 2 0.051484
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0488935
FNDC3A fibronectin type III domain containing 3A 0.0438407
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0427005
NABP1 nucleic acid binding protein 1 0.0402002
AREG amphiregulin 0.0377861
ATM ATM serine/threonine kinase 0.036663
SAMD4A sterile alpha motif domain containing 4A 0.0363337
WSB1 WD repeat and SOCS box containing 1 0.0359087
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0344346
ASPH aspartate beta-hydroxylase 0.0341587
CD44 CD44 molecule (Indian blood group) 0.0338468
BIRC3 baculoviral IAP repeat containing 3 0.0332588
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0323598
N4BP2L2 NEDD4 binding protein 2-like 2 0.0322373
CLIP1 CAP-GLY domain containing linker protein 1 0.0314082
ERRFI1 ERBB receptor feedback inhibitor 1 0.031081
IGF2 insulin-like growth factor 2 0.0307642
NCEH1 neutral cholesterol ester hydrolase 1 0.0306642
RIGI RNA sensor RIG-I 0.0304028
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0297482
C6ORF62 chromosome 6 open reading frame 62 0.0294796
DNER delta/notch-like EGF repeat containing 0.029076
PDE4D phosphodiesterase 4D, cAMP-specific 0.0289352
CDCP1 CUB domain containing protein 1 0.0285516
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.0282644
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.0278607
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0278374
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0278048
PBX3 pre-B-cell leukemia homeobox 3 0.0275814
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0275379
NLN neurolysin (metallopeptidase M3 family) 0.0271572
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0270072
WWC2 WW and C2 domain containing 2 0.0268375
KDM5A lysine (K)-specific demethylase 5A 0.0263434
ANO6 anoctamin 6 0.025782
BCAR3 breast cancer anti-estrogen resistance 3 0.0255755
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0255515
TOR1AIP2 torsin A interacting protein 2 0.0254279
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0247689
UBE2H ubiquitin-conjugating enzyme E2H 0.0247472
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0244573
FLNB filamin B, beta 0.0243891
GPC5 glypican 5 0.0243404
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0241875
ENO2 enolase 2 (gamma, neuronal) 0.0241428
NSRP1 nuclear speckle splicing regulatory protein 1 0.02399
MCL1 myeloid cell leukemia 1 0.0239772
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.0236301
ZFAND3 zinc finger, AN1-type domain 3 0.0235718
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0233592
SON SON DNA binding protein 0.0233065
VEGFC vascular endothelial growth factor C 0.023209
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0230805
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0229722
CEMIP2 cell migration inducing hyaluronidase 2 0.0227533
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0227239
DYM dymeclin 0.0222796
GLS2 glutaminase 2 (liver, mitochondrial) 0.0222418
MYO9B myosin IXB 0.0219586
USO1 USO1 vesicle transport factor 0.0218759
CAMKMT calmodulin-lysine N-methyltransferase 0.021345
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0212861
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0212427
MED13 mediator complex subunit 13 0.0209956
HLA-B major histocompatibility complex, class I, B 0.02084
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0208122
EXT1 exostosin glycosyltransferase 1 0.020735
OXSR1 oxidative stress responsive 1 0.020629
CELF1 CUGBP, Elav-like family member 1 0.0205594
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 0.0203878
EGFR epidermal growth factor receptor 0.0202973
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0199134
GPATCH2L G patch domain containing 2-like 0.0198323
HDAC9 histone deacetylase 9 0.0197848
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.019707
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0193269
PCLO piccolo presynaptic cytomatrix protein 0.0193234
SMAD3 SMAD family member 3 0.0191109
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0190493
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0189699
INTS6 integrator complex subunit 6 0.0189645
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0189195
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0188981
TAS2R14 taste receptor, type 2, member 14 0.0188918
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0188498
USP25 ubiquitin specific peptidase 25 0.0187808
PANK3 pantothenate kinase 3 0.0187329
TXNIP thioredoxin interacting protein 0.0186597
AATF apoptosis antagonizing transcription factor 0.01862
CD59 CD59 molecule, complement regulatory protein 0.018472
SNX13 sorting nexin 13 0.018458
MTREX Mtr4 exosome RNA helicase 0.0184516
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0184468
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0184398

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.15233
VIM vimentin -0.105532
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0906333
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0876606
NCOR1 nuclear receptor corepressor 1 -0.0665802
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0621206
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0539471
DST dystonin -0.0519968
WAC WW domain containing adaptor with coiled-coil -0.0498863
LDHA lactate dehydrogenase A -0.0476534
PARD3 par-3 family cell polarity regulator -0.0467437
HILPDA hypoxia inducible lipid droplet-associated -0.0452934
ANXA2 annexin A2 -0.0429827
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0426927
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0424282
RBM39 RNA binding motif protein 39 -0.0423778
SPAG9 sperm associated antigen 9 -0.0418651
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0413698
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0410542
SEPTIN7 septin 7 -0.0410064
GNAS GNAS complex locus -0.0406519
FUS FUS RNA binding protein -0.0404443
PTMA prothymosin, alpha -0.0394385
PTK2 protein tyrosine kinase 2 -0.039246
GOLGA4 golgin A4 -0.0385847
ZC3H13 zinc finger CCCH-type containing 13 -0.0384703
CANX calnexin -0.0370997
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0368346
RSF1 remodeling and spacing factor 1 -0.0353378
BIRC6 baculoviral IAP repeat containing 6 -0.0352563
ERBIN erbb2 interacting protein -0.0352066
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0342833
CALU calumenin -0.0340727
AHNAK AHNAK nucleoprotein -0.0337931
SQSTM1 sequestosome 1 -0.032139
LCORL ligand dependent nuclear receptor corepressor-like -0.0320857
ANXA1 annexin A1 -0.0319517
MAP1B microtubule-associated protein 1B -0.0318824
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0317998
TCF12 transcription factor 12 -0.0307217
EEF2 eukaryotic translation elongation factor 2 -0.0295627
BSG basigin (Ok blood group) -0.0295606
ZNF609 zinc finger protein 609 -0.02926
UBXN7 UBX domain protein 7 -0.0291183
GPC6 glypican 6 -0.02908
ADAM17 ADAM metallopeptidase domain 17 -0.0290494
RRBP1 ribosome binding protein 1 -0.0288521
HELZ helicase with zinc finger -0.0286083
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0285936
RACK1 receptor for activated C kinase 1 -0.0285435
TPT1 tumor protein, translationally-controlled 1 -0.0282029
TRIO trio Rho guanine nucleotide exchange factor -0.02819
NSD2 nuclear receptor binding SET domain protein 2 -0.0281833
PAIP2 poly(A) binding protein interacting protein 2 -0.027849
RPLP1 ribosomal protein, large, P1 -0.0275911
ASXL1 additional sex combs like transcriptional regulator 1 -0.0275907
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0275547
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0275123
ANKHD1 ankyrin repeat and KH domain containing 1 -0.027474
TRIM44 tripartite motif containing 44 -0.0274504
NAV3 neuron navigator 3 -0.0274111
R3HDM1 R3H domain containing 1 -0.0269545
ETNK1 ethanolamine kinase 1 -0.026913
KIF5B kinesin family member 5B -0.0264702
COG6 component of oligomeric golgi complex 6 -0.0264611
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0263483
RPL12 ribosomal protein L12 -0.0263011
RBM26 RNA binding motif protein 26 -0.0255211
ZNF292 zinc finger protein 292 -0.025432
THSD4 thrombospondin, type I, domain containing 4 -0.0249759
FMNL2 formin-like 2 -0.0248887
EXOC4 exocyst complex component 4 -0.0247809
OGA O-GlcNAcase -0.0247477
DIAPH3 diaphanous-related formin 3 -0.0247322
EIF1 eukaryotic translation initiation factor 1 -0.0247044
PRSS23 protease, serine, 23 -0.0244174
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0243547
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0242007
CAVIN1 caveolae associated protein 1 -0.0240624
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0240434
FTH1 ferritin, heavy polypeptide 1 -0.0237616
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0236653
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0235253
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0234595
SEPTIN10 septin 10 -0.0233112
ZBTB20 zinc finger and BTB domain containing 20 -0.0232682
VDAC1 voltage-dependent anion channel 1 -0.0232302
H3-3B H3.3 histone B -0.0232224
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0229903
SYNJ2 synaptojanin 2 -0.0229678
RAB2A RAB2A, member RAS oncogene family -0.022916
ZBTB10 zinc finger and BTB domain containing 10 -0.022875
HMGB1 high mobility group box 1 -0.0228038
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0227751
KMT2A lysine (K)-specific methyltransferase 2A -0.0226544
TPD52 tumor protein D52 -0.0226512
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0226036
PIAS1 protein inhibitor of activated STAT, 1 -0.022534
DERA deoxyribose-phosphate aldolase (putative) -0.0224368
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0224294